AR017979A1 - Formulaciones farmaceuticas de epotilonas, metodo para su preparacion y el uso de los mismos para la manufactura de un medicamento - Google Patents

Formulaciones farmaceuticas de epotilonas, metodo para su preparacion y el uso de los mismos para la manufactura de un medicamento

Info

Publication number
AR017979A1
AR017979A1 ARP990100446A ARP990100446A AR017979A1 AR 017979 A1 AR017979 A1 AR 017979A1 AR P990100446 A ARP990100446 A AR P990100446A AR P990100446 A ARP990100446 A AR P990100446A AR 017979 A1 AR017979 A1 AR 017979A1
Authority
AR
Argentina
Prior art keywords
manufacture
preparation
pharmaceutical formulations
epotilones
same
Prior art date
Application number
ARP990100446A
Other languages
English (en)
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26313062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR017979(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9802451.6A external-priority patent/GB9802451D0/en
Priority claimed from GBGB9813646.8A external-priority patent/GB9813646D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR017979A1 publication Critical patent/AR017979A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ARP990100446A 1998-02-05 1999-02-03 Formulaciones farmaceuticas de epotilonas, metodo para su preparacion y el uso de los mismos para la manufactura de un medicamento AR017979A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9802451.6A GB9802451D0 (en) 1998-02-05 1998-02-05 Organic compounds
GBGB9813646.8A GB9813646D0 (en) 1998-06-24 1998-06-24 Organic compounds

Publications (1)

Publication Number Publication Date
AR017979A1 true AR017979A1 (es) 2001-10-24

Family

ID=26313062

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100446A AR017979A1 (es) 1998-02-05 1999-02-03 Formulaciones farmaceuticas de epotilonas, metodo para su preparacion y el uso de los mismos para la manufactura de un medicamento

Country Status (36)

Country Link
US (5) US20030203876A1 (enExample)
EP (1) EP1052974B1 (enExample)
JP (2) JP4644364B2 (enExample)
KR (3) KR20060002022A (enExample)
CN (2) CN100396276C (enExample)
AR (1) AR017979A1 (enExample)
AT (1) ATE431733T1 (enExample)
AU (1) AU753519B2 (enExample)
BE (1) BE1012140A3 (enExample)
BR (1) BR9907647B1 (enExample)
CA (1) CA2320182C (enExample)
CL (1) CL2003002786A1 (enExample)
CO (1) CO4920246A1 (enExample)
CY (1) CY1109311T1 (enExample)
CZ (1) CZ303168B6 (enExample)
DE (1) DE69940904D1 (enExample)
DK (1) DK1052974T3 (enExample)
ES (1) ES2324378T3 (enExample)
FR (1) FR2774909B1 (enExample)
HU (1) HUP0101564A3 (enExample)
ID (1) ID26549A (enExample)
IL (2) IL137550A0 (enExample)
IT (1) IT1313549B1 (enExample)
MX (1) MXPA00007681A (enExample)
MY (1) MY125921A (enExample)
NO (2) NO329376B1 (enExample)
NZ (1) NZ506389A (enExample)
PE (1) PE20000272A1 (enExample)
PL (1) PL201329B1 (enExample)
PT (1) PT1052974E (enExample)
RU (1) RU2214246C2 (enExample)
SI (1) SI1052974T1 (enExample)
SK (2) SK287775B6 (enExample)
TR (1) TR200002299T2 (enExample)
TW (1) TW457095B (enExample)
WO (1) WO1999039694A2 (enExample)

Families Citing this family (54)

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EP1440973A3 (de) 1995-11-17 2004-10-20 Gesellschaft für biotechnologische Forschung mbH (GBF) Epothilonderivate, Herstellung und Mittel
PL193229B1 (pl) 1996-11-18 2007-01-31 F Biotechnologische Forschung Epotylon C, epotylon D, epotylon E i epotylon F, sposób biotransformacji epotylonu A, sposób biotransformacji epotylonu B oraz środek leczniczy
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP0977563B1 (en) 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
GB9802451D0 (en) * 1998-02-05 1998-04-01 Ciba Geigy Ag Organic compounds
FR2775187B1 (fr) * 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US6380395B1 (en) 1998-04-21 2002-04-30 Bristol-Myers Squibb Company 12, 13-cyclopropane epothilone derivatives
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US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
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UA75365C2 (en) * 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
EE05301B1 (et) 2001-01-25 2010-06-15 Bristol-Myers Squibb Company Meetod epotilooni analooge sisaldavate ravimvormide valmistamiseks ning nende kasutamine ravimi valmistamiseks
RU2003126171A (ru) 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
NZ526871A (en) * 2001-01-25 2006-01-27 Bristol Myers Squibb Co Pharmaceutical dosage forms of epothilones for oral administration
IL156578A0 (en) * 2001-01-25 2004-01-04 Bristol Myers Squibb Co A method for formulating an epothilone analog for pharmaceutical use and pharmaceutical preparations including an epothilone analog
US6893859B2 (en) 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
EP1368030A1 (en) 2001-02-20 2003-12-10 Bristol-Myers Squibb Company Epothilone derivatives for the treatment of refractory tumors
EE200300396A (et) 2001-02-20 2003-12-15 Bristol-Myers Squibb Company Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks
WO2002072085A1 (en) 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
DE60229922D1 (de) * 2001-03-19 2009-01-02 Novartis Ag Kombinationen, ein antidiarrhoikum und epothilon oder ein epothilonderivat enthaltend
WO2002098868A1 (en) 2001-06-01 2002-12-12 Bristol-Myers Squibb Company Epothilone derivatives
AU2008203233B2 (en) * 2001-07-19 2010-04-29 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
NZ533940A (en) 2002-01-14 2007-06-29 Novartis Ag Combinations comprising epothilones and anti-metabolites
US7211593B2 (en) 2002-03-12 2007-05-01 Bristol-Myers Squibb Co. C12-cyano epothilone derivatives
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BR0311714A (pt) * 2002-06-10 2005-03-01 Novartis Ag Combinações que compreendem epotilonas e seus usos farmacêuticos
AU2003243561A1 (en) 2002-06-14 2003-12-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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JP2006504743A (ja) 2002-10-09 2006-02-09 コーザン バイオサイエンシス インコーポレイテッド 治療製剤
DE60310975T2 (de) * 2002-10-15 2007-07-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Verwendung von epothilone zur behandlung hyperparathyreoidismus
KR100996996B1 (ko) 2002-11-07 2010-11-25 코산 바이오사이언시즈, 인코포레이티드 트랜스-9,10-디히드로에포틸론 ｃ 및 ｄ, 그것의 유사체 및 그것의 제조 방법
BRPI0415428A (pt) * 2003-10-09 2006-12-05 Kosan Biosciences Inc formulações terapêuticas
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CN100409846C (zh) * 2005-11-22 2008-08-13 菏泽睿鹰制药集团有限公司 一种埃坡霉素b脂质体制剂及应用
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CN101642453B (zh) * 2009-09-15 2011-03-16 湖南迪诺制药有限公司 一种含有埃坡霉素b的药物制剂
GB201505347D0 (en) * 2015-03-27 2015-05-13 Salupont Consulting Ltd Sterilisation of s-nitrosothiols
MX2020007270A (es) * 2017-09-27 2020-08-17 Novartis Ag Formulacion parenteral que comprende siponimod.

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Also Published As

Publication number Publication date
PL201329B1 (pl) 2009-03-31
CL2003002786A1 (es) 2005-02-04
EP1052974A2 (en) 2000-11-22
PT1052974E (pt) 2009-08-07
WO1999039694A3 (en) 1999-09-23
NO329376B1 (no) 2010-10-04
CZ303168B6 (cs) 2012-05-09
SK287487B6 (sk) 2010-11-08
DE69940904D1 (de) 2009-07-02
ID26549A (id) 2001-01-18
BR9907647A (pt) 2000-11-14
SK287775B6 (sk) 2011-09-05
US20080221065A1 (en) 2008-09-11
ITMI990208A1 (it) 2000-08-04
JP2002502810A (ja) 2002-01-29
NO20003930L (no) 2000-10-04
MY125921A (en) 2006-08-30
CA2320182C (en) 2008-11-25
CN100396276C (zh) 2008-06-25
US20060127423A1 (en) 2006-06-15
CN1623543A (zh) 2005-06-08
EP1052974B1 (en) 2009-05-20
NZ506389A (en) 2003-07-25
AU753519B2 (en) 2002-10-17
US20030203876A1 (en) 2003-10-30
KR20010040534A (ko) 2001-05-15
WO1999039694A2 (en) 1999-08-12
BE1012140A3 (fr) 2000-05-02
ES2324378T3 (es) 2009-08-05
FR2774909B1 (fr) 2000-07-28
PE20000272A1 (es) 2000-04-17
HUP0101564A2 (hu) 2001-11-28
AU2722699A (en) 1999-08-23
IL137550A (en) 2010-06-30
TR200002299T2 (tr) 2000-11-21
CN1292683A (zh) 2001-04-25
RU2214246C2 (ru) 2003-10-20
KR20080016756A (ko) 2008-02-21
KR20060002022A (ko) 2006-01-06
PL342629A1 (en) 2001-06-18
CY1109311T1 (el) 2014-07-02
JP4644364B2 (ja) 2011-03-02
HK1033809A1 (en) 2001-09-28
TW457095B (en) 2001-10-01
FR2774909A1 (fr) 1999-08-20
MXPA00007681A (es) 2003-07-14
SI1052974T1 (sl) 2009-10-31
HUP0101564A3 (en) 2002-06-28
NO20003930D0 (no) 2000-08-03
US20070060627A1 (en) 2007-03-15
IT1313549B1 (it) 2002-09-09
NO20100302L (no) 2000-10-04
IL137550A0 (en) 2001-07-24
US20110124691A1 (en) 2011-05-26
CO4920246A1 (es) 2000-05-29
ATE431733T1 (de) 2009-06-15
CZ20002834A3 (cs) 2000-11-15
JP2010090147A (ja) 2010-04-22
BR9907647B1 (pt) 2014-04-01
CA2320182A1 (en) 1999-08-12
DK1052974T3 (da) 2009-08-10
KR100669174B1 (ko) 2007-01-17
SK11702000A3 (sk) 2001-01-18

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