AR013838A1 - Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos - Google Patents

Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Info

Publication number
AR013838A1
AR013838A1 ARP970104362A ARP970104362A AR013838A1 AR 013838 A1 AR013838 A1 AR 013838A1 AR P970104362 A ARP970104362 A AR P970104362A AR P970104362 A ARP970104362 A AR P970104362A AR 013838 A1 AR013838 A1 AR 013838A1
Authority
AR
Argentina
Prior art keywords
olanzapine
dihydrates
methyl
substantially pure
piperazinyl
Prior art date
Application number
ARP970104362A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR013838(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR013838A1 publication Critical patent/AR013838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP970104362A 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos AR013838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23

Publications (1)

Publication Number Publication Date
AR013838A1 true AR013838A1 (es) 2001-01-31

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104362A AR013838A1 (es) 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Country Status (35)

Country Link
US (1) US6020487A (en:Method)
EP (1) EP0831098B1 (en:Method)
JP (2) JP2001500877A (en:Method)
KR (1) KR100560015B1 (en:Method)
CN (1) CN1122036C (en:Method)
AR (1) AR013838A1 (en:Method)
AT (1) ATE209208T1 (en:Method)
AU (1) AU719441B2 (en:Method)
BR (1) BR9712100A (en:Method)
CA (1) CA2265712C (en:Method)
CO (1) CO4910140A1 (en:Method)
CZ (1) CZ299248B6 (en:Method)
DE (1) DE69708428T2 (en:Method)
DK (1) DK0831098T3 (en:Method)
EA (1) EA001642B1 (en:Method)
EG (1) EG23861A (en:Method)
ES (1) ES2166051T3 (en:Method)
HU (1) HU226484B1 (en:Method)
ID (1) ID27275A (en:Method)
IL (1) IL128962A (en:Method)
IN (1) IN187156B (en:Method)
MY (1) MY125565A (en:Method)
NO (1) NO323980B1 (en:Method)
NZ (1) NZ334448A (en:Method)
PE (1) PE110398A1 (en:Method)
PL (3) PL194565B1 (en:Method)
PT (1) PT831098E (en:Method)
RS (1) RS49598B (en:Method)
SI (1) SI0831098T1 (en:Method)
SV (1) SV1997000081A (en:Method)
TR (1) TR199900640T2 (en:Method)
TW (1) TW470746B (en:Method)
UA (1) UA59371C2 (en:Method)
WO (1) WO1998012199A1 (en:Method)
ZA (1) ZA978515B (en:Method)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001243475A1 (en) * 2000-08-31 2002-03-13 Dr. Reddy's Laboratories Ltd. Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
CA2464306A1 (en) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
CA2471341C (en) 2001-12-24 2012-01-24 Sun Pharmaceutical Industries Limited Crystalline form i of 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
WO2003101997A1 (en) 2002-05-31 2003-12-11 Geneva Pharmaceuticals, Inc. Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
WO2004058773A1 (en) * 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
EP1684734A2 (en) * 2003-11-18 2006-08-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
ES2308304T3 (es) * 2003-12-22 2008-12-01 Teva Pharmaceutical Industries Ltd. Procedimientos de preparacion de la olanzapina.
DE602005027308D1 (de) 2004-01-27 2011-05-19 Synthon Bv Stabile salze von olanzapin
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
ES2289974T1 (es) * 2004-07-14 2008-02-16 Shasun Chemicals And Drugs Limited Metodo mejorado para producir la forma i de la olanzapina.
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
WO2006027800A1 (en) * 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited A novel process for preparation of a pharmaceutically pure polymorphic form 1 of olanzapine
AU2005307797B2 (en) * 2004-11-16 2011-06-02 Alkermes Pharma Ireland Limited Injectable nanoparticulate olanzapine formulations
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
NZ247703A (en) * 1992-05-29 1995-07-26 Lilly Industries Ltd Thienobenzdiazepine derivatives and medicaments thereof
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
CZ299247B6 (cs) * 1996-09-23 2008-05-28 Eli Lilly And Company Olanzapin dihydrát D

Also Published As

Publication number Publication date
YU15599A (sh) 2001-12-26
HUP0000066A3 (en) 2000-11-28
US6020487A (en) 2000-02-01
MY125565A (en) 2006-08-30
EP0831098B1 (en) 2001-11-21
CZ299248B6 (cs) 2008-05-28
CN1234802A (zh) 1999-11-10
ID27275A (id) 2001-03-22
IL128962A0 (en) 2000-02-17
SV1997000081A (es) 1999-01-14
JP2001500877A (ja) 2001-01-23
CA2265712C (en) 2006-10-31
CZ99099A3 (cs) 1999-11-17
DE69708428T2 (de) 2002-07-04
SI0831098T1 (en) 2002-04-30
TR199900640T2 (xx) 1999-06-21
UA59371C2 (uk) 2003-09-15
KR100560015B1 (ko) 2006-03-15
ZA978515B (en) 1999-03-23
DK0831098T3 (da) 2002-05-21
PL196069B1 (pl) 2007-12-31
CO4910140A1 (es) 2000-04-24
EP0831098A2 (en) 1998-03-25
NO323980B1 (no) 2007-07-30
NO991382D0 (no) 1999-03-22
PT831098E (pt) 2002-04-29
PE110398A1 (es) 1999-01-14
PL196068B1 (pl) 2007-12-31
EG23861A (en) 2007-11-18
NO991382L (no) 1999-03-22
HUP0000066A2 (hu) 2000-06-28
CA2265712A1 (en) 1998-03-26
IL128962A (en) 2003-01-12
BR9712100A (pt) 1999-08-31
TW470746B (en) 2002-01-01
JP2009242407A (ja) 2009-10-22
ATE209208T1 (de) 2001-12-15
IN187156B (en:Method) 2002-02-16
KR20000048520A (ko) 2000-07-25
NZ334448A (en) 2000-08-25
WO1998012199A1 (en) 1998-03-26
EA199900326A1 (ru) 1999-08-26
HU226484B1 (en) 2009-03-02
AU719441B2 (en) 2000-05-11
EP0831098A3 (en) 1998-04-29
RS49598B (sr) 2007-06-04
EA001642B1 (ru) 2001-06-25
PL194565B1 (pl) 2007-06-29
PL332482A1 (en) 1999-09-13
DE69708428D1 (de) 2002-01-03
HK1009807A1 (en) 1999-06-11
ES2166051T3 (es) 2002-04-01
CN1122036C (zh) 2003-09-24
AU4484197A (en) 1998-04-14

Similar Documents

Publication Publication Date Title
AR013838A1 (es) Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos
ES2191977T3 (es) Soluciones y dispersiones en estado solido de farmacos poco solubles en agua.
Bonser et al. The carcinogenic properties of 2-amino-1-naphthol hydrochloride and its parent amine 2-naphthylamine
PE20020179A1 (es) DERIVADOS DE (6S,9R,10S,11S,13S,16R, 17R)-9-CLORO-6-FLUORO-11-HIDROXI-10,13,16-TRIMETIL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHIDRO-3H-CICLOPENTA[a]FENANTRENO CARBOXILICO
GT200000168A (es) Compuestos farmaceuticamente activos.
PE50795A1 (es) Dispositivo de administracion de progesterona
SV2002000232A (es) Derivados nuevos de benzoimidazole utiles como agentes antiproliferativos ref. pc 10608abcz/bb
AR026064A1 (es) Compuestos de oxabispidina, formulacion farmaceutica, uso de estos compuestos para la manufactura de medicamentos, proceso para la preparacion de estos compuestos, e intermediarios.
BR9814729A (pt) Método e composição de uma preparação oral de itraconazol
ES2193658T3 (es) Procedimiento para la preparacion de formulaciones acuosas para uso oftalmico.
PE20030612A1 (es) Benzoimidazoles
BR0112014A (pt) Processo para a preparação de uma composição farmacêutica e, composição resultante
UY25148A1 (es) Método para producir una composición farmacéutica que comprende un análogo de ácido gama aminobutírico (gaba) y una droga antiinflamatoria no esteroide (nsaid)
ES2140391T3 (es) Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
AR024013A1 (es) Preparado farmaceutico con diamorfina como sustancia activa, y su utilizacion en un procedimiento para el tratamiento de la adiccion a los opiaceos
PE20060555A1 (es) Derivados de pirrol-oxindol como moduladores del receptor de progesterona
ES2196803T3 (es) Procedimiento en fase acuosa para fabricar dispersiones solidas de paroxetina.
AR037517A1 (es) Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
PE20001601A1 (es) Derivados de pirimidina como inhibidores de la sorbitol deshidrogenasa
ES2178268T3 (es) Formulaciones de liberacion controlada.
CO5060477A1 (es) Forma de dosificacion de nefazodona
DK2308496T3 (da) Formulering indeholdende fosfatderivater af elektrontransfermidler
ES2060015T3 (es) Derivados arilicos anti-inflamatorios.
BR9915018A (pt) Modificação de cristal da torasemida
AR001769A1 (es) Benzamida enterocinética composiciones farmacéuticas que las contienen procedimiento para la preparación de dichas composiciones farmacéuticas el uso de dichos compuestos para la manufactura de medicamentos y un procedimiento para su preparación

Legal Events

Date Code Title Description
FC Refusal