AR010752A1 - COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN. - Google Patents
COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN.Info
- Publication number
- AR010752A1 AR010752A1 ARP970105779A ARP970105779A AR010752A1 AR 010752 A1 AR010752 A1 AR 010752A1 AR P970105779 A ARP970105779 A AR P970105779A AR P970105779 A ARP970105779 A AR P970105779A AR 010752 A1 AR010752 A1 AR 010752A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- bind
- activate
- receptor
- thrombopoyetine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000005763 Thrombopoietin Receptors Human genes 0.000 abstract 1
- 108010070774 Thrombopoietin Receptors Proteins 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 206010043554 thrombocytopenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/764,640 US5869451A (en) | 1995-06-07 | 1996-12-11 | Peptides and compounds that bind to a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010752A1 true AR010752A1 (es) | 2000-07-12 |
Family
ID=25071323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105779A AR010752A1 (es) | 1996-12-11 | 1997-12-09 | COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN. |
| ARP070104172A AR062931A2 (es) | 1996-12-11 | 2007-09-20 | Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104172A AR062931A2 (es) | 1996-12-11 | 2007-09-20 | Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentos |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5869451A (enExample) |
| EP (3) | EP2336165A1 (enExample) |
| JP (1) | JP4128225B2 (enExample) |
| KR (3) | KR100625708B1 (enExample) |
| CN (1) | CN100379760C (enExample) |
| AR (2) | AR010752A1 (enExample) |
| AT (1) | ATE420893T1 (enExample) |
| AU (1) | AU725731B2 (enExample) |
| BR (1) | BRPI9713914B1 (enExample) |
| CA (1) | CA2274149C (enExample) |
| CO (1) | CO5080768A1 (enExample) |
| DE (1) | DE69739219D1 (enExample) |
| ES (1) | ES2321038T3 (enExample) |
| HR (1) | HRP970683B1 (enExample) |
| MA (1) | MA26454A1 (enExample) |
| PA (1) | PA8442601A1 (enExample) |
| PE (1) | PE27599A1 (enExample) |
| SV (1) | SV1997000104A (enExample) |
| TN (1) | TNSN97201A1 (enExample) |
| TR (2) | TR200401638T2 (enExample) |
| TW (1) | TW515804B (enExample) |
| UY (1) | UY24805A1 (enExample) |
| WO (1) | WO1998025965A2 (enExample) |
| ZA (1) | ZA9711045B (enExample) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| JP3059218B2 (ja) * | 1995-06-07 | 2000-07-04 | グラクソ・グループ・リミテッド | トロンボポエチン受容体に結合するペプチドおよび化合物 |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| US7083983B2 (en) * | 1996-07-05 | 2006-08-01 | Cancer Research Campaign Technology Limited | Inhibitors of the interaction between P53 and MDM2 |
| US6280959B1 (en) | 1997-10-31 | 2001-08-28 | Smithkline Beecham Corporation | Metal complexes |
| CA2308135A1 (en) * | 1997-10-31 | 1999-05-14 | John G. Gleason | Novel metal complexes |
| AU748063B2 (en) | 1997-10-31 | 2002-05-30 | Ligand Pharmaceuticals Incorporated | Novel metal complexes |
| US7153655B2 (en) | 1998-06-16 | 2006-12-26 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| SK287737B6 (sk) | 1998-10-23 | 2011-08-04 | Kirin-Amgen Inc. | Peptidová zlúčenina, spôsob jej výroby a použitie, farmaceutický prostriedok, polynukleotid, vektor a hostiteľská bunka |
| JP2003509478A (ja) * | 1999-09-21 | 2003-03-11 | エモリー・ユニバーシティ | 血小板関連障害を処置する方法および組成物 |
| US20030190644A1 (en) | 1999-10-13 | 2003-10-09 | Andreas Braun | Methods for generating databases and databases for identifying polymorphic genetic markers |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| WO2001036604A2 (en) | 1999-11-18 | 2001-05-25 | Corvas International, Inc. | Nucleic acids encoding endotheliases, endotheliases and uses thereof |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| US7700341B2 (en) * | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| CA2407956A1 (en) * | 2000-05-03 | 2001-11-08 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20050158838A1 (en) * | 2000-06-19 | 2005-07-21 | Dyax Corp., A Delaware Corporation | Novel enterokinase cleavage sequences |
| US20040253242A1 (en) * | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| ES2316919T3 (es) * | 2000-12-05 | 2009-04-16 | Alexion Pharmaceuticals, Inc. | Anticuerpos diseñados racionalmente. |
| US6958213B2 (en) | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
| WO2002072786A2 (en) | 2001-03-13 | 2002-09-19 | Corvas International, Inc. | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
| US7172892B2 (en) | 2001-03-22 | 2007-02-06 | Dendreon Corporation | Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon |
| NZ527971A (en) | 2001-03-27 | 2006-03-31 | Dendreon Corp | Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon |
| WO2002092841A2 (en) | 2001-05-14 | 2002-11-21 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
| US7332474B2 (en) * | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| US20030134794A1 (en) * | 2001-11-20 | 2003-07-17 | Madison Edwin L. | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| EP1501863A4 (en) | 2002-05-03 | 2007-01-24 | Sequenom Inc | KINASE ANCHOR PROTEIN, PEPTIDES AND RELATED METHODS THEREOF |
| WO2003097834A2 (en) | 2002-05-17 | 2003-11-27 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
| CA2448513A1 (en) * | 2002-06-29 | 2003-12-29 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Isoflavone concentrates, as well as methods for their production |
| US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
| AU2003255030A1 (en) | 2002-08-14 | 2004-03-03 | Nissan Chemical Industries, Ltd. | Thrombopoetin receptor activator and process for producing the same |
| US7166574B2 (en) | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| US8227411B2 (en) * | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
| US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
| US8067367B2 (en) * | 2002-09-18 | 2011-11-29 | Janssen Pharmaceutica, N.V. | Methods of increasing platelet and hematopoietic stem cell production |
| TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
| WO2004073624A2 (en) | 2003-02-14 | 2004-09-02 | The Curators Of The University Of Missouri | Contraceptive methods and compositions related to proteasomal interference |
| BRPI0411160A (pt) | 2003-05-12 | 2006-07-11 | Affymax Inc | novos compostos modificados com poli(glicol etilênico) e usos dos mesmos |
| MXPA05012316A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos novedosos que se unen al receptor de la eritropoyetina. |
| BRPI0411172A (pt) * | 2003-05-12 | 2006-07-18 | Affymax Inc | peptìdeo, dìmero de peptìdeo, seu uso e composição farmacêutica |
| EP1628686A2 (en) | 2003-05-12 | 2006-03-01 | Affymax, Inc. | Spacer moiety for poly (ethylene glycol)-modified peptides |
| CN103130739B (zh) * | 2003-08-12 | 2015-09-16 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的化合物 |
| US7723295B2 (en) * | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| ME00313B (me) * | 2003-08-28 | 2011-05-10 | Ortho Mcneil Pharm Inc | Peptidi i jedinjenja koja se vežu za receptor |
| EP1701969B1 (en) | 2003-12-31 | 2007-10-24 | F.Hoffmann-La Roche Ag | Process for peptide synthesis using a reduced amount of deprotection agent |
| US7414028B1 (en) * | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
| US20060024347A1 (en) * | 2004-02-10 | 2006-02-02 | Biosurface Engineering Technologies, Inc. | Bioactive peptide coatings |
| US7528105B1 (en) | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
| US7671012B2 (en) | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| EP1725576B1 (en) * | 2004-02-20 | 2010-09-22 | Biosurface Engineering Technologies, Inc. | Positive modulator of bone morphogenic protein-2 |
| MX2007000216A (es) * | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
| US20060210542A1 (en) * | 2004-08-16 | 2006-09-21 | Yurkow Edward J | Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia |
| CN101103045B (zh) * | 2004-09-24 | 2015-11-25 | 安姆根有限公司 | 修饰的Fc分子 |
| US7589063B2 (en) | 2004-12-14 | 2009-09-15 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| EP1814910A4 (en) * | 2004-11-11 | 2009-04-29 | Affymax Inc | NEW AT ERYTHROPOIETIN RECEPTOR BINDING PEPTIDES |
| WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| AU2005312585B2 (en) | 2004-12-08 | 2012-01-12 | Nissan Chemical Industries, Ltd. | 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators |
| KR101215207B1 (ko) | 2004-12-14 | 2012-12-26 | 닛산 가가쿠 고교 가부시키 가이샤 | 아미드 화합물 및 트롬보포이에틴 리셉터 활성화제 |
| EP1861417B1 (en) | 2005-03-10 | 2013-05-15 | BioNTech AG | Dimeric or multimeric microproteins |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| JP2008546732A (ja) * | 2005-06-23 | 2008-12-25 | アプラゲン ゲーエムベーハー | 多価化合物 |
| NZ563202A (en) | 2005-07-15 | 2011-02-25 | Nissan Chemical Ind Ltd | Thiophene compounds and thrombopoietin receptor activators |
| US7960425B2 (en) | 2005-07-20 | 2011-06-14 | Nissan Chemical Industries, Ltd. | Pyrazole compounds and thrombopoietin receptor activators |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US8026368B2 (en) | 2005-11-07 | 2011-09-27 | Nissan Chemical Industries, Ltd. | Hydrazide compounds and thrombopoietin receptor activators |
| US7879318B2 (en) * | 2006-01-23 | 2011-02-01 | Mcw Research Foundation, Inc. | Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand |
| WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
| AU2007208226A1 (en) * | 2006-01-25 | 2007-08-02 | Amgen Inc. | Thrombopoietic compounds |
| EP1834963A1 (en) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| JP2009529917A (ja) | 2006-03-22 | 2009-08-27 | ヴァイラル ロジック システムズ テクノロジー コーポレーション | 標的ポリペプチドの同定方法および免疫学的疾患の治療のためのその使用 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| JP2009537145A (ja) * | 2006-05-15 | 2009-10-29 | バイラル ロジック システムズ テクノロジー コーポレーション | 免疫学的疾患および障害を治療するためのcd47と関連した組成物および方法 |
| US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
| JP5157900B2 (ja) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
| US7981425B2 (en) * | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| WO2007150053A2 (en) * | 2006-06-22 | 2007-12-27 | Biosurface Engineering Technologies, Inc. | Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis |
| US20090252703A1 (en) * | 2006-10-19 | 2009-10-08 | Gegg Jr Colin V | Use of alcohol co-solvents to improve pegylation reaction yields |
| WO2008095004A2 (en) * | 2007-01-31 | 2008-08-07 | Affymax, Inc. | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules |
| JP5591691B2 (ja) * | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| WO2008157824A2 (en) * | 2007-06-21 | 2008-12-24 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
| WO2009029682A1 (en) * | 2007-08-28 | 2009-03-05 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
| US8183342B2 (en) * | 2007-11-06 | 2012-05-22 | Case Western Reserve University | Method of treating chemotherapy-induced thrombocytopenia |
| CN101481352A (zh) | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
| JP5701064B2 (ja) | 2008-01-25 | 2015-04-15 | アムジエン・インコーポレーテツド | フェロポーチン抗体およびその使用方法 |
| JP2011519279A (ja) | 2008-05-01 | 2011-07-07 | アムジエン・インコーポレーテツド | 抗ヘプシジン抗体及び使用の方法 |
| US8734796B2 (en) | 2009-03-20 | 2014-05-27 | Amgen Inc. | Carrier immunoglobulins |
| WO2011012306A2 (en) | 2009-07-30 | 2011-02-03 | Aplagen Gmbh | Use of emps for antagonising epo-stimulatory effects on epo-responsive tumors while maintaining erythropoiesis |
| WO2011049213A1 (ja) | 2009-10-23 | 2011-04-28 | 日産化学工業株式会社 | 縮環へテロ環化合物及びトロンボポエチンレセプター活性化剤 |
| WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
| US8993727B2 (en) | 2010-09-22 | 2015-03-31 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| WO2014159242A1 (en) | 2013-03-14 | 2014-10-02 | Novartis Ag | Notch 3 mutants and uses thereof |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| KR102330652B1 (ko) | 2014-09-11 | 2021-11-23 | 브리스톨-마이어스 스큅 컴퍼니 | Pd-1/pd-l1 및 cd80 (b7-1)/pd-li 단백질/단백질 상호작용의 마크로시클릭 억제제 |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| BR112017010268B1 (pt) | 2014-11-19 | 2024-01-16 | P & M Venge Ab | Agente de ligação, composição de diagnóstico, kit de diagnóstico, método de diagnóstico de uma infecção bacteriana ou de diferenciação entre uma infecção bacteriana e uma infecção de viral, métodos para descartar uma infecção bacteriana ou viral em um indivíduo, métodos para considerar uma infecção bacteriana ou viral em um indivíduo, método para distinguir entre uma infecção bacteriana ou mista e uma infecção viral em um indivíduo, método para descartar uma doença infecciosa, método para identificação do tipo de infecção e dispositivo para o diagnóstico de infecções bacterianas |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| ES2864091T3 (es) | 2016-05-19 | 2021-10-13 | Bristol Myers Squibb Co | Inmunomoduladores de producción de imágenes de tomografía por emisión de positrones (PET) |
| JP7085545B2 (ja) | 2016-11-07 | 2022-06-16 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫修飾因子 |
| EP3642220A1 (en) | 2017-06-23 | 2020-04-29 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of pd-1 |
| CA3070442A1 (en) * | 2017-07-26 | 2019-01-31 | Janssen Pharmaceutica Nv | Methods of protecting vascular integrity induced by targeted radiation therapy |
| US11492375B2 (en) | 2017-10-03 | 2022-11-08 | Bristol-Myers Squibb Company | Cyclic peptide immunomodulators |
| WO2020154637A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure |
| CA3127378A1 (en) | 2019-01-25 | 2020-10-15 | Janssen Pharmaceutica Nv | Methods of mitigating toxic effects of vesicants and caustic gas |
| WO2020154585A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments |
| US12403174B2 (en) | 2020-01-06 | 2025-09-02 | Bristol-Myers Squibb Company | Immunomodulators |
| ES2970547T3 (es) | 2020-03-30 | 2024-05-29 | Bristol Myers Squibb Co | Inmunomoduladores |
| US20230104658A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica Nv | Methods of increasing progenitor cell production |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3645090A (en) | 1969-06-19 | 1972-02-29 | Citizen Watch Co Ltd | Day-date quick-adjuster for calender timepiece |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4612132A (en) | 1984-07-20 | 1986-09-16 | Chevron Research Company | Modified succinimides |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5198424A (en) * | 1989-03-08 | 1993-03-30 | Board Of Regents Of The University Of Oklahoma | Functionally active selectin-derived peptides |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5326558A (en) * | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| IL96477A0 (en) * | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| US5571508A (en) * | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
| IT1241395B (it) * | 1990-04-02 | 1994-01-10 | Eniricerche Spa | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5250732A (en) * | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
| US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| EP0644771B2 (en) * | 1992-06-11 | 2006-12-06 | Alkermes Controlled Therapeutics, Inc. | Erythropoietin drug delivery system |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| AU685506B2 (en) | 1993-08-25 | 1998-01-22 | Systemix, Inc. | Method for producing a highly enriched population of hematopoietic stem cells |
| WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| GB2285446B (en) * | 1994-01-03 | 1999-07-28 | Genentech Inc | Thrombopoietin |
| FI963185L (fi) * | 1994-02-14 | 1996-08-14 | Zymogenetics Inc | Hematopoieettinen proteiini ja materiaalit ja menetelmät sen valmistamiseksi |
| WO1995021919A2 (en) * | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| EP0723456A1 (en) * | 1994-02-14 | 1996-07-31 | The University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
| SG79882A1 (en) * | 1994-02-14 | 2001-04-17 | Kirin Brewery | Protein having tpo activity |
| WO1995026746A1 (en) * | 1994-03-31 | 1995-10-12 | Amgen Inc. | Compositions and methods for stimulating megakaryocyte growth and differentiation |
| US5571686A (en) * | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
| US5641655A (en) * | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| WO1996017062A1 (en) * | 1994-11-30 | 1996-06-06 | Zymogenetics, Inc. | Low molecular weight thrombopoietin |
| ES2276401T3 (es) * | 1995-04-26 | 2007-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Proteinas de fusion g-csf tpo. |
| JP3059218B2 (ja) | 1995-06-07 | 2000-07-04 | グラクソ・グループ・リミテッド | トロンボポエチン受容体に結合するペプチドおよび化合物 |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| KR102127408B1 (ko) | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
-
1996
- 1996-12-11 US US08/764,640 patent/US5869451A/en not_active Expired - Lifetime
-
1997
- 1997-12-05 PE PE1997001095A patent/PE27599A1/es not_active IP Right Cessation
- 1997-12-08 SV SV1997000104A patent/SV1997000104A/es not_active Application Discontinuation
- 1997-12-09 CO CO97071692A patent/CO5080768A1/es unknown
- 1997-12-09 EP EP20100185440 patent/EP2336165A1/en not_active Withdrawn
- 1997-12-09 KR KR1019997005169A patent/KR100625708B1/ko not_active Expired - Lifetime
- 1997-12-09 CA CA002274149A patent/CA2274149C/en not_active Expired - Lifetime
- 1997-12-09 EP EP97954363A patent/EP0948539B1/en not_active Expired - Lifetime
- 1997-12-09 WO PCT/EP1997/006850 patent/WO1998025965A2/en not_active Ceased
- 1997-12-09 TR TR2004/01638T patent/TR200401638T2/xx unknown
- 1997-12-09 EP EP08075855A patent/EP2028191A1/en not_active Withdrawn
- 1997-12-09 ES ES97954363T patent/ES2321038T3/es not_active Expired - Lifetime
- 1997-12-09 KR KR1020057005233A patent/KR100668546B1/ko not_active Expired - Lifetime
- 1997-12-09 AR ARP970105779A patent/AR010752A1/es active IP Right Grant
- 1997-12-09 JP JP52619798A patent/JP4128225B2/ja not_active Expired - Lifetime
- 1997-12-09 ZA ZA9711045A patent/ZA9711045B/xx unknown
- 1997-12-09 DE DE69739219T patent/DE69739219D1/de not_active Expired - Lifetime
- 1997-12-09 TR TR1999/01971T patent/TR199901971T2/xx unknown
- 1997-12-09 CN CNB971816514A patent/CN100379760C/zh not_active Expired - Lifetime
- 1997-12-09 AT AT97954363T patent/ATE420893T1/de not_active IP Right Cessation
- 1997-12-09 AU AU58547/98A patent/AU725731B2/en not_active Expired
- 1997-12-09 BR BRPI9713914-9A patent/BRPI9713914B1/pt not_active IP Right Cessation
- 1997-12-09 KR KR1020067003807A patent/KR100679576B1/ko not_active Expired - Lifetime
- 1997-12-10 TW TW086118867A patent/TW515804B/zh active
- 1997-12-10 UY UY24805A patent/UY24805A1/es not_active IP Right Cessation
- 1997-12-10 MA MA24894A patent/MA26454A1/fr unknown
- 1997-12-10 HR HR970683A patent/HRP970683B1/xx not_active IP Right Cessation
- 1997-12-10 TN TNTNSN97201A patent/TNSN97201A1/fr unknown
- 1997-12-11 PA PA19978442601A patent/PA8442601A1/es unknown
-
1999
- 1999-02-03 US US09/244,298 patent/US6121238A/en not_active Expired - Lifetime
-
2007
- 2007-09-20 AR ARP070104172A patent/AR062931A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR010752A1 (es) | COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN. | |
| AR003431A1 (es) | Peptidos compuestos que se ligan al receptor de trombopoietina. | |
| GT199900070A (es) | Derivados de isotiazol, utiles como agentes anticancerosos. | |
| ES2058139T3 (es) | Compuestos complejos de bioflavonoides con fosfolipidos, su preparacion y uso, y composiciones farmaceuticas y cosmeticas que los contienen. | |
| AR003427A1 (es) | Péptidos relacionados con dolastatina, procedimiento para prepararlos, composiciones farmacéuticas que los contienen y el uso de los mismos para la preparación de dichas composiciones farmacéuticas. | |
| MX9301929A (es) | Derivados de pirimidina y procedimientos para su preparacion. | |
| AR011539A1 (es) | DERIVADOS DE BENZOILO-3-HETEROCICLIL-SUSTITUIDOS, PROCEDIMIENTO PARA SU PREPARACIoN,COMPUESTOS INTERMEDIARIOS DE APLICACIoN EN DICHO PROCEDIMIENTO, COMPOSICIONES QUE COMPRENDEN DICHOS DERIVADOS, Y PROCEDIMIENTO PARA SU PREPARACIoN, PROCEDIMIENTO PARA COMBATIR VEGETACIoN NO DESADA QUE LOS EMPLEA Y SU | |
| MX9403570A (es) | Conjugados de farmaco-ligando, proceso para su preparacion y composicionesfarmaceuticas que los incluyen. | |
| ES2191187T3 (es) | Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa. | |
| BR0314356A (pt) | Formulações de liberação retardada para administração oral de um agente terapêutico polipetìdeo e métodos utilizando as mesmas | |
| AR023574A1 (es) | Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios | |
| AR005703A1 (es) | Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen | |
| AR024516A1 (es) | Compuestos bi-aromaticos analogos de la vitamina d, su utilizacion, composicion farmaceutica y composicion cosmetica que comprenden al menos uno de dichos compuestos y utilizacion de dicha composicion cosmetica. | |
| BR0214137A (pt) | Anticorpos para o cd40, composição farmacêutica compreendendo os mesmos, uso dos mesmos na fabricação de um medicamento, linhagem, de célula isolada, molécula de ácido nucléico isolada, vetor compreendendo a mesma, célula hospedeira e método de fabricação dos referidos anticorpos | |
| CO5640082A2 (es) | Compuestos derivados de succinimida heterociclicos fusionados que son moduladores de la funcion del receptor de la hormona nuclear y composiciones farmaceuticas que los contienen | |
| BR9813378A (pt) | Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão | |
| YU34196A (sh) | Peptidi i jedinjenja koja se vezuju za receptor | |
| MX9305444A (es) | Derivados de rodanina como agentes hipoglucemicos y para el tratamiento de la enfermedad de alzheimer, composiciones farmaceuticas que los contienen y procedimiento para su preparacion. | |
| ES2153367T3 (es) | Derivados de clorofila y de bacterioclorofila, su preparacion y composiciones farmaceuticas que los contienen. | |
| UY23561A1 (es) | Procedimiento para la preparacion de tnf-muteinas | |
| EA199900734A1 (ru) | Микрокапсулы, содержащие цис-платину | |
| AR004545A1 (es) | Derivados de purin-6-ona, procedimientos para su preparacion, el uso de los mismos en la preparacion de medicamentos, medicamentos que los contieneny un procedimiento para preparar dichos medicamentos | |
| BR9608488A (pt) | Uso de derivados da vitamina d4 no tratamento de câncer | |
| GT199800106A (es) | Azetidinas. | |
| IL176007A0 (en) | Antibodies specific to c35 and pharmaceutical compositions containing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |