UY23561A1 - Procedimiento para la preparacion de tnf-muteinas - Google Patents
Procedimiento para la preparacion de tnf-muteinasInfo
- Publication number
- UY23561A1 UY23561A1 UY23561A UY23561A UY23561A1 UY 23561 A1 UY23561 A1 UY 23561A1 UY 23561 A UY23561 A UY 23561A UY 23561 A UY23561 A UY 23561A UY 23561 A1 UY23561 A1 UY 23561A1
- Authority
- UY
- Uruguay
- Prior art keywords
- mutein
- necrosis factor
- tumor necrosis
- human tumor
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedimiento para la preparación de una muteína del factor de necrosis tumoral humano o una sal farmacéuticamente aceptable de la misma, que tiene una afinidad de unión selectiva para el receptor del factor de necrosis tumoral humano p55, esta muteína se caracteriza porque la secuencia de aminoácidos del factor de necrosis tumoral humano se ha cambiado como mínimo en la posición 86 mostrando un resto de treonina en lugar de un resto de serina También es de alcance una secuencia de ADN que codifica dicha luteína, un vector que comprende dicha secuencia de ADN, una célula hospedadora transformada mediante dicho vector. La muteína según lo descrito y sus composiciones farmacéuticas son de utilidad en el tratamiento de enfermedades.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92810249 | 1992-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23561A1 true UY23561A1 (es) | 1993-09-20 |
Family
ID=8211902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23561A UY23561A1 (es) | 1992-04-02 | 1993-03-31 | Procedimiento para la preparacion de tnf-muteinas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5486463A (es) |
| EP (1) | EP0563714A3 (es) |
| JP (1) | JPH07285997A (es) |
| CN (1) | CN1037844C (es) |
| AU (1) | AU659927B2 (es) |
| BR (1) | BR9301420A (es) |
| CA (1) | CA2091313A1 (es) |
| CZ (1) | CZ283533B6 (es) |
| FI (1) | FI931488A (es) |
| HU (1) | HUT69790A (es) |
| IL (1) | IL105170A0 (es) |
| MX (1) | MX9301700A (es) |
| NO (1) | NO931141L (es) |
| NZ (1) | NZ247265A (es) |
| PL (1) | PL298345A1 (es) |
| SK (1) | SK376492A3 (es) |
| TW (1) | TW260707B (es) |
| UY (1) | UY23561A1 (es) |
| ZA (1) | ZA932177B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
| CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
| CN1049663C (zh) * | 1994-09-01 | 2000-02-23 | 中国科学院上海生物工程研究中心 | 突变的人肿瘤坏死因子 |
| US7070771B1 (en) | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US6379708B1 (en) * | 1999-11-20 | 2002-04-30 | Cytologic, Llc | Method for enhancing immune responses in mammals |
| DE60028830T2 (de) * | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
| EA007984B1 (ru) * | 2001-08-03 | 2007-02-27 | Дженентек, Инк. | ПОЛИПЕПТИДЫ TACIs И BR3 И ИХ ПРИМЕНЕНИЕ |
| US7786282B2 (en) * | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
| US20030199024A1 (en) * | 2002-04-19 | 2003-10-23 | Hansen Ted H. | Single chain trimers of class I MHC molecules |
| JP2005533863A (ja) * | 2002-07-25 | 2005-11-10 | ジェネンテック・インコーポレーテッド | Ｔａｃｉ抗体とその用途 |
| ES2347239T3 (es) * | 2002-12-02 | 2010-10-27 | Amgen Fremont Inc. | Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos. |
| US20040121971A1 (en) * | 2002-12-20 | 2004-06-24 | Gang Chen | Therapeutic use of tumor necrosis factor-alpha mutein |
| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| KR20060027801A (ko) * | 2003-06-05 | 2006-03-28 | 제넨테크, 인크. | Ｂ 세포 장애에 대한 조합 요법 |
| CN100390200C (zh) * | 2003-11-24 | 2008-05-28 | 中国医学科学院基础医学研究所 | 一种用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白 |
| TW200526780A (en) * | 2004-01-06 | 2005-08-16 | Hayashibara Biochem Lab | TNF antagonists and TNF inhibitors comprising the same as the active ingredient |
| CN1752211B (zh) * | 2004-09-23 | 2010-09-15 | 中国医学科学院基础医学研究所 | 用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白 |
| GB0425972D0 (en) | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
| US7850960B2 (en) | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| US20070065514A1 (en) * | 2005-09-22 | 2007-03-22 | Howell Mark D | Method for enhancing immune responses in mammals |
| AU2006318539B2 (en) * | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
| US8518697B2 (en) * | 2006-04-04 | 2013-08-27 | Washington University | Single chain trimers and uses therefor |
| WO2008019394A2 (en) * | 2006-08-11 | 2008-02-14 | The Government Of The United States Of America As Represented By The Secretary, Dept Of Health And Human Services | Methods for treatment and diagnosis of psychiatric disorders |
| WO2008127515A1 (en) * | 2007-03-01 | 2008-10-23 | Cytologic, Inc. | Compositions and method for enhancing immune responses in mammals |
| PT2953634T (pt) | 2013-02-07 | 2021-09-02 | Massachusetts Gen Hospital | Métodos de expansão ou depleção das células t reguladoras |
| US11224858B1 (en) | 2020-10-01 | 2022-01-18 | Immunicom, Inc. | Reduced leaching of a ligand |
| JP2023544347A (ja) | 2020-10-01 | 2023-10-23 | イミューニコム， インコーポレイテッド | リガンドの浸出の低減 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07106158B2 (ja) * | 1986-12-04 | 1995-11-15 | サントリー株式会社 | 抗腫瘍活性を有する新規ポリペプチドおよびその製造法 |
| CA2055168A1 (en) * | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
-
1992
- 1992-12-18 SK SK3764-92A patent/SK376492A3/sk unknown
- 1992-12-18 CZ CS923764A patent/CZ283533B6/cs unknown
-
1993
- 1993-02-25 TW TW082101370A patent/TW260707B/zh active
- 1993-03-09 CA CA002091313A patent/CA2091313A1/en not_active Abandoned
- 1993-03-20 EP EP19930104591 patent/EP0563714A3/en not_active Withdrawn
- 1993-03-24 HU HU9300843A patent/HUT69790A/hu unknown
- 1993-03-26 ZA ZA932177A patent/ZA932177B/xx unknown
- 1993-03-26 IL IL105170A patent/IL105170A0/xx unknown
- 1993-03-26 MX MX9301700A patent/MX9301700A/es unknown
- 1993-03-26 NZ NZ247265A patent/NZ247265A/en unknown
- 1993-03-26 NO NO93931141A patent/NO931141L/no unknown
- 1993-03-30 AU AU35611/93A patent/AU659927B2/en not_active Ceased
- 1993-03-31 UY UY23561A patent/UY23561A1/es unknown
- 1993-04-01 PL PL29834593A patent/PL298345A1/xx unknown
- 1993-04-01 US US08/041,648 patent/US5486463A/en not_active Expired - Fee Related
- 1993-04-01 FI FI931488A patent/FI931488A/fi unknown
- 1993-04-01 JP JP5075445A patent/JPH07285997A/ja active Pending
- 1993-04-01 CN CN93103419A patent/CN1037844C/zh not_active Expired - Fee Related
- 1993-04-02 BR BR9301420A patent/BR9301420A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW260707B (es) | 1995-10-21 |
| JPH07285997A (ja) | 1995-10-31 |
| PL298345A1 (en) | 1993-12-27 |
| FI931488A0 (fi) | 1993-04-01 |
| CA2091313A1 (en) | 1993-10-03 |
| EP0563714A2 (en) | 1993-10-06 |
| IL105170A0 (en) | 1993-07-08 |
| AU3561193A (en) | 1993-10-07 |
| US5486463A (en) | 1996-01-23 |
| NO931141D0 (no) | 1993-03-26 |
| MX9301700A (es) | 1993-10-29 |
| HUT69790A (en) | 1995-09-28 |
| SK376492A3 (en) | 1995-06-07 |
| AU659927B2 (en) | 1995-06-01 |
| FI931488A (fi) | 1993-10-03 |
| CN1037844C (zh) | 1998-03-25 |
| CN1079225A (zh) | 1993-12-08 |
| NZ247265A (en) | 1995-10-26 |
| BR9301420A (pt) | 1993-10-05 |
| ZA932177B (en) | 1993-10-04 |
| HU9300843D0 (en) | 1993-06-28 |
| EP0563714A3 (en) | 1993-11-10 |
| CZ283533B6 (cs) | 1998-04-15 |
| CZ376492A3 (en) | 1994-01-19 |
| NO931141L (no) | 1993-10-04 |
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