DE68916932D1 - Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus. - Google Patents

Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.

Info

Publication number
DE68916932D1
DE68916932D1 DE68916932T DE68916932T DE68916932D1 DE 68916932 D1 DE68916932 D1 DE 68916932D1 DE 68916932 T DE68916932 T DE 68916932T DE 68916932 T DE68916932 T DE 68916932T DE 68916932 D1 DE68916932 D1 DE 68916932D1
Authority
DE
Germany
Prior art keywords
cys
val
arg
thr
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916932T
Other languages
English (en)
Other versions
DE68916932T2 (de
Inventor
Craig Wilde
Joseph Griffith
Marian Marra
Randal Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Publication of DE68916932D1 publication Critical patent/DE68916932D1/de
Application granted granted Critical
Publication of DE68916932T2 publication Critical patent/DE68916932T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE68916932T 1988-05-26 1989-05-26 Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus. Expired - Fee Related DE68916932T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/199,206 US5032574A (en) 1988-05-26 1988-05-26 Novel antimicrobial peptide
PCT/US1989/002317 WO1989011291A1 (en) 1988-05-26 1989-05-26 Novel antimicrobial peptide, compositions containing same and uses thereof

Publications (2)

Publication Number Publication Date
DE68916932D1 true DE68916932D1 (de) 1994-08-25
DE68916932T2 DE68916932T2 (de) 1994-11-03

Family

ID=22736639

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916932T Expired - Fee Related DE68916932T2 (de) 1988-05-26 1989-05-26 Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.

Country Status (8)

Country Link
US (1) US5032574A (de)
EP (1) EP0378641B1 (de)
JP (1) JP2795286B2 (de)
AT (1) ATE108662T1 (de)
AU (1) AU633832B2 (de)
CA (1) CA1340379C (de)
DE (1) DE68916932T2 (de)
WO (1) WO1989011291A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304715A (en) * 1979-06-08 1981-12-08 Derek Hudson Enkephalin analogues
US5844072A (en) * 1992-05-26 1998-12-01 University Of California Antibiotic cryptdin peptides and methods of their use
US5066792A (en) * 1987-09-04 1991-11-19 Board Of Regents University Of Texas Gene probe for detection of specific human leukemias
US5242902A (en) * 1989-09-06 1993-09-07 The Regents Of The University Of California Defensin peptide compositions and methods for their use
US5631007A (en) * 1990-03-12 1997-05-20 Ciba-Geigy Corporation Anti-pathogenically effective compositions comprising lytic peptides and hydrolytic enzymes
PH30997A (en) * 1990-03-12 1997-12-23 Ciba Geigy Antipathologenically effective compositions comprising lytic peptides and hydrolytic enzymes.
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5202420A (en) * 1990-10-25 1993-04-13 The Children's Hospital Of Philadelphia Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof
US5432270A (en) * 1990-10-25 1995-07-11 Zasloff; Michael A. DNA encoding tracheal antimicrobial peptides
US5885965A (en) * 1991-11-01 1999-03-23 Periodontix, Inc. Anti-fungal D-amino acid histatin-based peptides
US5486503A (en) * 1991-11-01 1996-01-23 The Trustees Of Boston University Anti-fungal histatin-based peptides
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US5631228A (en) * 1991-11-01 1997-05-20 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
US5912230A (en) * 1991-11-01 1999-06-15 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
US5422424A (en) * 1992-05-26 1995-06-06 The Regents Of The University Of California Antibiotic cryptdin peptides and methods of their use
ES2152253T3 (es) * 1992-05-26 2001-02-01 Univ California Peptidos de criptdina antibioticos y metodos para su uso.
US6214789B1 (en) * 1993-03-12 2001-04-10 Xoma Corporation Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
US5708145A (en) * 1993-07-20 1998-01-13 University Of California Immunglobulins reactive with protegrins
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US5693486A (en) * 1993-07-20 1997-12-02 Intrabiotics DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
ES2146668T3 (es) * 1993-10-25 2000-08-16 Liposome Co Inc Defensinas liposomicas.
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
FR2767832B1 (fr) 1997-08-29 2001-08-10 Genset Sa Polypeptide defensine humaine def-x, adn genomique et adnc, composition les contenant et applications au diagnostic et au traitement therapeutique
US6531573B1 (en) 1997-12-18 2003-03-11 Trustees Of Boston University Antifungal and antibacterial peptides
AU5630800A (en) 1999-06-22 2001-01-09 Arno F Spatola Antimicrobial agents
GB0300597D0 (en) 2003-01-10 2003-02-12 Microbiological Res Authority Phage biofilms
CA2533352C (en) 2003-07-23 2016-01-19 Biocontrol Limited Bacteriophage-containing therapeutic agents
GB0704553D0 (en) 2007-03-09 2007-04-18 Harper David R Beneficial effects of bacteriophage treatments
US20100150985A1 (en) * 2008-04-24 2010-06-17 George Just Dental Implant, Endodontic Instrument, and Dental Filling Material Coated with a Peptide-Based Antimicrobial and Methods of Using and Making the Same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705777A (en) * 1985-02-25 1987-11-10 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity

Also Published As

Publication number Publication date
ATE108662T1 (de) 1994-08-15
WO1989011291A1 (en) 1989-11-30
EP0378641B1 (de) 1994-07-20
AU633832B2 (en) 1993-02-11
EP0378641A1 (de) 1990-07-25
JPH02504396A (ja) 1990-12-13
AU3778289A (en) 1989-12-12
US5032574A (en) 1991-07-16
JP2795286B2 (ja) 1998-09-10
EP0378641A4 (en) 1990-12-12
DE68916932T2 (de) 1994-11-03
CA1340379C (en) 1999-02-02

Similar Documents

Publication Publication Date Title
DE68916932D1 (de) Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.
PT792287E (pt) Analogos peptidicos da proteina basica da mielina humana
DE69627704D1 (en) Protegrine
PT73161A (fr) Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acids et peptides et son application terapeutique
DE59007517D1 (de) Neue proteine mit tnf-hemmender wirkung und ihre herstellung.
CA2142007A1 (en) Immunomodulatory peptides
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
WO1996028470A3 (en) Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
MX9703642A (es) Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.
HUT69169A (en) T-cell-suppressive peptide fragments of human myelin basic protein (hmbp) and pharmaceutical compositions containing them
DE69820449D1 (de) T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen
FI892185A (fi) Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi
IL76929A (en) Preparation for the treatment of hemophilia a inhibitor patients and processes for producing such a preparation
FI941860A0 (fi) Keskushermoston pesäkekovettumatautiaivo-selkäydinnesteestä peräisin olevan antimyeliiniemäsproteiinin synteettinen peptidispesifisyys
NZ235497A (en) Peptides (possibly related to hirudin) and pharmaceutical compositions for reducing blood coagulation
HUT52117A (en) Process for producing amblyommin and process for producing pharmaceutical compositions comprising such compound as active ingredient
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
EP0723016A3 (de) Leukocyten-aktivierender Faktor
DE69326145D1 (de) Synthetische peptide für die behandlung von myasthenia gravis
ATE27822T1 (de) Hexapeptid, verfahren zur herstellung und pharmazeutische zusammensetzungen hieraus.
KR920700224A (ko) 신규의 생리활성 펩티드 및 이를 유효성분으로서 함유한 칼슘대사 조절제
GEP19981435B (en) Peptides with Organo-Protective Activity, Pharmaceutical Composition and the Use Thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee