AR247590A1 - Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion - Google Patents

Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion

Info

Publication number
AR247590A1
AR247590A1 AR92321933A AR32193392A AR247590A1 AR 247590 A1 AR247590 A1 AR 247590A1 AR 92321933 A AR92321933 A AR 92321933A AR 32193392 A AR32193392 A AR 32193392A AR 247590 A1 AR247590 A1 AR 247590A1
Authority
AR
Argentina
Prior art keywords
dna sequence
factor viii
encodes
procedure
obtaining
Prior art date
Application number
AR92321933A
Other languages
English (en)
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Application granted granted Critical
Publication of AR247590A1 publication Critical patent/AR247590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UNA SECUENCIA DE ADN QUE CODIFICA A UN DERIVADO DE FACTOR VIII HUMANO RECOMBINANDO BIOLOGICAMENTE ACTIVO, QUE COMPRENDE UN PRIMER SEGMENTO DE ADN QUE CODIFICA A LOS AMINOACIDOS 1 HASTA 740 DEL FACTOR Y UN SEGUNDO SEGMENTO DE ADN QUE CODIFICA A LOS AMINOACIDOS 1649 HASTA 2332 DE FACTOR VIII HUMANO, ESTANDO DICHOS SEGMENTOS INTERCONECTADOS POR UN SEGMENTO LINKER DE ADN QUE CODIFICA A PEPTIDO LINKER DE DOS RESIDUOS AMINOACIDOS QUE SON SELECCIONADOS ENTRE LISINA Y ARGININA.
AR92321933A 1991-03-15 1992-03-13 Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion AR247590A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII

Publications (1)

Publication Number Publication Date
AR247590A1 true AR247590A1 (es) 1995-01-31

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
AR92321933A AR247590A1 (es) 1991-03-15 1992-03-13 Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion

Country Status (17)

Country Link
EP (1) EP0533862B1 (es)
JP (1) JP2655752B2 (es)
AR (1) AR247590A1 (es)
AT (1) ATE186055T1 (es)
AU (1) AU650730B2 (es)
CA (1) CA2081659C (es)
DE (1) DE69230206T2 (es)
DK (1) DK0533862T3 (es)
ES (1) ES2137182T3 (es)
FI (1) FI107539B (es)
GR (1) GR3032468T3 (es)
IE (1) IE920814A1 (es)
NO (1) NO308174B1 (es)
PT (1) PT100245B (es)
SE (1) SE468050C (es)
WO (1) WO1992016557A1 (es)
ZA (1) ZA921882B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
ES2127829T3 (es) 1992-07-31 1999-05-01 Medeva Holdings Bv Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
SI2292780T1 (sl) 2003-09-30 2017-12-29 The Trustees Of The University Of Pennsylvania Genotipske skupine, zaporedja, vektorji, ki vsebujejo le-te z adenovirusi povezanega virusa (aav) in njihova uporaba
ES2525143T3 (es) 2005-04-07 2014-12-18 The Trustees Of The University Of Pennsylvania Cápsides de AAVrh.64 modificado, composiciones que las contienen y usos de las mismas
AU2006233638A1 (en) * 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
MX342858B (es) 2010-03-29 2016-10-13 The Trustees Of The Univ Of Pennsylvania * Sistema de ablacion transgenica inducida farmacologicamente.
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
CN103502458B (zh) 2011-02-17 2016-11-16 宾夕法尼亚大学托管会 用于改变组织特异性和改善aav9-介导的基因转移的组合物和方法
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
CN108093639B (zh) 2015-04-16 2022-07-19 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
SG11201902998SA (en) 2016-10-03 2019-05-30 Daiichi Sankyo Co Ltd PROMOTER OF Hspa5 GENE
KR20230042754A (ko) 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
DK0500734T3 (da) * 1989-11-17 1998-03-30 Chiron Corp Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
SE9100799L (sv) 1992-09-16
IE920814A1 (en) 1992-09-23
SE9100799D0 (sv) 1991-03-15
WO1992016557A1 (en) 1992-10-01
NO924395L (no) 1993-01-13
EP0533862B1 (en) 1999-10-27
NO308174B1 (no) 2000-08-07
FI925131A0 (fi) 1992-11-11
JPH05507420A (ja) 1993-10-28
EP0533862A1 (en) 1993-03-31
ES2137182T3 (es) 1999-12-16
FI107539B (fi) 2001-08-31
DK0533862T3 (da) 2000-01-17
DE69230206D1 (de) 1999-12-02
PT100245B (pt) 1999-08-31
GR3032468T3 (en) 2000-05-31
ZA921882B (en) 1992-11-25
FI925131A (fi) 1992-11-11
ATE186055T1 (de) 1999-11-15
DE69230206T2 (de) 2000-05-18
PT100245A (pt) 1993-07-30
SE468050C (sv) 1998-04-27
AU650730B2 (en) 1994-06-30
CA2081659C (en) 2002-06-25
JP2655752B2 (ja) 1997-09-24
AU1351392A (en) 1992-10-21
CA2081659A1 (en) 1992-09-16
SE468050B (sv) 1992-10-26
NO924395D0 (no) 1992-11-13

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