PT100245A - Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii - Google Patents

Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii

Info

Publication number
PT100245A
PT100245A PT100245A PT10024592A PT100245A PT 100245 A PT100245 A PT 100245A PT 100245 A PT100245 A PT 100245A PT 10024592 A PT10024592 A PT 10024592A PT 100245 A PT100245 A PT 100245A
Authority
PT
Portugal
Prior art keywords
derivative
factor viii
recombinant
sequence
host cell
Prior art date
Application number
PT100245A
Other languages
English (en)
Other versions
PT100245B (pt
Inventor
Eva Maria Hellstroem
Peter Lind
Helena Inga Sandberg
Jack Spira
Mona Sydow-Backman
Annelie B Almstedt
Catherine Ljung
Helena Wiman
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of PT100245A publication Critical patent/PT100245A/pt
Publication of PT100245B publication Critical patent/PT100245B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Mold Materials And Core Materials (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT100245A 1991-03-15 1992-03-13 Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii PT100245B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII

Publications (2)

Publication Number Publication Date
PT100245A true PT100245A (pt) 1993-07-30
PT100245B PT100245B (pt) 1999-08-31

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100245A PT100245B (pt) 1991-03-15 1992-03-13 Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii

Country Status (17)

Country Link
EP (1) EP0533862B1 (pt)
JP (1) JP2655752B2 (pt)
AR (1) AR247590A1 (pt)
AT (1) ATE186055T1 (pt)
AU (1) AU650730B2 (pt)
CA (1) CA2081659C (pt)
DE (1) DE69230206T2 (pt)
DK (1) DK0533862T3 (pt)
ES (1) ES2137182T3 (pt)
FI (1) FI107539B (pt)
GR (1) GR3032468T3 (pt)
IE (1) IE920814A1 (pt)
NO (1) NO308174B1 (pt)
PT (1) PT100245B (pt)
SE (1) SE468050C (pt)
WO (1) WO1992016557A1 (pt)
ZA (1) ZA921882B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
JP3633933B2 (ja) 1992-07-31 2005-03-30 アカンビス、リサーチ、リミテッド 弱毒化細菌における組換え融合タンパク質の発現
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1038959A1 (en) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
CA3072423A1 (en) 2003-09-30 2005-04-14 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
ES2580044T3 (es) 2005-04-07 2016-08-18 The Trustees Of The University Of Pennsylvania Método de incremento de la función de un vector de AAV
KR20080007226A (ko) * 2005-04-14 2008-01-17 체에스엘 베링 게엠베하 증가된 안정성을 가진 변형된 응고 인자 ⅷ 및 이의 유도체
JP5922095B2 (ja) 2010-03-29 2016-05-24 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 薬理学的に誘導される導入遺伝子アブレーション系
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
US9884071B2 (en) 2011-02-17 2018-02-06 The Trustees Of The University Of Pennsylvania Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
CN115074366A (zh) 2015-04-16 2022-09-20 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
SG11201902998SA (en) 2016-10-03 2019-05-30 Daiichi Sankyo Co Ltd PROMOTER OF Hspa5 GENE
CA3188420A1 (en) 2020-08-07 2022-02-10 Joseph Bauman Vesicle targeting proteins and uses of same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
DK0500734T3 (da) * 1989-11-17 1998-03-30 Chiron Corp Proteinkomplekser med faktor VIII:C-aktivitet samt frembringelse deraf
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
JP2655752B2 (ja) 1997-09-24
NO924395D0 (no) 1992-11-13
EP0533862A1 (en) 1993-03-31
CA2081659C (en) 2002-06-25
JPH05507420A (ja) 1993-10-28
SE9100799D0 (sv) 1991-03-15
SE9100799L (sv) 1992-09-16
ATE186055T1 (de) 1999-11-15
AR247590A1 (es) 1995-01-31
GR3032468T3 (en) 2000-05-31
DE69230206D1 (de) 1999-12-02
AU1351392A (en) 1992-10-21
PT100245B (pt) 1999-08-31
FI107539B (fi) 2001-08-31
FI925131A0 (fi) 1992-11-11
DK0533862T3 (da) 2000-01-17
SE468050B (sv) 1992-10-26
WO1992016557A1 (en) 1992-10-01
NO308174B1 (no) 2000-08-07
CA2081659A1 (en) 1992-09-16
EP0533862B1 (en) 1999-10-27
SE468050C (sv) 1998-04-27
ZA921882B (en) 1992-11-25
IE920814A1 (en) 1992-09-23
ES2137182T3 (es) 1999-12-16
FI925131A (fi) 1992-11-11
DE69230206T2 (de) 2000-05-18
NO924395L (no) 1993-01-13
AU650730B2 (en) 1994-06-30

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