ZA921882B - Recombinant human factor viii derivatives - Google Patents

Recombinant human factor viii derivatives

Info

Publication number
ZA921882B
ZA921882B ZA921882A ZA921882A ZA921882B ZA 921882 B ZA921882 B ZA 921882B ZA 921882 A ZA921882 A ZA 921882A ZA 921882 A ZA921882 A ZA 921882A ZA 921882 B ZA921882 B ZA 921882B
Authority
ZA
South Africa
Prior art keywords
recombinant human
factor viii
human factor
viii derivatives
derivatives
Prior art date
Application number
ZA921882A
Other languages
English (en)
Inventor
Annelie B Almstedt
B Almstedt Annelie
Eva Maria Hellstrom
Maria Hellstrom Eva
Peter Lind
Lind Peter
Catherine Ljung
Ljung Catherine
Helena Inga Sandberg
Inga Sandberg Helena
Jack Spira
Spira Jack
Mona Sydow-Backman
Sydow-Backman Mona
Helena Wiman
Wiman Helena
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of ZA921882B publication Critical patent/ZA921882B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA921882A 1991-03-15 1992-03-13 Recombinant human factor viii derivatives ZA921882B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII

Publications (1)

Publication Number Publication Date
ZA921882B true ZA921882B (en) 1992-11-25

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921882A ZA921882B (en) 1991-03-15 1992-03-13 Recombinant human factor viii derivatives

Country Status (17)

Country Link
EP (1) EP0533862B1 (xx)
JP (1) JP2655752B2 (xx)
AR (1) AR247590A1 (xx)
AT (1) ATE186055T1 (xx)
AU (1) AU650730B2 (xx)
CA (1) CA2081659C (xx)
DE (1) DE69230206T2 (xx)
DK (1) DK0533862T3 (xx)
ES (1) ES2137182T3 (xx)
FI (1) FI107539B (xx)
GR (1) GR3032468T3 (xx)
IE (1) IE920814A1 (xx)
NO (1) NO308174B1 (xx)
PT (1) PT100245B (xx)
SE (1) SE468050C (xx)
WO (1) WO1992016557A1 (xx)
ZA (1) ZA921882B (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
EP0863211A1 (en) 1992-07-31 1998-09-09 Medeva Holdings B.V. Expression of recombinant fusion proteins in attenuated bacteria
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
DK2292780T3 (en) 2003-09-30 2017-12-04 Univ Pennsylvania Clades and sequences of adeno-associated virus (AAV), vectors containing them, and uses thereof
WO2006110689A2 (en) 2005-04-07 2006-10-19 The Trustees Of The University Of Pennsylvania Method of increasing the function of an aav vector
JP2008537680A (ja) * 2005-04-14 2008-09-25 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 安定性の増大された改変型凝固第ｖｉｉｉ因子およびその誘導体
SG183929A1 (en) 2010-03-29 2012-10-30 Univ Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
ES2724800T3 (es) 2011-02-17 2019-09-16 Univ Pennsylvania Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
WO2016168728A2 (en) 2015-04-16 2016-10-20 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
EP3521428A4 (en) * 2016-10-03 2020-06-24 Daiichi Sankyo Company, Limited PROMOTER OF THE HSPA5 GENE
JP2023537070A (ja) 2020-08-07 2023-08-30 アミカス セラピューティックス インコーポレイテッド 小胞を標的とするタンパク質及びその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
EP0500734B1 (en) * 1989-11-17 1998-02-11 Novo Nordisk A/S Protein complexes having factor viii:c activity and production thereof
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
ATE186055T1 (de) 1999-11-15
EP0533862B1 (en) 1999-10-27
CA2081659A1 (en) 1992-09-16
FI925131A0 (fi) 1992-11-11
AR247590A1 (es) 1995-01-31
AU650730B2 (en) 1994-06-30
SE468050B (sv) 1992-10-26
IE920814A1 (en) 1992-09-23
WO1992016557A1 (en) 1992-10-01
JPH05507420A (ja) 1993-10-28
DE69230206D1 (de) 1999-12-02
GR3032468T3 (en) 2000-05-31
SE9100799D0 (sv) 1991-03-15
NO924395D0 (no) 1992-11-13
AU1351392A (en) 1992-10-21
SE9100799L (sv) 1992-09-16
NO924395L (no) 1993-01-13
FI107539B (fi) 2001-08-31
FI925131A (fi) 1992-11-11
EP0533862A1 (en) 1993-03-31
ES2137182T3 (es) 1999-12-16
CA2081659C (en) 2002-06-25
JP2655752B2 (ja) 1997-09-24
PT100245A (pt) 1993-07-30
NO308174B1 (no) 2000-08-07
DK0533862T3 (da) 2000-01-17
PT100245B (pt) 1999-08-31
SE468050C (sv) 1998-04-27
DE69230206T2 (de) 2000-05-18

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