FI107539B - Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu - Google Patents

Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu Download PDF

Info

Publication number
FI107539B
FI107539B FI925131A FI925131A FI107539B FI 107539 B FI107539 B FI 107539B FI 925131 A FI925131 A FI 925131A FI 925131 A FI925131 A FI 925131A FI 107539 B FI107539 B FI 107539B
Authority
FI
Finland
Prior art keywords
factor viii
kda
dna
dna sequence
factor
Prior art date
Application number
FI925131A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI925131A0 (fi
FI925131A (fi
Inventor
Jack Spira
Peter Lind
Annelie B Almstedt
Eva Maria Gray
Catherine Ljung
Helena Inga Sandberg
Mona Sydow-Baeckman
Helena Wiman
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of FI925131A0 publication Critical patent/FI925131A0/fi
Publication of FI925131A publication Critical patent/FI925131A/fi
Application granted granted Critical
Publication of FI107539B publication Critical patent/FI107539B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI925131A 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu FI107539B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII
SE9100799 1991-03-15
SE9200150 1992-01-20
PCT/SE1992/000150 WO1992016557A1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives

Publications (3)

Publication Number Publication Date
FI925131A0 FI925131A0 (fi) 1992-11-11
FI925131A FI925131A (fi) 1992-11-11
FI107539B true FI107539B (fi) 2001-08-31

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925131A FI107539B (fi) 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu

Country Status (17)

Country Link
EP (1) EP0533862B1 (pt)
JP (1) JP2655752B2 (pt)
AR (1) AR247590A1 (pt)
AT (1) ATE186055T1 (pt)
AU (1) AU650730B2 (pt)
CA (1) CA2081659C (pt)
DE (1) DE69230206T2 (pt)
DK (1) DK0533862T3 (pt)
ES (1) ES2137182T3 (pt)
FI (1) FI107539B (pt)
GR (1) GR3032468T3 (pt)
IE (1) IE920814A1 (pt)
NO (1) NO308174B1 (pt)
PT (1) PT100245B (pt)
SE (1) SE468050C (pt)
WO (1) WO1992016557A1 (pt)
ZA (1) ZA921882B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
EP0863211A1 (en) 1992-07-31 1998-09-09 Medeva Holdings B.V. Expression of recombinant fusion proteins in attenuated bacteria
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
DK2292780T3 (en) 2003-09-30 2017-12-04 Univ Pennsylvania Clades and sequences of adeno-associated virus (AAV), vectors containing them, and uses thereof
WO2006110689A2 (en) 2005-04-07 2006-10-19 The Trustees Of The University Of Pennsylvania Method of increasing the function of an aav vector
JP2008537680A (ja) * 2005-04-14 2008-09-25 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 安定性の増大された改変型凝固第ｖｉｉｉ因子およびその誘導体
SG183929A1 (en) 2010-03-29 2012-10-30 Univ Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
ES2724800T3 (es) 2011-02-17 2019-09-16 Univ Pennsylvania Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
WO2016168728A2 (en) 2015-04-16 2016-10-20 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
EP3521428A4 (en) * 2016-10-03 2020-06-24 Daiichi Sankyo Company, Limited PROMOTER OF THE HSPA5 GENE
JP2023537070A (ja) 2020-08-07 2023-08-30 アミカス セラピューティックス インコーポレイテッド 小胞を標的とするタンパク質及びその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
EP0500734B1 (en) * 1989-11-17 1998-02-11 Novo Nordisk A/S Protein complexes having factor viii:c activity and production thereof
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
ATE186055T1 (de) 1999-11-15
EP0533862B1 (en) 1999-10-27
CA2081659A1 (en) 1992-09-16
FI925131A0 (fi) 1992-11-11
AR247590A1 (es) 1995-01-31
ZA921882B (en) 1992-11-25
AU650730B2 (en) 1994-06-30
SE468050B (sv) 1992-10-26
IE920814A1 (en) 1992-09-23
WO1992016557A1 (en) 1992-10-01
JPH05507420A (ja) 1993-10-28
DE69230206D1 (de) 1999-12-02
GR3032468T3 (en) 2000-05-31
SE9100799D0 (sv) 1991-03-15
NO924395D0 (no) 1992-11-13
AU1351392A (en) 1992-10-21
SE9100799L (sv) 1992-09-16
NO924395L (no) 1993-01-13
FI925131A (fi) 1992-11-11
EP0533862A1 (en) 1993-03-31
ES2137182T3 (es) 1999-12-16
CA2081659C (en) 2002-06-25
JP2655752B2 (ja) 1997-09-24
PT100245A (pt) 1993-07-30
NO308174B1 (no) 2000-08-07
DK0533862T3 (da) 2000-01-17
PT100245B (pt) 1999-08-31
SE468050C (sv) 1998-04-27
DE69230206T2 (de) 2000-05-18

Similar Documents

Publication Publication Date Title
FI107539B (fi) Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu
US5661008A (en) Recombinant human factor VIII derivatives
FI104260B (fi) Biologisesti aktiivista yhdistelmä-DNA-ihmisentekij-VIII-johdannaista koodittava DNA, tämän sisältävä yhdistelmä-DNA-ilmentämisvektori ja isäntäsolu sekä menetelmä biologisesti aktiivisen yhdistelmä-DNA-ihmisentekijä-VIII-johdannaisen valmistamiseksi
US5451521A (en) Procoagulant proteins
US6060447A (en) Protein complexes having Factor VIII:C activity and production thereof
US5422260A (en) Human factor VIII:c muteins
US6228620B1 (en) Protein complexes having factor VIII:C activity and production thereof
CA2068728A1 (en) Protein complexes having factor viii:c activity and production thereof
US5705484A (en) Biologically active polypeptide fusion dimers
US5359033A (en) Cleaved dimers of mullerian inhibiting substance-like polypeptides
WO1993016709A1 (en) Therapeutic domains of von willebrand factor
US6130203A (en) Hybrid proteins with modified activity

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

MA Patent expired