ES2127829T3 - Expresion de proteinas recombinantes fusionadas en bacterias atenuadas. - Google Patents

Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.

Info

Publication number
ES2127829T3
ES2127829T3 ES93917957T ES93917957T ES2127829T3 ES 2127829 T3 ES2127829 T3 ES 2127829T3 ES 93917957 T ES93917957 T ES 93917957T ES 93917957 T ES93917957 T ES 93917957T ES 2127829 T3 ES2127829 T3 ES 2127829T3
Authority
ES
Spain
Prior art keywords
sequence
dna
linked
expression
charnela
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93917957T
Other languages
English (en)
Inventor
Mohammed Anjam Khan
Carlos Estenio Cambr Hormaeche
Bernardo Camb Villarreal-Ramos
Steven N Chatfield
Gordon Dougan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medeva Holdings BV
Original Assignee
Medeva Holdings BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216317A external-priority patent/GB9216317D0/en
Priority claimed from GB939306398A external-priority patent/GB9306398D0/en
Application filed by Medeva Holdings BV filed Critical Medeva Holdings BV
Application granted granted Critical
Publication of ES2127829T3 publication Critical patent/ES2127829T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EN LA INVENCION SE PRESENTA UNA MOLECULA DE ADN QUE CONTIENE UNA SECUENCIA PROMOTORA ENLAZADA OPERATIVAMENTE A UNA SECUENCIA DE ADN QUE CODIFICA UNA PRIMERA Y UNA SEGUNDA PROTEINAS ENLAZADAS MEDIANTE UNA REGION DE CHARNELA EN DONDE EN ESA SECUENCIA PROMOTORA PUEDE HABER UNA QUE TENGA UNA ACTIVIDAD INDUCIDA EN RESPUESTA A UN CAMBIO EN EL ENTORNO CIRCUNDANTE Y LA PRIMERA PROTEINA PUEDE SER UN FRAGMENTO DE UNA TOXINA DEL TETANO C O UNO O MAS EPITOPES DEL MISMO. EN LA INVENCION TAMBIEN SE PRESENTAN MOLECULAS INTERMEDIAS QUE TIENEN UN PROMOTOR ENLAZADO DE FORMA OPERATIVA A UNA SECUENCIA DE ADN QUE CODIFICA UNA PRIMERA SECUENCIA ANTIGENICA Y UNA REGION DE CHARNELA Y EN O ADYACENTE AL EXTREMO 3'' DE LA MISMA PUEDE HABER UNO O MAS LUGARES DE RESTRICCION PARA LA INTRODUCCION DE UNA SEGUNDA SECUENCIA ANTIGENICA. ADEMAS EN LA INVENCION SE PRESENTAN VECTORES DE EXPRESION REPRODUCIBLES QUE CONTIENEN LAS PROTEINAS DE FUSION DE ADN EXPRESADAS A PARTIR DE LOS MISMOS, BACTERIAS TRANSFORMADAS CON LOS VECTORESY EL USO DE LAS BACTERIAS PARA VACUNAS.
ES93917957T 1992-07-31 1993-07-30 Expresion de proteinas recombinantes fusionadas en bacterias atenuadas. Expired - Lifetime ES2127829T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216317A GB9216317D0 (en) 1992-07-31 1992-07-31 Vaccines
GB939306398A GB9306398D0 (en) 1993-03-26 1993-03-26 Vaccines

Publications (1)

Publication Number Publication Date
ES2127829T3 true ES2127829T3 (es) 1999-05-01

Family

ID=26301354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93917957T Expired - Lifetime ES2127829T3 (es) 1992-07-31 1993-07-30 Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.

Country Status (14)

Country Link
US (1) US6680182B1 (es)
EP (2) EP0652962B1 (es)
JP (1) JP3633933B2 (es)
KR (1) KR950702635A (es)
AT (1) ATE174628T1 (es)
AU (1) AU4719393A (es)
CA (1) CA2141427C (es)
DE (1) DE69322645T2 (es)
DK (1) DK0652962T3 (es)
ES (1) ES2127829T3 (es)
FI (1) FI950396A0 (es)
GR (1) GR3029498T3 (es)
NO (1) NO318018B1 (es)
WO (1) WO1994003615A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430246T2 (de) * 1993-07-30 2002-12-12 Medeva Holdings Bv Rekombinante tetc-fusionsprotein enthaltene impfstoffzusammensetzungen
GB9401787D0 (en) 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
GB2295394B (en) * 1994-01-31 1997-09-24 Medeva Holdings Bv DNA encoding a fusion protein comprising the C fragment of tetanus toxin
GB9401795D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccines
GB9511909D0 (en) 1995-06-12 1995-08-09 Microbiological Res Authority Vaccine
US6372225B1 (en) 1996-03-23 2002-04-16 The Research Foundation Of Microbial Diseases Of Osaka University Tetanus toxin functional fragment antigen and tetanus vaccine
GB9608106D0 (en) * 1996-04-19 1996-06-26 Univ Newcastle Animal Vaccines
GB9621091D0 (en) * 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
GB9720033D0 (en) * 1997-09-19 1997-11-19 Medeva Plc Hepatitis B virus polypeptides
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6923964B1 (en) 1997-12-02 2005-08-02 Neuralab Limited Active immunization of AScr for prion disorders
US6710226B1 (en) 1997-12-02 2004-03-23 Neuralab Limited Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US6905691B1 (en) 1997-12-11 2005-06-14 Celltech Pharma Europe Limited Vaccines containing attenuated bacteria
GB9726233D0 (en) * 1997-12-11 1998-02-11 Medeva Europ Ltd Vaccines containing attenuated bacteria
US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US7026155B2 (en) * 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
TWI306458B (en) 2003-05-30 2009-02-21 Elan Pharma Int Ltd Humanized antibodies that recognize beta amyloid peptide
CA2590337C (en) 2004-12-15 2017-07-11 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
EP1790358A1 (en) 2005-11-23 2007-05-30 Université de Reims Champagne-Ardennes Protein constructs designed for targeting and lysis of cells
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2008023689A1 (fr) * 2006-08-21 2008-02-28 National University Corporation Kobe University Procédé de production d'une protéine de fusion
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
ES2498040T3 (es) 2007-07-27 2014-09-24 Janssen Alzheimer Immunotherapy Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
WO2009133882A1 (ja) * 2008-05-02 2009-11-05 出光興産株式会社 細菌毒素ワクチン
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
EP2788021B1 (en) 2011-12-09 2017-01-18 Bavarian Nordic A/S Poxvirus vector for the expression of bacterial antigens linked to tetanus toxin fragment c
PT2976355T (pt) 2013-03-18 2020-04-02 Statens Seruminstitut Vacinas contra chlamydia sp

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516442D0 (en) 1985-06-28 1985-07-31 Wellcome Found Cloned antigen
AU613583B2 (en) * 1986-08-22 1991-08-08 Transgene S.A. Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
DE68917126T2 (de) * 1988-02-01 1995-02-02 Praxis Biolog Inc T-zellen-epitope als träger für einen konjugierten impfstoff.
US4970147A (en) * 1988-03-17 1990-11-13 The General Hospital Corporation Oxygen regulatable gene expression
GB8912330D0 (en) * 1989-05-30 1989-07-12 Wellcome Found Live vaccines
GB8914122D0 (en) * 1989-06-20 1989-08-09 Wellcome Found Polypeptide expression
GB8924438D0 (en) * 1989-10-31 1989-12-20 Hoffmann La Roche Vaccine composition
IT1237764B (it) 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
US5389540A (en) * 1989-11-28 1995-02-14 Evans Medical Limited Expression of tetanus toxin fragment C in yeast
CA2031468A1 (en) * 1989-12-08 1991-06-09 Mitchell S. Gross Malaria vaccine
FR2656626B1 (fr) * 1989-12-29 1994-08-12 Pasteur Institut Fragment peptidique comprenant une sequence issue de la proteine 28 kda de schistosoma mansoni et compositions vaccinantes et/ou therapeutiques comprenant ledit fragment.
CZ285118B6 (cs) * 1991-03-05 1999-05-12 The Wellcome Foundation Limited Exprese rekombinačních proteinů v oslabených bakteriích
SE468050C (sv) 1991-03-15 1998-02-11 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
GB9112553D0 (en) * 1991-06-11 1991-07-31 Wellcome Found Fusion proteins
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
ES2185762T3 (es) * 1995-03-13 2003-05-01 Secr Defence Vacunas contra la peste.
US5877159A (en) * 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
US6190669B1 (en) * 1998-05-13 2001-02-20 University Of Maryland, Baltimore Attenuated mutants of salmonella which constitutively express the Vi antigen
US6142433A (en) * 1999-08-18 2000-11-07 Novelty Manufacturing Co. Window sash hanger

Also Published As

Publication number Publication date
AU4719393A (en) 1994-03-03
DK0652962T3 (da) 1999-08-23
EP0863211A1 (en) 1998-09-09
NO318018B1 (no) 2005-01-24
FI950396A (fi) 1995-01-30
KR950702635A (ko) 1995-07-29
GR3029498T3 (en) 1999-05-28
EP0652962A1 (en) 1995-05-17
CA2141427A1 (en) 1994-02-17
ATE174628T1 (de) 1999-01-15
JP3633933B2 (ja) 2005-03-30
EP0652962B1 (en) 1998-12-16
CA2141427C (en) 2008-07-22
FI950396A0 (fi) 1995-01-30
WO1994003615A1 (en) 1994-02-17
DE69322645D1 (de) 1999-01-28
DE69322645T2 (de) 1999-05-20
NO950348D0 (no) 1995-01-30
JPH08503602A (ja) 1996-04-23
US6680182B1 (en) 2004-01-20
NO950348L (no) 1995-03-28

Similar Documents

Publication Publication Date Title
ES2127829T3 (es) Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.
ES2165851T3 (es) Proteinas multivalentes que se unen a antigenos.
DK0574466T3 (da) Udtrykkelse af rekombinante proteiner i svækkede bakterier
MX6339E (es) Metodo para elaborar dentro de un huesped bacteriano y excretar a traves de la membrana de la celula huesped,una proteina o un polipeptido seleccionados
AR006999A1 (es) Una composición inmunogénica, terapéutica o profiláctica , que comprende un polipéptido omp106 aislado, un anticuerpo aislado que se liga a dicho polipéptido y una vacuna que lo comprende.
ES2170075T3 (es) Vacuna de proteina m recombinante multivalente.
ES2171454T3 (es) Proteinas de estres y sus usos.
ATE157397T1 (de) Lebende vakzine
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
DE69430246T2 (de) Rekombinante tetc-fusionsprotein enthaltene impfstoffzusammensetzungen
ES2060580T3 (es) Adn que tiene una secuencia adn codificante de la proteina flagelina y vector que la contiene.
ATE193208T1 (de) Verwendung synthetischer peptide zur induktion der toleranz gegen t- und b-zell epitope von autoantigenen
DE69434384D1 (de) Metalkomplexbildner
DK461884A (da) Beskyttende peptidantigen
ATE273388T1 (de) Veränderte menschliche c3-proteine
FI20070041A (fi) Parannettu rokote Flavivirusinfektioiden vastaiseen immuunisointiin
ES2069742T3 (es) Proteina de la capsida del calicivirus felino y secuencia nucleotida.
DK0625157T3 (da) Blodplade-GPIIIaP1A1- og -P1A2-epitoper og fremstilling og anvendelse deraf
EP0303983A3 (en) Synthetic peptides, antibodies directed against them and their use
ES2125236T3 (es) Mejoras relativas a la deteccion de virus.
AR006150A1 (es) Proteina de via complementaria natural modificada capaz de formar una convertasa c3 resistente a la regulacion descendente, secuencias de adn quecodifican dicha proteina, usos de dicha proteina y composiciones que la contienen
WO1996009391A3 (en) Dna sequence and protein of the non-structural reading frame i of the human parvovirus b19
ES2085163T3 (es) Vacunas contra los parasitos metazoos.
ATE435915T1 (de) Spezifische nukleinsäuren und polypeptide aus krankheitserregenden stämmen von neisseria
ES2032812T3 (es) Vacuna.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 652962

Country of ref document: ES