GB2295394B - DNA encoding a fusion protein comprising the C fragment of tetanus toxin - Google Patents
DNA encoding a fusion protein comprising the C fragment of tetanus toxinInfo
- Publication number
- GB2295394B GB2295394B GB9601739A GB9601739A GB2295394B GB 2295394 B GB2295394 B GB 2295394B GB 9601739 A GB9601739 A GB 9601739A GB 9601739 A GB9601739 A GB 9601739A GB 2295394 B GB2295394 B GB 2295394B
- Authority
- GB
- United Kingdom
- Prior art keywords
- fragment
- fusion protein
- dna encoding
- tetanus toxin
- tetanus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 108010055044 Tetanus Toxin Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 229940118376 tetanus toxin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9601739A GB2295394B (en) | 1994-01-31 | 1994-07-29 | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9401787A GB9401787D0 (en) | 1994-01-31 | 1994-01-31 | Vaccine compositions |
PCT/GB1994/001647 WO1995004151A2 (en) | 1993-07-30 | 1994-07-29 | Vaccine compositions containing recombinant tetc-fusion proteins |
GB9601739A GB2295394B (en) | 1994-01-31 | 1994-07-29 | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9601739D0 GB9601739D0 (en) | 1996-03-27 |
GB2295394A GB2295394A (en) | 1996-05-29 |
GB2295394B true GB2295394B (en) | 1997-09-24 |
Family
ID=26304238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9601739A Revoked GB2295394B (en) | 1994-01-31 | 1994-07-29 | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2295394B (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006974A2 (en) * | 1988-02-01 | 1989-08-10 | Praxis Biologics, Inc. | T-cell epitope as carriers molecule for conjugate vaccines |
EP0432965A1 (en) * | 1989-12-08 | 1991-06-19 | Smithkline Beecham Corporation | Malaria vaccine |
WO1991009621A1 (en) * | 1989-12-29 | 1991-07-11 | Institut Pasteur | PEPTIDE FRAGMENT COMPRISING A SEQUENCE FROM THE 28kDa PROTEIN OF SCHISTOSOMA MANSONI, AND VACCINATING AND/OR THERAPEUTIC COMPOSITIONS COMPRISING SAID FRAGMENT |
WO1992015689A1 (en) * | 1991-03-05 | 1992-09-17 | The Wellcome Foundation Limited | Expression of recombinant proteins in attenuated bacteria |
WO1993008290A1 (en) * | 1991-10-16 | 1993-04-29 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
WO1994003615A1 (en) * | 1992-07-31 | 1994-02-17 | Medeva Holdings B.V. | Expression of recombinant fusion proteins in attenuated bacteria |
-
1994
- 1994-07-29 GB GB9601739A patent/GB2295394B/en not_active Revoked
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006974A2 (en) * | 1988-02-01 | 1989-08-10 | Praxis Biologics, Inc. | T-cell epitope as carriers molecule for conjugate vaccines |
EP0432965A1 (en) * | 1989-12-08 | 1991-06-19 | Smithkline Beecham Corporation | Malaria vaccine |
WO1991009621A1 (en) * | 1989-12-29 | 1991-07-11 | Institut Pasteur | PEPTIDE FRAGMENT COMPRISING A SEQUENCE FROM THE 28kDa PROTEIN OF SCHISTOSOMA MANSONI, AND VACCINATING AND/OR THERAPEUTIC COMPOSITIONS COMPRISING SAID FRAGMENT |
WO1992015689A1 (en) * | 1991-03-05 | 1992-09-17 | The Wellcome Foundation Limited | Expression of recombinant proteins in attenuated bacteria |
WO1993008290A1 (en) * | 1991-10-16 | 1993-04-29 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
WO1994003615A1 (en) * | 1992-07-31 | 1994-02-17 | Medeva Holdings B.V. | Expression of recombinant fusion proteins in attenuated bacteria |
Non-Patent Citations (4)
Title |
---|
BIO/TECHNOLOGY, Vol. 10, No. 8, 1992, pages 888-892 * |
FEMS Symposium, No. 73, "Bacterial Protein Toxins", published 1994, Freer, J. et al (Ed.) * |
J. IMMUNOLOGY, Vol. 141, No. 5, 1988, pages 1687-1694 * |
NUCLEIC ACIDS RESEARCH, Vol. 19, No. 11, 1991, pages 2889-2892 * |
Also Published As
Publication number | Publication date |
---|---|
GB9601739D0 (en) | 1996-03-27 |
GB2295394A (en) | 1996-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
773K | Patent revoked under sect. 73(2)/1977 |
Free format text: PATENT REVOKED ON 20030915 |