IT1241395B - Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria - Google Patents
Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalariaInfo
- Publication number
- IT1241395B IT1241395B IT19914A IT1991490A IT1241395B IT 1241395 B IT1241395 B IT 1241395B IT 19914 A IT19914 A IT 19914A IT 1991490 A IT1991490 A IT 1991490A IT 1241395 B IT1241395 B IT 1241395B
- Authority
- IT
- Italy
- Prior art keywords
- amino acid
- lysine
- acid residue
- chem
- vaccines
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 5
- 235000019766 L-Lysine Nutrition 0.000 abstract 3
- 239000004472 Lysine Substances 0.000 abstract 3
- -1 poly(L-lysine) Polymers 0.000 abstract 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940124280 l-arginine Drugs 0.000 abstract 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19914A IT1241395B (it) | 1990-04-02 | 1990-04-02 | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
| DK91200727.5T DK0450715T3 (da) | 1990-04-02 | 1991-03-28 | Immunologiske forbindelser, en fremgangsmåde til fremstilling deraf og anvendelse deraf, ved fremstillingen af antimalaria-vacciner |
| DE69115539T DE69115539T2 (de) | 1990-04-02 | 1991-03-28 | Immunologische Komponente, Verfahren zur Synthese und Verwendung in Anit-Malaria-Impfstoff-Zusammensetzungen |
| EP91200727A EP0450715B1 (en) | 1990-04-02 | 1991-03-28 | Immunogenic compounds, the process for their synthesis and their use in the preparation of antimalaria vaccines |
| AT91200727T ATE131830T1 (de) | 1990-04-02 | 1991-03-28 | Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen |
| ES91200727T ES2082109T3 (es) | 1990-04-02 | 1991-03-28 | Compuestos inmunogenicos, el procedimiento para su sintesis y su uso en la preparacion de vacunas antimalaria. |
| GR960400139T GR3018750T3 (en) | 1990-04-02 | 1996-01-19 | Immunogenic compounds, the process for their synthesis and their use in the preparation of antimalaria vaccines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19914A IT1241395B (it) | 1990-04-02 | 1990-04-02 | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9019914A0 IT9019914A0 (it) | 1990-04-02 |
| IT9019914A1 IT9019914A1 (it) | 1991-10-02 |
| IT1241395B true IT1241395B (it) | 1994-01-10 |
Family
ID=11162291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19914A IT1241395B (it) | 1990-04-02 | 1990-04-02 | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0450715B1 (it) |
| AT (1) | ATE131830T1 (it) |
| DE (1) | DE69115539T2 (it) |
| DK (1) | DK0450715T3 (it) |
| ES (1) | ES2082109T3 (it) |
| GR (1) | GR3018750T3 (it) |
| IT (1) | IT1241395B (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107434D0 (en) * | 1991-04-09 | 1991-05-22 | Medical Res Council | Peptide-based assay |
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| MXPA05003057A (es) | 2002-09-18 | 2006-04-18 | Johnson & Johnson | Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas. |
| RS56387B1 (sr) | 2003-08-28 | 2017-12-29 | Ortho Mcneil Pharm Inc | Peptidi i jedinjenja koja se vežu za trombopoetinski receptor |
| US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| CN102153654B (zh) * | 2009-12-31 | 2012-10-10 | 中国疾病预防控制中心病毒病预防控制所 | 以免疫活性肽为载体的分支多肽及其衍生物与应用 |
| ES2623979T3 (es) | 2013-03-21 | 2017-07-12 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos peptídicos que contienen hidantoína |
| ES2624961T3 (es) | 2013-03-21 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos de péptido que contienen imida cíclica |
| WO2016084944A1 (ja) * | 2014-11-28 | 2016-06-02 | 国立大学法人 群馬大学 | 熱帯熱マラリア原虫のエノラーゼタンパク質の部分配列を用いた人工抗原とその製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1187710B (it) * | 1985-07-25 | 1987-12-23 | Eniricerche Spa | Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche |
| EP0253190B1 (en) * | 1986-07-16 | 1992-12-30 | ENIRICERCHE S.p.A. | Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them |
| IT1216908B (it) * | 1987-03-19 | 1990-03-14 | Eniricerche Spa | Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. |
| GB8812214D0 (en) * | 1988-05-24 | 1988-06-29 | Hoffmann La Roche | Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope |
| EP0378881B1 (en) * | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| AU5649290A (en) * | 1989-04-12 | 1990-11-05 | New York University | Dendritic polymer of multiple antigen peptide system useful as anti-malarial vaccine |
-
1990
- 1990-04-02 IT IT19914A patent/IT1241395B/it active IP Right Grant
-
1991
- 1991-03-28 EP EP91200727A patent/EP0450715B1/en not_active Expired - Lifetime
- 1991-03-28 ES ES91200727T patent/ES2082109T3/es not_active Expired - Lifetime
- 1991-03-28 DE DE69115539T patent/DE69115539T2/de not_active Expired - Fee Related
- 1991-03-28 AT AT91200727T patent/ATE131830T1/de not_active IP Right Cessation
- 1991-03-28 DK DK91200727.5T patent/DK0450715T3/da active
-
1996
- 1996-01-19 GR GR960400139T patent/GR3018750T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0450715A1 (en) | 1991-10-09 |
| IT9019914A0 (it) | 1990-04-02 |
| ES2082109T3 (es) | 1996-03-16 |
| DE69115539T2 (de) | 1996-08-01 |
| IT9019914A1 (it) | 1991-10-02 |
| ATE131830T1 (de) | 1996-01-15 |
| EP0450715B1 (en) | 1995-12-20 |
| DK0450715T3 (da) | 1996-02-26 |
| DE69115539D1 (de) | 1996-02-01 |
| GR3018750T3 (en) | 1996-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970415 |