AR062931A2 - Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentos - Google Patents
Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentosInfo
- Publication number
- AR062931A2 AR062931A2 ARP070104172A ARP070104172A AR062931A2 AR 062931 A2 AR062931 A2 AR 062931A2 AR P070104172 A ARP070104172 A AR P070104172A AR P070104172 A ARP070104172 A AR P070104172A AR 062931 A2 AR062931 A2 AR 062931A2
- Authority
- AR
- Argentina
- Prior art keywords
- thrombopoyetin
- medicines
- receptor
- activate
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto que comprende la siguiente secuencia de aminoácidos: I E G P T L R Q W. Reivindicacion 5: El compuesto e la reivindicacion 2, caracterizado porque dicho dímero está unido por K.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/764,640 US5869451A (en) | 1995-06-07 | 1996-12-11 | Peptides and compounds that bind to a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062931A2 true AR062931A2 (es) | 2008-12-17 |
Family
ID=25071323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105779A AR010752A1 (es) | 1996-12-11 | 1997-12-09 | COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN. |
| ARP070104172A AR062931A2 (es) | 1996-12-11 | 2007-09-20 | Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105779A AR010752A1 (es) | 1996-12-11 | 1997-12-09 | COMPUESTOS QUE SE ENLAZAN A Y ACTIVAN UN RECEPTOR DE LA TROMBOPOYETINA; COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, SU USO PARA LA PREPARACION DE MEDICAMENTOS, Y PROCESO PARA PREPARAR DICHA COMPOSICIoN. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5869451A (es) |
| EP (3) | EP2336165A1 (es) |
| JP (1) | JP4128225B2 (es) |
| KR (3) | KR100668546B1 (es) |
| CN (1) | CN100379760C (es) |
| AR (2) | AR010752A1 (es) |
| AT (1) | ATE420893T1 (es) |
| AU (1) | AU725731B2 (es) |
| BR (1) | BRPI9713914B1 (es) |
| CA (1) | CA2274149C (es) |
| CO (1) | CO5080768A1 (es) |
| DE (1) | DE69739219D1 (es) |
| ES (1) | ES2321038T3 (es) |
| HR (1) | HRP970683B1 (es) |
| MA (1) | MA26454A1 (es) |
| PA (1) | PA8442601A1 (es) |
| PE (1) | PE27599A1 (es) |
| SV (1) | SV1997000104A (es) |
| TN (1) | TNSN97201A1 (es) |
| TR (2) | TR200401638T2 (es) |
| TW (1) | TW515804B (es) |
| UY (1) | UY24805A1 (es) |
| WO (1) | WO1998025965A2 (es) |
| ZA (1) | ZA9711045B (es) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| AR003431A1 (es) * | 1995-06-07 | 1998-08-05 | Glaxo Group Ltd | Peptidos compuestos que se ligan al receptor de trombopoietina. |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| US7083983B2 (en) * | 1996-07-05 | 2006-08-01 | Cancer Research Campaign Technology Limited | Inhibitors of the interaction between P53 and MDM2 |
| EP1032388A4 (en) * | 1997-10-31 | 2002-10-02 | Smithkline Beecham Corp | NEW METAL COMPLEXES |
| JP2001521896A (ja) | 1997-10-31 | 2001-11-13 | スミスクライン・ビーチャム・コーポレイション | 新規な金属錯体 |
| WO1999022732A1 (en) | 1997-10-31 | 1999-05-14 | Smithkline Beecham Corporation | Novel metal complexes |
| US7153655B2 (en) | 1998-06-16 | 2006-12-26 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| PL219605B1 (pl) * | 1998-10-23 | 2015-06-30 | Kirin Amgen Inc | Dimeryczne mimetyki peptydów trombopoetynowych wiążące się z receptorem MP1 i wykazujące aktywność trombopoetyczną |
| US7488590B2 (en) * | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1225901A2 (en) * | 1999-09-21 | 2002-07-31 | Emory University | Uses and compositions for treating platelet-related disorders using anagrelide |
| US7668658B2 (en) | 1999-10-13 | 2010-02-23 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| WO2001036604A2 (en) | 1999-11-18 | 2001-05-25 | Corvas International, Inc. | Nucleic acids encoding endotheliases, endotheliases and uses thereof |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| US7700341B2 (en) | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| AU2001259432B2 (en) * | 2000-05-03 | 2005-04-21 | Amgen Inc. | Modified peptides, comprising an FC domain, as therapeutic agents |
| US20050158838A1 (en) * | 2000-06-19 | 2005-07-21 | Dyax Corp., A Delaware Corporation | Novel enterokinase cleavage sequences |
| DE60136656D1 (de) | 2000-12-05 | 2009-01-02 | Alexion Pharma Inc | Rationell entworfene Antikörper |
| US7396917B2 (en) | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| US20040253242A1 (en) * | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
| US6958213B2 (en) | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
| WO2002072786A2 (en) | 2001-03-13 | 2002-09-19 | Corvas International, Inc. | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
| JP2004535166A (ja) | 2001-03-22 | 2004-11-25 | デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー | セリンプロテアーゼcvsp14をコードする核酸分子、コードされるポリペプチドおよびそれに基づく方法 |
| JP2005506047A (ja) | 2001-03-27 | 2005-03-03 | デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー | 膜貫通型セリンプロテアーゼ9をコード化する核酸分子、コード化されたポリペプチドおよびそれらに基づく方法 |
| US7112430B2 (en) | 2001-05-14 | 2006-09-26 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
| US7332474B2 (en) * | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| AU2002357004A1 (en) * | 2001-11-20 | 2003-06-10 | Dendreon San Diego Llc | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| CA2484676A1 (en) | 2002-05-03 | 2003-11-13 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof, and related methods |
| WO2003097834A2 (en) | 2002-05-17 | 2003-11-27 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
| ES2254725T3 (es) * | 2002-06-29 | 2006-06-16 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Concentrados de isoflavonas y metodos para su preparacion. |
| US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
| JP4412173B2 (ja) | 2002-08-14 | 2010-02-10 | 日産化学工業株式会社 | トロンボポエチンレセプター活性化剤ならびにそれらの製造方法 |
| US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
| US8227411B2 (en) * | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
| US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| AU2003275077B2 (en) * | 2002-09-18 | 2010-02-04 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
| TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
| CA2515779A1 (en) | 2003-02-14 | 2004-09-02 | The Curators Of The University Of Missouri | Contraceptive method and compositions related to proteasomal interference |
| SG160224A1 (en) * | 2003-05-12 | 2010-04-29 | Affymax Inc | Novel peptides that bind to the erythropoietin receptor |
| CA2525464A1 (en) * | 2003-05-12 | 2004-11-25 | Qun Yin | Novel poly(ethylene glycol) modified compounds and uses thereof |
| CA2525399A1 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds |
| EA010099B1 (ru) * | 2003-05-12 | 2008-06-30 | Афимакс, Инк. | Пептиды, которые связываются с рецептором к эритропоэтину, и способы их применения |
| KR100776961B1 (ko) * | 2003-08-12 | 2007-11-28 | 시오노기세이야쿠가부시키가이샤 | 트롬보포이에틴 수용체 아고니스트 작용을 가지는 화합물 |
| PT1675606T (pt) * | 2003-08-28 | 2017-05-22 | Janssen Pharmaceuticals Inc | Péptidos e compostos que se ligam a um receptor |
| US7723295B2 (en) * | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| ES2295961T3 (es) | 2003-12-31 | 2008-04-16 | F. Hoffmann-La Roche Ag | Proceso para la sintesis peptidica utilizacndo una cantidad reducida de agente de desproteccion. |
| US7414028B1 (en) * | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
| US7671012B2 (en) | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US20060024347A1 (en) * | 2004-02-10 | 2006-02-02 | Biosurface Engineering Technologies, Inc. | Bioactive peptide coatings |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| US7528105B1 (en) | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
| DE602005023714D1 (de) | 2004-02-20 | 2010-11-04 | Biosurface Eng Tech Inc | Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2) |
| MX2007000216A (es) * | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
| US20060210542A1 (en) * | 2004-08-16 | 2006-09-21 | Yurkow Edward J | Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia |
| EP1797127B1 (en) | 2004-09-24 | 2017-06-14 | Amgen Inc. | Modified fc molecules |
| US7589063B2 (en) | 2004-12-14 | 2009-09-15 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| CA2587382A1 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| CA2588979C (en) | 2004-12-08 | 2013-01-22 | Nissan Chemical Industries, Ltd. | 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators |
| AU2005314788B2 (en) | 2004-12-14 | 2011-09-22 | Nissan Chemical Industries, Ltd. | Amide compound and thrombopoietin receptor activator |
| US8258258B2 (en) | 2005-03-10 | 2012-09-04 | Biontech Ag | Dimeric or multimeric microproteins |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| EA200800109A1 (ru) * | 2005-06-23 | 2008-06-30 | Аплаген Гмбх | Суправалентные соединения |
| NZ563202A (en) | 2005-07-15 | 2011-02-25 | Nissan Chemical Ind Ltd | Thiophene compounds and thrombopoietin receptor activators |
| EP1904488B1 (en) | 2005-07-20 | 2013-03-06 | Nissan Chemical Industries, Ltd. | Pyrazole compounds and thrombopoietin receptor activators |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| KR101350099B1 (ko) | 2005-11-07 | 2014-01-09 | 닛산 가가쿠 고교 가부시키 가이샤 | 하이드라지드 화합물 및 트롬보포이에틴 리셉터 활성화제 |
| US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
| US7879318B2 (en) | 2006-01-23 | 2011-02-01 | Mcw Research Foundation, Inc. | Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand |
| CA2635498A1 (en) * | 2006-01-25 | 2007-08-02 | Amgen Inc. | Thrombopoietic compounds |
| EP1834963A1 (en) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| DK2005185T3 (da) | 2006-03-22 | 2011-01-31 | Viral Logic Systems Technology Corp | Fremgangsmåde til identifikation af polypeptidtargets |
| JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| JP2009537145A (ja) * | 2006-05-15 | 2009-10-29 | バイラル ロジック システムズ テクノロジー コーポレーション | 免疫学的疾患および障害を治療するためのcd47と関連した組成物および方法 |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
| WO2007142308A1 (ja) | 2006-06-07 | 2007-12-13 | Nissan Chemical Industries, Ltd. | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
| US7981425B2 (en) * | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| EP2046350A4 (en) | 2006-06-22 | 2011-09-14 | Biosurface Eng Tech Inc | COMPOSITION AND METHOD FOR DELIVERING AMPLIFIER / CO-ACTIVATOR OF BMP-2 TO ENHANCE OSTEOGENESIS |
| US20090252703A1 (en) * | 2006-10-19 | 2009-10-08 | Gegg Jr Colin V | Use of alcohol co-solvents to improve pegylation reaction yields |
| WO2008095004A2 (en) * | 2007-01-31 | 2008-08-07 | Affymax, Inc. | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules |
| MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
| US20090054332A1 (en) * | 2007-06-21 | 2009-02-26 | Conjuchem Biotechnologies, Inc. | Thombopoietin peptide conjugates |
| WO2009029682A1 (en) * | 2007-08-28 | 2009-03-05 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
| US8183342B2 (en) * | 2007-11-06 | 2012-05-22 | Case Western Reserve University | Method of treating chemotherapy-induced thrombocytopenia |
| CN101481352A (zh) | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
| MX2010008096A (es) | 2008-01-25 | 2010-09-22 | Amgen Inc | Anticuerpos de ferroportina y metodos de uso. |
| EP2620448A1 (en) | 2008-05-01 | 2013-07-31 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| WO2011012306A2 (en) | 2009-07-30 | 2011-02-03 | Aplagen Gmbh | Use of emps for antagonising epo-stimulatory effects on epo-responsive tumors while maintaining erythropoiesis |
| EP2492262B1 (en) | 2009-10-23 | 2016-04-20 | Nissan Chemical Industries, Ltd. | Fused heterocyclic compound and thrombopoietin receptor activator |
| WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
| MX360946B (es) | 2010-09-22 | 2018-10-29 | Amgen Inc Star | Inmunoglobulinas portadoras y usos de las mismas. |
| WO2014159242A1 (en) | 2013-03-14 | 2014-10-02 | Novartis Ag | Notch 3 mutants and uses thereof |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| US10538555B2 (en) | 2014-09-11 | 2020-01-21 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| CN107001455B (zh) | 2014-11-19 | 2022-03-01 | 皇家飞利浦有限公司 | 利用hnl的诊断方法 |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| LT3458111T (lt) | 2016-05-19 | 2021-05-25 | Bristol-Myers Squibb Company | Pet vizualizacijos imunomoduliatoriai |
| EP3535280B1 (en) | 2016-11-07 | 2022-03-16 | Bristol-Myers Squibb Company | Immunomodulators |
| US11066445B2 (en) | 2017-06-23 | 2021-07-20 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of PD-1 |
| AU2018306329B8 (en) * | 2017-07-26 | 2025-02-20 | Janssen Pharmaceutica Nv | Methods of protecting vascular integrity induced by targeted radiation therapy |
| CN111051332B (zh) | 2017-10-03 | 2024-09-06 | 百时美施贵宝公司 | 免疫调节剂 |
| KR20210141460A (ko) * | 2019-01-25 | 2021-11-23 | 잔센파마슈티카엔.브이. | 방사선 및/또는 방사선 모방체 치료와 함께 간 손상을 완화하고 간 비대, 재생 및 세포 생착을 촉진하는 방법 |
| CN113660943A (zh) | 2019-01-25 | 2021-11-16 | 詹森药业有限公司 | 增强对全身放射/化学暴露反应的对器官和血管损伤的保护、造血恢复以及存活的方法 |
| MA54830A (fr) | 2019-01-25 | 2021-12-01 | Janssen Pharmaceutica Nv | Procédés d'atténuation des effets toxiques d'agents vésicants et de gaz caustiques |
| JP2023510737A (ja) | 2020-01-06 | 2023-03-15 | ブリストル-マイヤーズ スクイブ カンパニー | 免疫調節剤 |
| WO2021202501A1 (en) | 2020-03-30 | 2021-10-07 | Bristol-Myers Squibb Company | Immunomodulators |
| JP2024536246A (ja) | 2021-10-01 | 2024-10-04 | ヤンセン ファーマシューティカ エヌ.ベー. | 前駆細胞産生を増加させる方法 |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2046920B1 (es) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4612132A (en) | 1984-07-20 | 1986-09-16 | Chevron Research Company | Modified succinimides |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5198424A (en) * | 1989-03-08 | 1993-03-30 | Board Of Regents Of The University Of Oklahoma | Functionally active selectin-derived peptides |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5326558A (en) * | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| IL96477A0 (en) * | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| US5571508A (en) * | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
| IT1241395B (it) * | 1990-04-02 | 1994-01-10 | Eniricerche Spa | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5250732A (en) * | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
| US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| PT644771E (pt) * | 1992-06-11 | 2002-12-31 | Alkermes Inc | Sistema de entrega da droga eritropoietina |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| EP0722331A4 (en) | 1993-08-25 | 1997-10-01 | Systemix Inc | METHOD FOR PRODUCING A POPULATION OF HIGHLY ENRICHED HEMATOPOIETIC STEM CELLS |
| WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| GB2285446B (en) * | 1994-01-03 | 1999-07-28 | Genentech Inc | Thrombopoietin |
| PL178384B1 (pl) * | 1994-02-14 | 2000-04-28 | Univ Washington | Wydzielone białko, wydzielone cząsteczki polinukleotydowe, wektor ekspresji, hodowana komórka, kompozycja farmaceutyczna do stymulacji wytwarzania płytek krwi u ssaka, sposób wytwarzania białka homeopoezyjnego, sposób otrzymywania przeciwciał, sposób stymulacji i namnażania komórek |
| AU1843595A (en) * | 1994-02-14 | 1995-08-29 | University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
| WO1995021919A2 (en) * | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| EP0668352A1 (en) * | 1994-02-14 | 1995-08-23 | Kirin Brewery Company, Ltd. | Protein having TPO activity |
| RO115788B1 (ro) * | 1994-03-31 | 2000-06-30 | Amgen Inc. | Polipeptidă mgdf, derivat de polipeptidă mgdf, polipeptidă mgdf mono-pegilată şi procedee de obţinere a acestora |
| US5571686A (en) * | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
| AU4163196A (en) * | 1994-11-30 | 1996-06-19 | Zymogenetics Inc. | Low molecular weight thrombopoietin |
| US5641655A (en) * | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| WO1996034016A1 (en) * | 1995-04-26 | 1996-10-31 | Kyowa Hakko Kogyo Co., Ltd. | Novel polypeptides |
| AR003431A1 (es) * | 1995-06-07 | 1998-08-05 | Glaxo Group Ltd | Peptidos compuestos que se ligan al receptor de trombopoietina. |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| KR102127408B1 (ko) | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
-
1996
- 1996-12-11 US US08/764,640 patent/US5869451A/en not_active Expired - Lifetime
-
1997
- 1997-12-05 PE PE1997001095A patent/PE27599A1/es not_active IP Right Cessation
- 1997-12-08 SV SV1997000104A patent/SV1997000104A/es not_active Application Discontinuation
- 1997-12-09 EP EP20100185440 patent/EP2336165A1/en not_active Withdrawn
- 1997-12-09 TR TR2004/01638T patent/TR200401638T2/xx unknown
- 1997-12-09 TR TR1999/01971T patent/TR199901971T2/xx unknown
- 1997-12-09 EP EP97954363A patent/EP0948539B1/en not_active Expired - Lifetime
- 1997-12-09 JP JP52619798A patent/JP4128225B2/ja not_active Expired - Lifetime
- 1997-12-09 ZA ZA9711045A patent/ZA9711045B/xx unknown
- 1997-12-09 CN CNB971816514A patent/CN100379760C/zh not_active Expired - Lifetime
- 1997-12-09 WO PCT/EP1997/006850 patent/WO1998025965A2/en not_active Ceased
- 1997-12-09 CA CA002274149A patent/CA2274149C/en not_active Expired - Lifetime
- 1997-12-09 ES ES97954363T patent/ES2321038T3/es not_active Expired - Lifetime
- 1997-12-09 AR ARP970105779A patent/AR010752A1/es active IP Right Grant
- 1997-12-09 KR KR1020057005233A patent/KR100668546B1/ko not_active Expired - Lifetime
- 1997-12-09 DE DE69739219T patent/DE69739219D1/de not_active Expired - Lifetime
- 1997-12-09 EP EP08075855A patent/EP2028191A1/en not_active Withdrawn
- 1997-12-09 CO CO97071692A patent/CO5080768A1/es unknown
- 1997-12-09 AU AU58547/98A patent/AU725731B2/en not_active Expired
- 1997-12-09 BR BRPI9713914-9A patent/BRPI9713914B1/pt not_active IP Right Cessation
- 1997-12-09 KR KR1020067003807A patent/KR100679576B1/ko not_active Expired - Lifetime
- 1997-12-09 AT AT97954363T patent/ATE420893T1/de not_active IP Right Cessation
- 1997-12-09 KR KR1019997005169A patent/KR100625708B1/ko not_active Expired - Lifetime
- 1997-12-10 MA MA24894A patent/MA26454A1/fr unknown
- 1997-12-10 TW TW086118867A patent/TW515804B/zh active
- 1997-12-10 UY UY24805A patent/UY24805A1/es not_active IP Right Cessation
- 1997-12-10 TN TNTNSN97201A patent/TNSN97201A1/fr unknown
- 1997-12-10 HR HR970683A patent/HRP970683B1/xx not_active IP Right Cessation
- 1997-12-11 PA PA19978442601A patent/PA8442601A1/es unknown
-
1999
- 1999-02-03 US US09/244,298 patent/US6121238A/en not_active Expired - Lifetime
-
2007
- 2007-09-20 AR ARP070104172A patent/AR062931A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR062931A2 (es) | Compuestos que se enlazan a y activan un receptor de la trombopoyetina , composicones farmaceuticas que los contienen y su uso para la preparacion de medicamentos | |
| MX9304581A (es) | Desoxitaxoles y composiciones farmaceuticas que los contienen | |
| MX9301929A (es) | Derivados de pirimidina y procedimientos para su preparacion. | |
| BR9803179A (pt) | Antagonistas receptores de ccr-3. | |
| CU23393A3 (es) | Compuestos inhibidores de la raf kinasa y composiciones farmacéuticas que los contienen | |
| AR002268A1 (es) | Antagonistas de vasopresina de benzacepina triciclicos, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso dedichos compuestos para preparar composiciones farmaceuticas. | |
| MX9300261A (es) | Derivados de 1,5-benzodiacepina, proceso para su preparacion y composicion farmaceutica que los contiene. | |
| MX9204354A (es) | Compuestos heterociclicos de 5 miembros, procedimiento para prepararlos y composiciones farmaceuticas que los contienen. | |
| ES2175350T3 (es) | Compuestos triciclicos que tienen afinidad de union a receptores de melatonina, su produccion y uso. | |
| BR9813378A (pt) | Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão | |
| ES2128735T3 (es) | Composiciones farmaceuticas que comprenden un antagonista de opiaceos y de sales de calcio y su uso para el tratamiento de patologias en las que intervienen las endorfinas. | |
| ES2065701T3 (es) | Furoato de mometasona monohidrato, procedimiento para fabricar el mismo y composiciones farmaceuticas. | |
| ES2079719T3 (es) | Derivados de amidinofenilalanina, procedimiento para su preparacion, su utilizacion y agentes que los contienen en calidad de anticoagulantes. | |
| UY26199A1 (es) | Nuevos derivados de benceno, un procedimiento para su preparación y las composiciones farmacéuticas que los contienen | |
| ES2062239T3 (es) | Diamidas de acidos pirimidin-4,6-dicarboxilicos, procedimiento para su preparacion, utilizacion de las mismas, asi como medicamentos a base de estos compuestos. | |
| MX9302169A (es) | Fenoxialquilisoxazolas de 1,2,4-oxadiazolilo y su uso como agentes antivirales. | |
| MX9307654A (es) | Derivados de amina, proceso para su preparacion y composicion farmaceutica que los contiene. | |
| ES2178055T3 (es) | Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| MX9301197A (es) | Derivados de indol. | |
| AR002017A1 (es) | Derivados de fenil-4-tiazoles substituidos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y derivados defenil-4-tiazoles substituidos empleados en dicho procedimiento. | |
| MX9303933A (es) | Compuestos intermedios sinteticos novedosos y procedimiento para la preparacion de los derivados de los aminoacidos. | |
| MX9301112A (es) | Derivados de indol. | |
| SV1998000013A (es) | Derivados de 5-aroilnaftaleno ref.-ran 4070\115 | |
| MX9300840A (es) | Compuestos farmaceuticos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| MX9203577A (es) | Nuevos derivados de sinergistinas y composiciones farmaceuticas que los contienen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |