MA26454A1 - Peptides et composes se liant a un recepteur arriere-plan de l'invention. - Google Patents

Peptides et composes se liant a un recepteur arriere-plan de l'invention.

Info

Publication number
MA26454A1
MA26454A1 MA24894A MA24894A MA26454A1 MA 26454 A1 MA26454 A1 MA 26454A1 MA 24894 A MA24894 A MA 24894A MA 24894 A MA24894 A MA 24894A MA 26454 A1 MA26454 A1 MA 26454A1
Authority
MA
Morocco
Prior art keywords
peptides
compounds binding
receptor background
receptor
background
Prior art date
Application number
MA24894A
Other languages
English (en)
Inventor
Balasubramanian Palaniappan
Wayne Hendren Richard
E Cwirla Steven
J Schatz Peter
J Dower William
Yin Qun
Podduturi Surekha
R Wagstrom Christopher
W Barrett Ronald
B Deprince Randolph
M Gates Christian
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25071323&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA26454(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA26454A1 publication Critical patent/MA26454A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/524Thrombopoietin, i.e. C-MPL ligand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MA24894A 1996-12-11 1997-12-10 Peptides et composes se liant a un recepteur arriere-plan de l'invention. MA26454A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/764,640 US5869451A (en) 1995-06-07 1996-12-11 Peptides and compounds that bind to a receptor

Publications (1)

Publication Number Publication Date
MA26454A1 true MA26454A1 (fr) 2004-12-20

Family

ID=25071323

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24894A MA26454A1 (fr) 1996-12-11 1997-12-10 Peptides et composes se liant a un recepteur arriere-plan de l'invention.

Country Status (24)

Country Link
US (2) US5869451A (fr)
EP (3) EP2028191A1 (fr)
JP (1) JP4128225B2 (fr)
KR (3) KR100668546B1 (fr)
CN (1) CN100379760C (fr)
AR (2) AR010752A1 (fr)
AT (1) ATE420893T1 (fr)
AU (1) AU725731B2 (fr)
BR (1) BRPI9713914B1 (fr)
CA (1) CA2274149C (fr)
CO (1) CO5080768A1 (fr)
DE (1) DE69739219D1 (fr)
ES (1) ES2321038T3 (fr)
HR (1) HRP970683B1 (fr)
MA (1) MA26454A1 (fr)
PA (1) PA8442601A1 (fr)
PE (1) PE27599A1 (fr)
SV (1) SV1997000104A (fr)
TN (1) TNSN97201A1 (fr)
TR (2) TR200401638T2 (fr)
TW (1) TW515804B (fr)
UY (1) UY24805A1 (fr)
WO (1) WO1998025965A2 (fr)
ZA (1) ZA9711045B (fr)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
CN1315870C (zh) * 1995-06-07 2007-05-16 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US7083983B2 (en) * 1996-07-05 2006-08-01 Cancer Research Campaign Technology Limited Inhibitors of the interaction between P53 and MDM2
JP2001521896A (ja) 1997-10-31 2001-11-13 スミスクライン・ビーチャム・コーポレイション 新規な金属錯体
AU739173B2 (en) * 1997-10-31 2001-10-04 Ligand Pharmaceuticals Incorporated Novel metal complexes
AU748063B2 (en) 1997-10-31 2002-05-30 Ligand Pharmaceuticals Incorporated Novel metal complexes
HU228582B1 (en) * 1998-10-23 2013-04-29 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP1216037A2 (fr) * 1999-09-21 2002-06-26 Emory University Procedes et compositions pour le traitement de troubles lies aux plaquettes au moyen d'agents inhibiteurs de trajet de mpl
US20030190644A1 (en) 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
AU784746B2 (en) 1999-11-18 2006-06-08 Dendreon Corporation Nucleic acids encoding endotheliases, endotheliases and uses thereof
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
JP2003533187A (ja) * 2000-05-03 2003-11-11 アムジエン・インコーポレーテツド 治療薬としてのFcドメインを含む修飾ペプチド
US20050158838A1 (en) * 2000-06-19 2005-07-21 Dyax Corp., A Delaware Corporation Novel enterokinase cleavage sequences
AU3400102A (en) * 2000-12-05 2002-06-18 Alexion Pharma Inc Rationally designed antibodies
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7172892B2 (en) 2001-03-22 2007-02-06 Dendreon Corporation Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon
NZ527971A (en) 2001-03-27 2006-03-31 Dendreon Corp Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030134794A1 (en) * 2001-11-20 2003-07-17 Madison Edwin L. Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004002469A1 (fr) * 2002-06-29 2004-01-08 Aquanova German Solubilisate Technologies (Agt) Gmbh Concentres d'isoflavone et procede pour les preparer
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
WO2004016264A1 (fr) 2002-08-14 2004-02-26 Nissan Chemical Industries, Ltd. Activateur du recepteur de la thrombopoietine et procede de production
US7598224B2 (en) * 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7981862B2 (en) 2003-08-19 2011-07-19 Biosurface Engineering Technologies, Inc. Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis
ES2462916T3 (es) * 2002-09-18 2014-05-26 Janssen Pharmaceuticals, Inc. Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
WO2004073624A2 (fr) 2003-02-14 2004-09-02 The Curators Of The University Of Missouri Methodes et compositions contraceptives associees aux interferences des proteasomes
EP2204193A3 (fr) * 2003-05-12 2010-08-18 Affymax, Inc. Groupe espaceur pour composés à base de peptides de poly(éthylèneglycol) modifiés
CA2525568C (fr) * 2003-05-12 2017-07-25 Affymax, Inc. Nouveaux peptides se fixant au recepteur de l'erythropoietine
EA010099B1 (ru) * 2003-05-12 2008-06-30 Афимакс, Инк. Пептиды, которые связываются с рецептором к эритропоэтину, и способы их применения
CN1820024B (zh) * 2003-05-12 2011-06-22 阿费麦克斯公司 新的聚(乙二醇)修饰的化合物及其用途
US7601746B2 (en) * 2003-08-12 2009-10-13 Shionogi & Co., Ltd. Compounds exhibiting thrombopoietin receptor agonism
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
SI1675606T1 (sl) * 2003-08-28 2017-07-31 Janssen Pharmaceuticals, Inc. Peptidi in spojine, ki se vežejo na trombopoietinske receptorje
WO2005063791A2 (fr) 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Procede et systemes pour la synthese de peptides
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
WO2005082005A2 (fr) * 2004-02-20 2005-09-09 Biosurface Engineering Technologies, Inc., Et Al. Modulateur positif de la proteine 2 morphogenique osseuse
US8143380B2 (en) * 2004-07-08 2012-03-27 Amgen Inc. Therapeutic peptides
US20060210542A1 (en) * 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
JP5017116B2 (ja) * 2004-09-24 2012-09-05 アムジエン・インコーポレーテツド 修飾Fc分子
US7589063B2 (en) 2004-12-14 2009-09-15 Aplagen Gmbh Molecules which promote hematopoiesis
WO2006062685A2 (fr) * 2004-11-11 2006-06-15 Affymax, Inc. Nouveaux peptides se liant au recepteur de l'erythropoietine
AU2005310189A1 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
TWI351954B (en) 2004-12-08 2011-11-11 Nissan Chemical Ind Ltd Heterocyclic compounds and thrombopoietin receptor
TWI399368B (zh) 2004-12-14 2013-06-21 Nissan Chemical Ind Ltd Amide compounds and thrombopoietin receptor activators
WO2006094813A2 (fr) 2005-03-10 2006-09-14 Nascacell Technologies Ag. Microproteines dimeriques ou multimeriques
WO2006094530A1 (fr) * 2005-03-11 2006-09-14 Siegfried Ltd. Conjugues de proteines et de dipolymeres et leurs procedes de preparation
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
CA2648732A1 (fr) * 2005-06-23 2006-12-28 Aplagen Gmbh Composes supravalents
EP1904472A1 (fr) 2005-07-15 2008-04-02 Nissan Chemical Industries, Ltd. Composes thiophenes et activateurs du recepteur thrombopoietine
US7960425B2 (en) 2005-07-20 2011-06-14 Nissan Chemical Industries, Ltd. Pyrazole compounds and thrombopoietin receptor activators
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
EP1947101A4 (fr) 2005-11-07 2009-09-16 Nissan Chemical Ind Ltd Composé de type hydrazide et activateur du récepteur de la thrombopoïétine
US7879318B2 (en) 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
AU2007208226A1 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
EP1834963A1 (fr) * 2006-03-13 2007-09-19 Siegfried Ltd. Conjugues de proteines et de dipolymeres et leurs procedes de preparation
WO2007109370A2 (fr) 2006-03-22 2007-09-27 Viral Logic Systems Technology Corp. Procédés d'identification de polypeptides cibles et utilisations dans le traitement de maladies immunologiques
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
US20080131431A1 (en) * 2006-05-15 2008-06-05 Viral Logic Systems Technology Corp. CD47 related compositions and methods for treating immunological diseases and disorders
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2025671A4 (fr) 2006-06-07 2011-04-06 Nissan Chemical Ind Ltd Composé hétérocyclique azoté et activateur de récepteur de thrombopoïétine
US7981425B2 (en) * 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
WO2008051383A2 (fr) * 2006-10-19 2008-05-02 Amgen Inc. Utilisation de co-solvants d'alcool pour améliorer les rendements de réaction de pegylation
JP2010520855A (ja) * 2007-01-31 2010-06-17 アフィーマックス・インコーポレイテッド 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー
CA2687141C (fr) 2007-05-22 2014-04-01 Amgen Inc. Compositions et procedes pour produire des proteines de fusion bioactives
WO2008157824A2 (fr) * 2007-06-21 2008-12-24 Conjuchem Biotechnologies Inc. Conjugués de peptides thrombopoïétiques
WO2009029682A1 (fr) * 2007-08-28 2009-03-05 Rigel Pharmaceuticals, Inc. Thérapie de combinaison avec un inhibiteur de la kinase syk
US8183342B2 (en) * 2007-11-06 2012-05-22 Case Western Reserve University Method of treating chemotherapy-induced thrombocytopenia
CN101481352A (zh) 2008-01-10 2009-07-15 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用
WO2009094551A1 (fr) 2008-01-25 2009-07-30 Amgen Inc. Anticorps anti-ferroportine et procédés d'utilisation
ES2487846T3 (es) 2008-05-01 2014-08-25 Amgen, Inc. Anticuerpos anti-hepcindina y métodos de uso
MX2011009798A (es) 2009-03-20 2011-12-08 Amgen Inc Inmunoglobulinas portadoras y usos de las mismas.
WO2011012306A2 (fr) 2009-07-30 2011-02-03 Aplagen Gmbh Utilisation d'emp pour contrer les effets stimulants de l'epo sur des tumeurs sensibles à l'epo, tout en maintenant l'érythropoïèse
EP2492262B1 (fr) 2009-10-23 2016-04-20 Nissan Chemical Industries, Ltd. Composés hétérocycles fusionnés et activateur du récepteur de la thrombopoïétine
WO2011098095A1 (fr) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides se liant au récepteur de tpo
SG188591A1 (en) 2010-09-22 2013-04-30 Amgen Inc Carrier immunoglobulins and uses thereof
WO2014159242A1 (fr) 2013-03-14 2014-10-02 Novartis Ag Mutants de notch 3 et leurs utilisations
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
CA2960778C (fr) 2014-09-11 2023-03-07 Bristol-Myers Squibb Company Inhibiteurs macrocycliques des interactions proteine/proteine pd-1/pd-l1 et cd80(b7-1)/pd-l1
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
BR112017010268B1 (pt) 2014-11-19 2024-01-16 P & M Venge Ab Agente de ligação, composição de diagnóstico, kit de diagnóstico, método de diagnóstico de uma infecção bacteriana ou de diferenciação entre uma infecção bacteriana e uma infecção de viral, métodos para descartar uma infecção bacteriana ou viral em um indivíduo, métodos para considerar uma infecção bacteriana ou viral em um indivíduo, método para distinguir entre uma infecção bacteriana ou mista e uma infecção viral em um indivíduo, método para descartar uma doença infecciosa, método para identificação do tipo de infecção e dispositivo para o diagnóstico de infecções bacterianas
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
AU2017268291B2 (en) 2016-05-19 2022-09-29 Bristol-Myers Squibb Company PET-imaging immunomodulators
WO2018085750A2 (fr) 2016-11-07 2018-05-11 Bristol-Myers Squibb Company Immunomodulateurs
US11066445B2 (en) 2017-06-23 2021-07-20 Bristol-Myers Squibb Company Immunomodulators acting as antagonists of PD-1
EP3658191A1 (fr) * 2017-07-26 2020-06-03 Janssen Pharmaceutica NV Procédés de protection de l'intégrité vasculaire induite par une radiothérapie ciblée
US11492375B2 (en) 2017-10-03 2022-11-08 Bristol-Myers Squibb Company Cyclic peptide immunomodulators
MA54820A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques
CA3127378A1 (fr) 2019-01-25 2020-10-15 Janssen Pharmaceutica Nv Procedes d'attenuation des effets toxiques d'agents vesicants et de gaz caustiques
MA54821A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes pour augmenter la protection contre les lésions des organes et des vaisseaux, la récupération hématopoïétique et la survie en réponse à une exposition à une irradiation corporelle totale ou à des agents chimiques
WO2023056444A1 (fr) 2021-10-01 2023-04-06 Janssen Pharmaceutica N.V. Procédés d'augmentation de la production de cellules progénitrices
WO2024095178A1 (fr) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Mimétique de thrombopoïétine destiné à être utilisé dans le traitement d'une insuffisance hépatique aiguë

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645090A (en) 1969-06-19 1972-02-29 Citizen Watch Co Ltd Day-date quick-adjuster for calender timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4612132A (en) 1984-07-20 1986-09-16 Chevron Research Company Modified succinimides
EP0206448B1 (fr) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hémoglobine liée à un poly(oxyde d'alkylène)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5198424A (en) * 1989-03-08 1993-03-30 Board Of Regents Of The University Of Oklahoma Functionally active selectin-derived peptides
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
US5571508A (en) * 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
IT1241395B (it) * 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
PT644771E (pt) * 1992-06-11 2002-12-31 Alkermes Inc Sistema de entrega da droga eritropoietina
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
AU685506B2 (en) 1993-08-25 1998-01-22 Systemix, Inc. Method for producing a highly enriched population of hematopoietic stem cells
WO1995011922A1 (fr) * 1993-10-29 1995-05-04 Affymax Technologies N.V. Banques de presentation de peptides et d'anticorps in vitro
SG47030A1 (en) * 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
WO1995021626A1 (fr) * 1994-02-14 1995-08-17 University Of Washington Procede de stimulation de l'erythropoiese a l'aide de proteines hematopoietiques
WO1995021919A2 (fr) * 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Proteine a activite de thrombopoietine (tpo)
CN1148408A (zh) * 1994-02-14 1997-04-23 津莫吉尼蒂克斯公司 血细胞生成蛋白及其制造材料和方法
SG79882A1 (en) * 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
EP0755263A4 (fr) * 1994-03-31 2005-02-09 Amgen Inc Compositions et methodes de stimulation de la croissance et de la differentiation des megacaryocytes
US5571686A (en) * 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
US5641655A (en) * 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
WO1996017062A1 (fr) * 1994-11-30 1996-06-06 Zymogenetics, Inc. Thrombopoietine de faible poids moleculaire
CA2194070A1 (fr) * 1995-04-26 1996-10-31 Haruhiko Yokoi Nouveaux polypeptides
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
CN1315870C (zh) 1995-06-07 2007-05-16 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
KR102127408B1 (ko) 2014-01-29 2020-06-29 삼성전자주식회사 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체

Also Published As

Publication number Publication date
ATE420893T1 (de) 2009-01-15
AR062931A2 (es) 2008-12-17
KR100668546B1 (ko) 2007-01-16
EP2028191A1 (fr) 2009-02-25
TR199901971T2 (xx) 1999-12-21
UY24805A1 (es) 2000-12-29
JP2001505898A (ja) 2001-05-08
PE27599A1 (es) 1999-03-29
CA2274149A1 (fr) 1998-06-18
KR100679576B1 (ko) 2007-02-07
KR100625708B1 (ko) 2006-09-20
EP0948539A2 (fr) 1999-10-13
US6121238A (en) 2000-09-19
HRP970683A2 (en) 1998-10-31
BRPI9713914B1 (pt) 2017-06-20
TR200401638T2 (tr) 2004-11-22
BRPI9713914B8 (fr) 2021-05-25
CA2274149C (fr) 2008-07-15
AU5854798A (en) 1998-07-03
KR20000069408A (ko) 2000-11-25
ES2321038T3 (es) 2009-06-01
KR20050042505A (ko) 2005-05-09
EP2336165A1 (fr) 2011-06-22
SV1997000104A (es) 1998-09-18
JP4128225B2 (ja) 2008-07-30
CO5080768A1 (es) 2001-09-25
CN1245504A (zh) 2000-02-23
EP0948539B1 (fr) 2009-01-14
HRP970683B1 (en) 2002-10-31
PA8442601A1 (es) 2000-05-24
US5869451A (en) 1999-02-09
BR9713914A (pt) 2000-02-29
KR20060025611A (ko) 2006-03-21
WO1998025965A2 (fr) 1998-06-18
CN100379760C (zh) 2008-04-09
TW515804B (en) 2003-01-01
DE69739219D1 (de) 2009-03-05
ZA9711045B (en) 1999-06-09
AU725731B2 (en) 2000-10-19
WO1998025965A3 (fr) 1998-08-13
AR010752A1 (es) 2000-07-12
TNSN97201A1 (fr) 2005-03-15

Similar Documents

Publication Publication Date Title
MA26454A1 (fr) Peptides et composes se liant a un recepteur arriere-plan de l'invention.
IL175399A (en) Antibodies binding to ob receptor variants
IL127666A0 (en) IL-8 receptor antagonists
IL127667A0 (en) IL-8 receptor antagonists
EP0932405A4 (fr) Antagonistes des recepteurs d'il-8
DE69734833D1 (de) Vitronektin rezeptor antagonisten
PL331539A1 (en) Antagonists of il-8 receptor
EP0907362A4 (fr) Antagonistes des recepteurs d'il-8
EP1019035A4 (fr) Antagonistes du recepteur d'il-8
EP0920417A4 (fr) Antagonistes du recepteur de l'il-8
BR9701201A (pt) Saco de pilastra
GB9617923D0 (en) Novel receptor
FR2755165B1 (fr) Dispositif d'ancrage
EP0923373A4 (fr) Antagonistes du recepteur d'il-8
EP0939634A4 (fr) Antagonistes du recepteur il-8
EP0957907A4 (fr) Antagonistes du recepteur de l'il-8
DE69616364D1 (de) Endothelinrezeptorantagonisten
EP0934066A4 (fr) Antagonistes du recepteur de l'interleukine-8 (il-8)
BR9709521A (pt) "3-Cianoaril-pirazóis"
EP0920253A4 (fr) Antagonistes du recepteur il-8
GB9505447D0 (en) Competitive binding assay
EP0948330A4 (fr) Antagonistes du recepteur d'il-8
BR9710019A (pt) Mistura de virginiamicina
FR2753600B1 (fr) Receveur d'arrosage
KR960037909U (ko) 볼 조인트의 더스트 커버 결착구조