AR010448A1 - PROCEDIMIENTO PARA OBTENER LA FORMA II POLIMORFA DE 2-METIL-4-[4-METIL-1- PIPERACINIL]-10H-TIENO-[2,3-b]-[1,5]-BENZODIACEPINA (OLANZAPINA) - Google Patents

PROCEDIMIENTO PARA OBTENER LA FORMA II POLIMORFA DE 2-METIL-4-[4-METIL-1- PIPERACINIL]-10H-TIENO-[2,3-b]-[1,5]-BENZODIACEPINA (OLANZAPINA)

Info

Publication number
AR010448A1
AR010448A1 ARP960101875A ARP010187596A AR010448A1 AR 010448 A1 AR010448 A1 AR 010448A1 AR P960101875 A ARP960101875 A AR P960101875A AR P010187596 A ARP010187596 A AR P010187596A AR 010448 A1 AR010448 A1 AR 010448A1
Authority
AR
Argentina
Prior art keywords
methyl
olanzapine
procedure
benzodiacepine
piperacinyl
Prior art date
Application number
ARP960101875A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23621056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR010448(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR010448A1 publication Critical patent/AR010448A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para obtener la Forma II polimorfa estable de olanzapina (2-metil-4-[4-metil piperacinil)-10H-tieno[2,3-b][1,5] benzodiacepina, cuya patrón de difracción Rx (en polvo) se ilustra en la descripción; que comprende suspender olanzapina grado técnico en acetato de etilo en condiciones anhidras y cristalizar la Forma II de la solución formada. Dicha Forma II es útil para formular composiciones farmacéuticas para el tratamiento de estados psicóticos, esquizofrenia, manías agudas, trastornos gastrointestinales, y estados de ansiedad leves.
ARP960101875A 1995-03-24 1996-03-22 PROCEDIMIENTO PARA OBTENER LA FORMA II POLIMORFA DE 2-METIL-4-[4-METIL-1- PIPERACINIL]-10H-TIENO-[2,3-b]-[1,5]-BENZODIACEPINA (OLANZAPINA) AR010448A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40956695A 1995-03-24 1995-03-24

Publications (1)

Publication Number Publication Date
AR010448A1 true AR010448A1 (es) 2000-06-28

Family

ID=23621056

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP960101875A AR010448A1 (es) 1995-03-24 1996-03-22 PROCEDIMIENTO PARA OBTENER LA FORMA II POLIMORFA DE 2-METIL-4-[4-METIL-1- PIPERACINIL]-10H-TIENO-[2,3-b]-[1,5]-BENZODIACEPINA (OLANZAPINA)
ARP960101876A AR002719A1 (es) 1995-03-24 1996-03-22 Forma ii polimorfa 2-metil-4-(4-metil-1-piperacinil)-10h-tieno[2,3-b]-[1,5] benzodiacepina(olanzapina) y formulaciones farmaceuticas que las contienen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP960101876A AR002719A1 (es) 1995-03-24 1996-03-22 Forma ii polimorfa 2-metil-4-(4-metil-1-piperacinil)-10h-tieno[2,3-b]-[1,5] benzodiacepina(olanzapina) y formulaciones farmaceuticas que las contienen.

Country Status (49)

Country Link
US (1) US5736541A (es)
EP (3) EP1445259B1 (es)
JP (1) JPH11502535A (es)
KR (1) KR100399688B1 (es)
CN (1) CN1065536C (es)
AP (1) AP828A (es)
AR (2) AR010448A1 (es)
AT (4) AT406771B (es)
AU (1) AU706471B2 (es)
BG (1) BG62619B1 (es)
BR (1) BR9607790A (es)
CA (1) CA2214005C (es)
CH (1) CH690579A5 (es)
CO (1) CO4650278A1 (es)
CZ (1) CZ292688B6 (es)
DE (4) DE69630324T2 (es)
DK (4) DK1095941T3 (es)
EA (1) EA000149B1 (es)
EE (1) EE03489B1 (es)
EG (1) EG23659A (es)
ES (3) ES2266719T3 (es)
FI (1) FI973750A0 (es)
GB (1) GB2313835B (es)
HK (1) HK1013988A1 (es)
HU (1) HU224989B1 (es)
IL (1) IL117610A (es)
IS (1) IS1896B (es)
LT (1) LT4349B (es)
LU (1) LU90096B1 (es)
LV (1) LV12018B (es)
MY (1) MY114701A (es)
NO (1) NO314663B1 (es)
NZ (1) NZ306110A (es)
OA (1) OA10510A (es)
PA (1) PA8353701A1 (es)
PE (1) PE44897A1 (es)
PL (1) PL183723B1 (es)
PT (3) PT733635E (es)
RO (1) RO118872B1 (es)
SE (1) SE9703205D0 (es)
SI (4) SI1095941T1 (es)
SK (1) SK284143B6 (es)
SV (1) SV1996000031A (es)
TR (1) TR199701017T1 (es)
TW (2) TW442488B (es)
UA (1) UA44765C2 (es)
WO (1) WO1996030375A1 (es)
YU (1) YU49478B (es)
ZA (2) ZA962344B (es)

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LV12018A (lv) 1998-04-20
TR199701017T1 (xx) 1998-01-21
ATE331719T1 (de) 2006-07-15
GB2313835A (en) 1997-12-10
PE44897A1 (es) 1997-10-22
SK121897A3 (en) 1998-03-04
GB2313835B (en) 1998-09-16
SE9703205L (sv) 1997-09-05
EP0733635A1 (en) 1996-09-25
BR9607790A (pt) 1998-07-07
NZ306110A (en) 1998-09-24
OA10510A (en) 2002-04-24
PL183723B1 (pl) 2002-07-31
EA000149B1 (ru) 1998-10-29
ES2159346T3 (es) 2001-10-01
DE69630324T2 (de) 2004-07-29
UA44765C2 (uk) 2002-03-15
ES2266719T3 (es) 2007-03-01
AP9701065A0 (en) 1997-10-31
DE69636313D1 (de) 2006-08-10
AT406771B (de) 2000-08-25
KR19980703188A (ko) 1998-10-15
AR002719A1 (es) 1998-04-29
EE9700232A (et) 1998-04-15
CZ292688B6 (cs) 2003-11-12
DK1095941T3 (da) 2004-02-16
EP0733635B1 (en) 2001-08-16
NO974365D0 (no) 1997-09-22
WO1996030375A1 (en) 1996-10-03
RO118872B1 (ro) 2003-12-30
ES2208220T3 (es) 2004-06-16
FI973750A (fi) 1997-09-22
ATA902196A (de) 2000-01-15
EP1095941A1 (en) 2001-05-02
DK1445259T3 (da) 2006-10-16
EP1445259B1 (en) 2006-06-28
SI9620040B (sl) 2002-02-28
ATE204280T1 (de) 2001-09-15
SI1445259T1 (sl) 2006-10-31
MX9707183A (es) 1997-11-29
ZA962342B (en) 1997-09-22
CA2214005C (en) 2001-07-03
YU17796A (sh) 1999-03-04
DE69630324D1 (de) 2003-11-13
SE9703205D0 (sv) 1997-09-05
SV1996000031A (es) 1998-03-27
DE69614426D1 (de) 2001-09-20
BG62619B1 (bg) 2000-03-31
IL117610A (en) 2001-08-26
HUP9802824A3 (en) 2000-01-28
DE69636313T2 (de) 2007-05-31
SK284143B6 (sk) 2004-10-05
CZ300097A3 (en) 1997-12-17
FI973750A0 (fi) 1997-09-22
CA2214005A1 (en) 1996-10-03
HUP9802824A2 (hu) 1999-06-28
DK108997A (da) 1997-11-12
PA8353701A1 (es) 1998-09-18
PT1445259E (pt) 2006-10-31
IL117610A0 (en) 1996-07-23
HU224989B1 (en) 2006-05-29
BG101900A (en) 1999-03-31
NO314663B1 (no) 2003-04-28
KR100399688B1 (ko) 2004-02-18
PT1095941E (pt) 2004-02-27
SI0733635T1 (en) 2002-06-30
GB9719819D0 (en) 1997-11-19
CO4650278A1 (es) 1998-09-03
YU49478B (sh) 2006-05-25
JPH11502535A (ja) 1999-03-02
AP828A (en) 2000-04-28
PT733635E (pt) 2001-12-28
EE03489B1 (et) 2001-08-15
LT4349B (lt) 1998-05-25
LU90096B1 (fr) 1997-07-22
SI1095941T1 (en) 2003-12-31
LV12018B (en) 1998-09-20
ZA962344B (en) 1997-09-22
DE19681286T1 (de) 1998-04-02
LT97148A (en) 1998-01-26
CN1065536C (zh) 2001-05-09
EP1445259A1 (en) 2004-08-11
US5736541A (en) 1998-04-07
TW442488B (en) 2001-06-23
AU5427996A (en) 1996-10-16
DE69614426T2 (de) 2002-05-23
ATE251627T1 (de) 2003-10-15
IS1896B (is) 2003-10-20
TW513432B (en) 2002-12-11
CN1179160A (zh) 1998-04-15
EA199700262A1 (ru) 1998-02-26
NO974365L (no) 1997-09-22
EP1095941B1 (en) 2003-10-08
DK0733635T3 (da) 2001-10-08
EG23659A (en) 2007-03-26
HK1013988A1 (en) 1999-09-17
AU706471B2 (en) 1999-06-17
SI9620040A (sl) 1998-06-30
IS4564A (is) 1997-09-22
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PL322501A1 (en) 1998-02-02

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