YU21391A - Triciklični-ciklični amini kao novi inhibitori holinesteraze - Google Patents
Triciklični-ciklični amini kao novi inhibitori holinesterazeInfo
- Publication number
- YU21391A YU21391A YU21391A YU21391A YU21391A YU 21391 A YU21391 A YU 21391A YU 21391 A YU21391 A YU 21391A YU 21391 A YU21391 A YU 21391A YU 21391 A YU21391 A YU 21391A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- cholinesterase inhibitors
- tricyclic
- hydrogen
- ring
- cyclic amines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Abstract
TRICIKLIČNI-CIKLIČNI AMINI KAO NOVI INHIBITORI HOLINESTERAZE, opisana su jedinjenja formule (I) u kojoj E je ugljenik ili azot, G je azot, prstena je benzo, pirido ili tieno, dva od R3, R4, R5 i R6 su vodonik, a druga dva su nezavisno odabrani iz grupe koju sačinjavaju vodonik, metil, etil, propil, metoksi, etoksi, propiloksi, benziloksi, hidroksi, toziloksi, fluoro, acetoksi, N-etilkarbamatni ester i N-metilkarbamatni estar; X je kiseonik ili sumpor i vezano je za ugljenik u položaju "I" prstena D, svako od R2, R11, R12 i R13 je vodonik, ugljovodonični niz za koje P je vezano je prosta ili dvoguba veza vezana za prsten D, i P je: jedinjenja formule I su inhibitori holinestereze i koriste se za povećanje pamćenja kod pacijenta koji pate od ludila i Alzheimerove bolesti.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47692890A | 1990-02-08 | 1990-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU21391A true YU21391A (sh) | 1994-01-20 |
Family
ID=23893824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU21391A YU21391A (sh) | 1990-02-08 | 1991-02-07 | Triciklični-ciklični amini kao novi inhibitori holinesteraze |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0441517A3 (sh) |
JP (1) | JPH07119214B2 (sh) |
KR (1) | KR950013562B1 (sh) |
CN (1) | CN1054600A (sh) |
AU (1) | AU631723B2 (sh) |
BR (1) | BR9100519A (sh) |
CA (1) | CA2035805C (sh) |
CS (1) | CS29991A2 (sh) |
DE (1) | DE9101348U1 (sh) |
EG (1) | EG19644A (sh) |
FI (1) | FI910592A (sh) |
HU (1) | HUT70051A (sh) |
IE (1) | IE910402A1 (sh) |
IL (1) | IL97140A (sh) |
NO (1) | NO177534C (sh) |
NZ (1) | NZ237040A (sh) |
PL (2) | PL166757B1 (sh) |
PT (1) | PT96681A (sh) |
TW (1) | TW197442B (sh) |
YU (1) | YU21391A (sh) |
ZA (1) | ZA91916B (sh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
EP0475908A1 (de) * | 1990-09-14 | 1992-03-18 | Ciba-Geigy Ag | Chromogene Lactamverbindungen und ihre Herstellung und Verwendung |
TW263504B (sh) * | 1991-10-03 | 1995-11-21 | Pfizer | |
TW248556B (sh) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
US5620973A (en) * | 1993-11-30 | 1997-04-15 | Takeda Chemical Industries, Ltd. | Tetracyclic condensed heterocyclic compounds and their use |
WO2000018391A1 (fr) | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Medicaments qui ameliorent le pouvoir de vidange de la vessie |
CA2503767C (en) * | 2002-10-30 | 2009-09-22 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Pyridopyrrolizine and pyridoindolizine derivatives |
US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
WO2012038966A1 (en) | 2010-09-22 | 2012-03-29 | Tyche Industries Ltd. | Process for the preparation of donepezil intermediate |
TWI707859B (zh) * | 2017-09-07 | 2020-10-21 | 日商衛材R&D企管股份有限公司 | 五環化合物 |
AU2020233452A1 (en) | 2019-03-05 | 2021-09-02 | Eisai R&D Management Co., Ltd. | Salt of pentacyclic compound and crystals thereof |
AR118235A1 (es) | 2019-03-05 | 2021-09-22 | Eisai R&D Man Co Ltd | Heterociclos pentacíclicos |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3910947A (en) * | 1969-07-24 | 1975-10-07 | Sandoz Ag | Preparation of imidazo{8 2,1-a{9 isoindoles |
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
US4563469A (en) * | 1984-07-20 | 1986-01-07 | Warner-Lambert Company | Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine as cognition activators |
EP0187619A3 (de) * | 1985-01-03 | 1987-08-26 | Ciba-Geigy Ag | 1,3-disubstituierte Tetrahydropyridine |
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
US4778812A (en) * | 1987-06-12 | 1988-10-18 | American Home Products Corporation | 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives thereof |
EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
-
1991
- 1991-01-23 TW TW080100556A patent/TW197442B/zh active
- 1991-01-29 EP EP19910300662 patent/EP0441517A3/en not_active Withdrawn
- 1991-02-03 IL IL9714091A patent/IL97140A/en not_active IP Right Cessation
- 1991-02-06 PL PL91288977A patent/PL166757B1/pl unknown
- 1991-02-06 DE DE9101348U patent/DE9101348U1/de not_active Expired - Lifetime
- 1991-02-06 CA CA002035805A patent/CA2035805C/en not_active Expired - Fee Related
- 1991-02-06 PL PL91304632A patent/PL167078B1/pl unknown
- 1991-02-06 PT PT96681A patent/PT96681A/pt unknown
- 1991-02-07 CN CN91100860A patent/CN1054600A/zh active Pending
- 1991-02-07 HU HU91406A patent/HUT70051A/hu unknown
- 1991-02-07 AU AU70879/91A patent/AU631723B2/en not_active Ceased
- 1991-02-07 NZ NZ237040A patent/NZ237040A/xx unknown
- 1991-02-07 YU YU21391A patent/YU21391A/sh unknown
- 1991-02-07 EG EG7591A patent/EG19644A/xx active
- 1991-02-07 IE IE040291A patent/IE910402A1/en unknown
- 1991-02-07 KR KR1019910002113A patent/KR950013562B1/ko active IP Right Grant
- 1991-02-07 NO NO910473A patent/NO177534C/no unknown
- 1991-02-07 FI FI910592A patent/FI910592A/fi not_active Application Discontinuation
- 1991-02-07 BR BR919100519A patent/BR9100519A/pt not_active Application Discontinuation
- 1991-02-07 CS CS91299A patent/CS29991A2/cs unknown
- 1991-02-07 ZA ZA91916A patent/ZA91916B/xx unknown
- 1991-02-08 JP JP3103992A patent/JPH07119214B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ZA91916B (en) | 1992-09-30 |
EG19644A (en) | 1995-08-30 |
NO177534C (no) | 1995-10-04 |
NO910473L (no) | 1991-08-09 |
JPH04234845A (ja) | 1992-08-24 |
KR910015580A (ko) | 1991-09-30 |
NO910473D0 (no) | 1991-02-07 |
PL288977A1 (en) | 1992-01-13 |
PT96681A (pt) | 1991-10-31 |
IL97140A (en) | 1995-07-31 |
CN1054600A (zh) | 1991-09-18 |
NO177534B (no) | 1995-06-26 |
IE910402A1 (en) | 1991-08-14 |
HUT70051A (en) | 1995-09-28 |
IL97140A0 (en) | 1992-05-25 |
AU631723B2 (en) | 1992-12-03 |
CS29991A2 (en) | 1991-09-15 |
FI910592A0 (fi) | 1991-02-07 |
FI910592A (fi) | 1991-08-09 |
PL166757B1 (pl) | 1995-06-30 |
EP0441517A3 (en) | 1992-08-19 |
AU7087991A (en) | 1991-08-29 |
JPH07119214B2 (ja) | 1995-12-20 |
NZ237040A (en) | 1993-10-26 |
CA2035805C (en) | 1995-06-27 |
HU910406D0 (en) | 1991-08-28 |
KR950013562B1 (ko) | 1995-11-09 |
EP0441517A2 (en) | 1991-08-14 |
PL167078B1 (pl) | 1995-07-31 |
TW197442B (sh) | 1993-01-01 |
DE9101348U1 (sh) | 1991-06-06 |
BR9100519A (pt) | 1991-10-29 |
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