YU68292A - 2-(2-supstituisani pirolidiniltio) karbapenem derivati - Google Patents

2-(2-supstituisani pirolidiniltio) karbapenem derivati

Info

Publication number
YU68292A
YU68292A YU68292A YU68292A YU68292A YU 68292 A YU68292 A YU 68292A YU 68292 A YU68292 A YU 68292A YU 68292 A YU68292 A YU 68292A YU 68292 A YU68292 A YU 68292A
Authority
YU
Yugoslavia
Prior art keywords
group
atom
hydrogen atom
substituents
substituted
Prior art date
Application number
YU68292A
Other languages
English (en)
Inventor
S. Nakagawa
N. Othake
S. Okada
R. Ushijama
Original Assignee
Banyu Pharmaceutical Co.Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co.Ltd. filed Critical Banyu Pharmaceutical Co.Ltd.
Publication of YU68292A publication Critical patent/YU68292A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-(2-SUPSTITUISANI PIROLIDINILTIO) KARBAPENEM DERIVATI, jedinjenje formule (I) gde R1 je atom vodonika ili metil grupa, R2 je atom vodonika ili negativno naelektrisanj, R3 je atom vodonika ili niža alkil grupa, svaki od R4, R5 i R6 je atom vodonika, cijano grupa, metansulfonil grupa, niža alkil grupa koja može imati supstitente, karbamoil grupa koja može imati supstituente ili grupa formule -X-N(R7)R8 (gde svaki od R7 i R8 koji mogu biti isti ili različiti je atom vodonika ili niža alkil grupa koja može imati supstituente ili R7 i R8 grade sa susednim atomom azota, i ako je potrebno, zajedno sa hetero atomom odabranim iz grupe koju čine atom azota, kiseonika i sumpora dodato susednom atomu azota 3-do 8-članu heterocikličnu grupu koja može biti supstituisana (uz predpostavku da atom azota uz X ili drugi atom azota na heterocikličnom prstenu može da gradi amonio grupu) i X je niža alkilen grupa koja može imati supstituente) uz predpostavku da bar jedan od R4, R5 i R6 je grupa formule -X-N(R7)R8 gde R7, R8 i X su kao što je definisano napred, i Y je niža alkilen grupa ili jednostruka veza ili farmaceutski prihvatljiva njegova so ili estar.
YU68292A 1991-07-09 1992-07-08 2-(2-supstituisani pirolidiniltio) karbapenem derivati YU68292A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19476791 1991-07-09
JP34959191 1991-12-07

Publications (1)

Publication Number Publication Date
YU68292A true YU68292A (sh) 1995-03-27

Family

ID=26508721

Family Applications (1)

Application Number Title Priority Date Filing Date
YU68292A YU68292A (sh) 1991-07-09 1992-07-08 2-(2-supstituisani pirolidiniltio) karbapenem derivati

Country Status (12)

Country Link
EP (1) EP0522504A1 (sh)
KR (1) KR930702353A (sh)
AU (1) AU646577B2 (sh)
CA (1) CA2073377A1 (sh)
CZ (1) CZ214492A3 (sh)
FI (1) FI931015A (sh)
IE (1) IE922225A1 (sh)
IL (1) IL102453A (sh)
NO (1) NO930844L (sh)
TW (1) TW206226B (sh)
WO (1) WO1993001192A1 (sh)
YU (1) YU68292A (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216102D0 (en) * 1992-07-29 1992-09-09 Smithkline Beecham Plc Pharmaceutical substances
KR950014111A (ko) * 1993-11-23 1995-06-15 유충식 새로운 카바페넴 유도체 및 그 제조방법
KR970010769A (ko) * 1995-08-01 1997-03-27 유충식 카바페넴 유도체의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1281720C (en) * 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
AU631671B2 (en) * 1989-08-04 1992-12-03 Banyu Pharmaceutical Co., Ltd. 2-(2-vinylpyrrolidinylthio)carbapenem derivatives

Also Published As

Publication number Publication date
KR930702353A (ko) 1993-09-08
TW206226B (sh) 1993-05-21
NO930844D0 (no) 1993-03-08
NO930844L (no) 1993-05-07
CZ214492A3 (en) 1993-01-13
EP0522504A1 (en) 1993-01-13
AU646577B2 (en) 1994-02-24
IL102453A (en) 1996-01-19
CA2073377A1 (en) 1993-01-10
IE922225A1 (en) 1993-01-13
AU1947192A (en) 1993-01-14
FI931015A0 (fi) 1993-03-08
FI931015A (fi) 1993-03-08
IL102453A0 (en) 1993-01-14
WO1993001192A1 (en) 1993-01-21

Similar Documents

Publication Publication Date Title
SE8105240L (sv) Teofyllin- och teobrominderivat
YU48855B (sh) Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja
NL180206C (nl) Verbinding en geneesmiddel met analgetische werking.
FI862757A (fi) Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
IE811085L (en) Pyridoxine derivatives
DE69402514D1 (de) 2-Beta-Morpholino-substituierte Androstanderivate
DE68911773D1 (de) Benzimidazol-Derivate mit pharmakologischer Aktivität.
ES8307792A1 (es) Un metodo de produccion de compuesto de dihidropiridina.
YU21391A (sh) Triciklični-ciklični amini kao novi inhibitori holinesteraze
EP0757988A4 (en) IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
MY131762A (en) Pharmaceutical compounds
YU68292A (sh) 2-(2-supstituisani pirolidiniltio) karbapenem derivati
ES8702433A1 (es) Un procedimiento para la preparacion de un compuesto heterociclico sustituido con peptidos.
YU54891A (sh) 2-(supstituisani pirolidiniltio) karbapenem derivati
GB1195932A (en) Quinazolinylureas
ES483116A1 (es) Procedimiento para la preparacion de derivados de acidos aziridin-2-carboxilicos substituidos en n, inmunoestimulan- tes
DE68911006D1 (de) Pharmakologisch-aktive Alkylthiobenzimidazol-Derivate und Verfahren zu deren Herstellung.
FI971177A (fi) Bisyklisiä karboksiamideja 5-HT1A-antagonisteina
ES8607939A1 (es) Procedimiento de preparacion de nuevos derivados de la 8-al-coxicarbonilaminoisoquinolina y de sus sales de adicion aci-da
GB1377353A (en) N-phenyl amidines
ES474282A1 (es) Un procedimiento para producir un compuesto de piridazinoma.
GB1383291A (en) N-phenyl amidines