FI101379B1 - Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-piperatsinyyli)-4H-tieno[2,3-b][1,5]bentsodiatsepiinin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-piperatsinyyli)-4H-tieno[2,3-b][1,5]bentsodiatsepiinin valmistamiseksi

Info

Publication number
FI101379B1
FI101379B1 FI911986A FI911986A FI101379B1 FI 101379 B1 FI101379 B1 FI 101379B1 FI 911986 A FI911986 A FI 911986A FI 911986 A FI911986 A FI 911986A FI 101379 B1 FI101379 B1 FI 101379B1
Authority
FI
Finland
Prior art keywords
methyl
thieno
piperazinyl
benzodiazepine
preparation
Prior art date
Application number
FI911986A
Other languages
English (en)
Swedish (sv)
Other versions
FI101379B (fi
FI911986A0 (fi
FI911986A (fi
Inventor
Jiban Kumar Chakrabarti
Terrence Michael Hotten
David Edward Tupper
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10674942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI101379(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI911986A0 publication Critical patent/FI911986A0/fi
Publication of FI911986A publication Critical patent/FI911986A/fi
Priority to FI971316A priority Critical patent/FI971316A/fi
Application granted granted Critical
Publication of FI101379B publication Critical patent/FI101379B/fi
Publication of FI101379B1 publication Critical patent/FI101379B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
FI911986A 1990-04-25 1991-04-24 Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-piperatsinyyli)-4H-tieno[2,3-b][1,5]bentsodiatsepiinin valmistamiseksi FI101379B1 (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI971316A FI971316A (fi) 1990-04-25 1997-03-27 Farmaseuttinen yhdiste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9009229 1990-04-25
GB909009229A GB9009229D0 (en) 1990-04-25 1990-04-25 Pharmaceutical compounds

Publications (4)

Publication Number Publication Date
FI911986A0 FI911986A0 (fi) 1991-04-24
FI911986A FI911986A (fi) 1991-10-26
FI101379B FI101379B (fi) 1998-06-15
FI101379B1 true FI101379B1 (fi) 1998-06-15

Family

ID=10674942

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911986A FI101379B1 (fi) 1990-04-25 1991-04-24 Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-piperatsinyyli)-4H-tieno[2,3-b][1,5]bentsodiatsepiinin valmistamiseksi

Country Status (33)

Country Link
EP (1) EP0454436B1 (fi)
JP (1) JP2527860B2 (fi)
KR (1) KR100195566B1 (fi)
CN (1) CN1028429C (fi)
AT (1) ATE127804T1 (fi)
AU (1) AU643267B2 (fi)
BG (1) BG61710B2 (fi)
CA (1) CA2041113C (fi)
CY (1) CY1900A (fi)
CZ (1) CZ279937B6 (fi)
DE (3) DE69112895T4 (fi)
DK (1) DK0454436T3 (fi)
ES (1) ES2078440T3 (fi)
FI (1) FI101379B1 (fi)
GB (1) GB9009229D0 (fi)
GE (1) GEP20032965B (fi)
GR (1) GR3017877T3 (fi)
HK (1) HK87596A (fi)
HU (2) HU212416B (fi)
IE (1) IE68401B1 (fi)
IL (2) IL97912A (fi)
LU (2) LU90009I2 (fi)
LV (1) LV10262B (fi)
MX (1) MX173791B (fi)
NL (2) NL970015I2 (fi)
NO (3) NO178766C (fi)
NZ (1) NZ237932A (fi)
PT (1) PT97446B (fi)
RU (1) RU2043992C1 (fi)
SI (1) SI9110739A (fi)
SK (1) SK279196B6 (fi)
YU (1) YU48049B (fi)
ZA (1) ZA913085B (fi)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817657A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Psychoactive substance disorders
US5817655A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Methods of treatment using a thieno-benzodiazepine
US5817656A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5627178A (en) * 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
ATE198891T1 (de) * 1992-05-29 2001-02-15 Lilly Co Eli Thienobenzodiazepinderivate zur behandlung von störungen des zentralnervensystems
US6034078A (en) * 1992-05-29 2000-03-07 Eli Lilly And Company Limited Thienobenzodiazepine compounds
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EP0733368A1 (en) * 1995-03-24 1996-09-25 Eli Lilly And Company Granule fomulation for olanzapine
CN1131035C (zh) * 1995-05-30 2003-12-17 伊莱利利公司 治疗识别机能障碍的方法
PL189714B1 (pl) * 1995-05-30 2005-09-30 Lilly Co Eli Zastosowanie 2-metylo-4-(4-metylo-1-piperazynylo)-10H-tieno[2,3-b] [1,5]benzodiazepiny
US6506746B2 (en) 1995-05-30 2003-01-14 Eli Lilly And Company Method for treating cognitive dysfunction
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
CA2240836A1 (en) * 1995-12-21 1997-07-03 Pierre Van Tran Method for treating dermatitis
UA57727C2 (uk) * 1996-03-11 2003-07-15 Елі Ліллі Енд Компані Спосіб лікування надмірної агресивності
CA2266444C (en) * 1996-09-23 2007-01-09 Eli Lilly And Company Olanzapine dihydrate d
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO1999011647A1 (fr) * 1997-09-02 1999-03-11 Yoshitomi Pharmaceutical Industries, Ltd. Composes thiophene condenses et leur utilisation en medecine
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
CN1239158C (zh) * 1997-09-30 2006-02-01 伊莱利利公司 2－甲基－噻吩并－苯并二氮杂䓬制剂
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
IL154688A0 (en) 2000-08-31 2003-09-17 Reddys Lab Ltd Dr Hydrates of olanzapine and processes for the preparation thereof
US6906062B2 (en) * 2001-12-24 2005-06-14 Sun Pharmaceutical Industries Limited Crystalline form I of 2-methyl-4-(4-menthyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
PL196814B1 (pl) 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
US20040063694A1 (en) * 2002-06-05 2004-04-01 Browder Monte R. Compound useful for the treatment of CNS disorders
PL199016B1 (pl) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Sposób wytwarzania olanzapiny
SI21303A (sl) 2002-10-18 2004-04-30 Krka, Tovarna Zdravil, D.D.,, Novo Mesto Farmacevtska formulacija olanzapina
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
DE10301923B3 (de) 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
HU226410B1 (en) 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
CA2551806A1 (en) 2003-12-22 2005-07-14 Teva Pharmaceutical Industries, Ltd. Methods of preparing olanzapine
AR047459A1 (es) 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
WO2005070937A1 (en) * 2004-01-27 2005-08-04 Synthon B.V. A process for making olanzapine in a polymorph form i
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
BRPI0518187A (pt) * 2004-11-16 2008-11-04 Elan Pharma Int Ltd formulações de olanzapina em nanopartìcula injetáveis
PL198589B1 (pl) 2004-11-22 2008-06-30 Adamed Sp Z Oo Sposób wytwarzania N-demetyloolanzapiny
WO2006073886A1 (en) 2005-01-05 2006-07-13 Eli Lilly And Company Olanzapine pamoate dihydrate
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CN100383144C (zh) * 2006-09-11 2008-04-23 杭州盛美医药科技开发有限公司 一种奥氮平的中间体及其制备与应用
CL2007002807A1 (es) * 2006-09-29 2008-04-11 Synthon Bv Composicion farmaceutica en estado solido que comprende olanzapina o una sal farmaceuticamente aceptable de la misma y lactosa anhidra; tableta farmaceutica oral; procedimiento de preparacion de dicha tableta, util en el tratamiento de la esquizofren
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en) 2007-06-22 2008-12-22 Apotex Pharmachem Inc. Improved processes for the synthesis of olanzapine
CN101168544B (zh) * 2007-11-16 2010-11-17 西南合成制药股份有限公司 奥氮平的制备工艺
CN101735239B (zh) * 2008-11-06 2011-08-31 齐鲁制药有限公司 一种无水奥氮平晶型ii的制备方法
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine
CN102532158A (zh) * 2010-12-17 2012-07-04 北大方正集团有限公司 一种合成奥氮平的方法
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
WO2012153347A2 (en) 2011-05-04 2012-11-15 Zentiva K.S. Oral pharmaceutical composition of olanzapine form 1
CN102225941B (zh) * 2011-06-01 2013-11-27 宁波人健医药化工有限公司 抗精神病药奥氮平的制备方法
WO2013066280A1 (en) * 2011-10-31 2013-05-10 Mahmut Bilgic Water soluble antipsychotic formulations
JP5934004B2 (ja) * 2012-03-22 2016-06-15 株式会社トクヤマ 結晶構造を有する４−アミノ−２−メチル−１０Ｈ−チエノ〔２，３−ｂ〕〔１，５〕ベンゾジアゼピン塩酸塩水和物及びその製造方法
EA201590048A1 (ru) 2012-07-31 2015-09-30 Сановел Хайван Саглиги Юрюнлери Санайи Ве Тиджарет А.С. Применение оланзапина у животных
EP2879519A1 (en) 2012-07-31 2015-06-10 Sanovel Hayvan Sagligi Ürünleri Sanayi ve Ticaret A.S. A method for increasing meat and milk production
JP6042153B2 (ja) * 2012-09-26 2016-12-14 株式会社トクヤマ オランザピンの製造方法
KR101641902B1 (ko) 2015-06-24 2016-07-22 주식회사 네이처센스 농업회사법인 스트레스의 완화용 조성물
CN106265541A (zh) * 2016-08-31 2017-01-04 安徽省润生医药股份有限公司 一种注射用奥氮平及其制备方法
CN111004210A (zh) * 2019-10-23 2020-04-14 中山大学 化合物单晶及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
GB1533236A (en) * 1975-11-24 1978-11-22 Lilly Industries Ltd Thieno(1,5)benzodiazepine intermediates
GB1577743A (en) * 1977-05-17 1980-10-29 Lilly Industries Ltd Benzodiazepine derivatives

Also Published As

Publication number Publication date
NL970015I2 (nl) 1997-09-01
IE911348A1 (en) 1991-11-06
IL112575A0 (en) 1995-05-26
BG61710B2 (bg) 1998-03-31
GB9009229D0 (en) 1990-06-20
YU73991A (sh) 1994-01-20
RU2043992C1 (ru) 1995-09-20
DE69112895T2 (de) 1996-03-07
PT97446B (pt) 1997-07-31
CA2041113C (en) 1998-07-14
HK87596A (en) 1996-05-24
LV10262B (en) 1995-04-20
CY1900A (en) 1991-04-24
HU212416B (en) 1996-06-28
MX173791B (es) 1994-03-25
GEP20032965B (en) 2003-05-12
NO178766B (no) 1996-02-19
HUT60503A (en) 1992-09-28
DE19675046I2 (de) 2001-05-23
DE69112895T4 (de) 2009-11-12
FI101379B (fi) 1998-06-15
GR3017877T3 (en) 1996-01-31
CS9101168A2 (en) 1991-12-17
SI9110739A (en) 1997-10-31
YU48049B (sh) 1996-10-18
NO911624L (no) 1991-10-28
CN1056693A (zh) 1991-12-04
IL97912A (en) 1995-10-31
DK0454436T3 (da) 1995-11-13
FI911986A0 (fi) 1991-04-24
KR910018387A (ko) 1991-11-30
IE68401B1 (en) 1996-06-12
AU7518691A (en) 1991-11-07
FI911986A (fi) 1991-10-26
NO178766C (no) 1996-05-29
NL300078I1 (nl) 2002-03-01
NL970015I1 (nl) 1997-06-02
SK279196B6 (sk) 1998-07-08
NO2001028I1 (no) 2002-01-28
HU911372D0 (en) 1991-10-28
KR100195566B1 (ko) 1999-06-15
NO911624D0 (no) 1991-04-24
HU211575A9 (en) 1995-12-28
LV10262A (lv) 1994-10-20
CA2041113A1 (en) 1991-10-26
MX25502A (es) 1993-10-01
NZ237932A (en) 1993-08-26
CZ279937B6 (cs) 1995-09-13
DE69112895D1 (de) 1995-10-19
EP0454436B1 (en) 1995-09-13
JP2527860B2 (ja) 1996-08-28
LU90869I2 (fr) 2002-02-21
LU90009I2 (fr) 1997-01-31
ES2078440T3 (es) 1995-12-16
EP0454436A1 (en) 1991-10-30
ZA913085B (en) 1992-12-30
JPH0789965A (ja) 1995-04-04
CN1028429C (zh) 1995-05-17
PT97446A (pt) 1992-01-31
ATE127804T1 (de) 1995-09-15
IL97912A0 (en) 1992-06-21
AU643267B2 (en) 1993-11-11
NO1997005I1 (no) 1997-05-12

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