IL112575A0 - 4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine - Google Patents

4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine

Info

Publication number
IL112575A0
IL112575A0 IL11257595A IL11257595A IL112575A0 IL 112575 A0 IL112575 A0 IL 112575A0 IL 11257595 A IL11257595 A IL 11257595A IL 11257595 A IL11257595 A IL 11257595A IL 112575 A0 IL112575 A0 IL 112575A0
Authority
IL
Israel
Prior art keywords
methyl
thieno
benzodiazepine
substituted
piperazinyl
Prior art date
Application number
IL11257595A
Other languages
English (en)
Inventor
Jiban Kumar Chakrabarti
Terrence Michael Hotten
David Edward Tupper
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10674942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL112575(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of IL112575A0 publication Critical patent/IL112575A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
IL11257595A 1990-04-25 1995-02-08 4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine IL112575A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909009229A GB9009229D0 (en) 1990-04-25 1990-04-25 Pharmaceutical compounds
IL9791295 1995-02-08

Publications (1)

Publication Number Publication Date
IL112575A0 true IL112575A0 (en) 1995-05-26

Family

ID=10674942

Family Applications (2)

Application Number Title Priority Date Filing Date
IL9791291A IL97912A (en) 1990-04-25 1991-04-22 2-Methyl-01-) 4-Methyl-1-piperazinyl (-H4- thiano] B-2,3 [] 1,5 [Benzodiazepine, its preparation and pharmaceutical preparations containing it
IL11257595A IL112575A0 (en) 1990-04-25 1995-02-08 4-substituted 2-methyl-10h-thieno [2,3-b][1,5] benzodiazepine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL9791291A IL97912A (en) 1990-04-25 1991-04-22 2-Methyl-01-) 4-Methyl-1-piperazinyl (-H4- thiano] B-2,3 [] 1,5 [Benzodiazepine, its preparation and pharmaceutical preparations containing it

Country Status (33)

Country Link
EP (1) EP0454436B1 (xx)
JP (1) JP2527860B2 (xx)
KR (1) KR100195566B1 (xx)
CN (1) CN1028429C (xx)
AT (1) ATE127804T1 (xx)
AU (1) AU643267B2 (xx)
BG (1) BG61710B2 (xx)
CA (1) CA2041113C (xx)
CY (1) CY1900A (xx)
CZ (1) CZ279937B6 (xx)
DE (3) DE69112895T4 (xx)
DK (1) DK0454436T3 (xx)
ES (1) ES2078440T3 (xx)
FI (1) FI101379B (xx)
GB (1) GB9009229D0 (xx)
GE (1) GEP20032965B (xx)
GR (1) GR3017877T3 (xx)
HK (1) HK87596A (xx)
HU (2) HU212416B (xx)
IE (1) IE68401B1 (xx)
IL (2) IL97912A (xx)
LU (2) LU90009I2 (xx)
LV (1) LV10262B (xx)
MX (1) MX173791B (xx)
NL (2) NL970015I2 (xx)
NO (3) NO178766C (xx)
NZ (1) NZ237932A (xx)
PT (1) PT97446B (xx)
RU (1) RU2043992C1 (xx)
SI (1) SI9110739A (xx)
SK (1) SK279196B6 (xx)
YU (1) YU48049B (xx)
ZA (1) ZA913085B (xx)

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US5817657A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Psychoactive substance disorders
US5817656A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
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PT582368E (pt) * 1992-05-29 2001-05-31 Lilly Co Eli Derivados de tienobenzodiazepina para o tratamento de doencas de cns
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CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
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CN1131035C (zh) * 1995-05-30 2003-12-17 伊莱利利公司 治疗识别机能障碍的方法
US6506746B2 (en) 1995-05-30 2003-01-14 Eli Lilly And Company Method for treating cognitive dysfunction
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
JP2000502346A (ja) * 1995-12-21 2000-02-29 イーライ・リリー・アンド・カンパニー 皮膚炎の処置方法
UA57727C2 (uk) * 1996-03-11 2003-07-15 Елі Ліллі Енд Компані Спосіб лікування надмірної агресивності
HU226167B1 (hu) 1996-09-23 2008-05-28 Lilly Co Eli Olanzapin-dihidrát D, elõállítása és az azt tartalmazó gyógyszerkészítmények
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
JP3156933B2 (ja) 1997-09-02 2001-04-16 ウェルファイド株式会社 縮合チオフェン化合物およびその医薬用途
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
CZ300725B6 (cs) * 1997-09-30 2009-07-29 Eli Lilly And Company 2-Methylthienbenzodiazepinová formulace
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
IL154688A0 (en) 2000-08-31 2003-09-17 Reddys Lab Ltd Dr Hydrates of olanzapine and processes for the preparation thereof
AU2002367119A1 (en) * 2001-12-24 2003-07-15 Sun Pharmaceutical Industries Limited Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
PL196814B1 (pl) 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
SI1513846T1 (sl) 2002-05-31 2011-11-30 Sandoz Ag Postopek za pripravo olanzapina form I
WO2003104239A1 (en) * 2002-06-05 2003-12-18 Ivax Corporation Compound for the treatment of cns disorders
PL199016B1 (pl) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Sposób wytwarzania olanzapiny
SI21303A (sl) 2002-10-18 2004-04-30 Krka, Tovarna Zdravil, D.D.,, Novo Mesto Farmacevtska formulacija olanzapina
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
DE10301923B3 (de) * 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
JP2007515428A (ja) 2003-12-22 2007-06-14 テバ ファーマシューティカル インダストリーズ リミティド オランザピンの合成方法
EP1720885A1 (en) * 2004-01-27 2006-11-15 Synthon B.V. A process for making olanzapine in a polymorph form i
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
CN101106972A (zh) * 2004-11-16 2008-01-16 伊兰制药国际有限公司 注射用纳米微粒奥氮平制剂
PL198589B1 (pl) 2004-11-22 2008-06-30 Adamed Sp Z Oo Sposób wytwarzania N-demetyloolanzapiny
US7932249B2 (en) 2005-01-05 2011-04-26 Eli Lilly And Company Olanzapine pamoate dihydrate
HUP0501046A2 (en) * 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CN100383144C (zh) * 2006-09-11 2008-04-23 杭州盛美医药科技开发有限公司 一种奥氮平的中间体及其制备与应用
AR063043A1 (es) * 2006-09-29 2008-12-23 Synthon Bv Composicion farmaceutica de olanzapina
PL381564A1 (pl) 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en) 2007-06-22 2008-12-22 Apotex Pharmachem Inc. Improved processes for the synthesis of olanzapine
CN101168544B (zh) * 2007-11-16 2010-11-17 西南合成制药股份有限公司 奥氮平的制备工艺
CN101735239B (zh) * 2008-11-06 2011-08-31 齐鲁制药有限公司 一种无水奥氮平晶型ii的制备方法
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine
CN102532158A (zh) * 2010-12-17 2012-07-04 北大方正集团有限公司 一种合成奥氮平的方法
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
WO2012153347A2 (en) 2011-05-04 2012-11-15 Zentiva K.S. Oral pharmaceutical composition of olanzapine form 1
CN102225941B (zh) * 2011-06-01 2013-11-27 宁波人健医药化工有限公司 抗精神病药奥氮平的制备方法
WO2013066280A1 (en) * 2011-10-31 2013-05-10 Mahmut Bilgic Water soluble antipsychotic formulations
JP5934004B2 (ja) * 2012-03-22 2016-06-15 株式会社トクヤマ 結晶構造を有する４−アミノ−２−メチル−１０Ｈ−チエノ〔２，３−ｂ〕〔１，５〕ベンゾジアゼピン塩酸塩水和物及びその製造方法
EA201590056A1 (ru) 2012-07-31 2015-09-30 Сановел Хайван Саглиги Юрюнлери Санайи Ве Тиджарет А.С. Способ увеличения мясной и молочной продуктивности
EA201590048A1 (ru) 2012-07-31 2015-09-30 Сановел Хайван Саглиги Юрюнлери Санайи Ве Тиджарет А.С. Применение оланзапина у животных
JP6042153B2 (ja) * 2012-09-26 2016-12-14 株式会社トクヤマ オランザピンの製造方法
KR101641902B1 (ko) 2015-06-24 2016-07-22 주식회사 네이처센스 농업회사법인 스트레스의 완화용 조성물
CN106265541A (zh) * 2016-08-31 2017-01-04 安徽省润生医药股份有限公司 一种注射用奥氮平及其制备方法
CN111004210A (zh) * 2019-10-23 2020-04-14 中山大学 化合物单晶及其制备方法

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SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
GB1533236A (en) * 1975-11-24 1978-11-22 Lilly Industries Ltd Thieno(1,5)benzodiazepine intermediates
GB1577743A (en) * 1977-05-17 1980-10-29 Lilly Industries Ltd Benzodiazepine derivatives

Also Published As

Publication number Publication date
NZ237932A (en) 1993-08-26
LU90869I2 (fr) 2002-02-21
FI101379B1 (fi) 1998-06-15
DE69112895T2 (de) 1996-03-07
NL970015I2 (nl) 1997-09-01
FI101379B (fi) 1998-06-15
CN1056693A (zh) 1991-12-04
KR100195566B1 (ko) 1999-06-15
CS9101168A2 (en) 1991-12-17
DE19675046I2 (de) 2001-05-23
KR910018387A (ko) 1991-11-30
DK0454436T3 (da) 1995-11-13
MX173791B (es) 1994-03-25
HUT60503A (en) 1992-09-28
JP2527860B2 (ja) 1996-08-28
ATE127804T1 (de) 1995-09-15
IE911348A1 (en) 1991-11-06
SI9110739A (en) 1997-10-31
NL300078I1 (nl) 2002-03-01
LU90009I2 (fr) 1997-01-31
LV10262A (lv) 1994-10-20
MX25502A (es) 1993-10-01
SK279196B6 (sk) 1998-07-08
CY1900A (en) 1991-04-24
DE69112895T4 (de) 2009-11-12
PT97446A (pt) 1992-01-31
NO178766B (no) 1996-02-19
NO911624D0 (no) 1991-04-24
GEP20032965B (en) 2003-05-12
NO2001028I1 (no) 2002-01-28
PT97446B (pt) 1997-07-31
YU48049B (sh) 1996-10-18
NO1997005I1 (no) 1997-05-12
CA2041113C (en) 1998-07-14
EP0454436A1 (en) 1991-10-30
FI911986A (fi) 1991-10-26
YU73991A (sh) 1994-01-20
NL970015I1 (nl) 1997-06-02
LV10262B (en) 1995-04-20
AU7518691A (en) 1991-11-07
RU2043992C1 (ru) 1995-09-20
AU643267B2 (en) 1993-11-11
GR3017877T3 (en) 1996-01-31
IL97912A0 (en) 1992-06-21
HK87596A (en) 1996-05-24
FI911986A0 (fi) 1991-04-24
HU212416B (en) 1996-06-28
CN1028429C (zh) 1995-05-17
ZA913085B (en) 1992-12-30
ES2078440T3 (es) 1995-12-16
IL97912A (en) 1995-10-31
BG61710B2 (bg) 1998-03-31
JPH0789965A (ja) 1995-04-04
CZ279937B6 (cs) 1995-09-13
CA2041113A1 (en) 1991-10-26
NO911624L (no) 1991-10-28
GB9009229D0 (en) 1990-06-20
HU211575A9 (en) 1995-12-28
NO178766C (no) 1996-05-29
IE68401B1 (en) 1996-06-12
EP0454436B1 (en) 1995-09-13
DE69112895D1 (de) 1995-10-19
HU911372D0 (en) 1991-10-28

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