JP6633522B2 - バイオリアクターにおける細胞増殖 - Google Patents
バイオリアクターにおける細胞増殖 Download PDFInfo
- Publication number
- JP6633522B2 JP6633522B2 JP2016530921A JP2016530921A JP6633522B2 JP 6633522 B2 JP6633522 B2 JP 6633522B2 JP 2016530921 A JP2016530921 A JP 2016530921A JP 2016530921 A JP2016530921 A JP 2016530921A JP 6633522 B2 JP6633522 B2 JP 6633522B2
- Authority
- JP
- Japan
- Prior art keywords
- bioreactor
- cells
- fluid
- hollow fiber
- circulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000010261 cell growth Effects 0.000 title claims description 131
- 239000012530 fluid Substances 0.000 claims description 235
- 239000012510 hollow fiber Substances 0.000 claims description 207
- 238000000034 method Methods 0.000 claims description 79
- 239000012528 membrane Substances 0.000 claims description 37
- 230000001464 adherent effect Effects 0.000 claims description 25
- 230000012010 growth Effects 0.000 claims description 22
- 230000005484 gravity Effects 0.000 claims description 18
- 230000004663 cell proliferation Effects 0.000 claims description 14
- 239000013049 sediment Substances 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 description 385
- 239000002609 medium Substances 0.000 description 66
- 230000008569 process Effects 0.000 description 31
- 239000007789 gas Substances 0.000 description 27
- 239000000243 solution Substances 0.000 description 19
- 238000003306 harvesting Methods 0.000 description 17
- 238000009826 distribution Methods 0.000 description 14
- 239000000725 suspension Substances 0.000 description 14
- 239000000463 material Substances 0.000 description 12
- 230000004048 modification Effects 0.000 description 12
- 238000012986 modification Methods 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- 238000004062 sedimentation Methods 0.000 description 10
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 9
- 230000002572 peristaltic effect Effects 0.000 description 9
- 210000000130 stem cell Anatomy 0.000 description 9
- 239000002699 waste material Substances 0.000 description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 239000006285 cell suspension Substances 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 7
- 239000004952 Polyamide Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 229920002647 polyamide Polymers 0.000 description 6
- 238000004382 potting Methods 0.000 description 6
- 238000011072 cell harvest Methods 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 238000010899 nucleation Methods 0.000 description 5
- 230000037361 pathway Effects 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 150000003384 small molecules Chemical class 0.000 description 5
- 208000014392 Cat-eye syndrome Diseases 0.000 description 4
- 102000016359 Fibronectins Human genes 0.000 description 4
- 108010067306 Fibronectins Proteins 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004814 polyurethane Substances 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- VLCQZHSMCYCDJL-UHFFFAOYSA-N tribenuron methyl Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)N(C)C1=NC(C)=NC(OC)=N1 VLCQZHSMCYCDJL-UHFFFAOYSA-N 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920003235 aromatic polyamide Polymers 0.000 description 2
- 229920000249 biocompatible polymer Polymers 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 230000021164 cell adhesion Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- -1 ether sulfone Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 229920001600 hydrophobic polymer Polymers 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004697 Polyetherimide Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 210000003995 blood forming stem cell Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000017455 cell-cell adhesion Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 230000001706 oxygenating effect Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920006162 poly(etherimide sulfone) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/50—Means for positioning or orientating the apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
- C12M25/12—Hollow fibers or tubes the culture medium flowing outside the fiber or tube
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/10—Rotating vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Clinical Laboratory Science (AREA)
- Cell Biology (AREA)
- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Description
以下では、本発明の実施形態に係るいくつかの例が記載される。しかしながら、以下の実施形態において、例えば、CES(すなわち、QUANTUM(登録商標)細胞増殖システム)のプログラミングを行うために、パラメータ、特徴事項及び/又は値が以下で記載されるが、それらはあくまでも例示のためであり、本発明は、以下で記載されるそれら特定の事項に限定されない。
ここでの目的は、QUANTUM(登録商標)細胞増殖システムにおいて2つの特徴的な細胞播種方法を用いたヒト骨髄由来間葉系幹細胞(hMSCs)の増殖を説明することである。
本発明において中心となる細胞投入プロシージャは、QUANTUM(登録商標)細胞増殖システムのバイオリアクター内において、より均一な細胞分布を可能にすることによって、また播種プロセスにおいて失われる細胞数を減らすことによって、細胞収率を増加するように設計された一連のステップである。
実施例2で記載された同じプロトコルを用いて、本発明の中心となる付着プロトコルの変更例を研究した。上記形態及び上記プロトコルに対する変形(実施形態2)は、循環レート(100ml/分;−50ml/分;25ml/分)後の付着期間の省略である。すなわち、上記した7分間停止の条件の代わりに、停止条件を省略して、次の循環レートが前回の循環レートの直後に続く。対照実験及び実施例2の本発明実験(実施形態1)も比較として行った。
Claims (17)
- 細胞増殖システムにおいて細胞を成長させる方法であって、該方法は、
接着性細胞を含む複数の細胞を有する流体を、細胞増殖システムのバイオリアクター内において循環させるステップと、
流体の循環レートを減少させるステップと、
第1所定期間の間、前記バイオリアクターを、第1水平方向に維持して、前記複数の細胞の少なくとも一部を沈殿させ、前記バイオリアクターの第1部分に付着させるステップと、
前記第1所定期間の後、前記バイオリアクターを、前記第1水平方向から180度回転した第2水平方向に回転させるステップと、
前記回転させるステップの後、前記第2水平方向にある前記バイオリアクターにおいて、前記複数の細胞の少なくとも前記一部を増殖させることにより、前記複数の細胞の前記第1部分の成長に重力を影響させて、前記複数の細胞の前記第1部分を、前記バイオリアクターの下方に向かって成長させるステップと、
を有することを特徴とする方法。 - 請求項1記載の方法において、前記バイオリアクターは、中空糸膜を備えることを特徴とする方法。
- 請求項2記載の方法において、前記中空糸膜は、複数の中空糸を備えることを特徴とする方法。
- 請求項3記載の方法において、前記バイオリアクターの前記第1部分は、中空糸の少なくとも頂部であることを特徴とする方法。
- 請求項1記載の方法において、前記第1所定期間は、前記複数の細胞の前記一部を付着及び増殖させるに十分な長さの時間であることを特徴とする方法。
- 請求項5記載の方法において、前記第1所定期間は、10時間よりも長いことを特徴とする方法。
- 請求項1記載の方法において、前記第1所定期間は、8分よりも短いことを特徴とする方法。
- 請求項7記載の方法において、前記第1所定期間は、5分であることを特徴とする方法。
- 請求項1記載の方法において、該方法はさらに、前記第1所定期間の後で且つ前記バイオリアクターを第2水平方向に回転させるステップの前に、
前記バイオリアクターを第1鉛直方向に回転させ、前記バイオリアクターを、第2所定期間の間、前記第1鉛直方向に維持するステップと、
前記第2所定期間の後、前記バイオリアクターを、前記第1鉛直方向から180度回転させた第2鉛直方向に回転させ、前記バイオリアクターを、第3所定期間の間、前記第2鉛直方向に維持するステップと、
を有することを特徴とする方法。 - 請求項9記載の方法において、前記第2所定期間は、前記複数の細胞の前記一部を増殖させるのに十分な長さであることを特徴とする方法。
- 請求項10記載の方法において、前記第3所定期間は、前記第2所定期間と同じ長さであることを特徴とする方法。
- 請求項10記載の方法において、前記第2所定期間は、少なくとも10時間であることを特徴とする方法。
- 細胞を増殖させるシステムであって、該システムは、
バイオリアクターと、
前記バイオリアクターに接続され前記バイオリアクターを回転させる少なくとも1つのモータと、
前記バイオリアクターと流体的に結合された少なくとも1つの流体循環路と、
前記少なくとも1つの流体循環路と前記バイオリアクターとにおいて流体を循環させる少なくとも1つのポンプと、
プロセッサ実行可能命令を実行するプロセッサと、
プロセッサ実行可能命令を記憶するメモリと、
を備えたシステムであって、
前記プロセッサ実行可能命令は、前記プロセッサによって実行される場合、
前記少なくとも1つのポンプを作動させて、接着性細胞を含む複数の細胞を有する流体を、前記バイオリアクター内において循環させるステップと、
前記少なくとも1つのポンプの流量を減少させるステップと、
第1所定期間の間、前記バイオリアクターを第1水平方向に維持して、前記複数の細胞の少なくとも一部を沈殿させ、前記バイオリアクターの第1部分に付着させるステップと、
前記第1所定期間の後、前記少なくとも1つのモータを作動させて、前記バイオリアクターを、前記第1水平方向から180度回転した第2水平方向に回転させるステップと、
前記回転の後、前記少なくとも1つのポンプを作動させて、前記バイオリアクターにおいて流体を循環させ、前記第2水平方向に位置づけた前記バイオリアクターにおいて、前記複数の細胞の前記一部を増殖させ、前記複数の細胞の前記第1部分の成長に重力を影響させて、前記複数の細胞の前記第1部分を、前記第1部分の下方に位置する前記バイオリアクターの第2部分に向かって成長させるステップと、
を有する方法を実行することを特徴とするシステム。 - 請求項13記載のシステムにおいて、前記バイオリアクターは、中空糸膜を備えることを特徴とするシステム。
- 請求項14記載のシステムにおいて、前記中空糸膜は、複数の中空糸を備えることを特徴とするシステム。
- 請求項15記載のシステムにおいて、前記バイオリアクターの前記第1部分は、中空糸の少なくとも頂部であることを特徴とするシステム。
- 請求項16記載のシステムにおいて、前記バイオリアクターの前記第2部分は、中空糸の少なくとも底部であることを特徴とするシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361905182P | 2013-11-16 | 2013-11-16 | |
US61/905,182 | 2013-11-16 | ||
PCT/US2014/065829 WO2015073918A1 (en) | 2013-11-16 | 2014-11-14 | Expanding cells in a bioreactor |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016536998A JP2016536998A (ja) | 2016-12-01 |
JP2016536998A5 JP2016536998A5 (ja) | 2017-12-21 |
JP6633522B2 true JP6633522B2 (ja) | 2020-01-22 |
Family
ID=52003076
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016530921A Active JP6633522B2 (ja) | 2013-11-16 | 2014-11-14 | バイオリアクターにおける細胞増殖 |
JP2016531019A Active JP6612227B2 (ja) | 2013-11-16 | 2014-11-14 | バイオリアクターにおける細胞増殖 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016531019A Active JP6612227B2 (ja) | 2013-11-16 | 2014-11-14 | バイオリアクターにおける細胞増殖 |
Country Status (5)
Country | Link |
---|---|
US (5) | US10633625B2 (ja) |
EP (2) | EP3068866B1 (ja) |
JP (2) | JP6633522B2 (ja) |
CN (2) | CN105793411B (ja) |
WO (2) | WO2015073918A1 (ja) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
CN106232800B (zh) | 2014-03-25 | 2020-07-03 | 泰尔茂比司特公司 | 介质的被动替代 |
CN106715676A (zh) * | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
JP6127301B1 (ja) * | 2016-01-08 | 2017-05-17 | 株式会社ジェイテックコーポレーション | 回転培養装置及び該回転培養装置に用いる培養ベッセル |
KR102231394B1 (ko) * | 2016-05-19 | 2021-03-24 | 코지 사이토 | 배양 장치 및 배양 방법, 및 이 배양 방법에 의해 제조된 배양 장기 |
WO2017205667A1 (en) * | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US10577575B2 (en) * | 2016-06-07 | 2020-03-03 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
CN115044471A (zh) | 2016-08-27 | 2022-09-13 | 三维生物科技有限公司 | 生物反应器 |
BE1024733B1 (fr) | 2016-11-09 | 2018-06-14 | Univercells Sa | Matrice de croissance cellulaire |
CN110612344B (zh) * | 2017-03-31 | 2023-09-12 | 泰尔茂比司特公司 | 细胞扩增 |
PT3645719T (pt) | 2017-06-30 | 2022-05-18 | Inscripta Inc | Métodos, módulos, instrumentos e sistemas automatizados de processamento de células |
AU2018313167A1 (en) * | 2017-08-08 | 2020-02-27 | Sangamo Therapeutics, Inc. | Chimeric antigen receptor mediated cell targeting |
CN111065728B (zh) * | 2017-08-24 | 2023-12-12 | 泰尔茂比司特公司 | 细胞扩增 |
WO2019122239A1 (en) | 2017-12-20 | 2019-06-27 | Univercells S.A. | Bioreactor and related methods |
WO2020017407A1 (ja) * | 2018-07-17 | 2020-01-23 | 国立大学法人神戸大学 | サンプリング装置 |
US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
WO2020036206A1 (en) | 2018-08-16 | 2020-02-20 | Terumo Kabushiki Kaisha | Cell culture substrate |
WO2020036204A1 (en) | 2018-08-16 | 2020-02-20 | Terumo Kabushiki Kaisha | Cell culture substrate |
WO2020036205A1 (en) | 2018-08-16 | 2020-02-20 | Terumo Kabushiki Kaisha | Cell culture substrate |
JP7315653B2 (ja) | 2018-08-16 | 2023-07-26 | テルモ株式会社 | 細胞培養基材 |
JP7133409B2 (ja) * | 2018-09-18 | 2022-09-08 | テルモ株式会社 | バイオリアクタ、細胞培養システム及び細胞培養方法 |
EP3887497A1 (en) | 2018-12-20 | 2021-10-06 | TERUMO Kabushiki Kaisha | Cell culture substrate |
EP3887498A1 (en) | 2018-12-20 | 2021-10-06 | TERUMO Kabushiki Kaisha | Cell culture substrate |
US20200248124A1 (en) | 2019-02-05 | 2020-08-06 | Corning Incorporated | Methods of culturing cells on woven cell culture substrates and bioreactors using the same |
US10907125B2 (en) | 2019-06-20 | 2021-02-02 | Inscripta, Inc. | Flow through electroporation modules and instrumentation |
WO2021054262A1 (en) | 2019-09-20 | 2021-03-25 | Terumo Kabushiki Kaisha | Method for evaluating a coating state of either an adsorbent of a sample protein or an adsorption state of a sample protein |
US11118151B2 (en) | 2019-11-05 | 2021-09-14 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
JP2023072702A (ja) | 2020-06-18 | 2023-05-25 | テルモ株式会社 | 細胞培養基材 |
US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
US20230235268A1 (en) * | 2022-01-24 | 2023-07-27 | Octane Biotech Inc. | Support structures for automated cell engineering systems |
US11981884B2 (en) | 2022-10-17 | 2024-05-14 | Upside Foods, Inc. | Pipe-based bioreactors for producing comestible meat products and methods of using the same |
Family Cites Families (1141)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3013435A (en) | 1959-04-06 | 1961-12-19 | Microchemical Specialties Co | Buret |
US2997077A (en) | 1959-04-06 | 1961-08-22 | Microchemical Specialties Co | Fraction collector |
US3067915A (en) | 1960-05-23 | 1962-12-11 | Microchemical Specialties Co | Liquid dispensing devices |
US3191807A (en) | 1961-11-13 | 1965-06-29 | Microchemical Specialties Co | Dispenser adapted for ultra-micro range |
US3283727A (en) | 1964-11-02 | 1966-11-08 | Microchemical Specialties Co | Liquid dispenser with automatic air purge |
FR2035725A5 (ja) | 1969-02-26 | 1970-12-18 | Nunc As | |
BE793952A (fr) | 1972-01-14 | 1973-05-02 | Nunc As | Procede en vue d'ameliorer les proprietes superficielles d'un article forme a partir d'une matiere plastique |
US3821087A (en) | 1972-05-18 | 1974-06-28 | Dedrick R | Cell culture on semi-permeable tubular membranes |
US3883393A (en) | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
US3896061A (en) | 1972-08-16 | 1975-07-22 | Toray Industries | Semi-permeable membranes, their preparation and their use |
CH593339A5 (ja) | 1973-07-02 | 1977-11-30 | Monsanto Co | |
US4173415A (en) | 1976-08-20 | 1979-11-06 | Science Spectrum, Inc. | Apparatus and process for rapidly characterizing and differentiating large organic cells |
US4200689A (en) | 1977-11-11 | 1980-04-29 | United States Of America | Method of cell culture using a dual circuit, woven artificial capillary bundle |
US4184922A (en) | 1977-11-11 | 1980-01-22 | The Government Of The United States | Dual circuit, woven artificial capillary bundle for cell culture |
US4220725A (en) | 1978-04-03 | 1980-09-02 | United States Of America | Capillary cell culture device |
DE2848529A1 (de) | 1978-11-09 | 1980-05-29 | Behringwerke Ag | Verfahren zur herstellung des kaelteunloeslichen globulins und dieses enthaltende arzneimittel |
JPS5642584A (en) | 1979-09-18 | 1981-04-20 | Asahi Chem Ind Co Ltd | Cell cultivation method |
US4301118A (en) | 1980-03-06 | 1981-11-17 | Spectrum Medical Industries, Inc. | Protein concentrator |
US4301010A (en) | 1980-03-10 | 1981-11-17 | Spectrum Medical Industries, Inc. | Vacuum filter |
JPS5714640A (en) | 1980-07-02 | 1982-01-25 | Toray Ind Inc | Separating membrane of methyl methacrylate type |
US4486188A (en) | 1980-08-14 | 1984-12-04 | Applied Medical Devices, Inc. | Bone marrow transplant method and apparatus |
US4418691A (en) | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
US4629686A (en) | 1982-02-19 | 1986-12-16 | Endotronics, Inc. | Apparatus for delivering a controlled dosage of a chemical substance |
US4412990A (en) | 1982-07-02 | 1983-11-01 | Cutter Laboratories, Inc. | Composition having enhanced opsonic activity |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4439901A (en) | 1983-03-28 | 1984-04-03 | Spectrum Medical Industries, Inc. | Clamp |
US4618586A (en) | 1983-04-08 | 1986-10-21 | Endotronics, Inc. | Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber |
US4478829A (en) | 1983-04-28 | 1984-10-23 | Armour Pharmaceutical Company | Pharmaceutical preparation containing purified fibronectin |
US4585654A (en) | 1983-04-29 | 1986-04-29 | Armour Pharmaceutical Co. | Process for pasteurizing fibronectin |
US4509695A (en) | 1983-07-18 | 1985-04-09 | Spectrum Medical Industries, Inc. | Tissue pulverizer |
WO1986002379A1 (en) | 1984-10-09 | 1986-04-24 | Endotronics, Inc. | Hollow fiber culture device for improved nutrient perfusion and product concentration and method of operation |
US4804628A (en) | 1984-10-09 | 1989-02-14 | Endotronics, Inc. | Hollow fiber cell culture device and method of operation |
US4650766A (en) | 1984-10-09 | 1987-03-17 | Endotronics, Inc. | Culturing apparatus |
AT385658B (de) | 1985-03-28 | 1988-05-10 | Serotherapeutisches Inst Wien | Verfahren zur herstellung einer fuer die anwendung beim menschen geeigneten fibronektinloesung |
US4647539A (en) | 1985-05-24 | 1987-03-03 | Endotronics, Inc. | Method and apparatus for growing cells in vitro |
EP0220650A3 (en) | 1985-10-21 | 1988-08-24 | Endotronics Inc. | Method and device for culturing cells |
US4722902A (en) | 1985-11-04 | 1988-02-02 | Endotronics, Inc. | Apparatus and method for culturing cells, removing waste and concentrating product |
US4897358A (en) | 1985-12-02 | 1990-01-30 | Carrasco Jose I | Tissue storage system |
US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
EP0302894B1 (en) | 1986-04-28 | 1992-11-19 | Endotronics Inc. | Method of culturing leukocytes |
US4894342A (en) | 1986-05-12 | 1990-01-16 | C. D. Medical, Inc. | Bioreactor system |
US4918019A (en) | 1986-05-12 | 1990-04-17 | C. D. Medical, Incorporated | Bioreactor system with plasticizer removal |
US4889812A (en) | 1986-05-12 | 1989-12-26 | C. D. Medical, Inc. | Bioreactor apparatus |
WO1988001643A1 (en) | 1986-08-29 | 1988-03-10 | Endotronics, Inc. | Method of culturing cells |
US4885087A (en) | 1986-11-26 | 1989-12-05 | Kopf Henry B | Apparatus for mass transfer involving biological/pharmaceutical media |
US5868930A (en) | 1986-11-26 | 1999-02-09 | Kopf; Henry B. | Filtration cassette article and filter comprising same |
US6022742A (en) | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
US5593580A (en) | 1986-11-26 | 1997-01-14 | Kopf; Henry B. | Filtration cassette article, and filter comprising same |
US5744347A (en) | 1987-01-16 | 1998-04-28 | Ohio University Edison Biotechnology Institute | Yolk sac stem cells and their uses |
US5476922A (en) | 1987-06-24 | 1995-12-19 | Arch Development Corporation | Methods and compositions for the preparation and use of autocrine growth factors |
US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
US5015585A (en) | 1988-02-23 | 1991-05-14 | Robinson James R | Method and apparatus for culturing and diffusively oxygenating cells on isotropic membranes |
US4828706A (en) | 1988-03-07 | 1989-05-09 | Spectrum Medical Industries | Process for performing a dialysis operation |
US5258494A (en) | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
DE68929453T2 (de) | 1988-04-08 | 2003-11-20 | Stryker Corp | Osteogene Vorrichtungen |
US4999298A (en) | 1988-04-27 | 1991-03-12 | W. R. Grace & Co.-Conn. | Hollow fiber bioreactor culture system and method |
US4973558A (en) | 1988-04-28 | 1990-11-27 | Endotronics, Inc. | Method of culturing cells using highly gas saturated media |
US5605835A (en) | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
US5595909A (en) | 1988-05-23 | 1997-01-21 | Regents Of The University Of Minnesota | Filter device |
US5130141A (en) | 1988-05-24 | 1992-07-14 | Law Peter K | Compositions for and methods of treating muscle degeneration and weakness |
US4988623A (en) | 1988-06-30 | 1991-01-29 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Rotating bio-reactor cell culture apparatus |
US5240861A (en) | 1988-07-29 | 1993-08-31 | Spectrum Medical Industries, Inc. | Device and process for concentrating biologic specimens in liquid form |
US5079168A (en) | 1988-08-10 | 1992-01-07 | Endotronics, Inc. | Cell culture apparatus |
US5416022A (en) | 1988-08-10 | 1995-05-16 | Cellex Biosciences, Inc. | Cell culture apparatus |
WO1990002171A1 (en) | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
NZ230723A (en) | 1988-09-21 | 1992-07-28 | Cambridge Animal Biotech | Pluripotential embryonic stem cells isolated from an embryonic disc, methods of producing transgenic cells and a chimeric foetus |
US5002890A (en) * | 1988-11-29 | 1991-03-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Spiral vane bioreactor |
US5162225A (en) | 1989-03-17 | 1992-11-10 | The Dow Chemical Company | Growth of cells in hollow fibers in an agitated vessel |
JPH066053B2 (ja) | 1989-03-17 | 1994-01-26 | タバイエスペック株式会社 | 細胞培養装置 |
ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
IL94611A (en) | 1989-06-05 | 1994-12-29 | Organogenesis Inc | Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use |
USH1509H (en) | 1989-06-09 | 1995-12-05 | Eran; Harutyun | Heparin enhanced process for separating antihemophilic factor (Factor VIII) and fibronectin from cryoprecipitate |
US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
US4960521A (en) | 1989-06-16 | 1990-10-02 | Andreas Keller | Process for performing a dialysis operation using a magnetic weighted clamp |
CA1340565C (en) | 1989-06-29 | 1999-05-25 | Thomas B. Okarma | Device and process for cell capture and recovery |
EP0455757B1 (en) | 1989-08-04 | 1999-03-31 | GRANDICS, Peter | An integrated cell culture-protein purification system for the automated production and purification of cell culture products |
US5112745A (en) | 1989-09-29 | 1992-05-12 | Space Medical Systems, Inc. | Rapid identification of microbial organisms and determination of antibiotic sensitivity by infrared spectroscopy |
US5510257A (en) | 1989-10-04 | 1996-04-23 | Sirkar; Kamalesh K. | Hollow fiber immobilization with chopped microporous hollow fibers |
US6248319B1 (en) | 1989-10-16 | 2001-06-19 | Krisztina M. Zsebo | Method for increasing hematopoietic progenitor cells by stem cell factor polypeptides |
EP0500652A4 (en) | 1989-10-30 | 1992-12-02 | California Institute Of Technology | Enhancement of cell growth by expression of a cloned hemoglobin gene |
US5019054A (en) | 1989-11-06 | 1991-05-28 | Mectra Labs, Inc. | Medical device valving mechanism |
WO1991007485A1 (en) | 1989-11-09 | 1991-05-30 | Bio-Metric Systems, Inc. | Improved bioreactor surfaces and methods of making same |
US5149544A (en) | 1989-11-13 | 1992-09-22 | Research Corporation Technologies, Inc. | Method of inhibiting progenitor cell proliferation |
US5215895A (en) | 1989-11-22 | 1993-06-01 | Genetics Institute, Inc. | Dna encoding a mammalian cytokine, interleukin-11 |
NO168721C (no) | 1989-12-20 | 1992-03-25 | Steinar Risa | Apparat til automatisk setting av broeytestikker o.l. |
US5169930A (en) | 1990-01-05 | 1992-12-08 | La Jolla Cancer Research Foundation | Fibronectin receptor |
US5834312A (en) | 1990-01-29 | 1998-11-10 | Hy-Gene, Inc. | Process and media for the growth of human epithelia |
US7037721B1 (en) | 1990-01-29 | 2006-05-02 | Hy-Gene Biomedical, Inc. | Protein-free defined media for the growth of normal human keratinocytes |
US5126238A (en) | 1990-02-15 | 1992-06-30 | Unisyn Fibertec Corporation | Hollow fiber cell propagation system and method |
US5656421A (en) | 1990-02-15 | 1997-08-12 | Unisyn Technologies, Inc. | Multi-bioreactor hollow fiber cell propagation system and method |
DE4007703A1 (de) | 1990-03-10 | 1991-09-12 | Helmut Pelzer | Transportabler, multipler bioreaktor zur reinigung von kontaminierten erdmassen |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
ZA912842B (en) | 1990-04-16 | 1992-03-25 | Cryopharm Corp | Method of inactivation of viral and bacterial blood contaminants |
US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
US5840580A (en) | 1990-05-01 | 1998-11-24 | Becton Dickinson And Company | Phenotypic characterization of the hematopoietic stem cell |
WO1991018972A1 (en) | 1990-05-30 | 1991-12-12 | Cellco, Inc. | Culturing bone marrow cells for adoptive immunotherapy |
US5612211A (en) | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5262320A (en) * | 1990-06-18 | 1993-11-16 | Massachusetts Institute Of Technology | Cell-culturing apparatus and method employing a macroporous support |
EP0471947A1 (en) | 1990-06-29 | 1992-02-26 | Sekisui Chemical Co., Ltd. | Culture bag |
US5283058A (en) | 1990-08-30 | 1994-02-01 | The General Hospital Corporation | Methods for inhibiting rejection of transplanted tissue |
US5202254A (en) | 1990-10-11 | 1993-04-13 | Endotronics, Inc. | Process for improving mass transfer in a membrane bioreactor and providing a more homogeneous culture environment |
CA2094258A1 (en) | 1990-10-18 | 1992-04-19 | Dale Kalamasz | An apparatus and method for separating particles using a pliable vessel |
US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
WO1992010564A1 (en) | 1990-12-13 | 1992-06-25 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy |
DE69115928T2 (de) | 1991-02-18 | 1996-09-05 | Computer Cell Culture Center | Träger zum züchten von zellen und verfahren zu seiner herstellung |
CA2363965C (en) | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
GB2254289B (en) | 1991-04-05 | 1995-03-22 | Gerber Garment Technology Inc | Readily transferrable adherent tape and methods of use and making |
DE69226431T2 (de) | 1991-04-05 | 1999-04-22 | Univ Washington | Zellrezeptor spezifische monoklonale antikörper gegen stammzell-faktor-rezeptor |
US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
US5330915A (en) | 1991-10-18 | 1994-07-19 | Endotronics, Inc. | Pressure control system for a bioreactor |
US5240856A (en) | 1991-10-23 | 1993-08-31 | Cellpro Incorporated | Apparatus for cell separation |
CA2123094C (en) | 1991-11-06 | 1999-08-10 | Paulo N. Correa | Cell culture medium |
US5310676A (en) | 1991-11-15 | 1994-05-10 | A/S Nunc | Cell cultivating device |
US5240614A (en) | 1992-01-10 | 1993-08-31 | Baxter International Inc. | Process for removing unwanted materials from fluids and for producing biological products |
US5527467A (en) | 1992-01-10 | 1996-06-18 | Baxter International Inc. | Rectifying dialyzer, bioreactor and membrane |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6060270A (en) | 1992-03-02 | 2000-05-09 | The University Of Michigan | Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
US5549674A (en) | 1992-03-02 | 1996-08-27 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US6410320B1 (en) | 1992-03-02 | 2002-06-25 | The University Of Michigan | Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
DE69325649T2 (de) | 1992-03-13 | 1999-11-18 | Atrium Medical Corp | Gegenstände aus expandiertem fluorpolymer (z. b. polytetrafluorethylen) mit komtrolliert eingestellter porosität, sowie seine herstellung |
US5507949A (en) | 1992-03-20 | 1996-04-16 | Monsanto Company | Supported liquid membrane and separation process employing same |
DE69320512T2 (de) | 1992-03-20 | 1999-03-11 | Monsanto Co | Extraktion organischer Verbindungen aus wässrigen Lösungen |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
US5436151A (en) | 1992-04-03 | 1995-07-25 | Regents Of The University Of Minnesota | Method for culturing human hematopoietic stem cells in vitro |
US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
US5564183A (en) | 1992-09-30 | 1996-10-15 | Matsushita Electric Industrial Co., Ltd. | Producing system of printed circuit board and method therefor |
US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
US7153684B1 (en) | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
US5496659A (en) | 1992-10-14 | 1996-03-05 | National Power Plc | Electrochemical apparatus for energy storage and/or power delivery comprising multi-compartment cells |
US5439757A (en) | 1992-10-14 | 1995-08-08 | National Power Plc | Electrochemical energy storage and/or power delivery cell with pH control |
US5422197A (en) | 1992-10-14 | 1995-06-06 | National Power Plc | Electrochemical energy storage and power delivery process utilizing iron-sulfur couple |
US5545492A (en) | 1992-10-14 | 1996-08-13 | National Power Plc | Electrochemical apparatus for power delivery utilizing an air electrode |
US5478739A (en) | 1992-10-23 | 1995-12-26 | Advanced Tissue Sciences, Inc. | Three-dimensional stromal cell and tissue culture system |
US5766951A (en) | 1992-11-12 | 1998-06-16 | Quality Biological, Inc. | Serum-free medium supporting growth and proliferation of normal bone marrow cells |
JPH08506007A (ja) | 1992-11-16 | 1996-07-02 | アプライド イミューン サイエンシーズ,インコーポレイテッド | 多能性の休止状態の幹細胞集団 |
JPH08503489A (ja) | 1992-11-24 | 1996-04-16 | ジー.ディー.サール アンド カンパニー | インターロイキン−3(il−3)突然変異ポリペプチド |
US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
US6054121A (en) | 1993-02-26 | 2000-04-25 | The Picower Institute For Medical Research | Modulation of immune responses in blood-borne mesenchymal cells |
US5804446A (en) | 1993-02-26 | 1998-09-08 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
IL106255A0 (en) | 1993-04-23 | 1993-11-15 | Baxter Int | Method for isolating human blood cells |
US5772994A (en) | 1993-05-28 | 1998-06-30 | The University Of Pittsburgh | Hematopoietic facilitatory cells and their uses |
US5324428A (en) | 1993-07-19 | 1994-06-28 | Spectrum Medical Industries, Inc. | Disposable dialysis apparatus |
WO1995004813A1 (en) | 1993-08-06 | 1995-02-16 | Unisyn Technologies, Inc. | Hollow fiber bioreactor system with improved nutrient oxygenation |
WO1995005083A1 (en) | 1993-08-13 | 1995-02-23 | Smith & Nephew Richards Inc | Microporous polymeric foams and microtextured surfaces |
US6037174A (en) | 1993-08-23 | 2000-03-14 | Nexell Therapeutics, Inc. | Preparation of serum-free suspensions of human hematopoietic cells or precursor cells |
US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
CA2173592C (en) | 1993-10-06 | 2007-09-25 | Michael J. P. Lawman | Stem cell proliferation factor |
US5866420A (en) | 1993-10-08 | 1999-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Artificial liver device |
US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
US5599703A (en) | 1993-10-28 | 1997-02-04 | The United States Of America As Represented By The Secretary Of The Navy | In vitro amplification/expansion of CD34+ stem and progenitor cells |
DE69432563T2 (de) | 1993-10-29 | 2004-02-26 | Unisearch Ltd., Kensington | Vorrichtung zur zelltrennung |
IL107483A0 (en) | 1993-11-03 | 1994-02-27 | Yeda Res & Dev | Bone marrow transplantation |
US6432711B1 (en) | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
US6555324B1 (en) | 1993-11-04 | 2003-04-29 | Becton Dickinson & Company | Method to distinguish hematopoietic progenitor cells |
WO1995013088A1 (en) | 1993-11-12 | 1995-05-18 | Regents Of The University Of Minnesota | Stroma-derived stem cell growth factors |
US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US6488925B2 (en) | 1993-12-22 | 2002-12-03 | Human Genome Sciences, Inc. | Macrophage inflammatory protein-4 (MIP-4) polypeptides |
US6811773B1 (en) | 1993-12-22 | 2004-11-02 | Human Genome Sciences, Inc. | Human monocyte colony inhibitory factor (M-CIF) polypeptides |
WO1995021911A1 (en) | 1994-02-09 | 1995-08-17 | Unisyn Technologies, Inc. | High performance cell culture bioreactor and method |
US5882918A (en) | 1995-08-08 | 1999-03-16 | Genespan Corporation | Cell culture incubator |
US5622857A (en) | 1995-08-08 | 1997-04-22 | Genespan Corporation | High performance cell culture bioreactor and method |
US5607844A (en) | 1994-02-16 | 1997-03-04 | University Of Pittsburgh | Mammalian augmenter of liver regeneration and variants thereof |
US6623942B2 (en) | 1994-03-08 | 2003-09-23 | Human Genome Sciences, Inc. | Macrophage inflammatory protein-4 (MIP-4) polynucleotides |
US6495129B1 (en) | 1994-03-08 | 2002-12-17 | Human Genome Sciences, Inc. | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) |
US5679340A (en) | 1994-03-31 | 1997-10-21 | Diacrin, Inc. | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
GB9407048D0 (en) | 1994-04-08 | 1994-06-01 | Nat Power Plc | Method for the fabrication of an electrochemical cell |
ZA952384B (en) | 1994-04-13 | 1996-09-23 | Nat Power Plc | Cation exchange membranes and method for the preparation of such membranes |
DE4412794A1 (de) | 1994-04-14 | 1995-12-14 | Univ Ludwigs Albert | Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens |
US5543316A (en) | 1994-04-20 | 1996-08-06 | Diacrin, Inc. | Injectable culture medium for maintaining viability of myoblast cells |
US7033339B1 (en) | 1998-05-29 | 2006-04-25 | Becton Dickinson And Company (Part Interest) | Self sealing luer receiving stopcock |
US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5855608A (en) | 1994-05-13 | 1999-01-05 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
US5906827A (en) | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
DK0952792T3 (da) | 1994-06-06 | 2003-12-08 | Osiris Therapeutics Inc | Biomatrix til vævsregeneration |
US6174333B1 (en) | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
GB9413029D0 (en) | 1994-06-29 | 1994-08-17 | Common Services Agency | Stem cell immobilisation |
US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
US5935849A (en) | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US6103522A (en) | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
US5972703A (en) | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
US5840502A (en) | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
US6054433A (en) | 1994-11-03 | 2000-04-25 | The Regents Of The University Of California | Methods and compositions for stimulating tissue growth and epithelial moisturization |
ES2217285T3 (es) | 1994-11-08 | 2004-11-01 | Cellfactors Plc | Metodo para producir una linea celular neural humana. |
US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
US7001328B1 (en) | 1994-11-15 | 2006-02-21 | Kenton W. Gregory | Method for using tropoelastin and for producing tropoelastin biomaterials |
US6472200B1 (en) | 1999-07-23 | 2002-10-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
MX9701512A (es) | 1994-11-16 | 1997-05-31 | Amgen Inc | Uso del factor de celulas madre y receptor de interleucina-6 soluble para la expansion ex vivo de celulas multipotenciales hematopoyeticas. |
US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
US6558664B1 (en) | 1994-12-13 | 2003-05-06 | Cell Factors Plc | Chondrocyte cell-lines |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US7410773B2 (en) | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
US5643736A (en) | 1995-02-06 | 1997-07-01 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human osteogenic cell surface antigens |
US5788851A (en) | 1995-02-13 | 1998-08-04 | Aksys, Ltd. | User interface and method for control of medical instruments, such as dialysis machines |
GB9503197D0 (en) | 1995-02-18 | 1995-04-05 | Atomic Energy Authority Uk | A bioreactor |
US7008634B2 (en) | 1995-03-03 | 2006-03-07 | Massachusetts Institute Of Technology | Cell growth substrates with tethered cell growth effector molecules |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US7094564B1 (en) | 1995-03-15 | 2006-08-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
GB9505663D0 (en) | 1995-03-21 | 1995-05-10 | Stringer Bradley M J | Genetically modified neural cells |
US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
US5837670A (en) | 1995-04-18 | 1998-11-17 | Hartshorn; Richard Timothy | Detergent compositions having suds suppressing properties |
US5733541A (en) | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
BE1009306A5 (fr) | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
US5925567A (en) | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
US5674750A (en) | 1995-05-19 | 1997-10-07 | T. Breeders | Continuous selective clonogenic expansion of relatively undifferentiated cells |
US6495364B2 (en) | 1995-05-23 | 2002-12-17 | Neurotech, S.A. | Mx-1 conditionally immortalized cells |
DE19520188C2 (de) | 1995-06-01 | 1999-04-08 | Geesthacht Gkss Forschung | Verfahren zur Herstellung von Polymer-Hohlfadenmembranen |
MY115206A (en) | 1995-06-04 | 2003-04-30 | Regenesys Tech Ltd | Method for the preparation of cation exchange membranes doped with insoluble metal salts |
US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
AU706026B2 (en) | 1995-06-06 | 1999-06-10 | Case Western Reserve University | Myogenic differentiation of human mesenchymal stem cells |
EP0838033A1 (en) | 1995-06-06 | 1998-04-29 | Stemcell Therapeutics L.L.C. | GLYCOPROTEIN gp105 ON BL3 HEMATOPOIETIC STEM CELLS |
US5728581A (en) | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
US5985653A (en) | 1995-06-07 | 1999-11-16 | Aastrom Biosciences, Inc. | Incubator apparatus for use in a system for maintaining and growing biological cells |
US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
US5688687A (en) | 1995-06-07 | 1997-11-18 | Aastrom Biosciences, Inc. | Bioreactor for mammalian cell growth and maintenance |
US6096532A (en) | 1995-06-07 | 2000-08-01 | Aastrom Biosciences, Inc. | Processor apparatus for use in a system for maintaining and growing biological cells |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
US6228635B1 (en) | 1995-06-07 | 2001-05-08 | Aastrom Bioscience, Inc. | Portable cell growth cassette for use in maintaining and growing biological cells |
US5712154A (en) | 1995-06-07 | 1998-01-27 | W.R. Grace & Co.-Conn. | Dual fiber bioreactor |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
US6680166B1 (en) | 1995-06-07 | 2004-01-20 | Claudy Jean Paul Mullon | Dual fiber bioreactor |
US6015554A (en) | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
US5655546A (en) | 1995-06-07 | 1997-08-12 | Halpern; Alan A. | Method for cartilage repair |
US6117985A (en) | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
DE69634352T2 (de) | 1995-06-30 | 2006-01-12 | Toray Industries, Inc. | Methode zur Herstellung einer teildurchlässigen Hohlfasermembran aus Polysulfon |
US5627070A (en) | 1995-07-26 | 1997-05-06 | Celltherapy, Inc. | Cell growing device for in vitro cell population expansion |
WO1997005826A1 (en) | 1995-08-08 | 1997-02-20 | Laser Centers Of America | System for extracting tissue samples in laparoscopy |
US5705534A (en) | 1995-09-22 | 1998-01-06 | National Power Plc | Method for the preparation of cation exchange membranes doped with insoluble metal salts |
MX9504097A (es) | 1995-09-26 | 1997-03-29 | Luis Carlos Montemayor Uzeta | Aparato purificador de fluidos de alta capacidad de flujo. |
US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
ATE274052T1 (de) * | 1995-10-06 | 2004-09-15 | Az Univ Amsterdam | Fester träger für die zellkultur insbesondere für leberzellenkultur, biologischer reaktor und diese träger enthaltendes biologischer reaktor und ihre verwendung in einem künstliche leber vorrichtung |
US5855613A (en) | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US5700289A (en) | 1995-10-20 | 1997-12-23 | North Shore University Hospital Research Corporation | Tissue-engineered bone repair using cultured periosteal cells |
EP0801674A4 (en) | 1995-10-30 | 1999-07-07 | Cellex Biosciences Inc | APPARATUS FOR CULTIVATING BIOARTIFICIAL LIVER |
US5858782A (en) | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
DK0877941T3 (da) | 1995-11-13 | 2003-05-05 | Biotransplant Inc | Fremgangsmåde til masseforøgelse af en population eller subpopulation af celler |
US5922597A (en) | 1995-11-14 | 1999-07-13 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
US5908784A (en) | 1995-11-16 | 1999-06-01 | Case Western Reserve University | In vitro chondrogenic induction of human mesenchymal stem cells |
US6482231B1 (en) | 1995-11-20 | 2002-11-19 | Giovanni Abatangelo | Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative |
IT1282207B1 (it) | 1995-11-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico |
US5658995A (en) | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
GB9526577D0 (en) | 1995-12-28 | 1996-02-28 | Nat Power Plc | Method for the fabrication of electrochemical cells |
US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US6322786B1 (en) | 1996-02-15 | 2001-11-27 | Kansas University Medical Center Research Institute, Inc. | Method of producing bone-inducing agent |
EP0885020A1 (en) | 1996-02-20 | 1998-12-23 | Cohesion Corporation | Tissue sealant compositions and methods of use thereof |
US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
CA2198978A1 (en) | 1996-03-01 | 1997-09-01 | Clemens Antoni Van Blitterswijk | Method for the in vitro production of bone |
EP0891419A4 (en) | 1996-03-12 | 2000-03-01 | Life Technologies Inc | NUTRIENT ADDITIVE FOR HEMATOPOETIC CELL CULTURES |
US6479254B2 (en) | 1996-03-22 | 2002-11-12 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II |
US20010017188A1 (en) | 1996-04-10 | 2001-08-30 | Cooley Graham Edward | Process for the fabrication of electrochemical cell components |
WO1997039104A1 (en) | 1996-04-17 | 1997-10-23 | Osiris Therapeutics, Inc. | Cryopreservation and extensive subculturing of human mesenchymal stem cells |
EP2311471A3 (en) | 1996-04-19 | 2013-05-15 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
JP2000508922A (ja) | 1996-04-26 | 2000-07-18 | ケース ウエスターン リザーブ ユニバーシティ | 間葉幹細胞を用いる皮膚再生 |
US6455678B1 (en) | 1996-04-26 | 2002-09-24 | Amcell Corporation | Human hematopoietic stem and progenitor cell antigen |
US5843633A (en) | 1996-04-26 | 1998-12-01 | Amcell Corporation | Characterization of a human hematopoietic progenitor cell antigen |
US6190910B1 (en) | 1996-05-21 | 2001-02-20 | The Institute Of Physical And Chemical Research | Mouse embryonic stem cell lines |
US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
US6165785A (en) | 1996-05-24 | 2000-12-26 | University Of Cincinnati | Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications |
US5939323A (en) | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
WO1997046665A1 (de) | 1996-06-04 | 1997-12-11 | Sulzer Orthopedics Ltd. | Verfahren zur herstellung von knorpelgewebe und von implantaten |
US5824084A (en) | 1996-07-03 | 1998-10-20 | The Cleveland Clinic Foundation | Method of preparing a composite bone graft |
US6145688A (en) | 1996-07-17 | 2000-11-14 | Smith; James C. | Closure device for containers |
US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
US6458585B1 (en) | 1996-08-14 | 2002-10-01 | Nexell Therapeutics Inc. | Cytokine-free culture of dendritic cells |
GB9617058D0 (en) | 1996-08-14 | 1996-09-25 | Sandoz Ltd | Organic compounds |
US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
US5667985A (en) | 1996-09-24 | 1997-09-16 | Becton Dickinson And Company | Tissue biopsy cell suspender for cell analysis |
US6150164A (en) | 1996-09-30 | 2000-11-21 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
US5980887A (en) | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
US6372796B1 (en) | 1996-11-13 | 2002-04-16 | Cold Spring Harbor Laboratory | Therapeutic uses for nitric oxide inhibitors |
DE69736526T2 (de) | 1996-11-13 | 2007-04-26 | Cold Spring Harbor Laboratory | Therapeutische verwendung von stickstoffmonoxydinhibitoren |
EP0941027A4 (en) | 1996-11-15 | 2000-08-09 | Osiris Therapeutics Inc | MSC megakaryocyte precursor composition and method for isolating MSCS associated with isolated megakaryocytes by isolating megakaryocytes |
US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
US5928945A (en) | 1996-11-20 | 1999-07-27 | Advanced Tissue Sciences, Inc. | Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage |
US6331409B1 (en) | 1996-11-21 | 2001-12-18 | The Regents Of The University Of Michigan | Methods and compositions for wound healing |
US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
US6084060A (en) | 1996-12-09 | 2000-07-04 | Imclone Systems Incorporated | Composition and method for preserving progenitor cells |
CA2274033C (en) | 1996-12-10 | 2010-05-11 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
WO1998027210A1 (en) | 1996-12-16 | 1998-06-25 | Zymogenetics, Inc. | Compositions and methods for stimulating pancreatic islet cell regeneration |
US5766944A (en) | 1996-12-31 | 1998-06-16 | Ruiz; Margaret Eileen | T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments |
AU6238698A (en) | 1997-01-14 | 1998-08-03 | Human Genome Sciences, Inc. | Tumor necrosis factor receptor 5 |
CA2277814A1 (en) | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
US20020031757A1 (en) | 1997-01-24 | 2002-03-14 | Asahi Medical Co., Ltd. | Method of regenerating a tissue |
ATE362982T1 (de) | 1997-01-28 | 2007-06-15 | Human Genome Sciences Inc | ßDEATH-DOMAINß-ENTHALTENDER REZEPTOR 4 (DR4), EIN MITGLIED DER TNF-REZEPTOR SUPERFAMILIE, WELCHER AN TRAIL (APO-2L) BINDET |
US6335195B1 (en) | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
EP2332564A1 (en) | 1997-02-07 | 2011-06-15 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods thereof |
GB9704749D0 (en) | 1997-03-07 | 1997-04-23 | Univ London | Tissue Implant |
US6632425B1 (en) | 1997-03-20 | 2003-10-14 | Human Genome Sciences, Inc. | Chemokine compositions |
AU6869198A (en) | 1997-03-25 | 1998-10-20 | Morphogenesis, Inc. | Universal stem cells |
US6361996B1 (en) | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
DE69837141T2 (de) | 1997-05-12 | 2007-10-31 | Metabolix, Inc., Cambridge | Polyhydroxyalkanoate für in vivo anwendungen |
AU7481098A (en) | 1997-05-13 | 1998-12-08 | Case Western Reserve University | Osteoarthritis cartilage regeneration using human mesenchymal stem ce lls |
WO1998051785A1 (en) | 1997-05-14 | 1998-11-19 | The General Hospital Corporation | Co-cultivation of cells in a micropatterned configuration |
US5955353A (en) | 1997-05-22 | 1999-09-21 | Excorp Medical, Inc. | Hollow fiber bioreactor with an extrafilament flow plug |
US5853247A (en) | 1997-05-27 | 1998-12-29 | Shroyer; John Bruce | Sample bag container |
US5783075A (en) | 1997-06-23 | 1998-07-21 | Spectrum Medical Laboratories, Inc. | Disposable dialyzer apparatus |
US6310195B1 (en) | 1997-06-24 | 2001-10-30 | Imclone Systems Incorporated | Nucleic acid encoding a lectin-derived progenitor cell preservation factor |
US6979307B2 (en) | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
US5913859A (en) | 1997-07-01 | 1999-06-22 | Shapira; Ira L. | Apparatus for extracting bone marrow |
US6261549B1 (en) | 1997-07-03 | 2001-07-17 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
KR20060002033A (ko) | 1997-07-04 | 2006-01-06 | 유니버시티 오브 유타 리서치 파운데이션 | 계통이 예정된 신경세포 전구체 |
CA2296704C (en) | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
DE69805920T2 (de) | 1997-07-16 | 2003-01-02 | Isotis Nv | Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen |
TWI239352B (en) | 1997-07-23 | 2005-09-11 | Takara Bio Inc | Gene transfer method with the use of serum-free medium |
AU8662798A (en) | 1997-07-28 | 1999-02-16 | Academy Of Finland | Collagen type i and type iii adhesive compositions |
US6001643A (en) | 1997-08-04 | 1999-12-14 | C-Med Inc. | Controlled hydrodynamic cell culture environment for three dimensional tissue growth |
US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
DE69714035T2 (de) | 1997-08-14 | 2003-03-06 | Sulzer Innotec Ag | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
US6908763B1 (en) | 1997-08-22 | 2005-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian common lymphoid progenitor cell |
EP1003847A4 (en) | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS |
WO1999011287A1 (en) | 1997-09-04 | 1999-03-11 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
CA2302339A1 (en) | 1997-09-20 | 1999-04-01 | Osiris Therapeutics, Inc. | Antigen presenting mesenchymal stem cells |
US6440734B1 (en) | 1998-09-25 | 2002-08-27 | Cytomatrix, Llc | Methods and devices for the long-term culture of hematopoietic progenitor cells |
CA2304206A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
US6194168B1 (en) | 1997-09-30 | 2001-02-27 | Human Genome Sciences, Inc. | Expression control sequences |
US6429012B1 (en) | 1997-10-06 | 2002-08-06 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
US5998184A (en) | 1997-10-08 | 1999-12-07 | Unisyn Technologies, Inc. | Basket-type bioreactor |
CA2307807C (en) | 1997-10-23 | 2008-09-02 | Andrea G. Bodnar | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
US6649631B1 (en) | 1997-10-23 | 2003-11-18 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating bone deficit conditions |
WO1999023219A1 (en) | 1997-10-31 | 1999-05-14 | Osiris Therapeutics, Inc. | Human slit polypeptide and polynucleotides encoding same |
WO1999024490A1 (en) | 1997-11-07 | 1999-05-20 | Rutgers, The State University | Strictly alternating poly(alkylene oxide ether) copolymers |
WO1999024557A1 (en) | 1997-11-10 | 1999-05-20 | The Regents Of The University Of Michigan | Human bone accessory cells |
US6001585A (en) | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
US6475481B2 (en) | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
GB9724879D0 (en) | 1997-11-26 | 1998-01-21 | Univ London | Process for the production of protein and products thereof |
US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
AU753975B2 (en) | 1997-12-04 | 2002-10-31 | Duke University | Methods of isolating and using CD7+CD34-Lin-hematopoietic cells |
US6082364A (en) | 1997-12-15 | 2000-07-04 | Musculoskeletal Development Enterprises, Llc | Pluripotential bone marrow cell line and methods of using the same |
DE69739210D1 (de) | 1997-12-16 | 2009-02-26 | Univ Zuerich | Diagnostik für übertragbare spongiforme Enzephalopathie |
US6171548B1 (en) | 1997-12-29 | 2001-01-09 | Spectrum Environmental Technologies, Inc. | Surface and air sterilization using ultraviolet light and ultrasonic waves |
EP1044261A1 (en) | 1997-12-29 | 2000-10-18 | Monsanto Company | A membrane process for making enhanced flavor fluids |
US6074366A (en) | 1998-01-16 | 2000-06-13 | Tandem Medical Inc. | Medication delivery apparatus |
JP2002500879A (ja) | 1998-01-23 | 2002-01-15 | イムクローン システムズ インコーポレーテッド | 幹細胞の精製ポピュレーション |
US6653105B2 (en) | 1998-02-11 | 2003-11-25 | Vitagen, Inc. | Clonal cells and cell lines derived from C3A cells and methods of making and using them |
US6962698B1 (en) | 1998-02-17 | 2005-11-08 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US20020034819A1 (en) | 1998-02-23 | 2002-03-21 | Alan K. Smith | Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses |
ATE286118T1 (de) | 1998-03-13 | 2005-01-15 | Osiris Therapeutics Inc | Anwendungen für humane nicht autologe, mesenchymale stammzellen |
US6197575B1 (en) | 1998-03-18 | 2001-03-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
EP1066052B1 (en) | 1998-03-18 | 2006-02-01 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
EP1064356A2 (en) | 1998-03-23 | 2001-01-03 | ZymoGenetics, Inc. | Cardiac-derived stem cells |
US6143293A (en) | 1998-03-26 | 2000-11-07 | Carnegie Mellon | Assembled scaffolds for three dimensional cell culturing and tissue generation |
ES2205792T3 (es) | 1998-04-03 | 2004-05-01 | Osiris Therapeutics, Inc. | Celulas madre mesenquimatosas como inmunosupresores. |
US5882929A (en) | 1998-04-07 | 1999-03-16 | Tissue Engineering, Inc. | Methods and apparatus for the conditioning of cartilage replacement tissue |
US5882295A (en) | 1998-04-13 | 1999-03-16 | Spectrum Medical Industries, Inc. | Video camera drape |
US6071691A (en) | 1998-04-27 | 2000-06-06 | Oregon Health Science University | Materials and methods for modulating differentiation |
GB2337150B (en) | 1998-05-07 | 2000-09-27 | Nat Power Plc | Carbon based electrodes |
WO1999056759A1 (en) | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
US6576428B1 (en) | 1998-05-11 | 2003-06-10 | Miltenyi Biotech Gmbh | Direct selection of antigen-specific T cells, compositions obtained thereby and methods of use thereof |
US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
EP1078042A1 (en) | 1998-05-22 | 2001-02-28 | Osiris Therapeutics, Inc. | Production of megakaryocytes by co-culturing human mesenchymal stem cells with cd34+ cells |
US6548734B1 (en) | 1998-05-28 | 2003-04-15 | President And Fellows Of Harvard College | Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity |
WO1999061587A1 (en) | 1998-05-29 | 1999-12-02 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
CA2330208A1 (en) | 1998-05-29 | 1999-12-02 | Thomas Jefferson University | Compositions and methods for use in affecting hematopoietic stem cell populations in mammals |
PT1084230E (pt) | 1998-06-08 | 2008-01-25 | Osiris Therapeutics Inc | Regulação da diferenciação de células estaminais hematopoiéticas através da utilização de células estaminais mesenquimatosas humanas |
US6030836A (en) | 1998-06-08 | 2000-02-29 | Osiris Therapeutics, Inc. | Vitro maintenance of hematopoietic stem cells |
RU2139085C1 (ru) | 1998-06-23 | 1999-10-10 | Санкт-Петербургская общественная организация "Институт биорегуляции и геронтологии" | Средство, стимулирующее репаративные процессы, и способ его применения |
US6414219B1 (en) | 1998-06-30 | 2002-07-02 | Rutgers, The State University Of New Jersey | Osteopontin knock-out mouse and methods of use thereof |
US20090047289A1 (en) | 1998-06-30 | 2009-02-19 | Denhardt David T | Osteopontin Specific Antibodies and Methods of Use Thereof |
US6080581A (en) | 1998-07-02 | 2000-06-27 | Charles Daniel Anderson | Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same |
US6129911A (en) | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
GB9815173D0 (en) | 1998-07-13 | 1998-09-09 | Nat Power Plc | Process for the removal of sulphate ions |
AU756785B2 (en) | 1998-07-13 | 2003-01-23 | University Of Southern California | Methods for accelerating bone and cartilage growth and repair |
DE19833476B4 (de) | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
IL125532A0 (en) | 1998-07-27 | 1999-03-12 | Yeda Res & Dev | Hematopoietic cell composition for use in transplantation |
US6677306B1 (en) | 1998-07-29 | 2004-01-13 | Northwestern University | Chondrogenic and osteogenic inducing molecule |
US20020015724A1 (en) | 1998-08-10 | 2002-02-07 | Chunlin Yang | Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing |
EP1105051A4 (en) | 1998-08-10 | 2003-08-06 | Fibrogen Inc | HEMOSTATIC COMPOSITION BASED ON COLLAGEN I AND II FOR USE AS BLOCKING OF BLOOD TREATS AND AS WUNDAUFLAGE |
US6703209B1 (en) | 1998-08-13 | 2004-03-09 | Biotransplant, Inc. | Porcine totipotent cells and method for long-term culture |
US6849255B2 (en) | 1998-08-18 | 2005-02-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for enhancing cartilage repair |
US6894022B1 (en) | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US6767737B1 (en) | 1998-08-31 | 2004-07-27 | New York University | Stem cells bearing an FGF receptor on the cell surface |
US6530956B1 (en) | 1998-09-10 | 2003-03-11 | Kevin A. Mansmann | Resorbable scaffolds to promote cartilage regeneration |
GB2341601B (en) | 1998-09-15 | 2000-07-26 | Nat Power Plc | Process for the preparation of reticulated copper or nickel sulfide |
AU766735B2 (en) | 1998-09-15 | 2003-10-23 | Isotis N.V. | Osteoinduction |
CN1318075A (zh) | 1998-09-15 | 2001-10-17 | 国际电力有限公司 | 水基接枝 |
GB9820109D0 (en) | 1998-09-15 | 1998-11-11 | Nat Power Plc | Vitrified carbon compositions |
US7338798B2 (en) | 1998-09-15 | 2008-03-04 | The Regents Of The University Of Michigan | System and method for forming a cardiac muscle construct |
US6569654B2 (en) | 1998-09-18 | 2003-05-27 | Massachusetts Institute Of Technology | Electroactive materials for stimulation of biological activity of stem cells |
AU6056299A (en) | 1998-09-21 | 2000-04-10 | Musc Foundation For Research Development | Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them |
GB9821156D0 (en) | 1998-09-29 | 1998-11-25 | Nat Power Plc | Manufacturable electrochemical cell |
US6632934B1 (en) | 1998-09-30 | 2003-10-14 | Board Of Regents, The University Of Texas System | MORC gene compositions and methods of use |
JP2000106882A (ja) | 1998-10-02 | 2000-04-18 | Chemo Sero Therapeut Res Inst | 癌転移増殖抑制作用を有する血漿蛋白断片産生酵素および当該酵素により断片化された血漿蛋白断片 |
US20070166834A1 (en) | 1998-10-05 | 2007-07-19 | Biopath Automation, L.L.C. | Apparatus and method for harvesting and handling tissue samples for biopsy analysis |
US8026096B1 (en) | 1998-10-08 | 2011-09-27 | Protein Sciences Corporation | In vivo active erythropoietin produced in insect cells |
JP2002527144A (ja) | 1998-10-12 | 2002-08-27 | セリックス, インコーポレイテッド | 組織再生のための複合体およびその製造方法 |
WO2000023799A1 (en) | 1998-10-21 | 2000-04-27 | Steven Jay Smith | Protein quantitation with cell imaging densitometry |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
CA2348687A1 (en) | 1998-11-09 | 2000-05-18 | Consorzio Per La Gestione Del Centro Di Biotecnologie Avanzate | Serum free medium for chondrocyte-like cells |
EP1129176A4 (en) | 1998-11-09 | 2002-10-30 | Es Cell Int Pte Ltd | EMBRYONIC STEM CELLS |
CA2347914A1 (en) | 1998-11-13 | 2000-05-25 | Osiris Therapeutics, Inc. | Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation |
AU1478000A (en) | 1998-11-13 | 2000-06-05 | Osiris Therapeutics, Inc. | (in utero) transplantation of human mesenchymal stem cells |
US6761887B1 (en) | 1998-11-16 | 2004-07-13 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
US6184035B1 (en) | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
GB9826658D0 (en) | 1998-12-03 | 1999-01-27 | Univ London | Tissue repair |
DE19855890A1 (de) | 1998-12-03 | 2000-06-08 | Nerlich Michael | Poröse Kompositmatrix, deren Herstellung und Verwendung |
NZ511685A (en) | 1998-12-04 | 2003-12-19 | Naval Medical Res Ct | Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38- bone marrow stem cells |
GB2346006B (en) | 1999-01-20 | 2001-01-31 | Nat Power Plc | Method of carrying out electrochemical reactions |
WO2000043499A2 (en) | 1999-01-25 | 2000-07-27 | Seattle Biomedical Research Institute | ANTI-TRANSFORMING GROWTH FACTOR BETA (TGF-β) TREATED STEM CELL COMPOSITION AND METHOD |
ES2147163B1 (es) | 1999-01-25 | 2001-03-01 | Esp Farmaceuticas Centrum Sa | Una composicion farmaceutica con actividad reguladora de la expresion de las moleculas de adhesion. |
CN100402642C (zh) | 1999-02-04 | 2008-07-16 | 技术研究及发展基金有限公司 | 维持和扩增造血干细胞和/或祖细胞的方法和仪器 |
EP1144595A2 (en) | 1999-02-04 | 2001-10-17 | McGILL UNIVERSITY | Platform for the differentiation of cells |
EP1175487A2 (en) | 1999-02-10 | 2002-01-30 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
US6767738B1 (en) | 1999-02-11 | 2004-07-27 | The Salk Institute For Biological Studies | Method of isolating adult mammalian CNS-derived progenitor stem cells using density gradient centrifugation |
US6468794B1 (en) | 1999-02-12 | 2002-10-22 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
US6376742B1 (en) | 1999-02-17 | 2002-04-23 | Richard J. Zdrahala | In vivo tissue engineering with biodegradable polymers |
US6821790B2 (en) | 1999-03-02 | 2004-11-23 | Vijay Mahant | Methods and apparatus for separation of biological fluids |
JP3863373B2 (ja) | 1999-03-02 | 2006-12-27 | クオリジエン・インコーポレイテツド | 生物学的流体の分離のための装置を用いる方法 |
US20050153442A1 (en) | 1999-03-10 | 2005-07-14 | Adam Katz | Adipose-derived stem cells and lattices |
US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
CN1352696A (zh) | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
AU3881100A (en) | 1999-03-15 | 2000-10-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like genes |
AU3766700A (en) | 1999-03-22 | 2000-10-09 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like 2 |
US6662805B2 (en) | 1999-03-24 | 2003-12-16 | The Johns Hopkins University | Method for composite cell-based implants |
GB9907243D0 (en) | 1999-03-29 | 1999-05-26 | Reneuron Ltd | Therapy |
US20040131601A1 (en) | 2000-03-30 | 2004-07-08 | Foundry Networks, Inc., A Delaward Corporation | Injection of bone marrow-derived cells and medium for angiogenesis |
AU4329300A (en) | 1999-04-01 | 2000-10-23 | Osiris Therapeutics, Inc. | Human mesenchymal dnas and expression products |
US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
US6423681B1 (en) | 1999-05-04 | 2002-07-23 | The Trustees Of Columbia University In The City Of New York | Method of inducing formation of kidney epithelia from mesenchymal precursors |
JP2002544486A (ja) | 1999-05-10 | 2002-12-24 | プロリンクス・インコーポレイテッド | 細胞分離装置およびその使用法 |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
US6339141B1 (en) | 1999-05-20 | 2002-01-15 | Hycey Inc. | Interleukin-1 Hy2 materials and methods |
US6312952B1 (en) | 1999-05-27 | 2001-11-06 | The Research Foundation Of State University Of New York | In vitro cell culture device including cartilage and methods of using the same |
US7135335B2 (en) | 1999-05-28 | 2006-11-14 | Stemcell Technologies Inc. | Method for separating cells using immunorosettes |
US6979308B1 (en) | 1999-06-03 | 2005-12-27 | University Of North Carolina At Chapel Hill | Bioreactor design and process for engineering tissue from cells |
ES2226850T3 (es) | 1999-06-03 | 2005-04-01 | The University Of North Carolina At Chapel Hill | Diseño de biorreactor y procedimiento para preparar tejido a partir de celulas. |
GB2350895B (en) | 1999-06-07 | 2001-08-29 | Nat Power Plc | Methods for monitoting sulfonyl halide functional group content of materials |
GB9913185D0 (en) | 1999-06-07 | 1999-08-04 | Nat Power Plc | Sulfur precipitation detector |
CA2376487A1 (en) | 1999-06-15 | 2000-12-21 | Allan S. Lau | Methods for enhancing the production of cytokines in cell culture |
WO2000078920A1 (en) | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
JP4605734B2 (ja) | 1999-06-21 | 2011-01-05 | ザ ジェネラル ホスピタル コーポレイション | 臓器補助装置のための細胞培養システム及び方法 |
US6821513B1 (en) | 1999-06-23 | 2004-11-23 | Oregon Health & Science University | Method for enhancing hematopoiesis |
AU5767900A (en) | 1999-06-25 | 2001-01-31 | Advanced Tissue Sciences, Inc. | Monitorable three-dimensional scaffolds and tissue culture systems |
DK1194035T3 (da) | 1999-06-29 | 2008-01-28 | Univ Leland Stanford Junior | Delmængder af myeloide progenitorceller i pattedyr |
US6761883B2 (en) | 1999-06-29 | 2004-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian myeloid progenitor cell subsets |
US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
GB9915413D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Propagation method |
RU2001134619A (ru) | 1999-07-02 | 2003-08-27 | Ридженезис Текнолоджиз Лимитед (Gb) | Система ребалансирования электролита |
AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
US20050158289A1 (en) | 1999-07-07 | 2005-07-21 | Simmons Paul J. | Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals |
AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
US7670628B2 (en) | 1999-07-07 | 2010-03-02 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
US6872389B1 (en) | 1999-07-08 | 2005-03-29 | Rhode Island Hospital | Liver stem cell |
DE19932439C2 (de) | 1999-07-12 | 2002-06-13 | Sefar Ag Rueschlikon | Bioreaktor |
US6951738B2 (en) | 1999-07-16 | 2005-10-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors TR13 and TR14 |
DE60040292D1 (de) | 1999-07-20 | 2008-10-30 | Univ Southern California | Identifizierung pluripotenter prämesenchymaler, prähämotopoietischer vorläuferzellen |
JP5143988B2 (ja) | 1999-07-22 | 2013-02-13 | オルガノジェネシス インク. | 単離された肝細胞の機能を増強させるためのイン・ビボ誘導 |
AU778386B2 (en) | 1999-07-28 | 2004-12-02 | Board Of Trustees Of The Leland Stanford Junior University | Nicotine receptor agonists in stem cell and progenitor cell recruitment |
US6417205B1 (en) | 1999-07-28 | 2002-07-09 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
WO2001011011A2 (en) | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
US7927587B2 (en) | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
US6719969B1 (en) | 1999-08-09 | 2004-04-13 | The Regents Of The University Of Michigan | Treatment of liver disease and injury with CXC chemokines |
US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
WO2001016180A2 (en) | 1999-08-27 | 2001-03-08 | Board Of Regents, The University Of Texas System | Cd40 agonist compositions and methods of use |
EP1210409B1 (en) | 1999-09-07 | 2006-11-29 | Tyco Healthcare Group LP | Cell growth substrate |
EP2290050B1 (de) | 1999-09-08 | 2012-06-13 | Levitronix Technologies, LLC | Bioreaktor |
US6239157B1 (en) | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
WO2001021766A2 (en) | 1999-09-23 | 2001-03-29 | Cell Science Therapeutics | Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells |
US20030161817A1 (en) | 2001-03-28 | 2003-08-28 | Young Henry E. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
EP1218489B1 (en) | 1999-09-24 | 2009-03-18 | Cybios LLC | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
WO2001022810A2 (en) | 1999-09-28 | 2001-04-05 | Us Transgenics, Inc. | Transgenic animals expressing von willebrand factor (vwf) and vwf-related polypeptides |
AUPQ319199A0 (en) | 1999-09-30 | 1999-10-28 | Unisearch Limited | Method and apparatus for culturing cells |
US6528052B1 (en) | 2000-09-29 | 2003-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling |
DE19948184C2 (de) | 1999-10-06 | 2001-08-09 | Fraunhofer Ges Forschung | Elektrochemische Herstellung von Peroxo-dischwefelsäure unter Einsatz von diamantbeschichteten Elektroden |
PT1282690E (pt) | 1999-10-06 | 2005-02-28 | Tigenix Nv | Isolamento de celulas e sua utilizacao na reparacao de tecidos |
US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
US6599520B2 (en) | 1999-10-14 | 2003-07-29 | Osteotech, Inc. | Method of inducing new bone growth in porous bone sites |
EP1226232A2 (en) | 1999-10-15 | 2002-07-31 | Mount Sinai Hospital | Synthetic substrate for tissue formation |
JP2003513648A (ja) | 1999-10-29 | 2003-04-15 | フイラデルフイア・ヘルス・アンド・エデユケーシヨン・コーポレーシヨン | ヒト骨髄ストローマ細胞の単離および拡張 |
US20040033599A1 (en) | 1999-10-29 | 2004-02-19 | Lawrence Rosenberg | Medium for preparing dedifferentiated cells |
US20050037490A1 (en) | 1999-10-29 | 2005-02-17 | Lawrence Rosenberg | Medium for preparing dedifferentiated cells |
US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
AU1939801A (en) | 1999-12-01 | 2001-06-12 | Selective Genetics, Inc. | In situ bioreactors and methods of use thereof |
US20010046489A1 (en) | 1999-12-06 | 2001-11-29 | Habener Joel E. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
US6541249B2 (en) | 1999-12-22 | 2003-04-01 | Human Genome Sciences, Inc. | Immortalized human stromal cell lines |
US6811776B2 (en) | 2000-12-27 | 2004-11-02 | The Regents Of The University Of Michigan | Process for ex vivo formation of mammalian bone and uses thereof |
DE60009956T2 (de) | 1999-12-28 | 2005-04-28 | Iso Tis N.V. | Wachstumsfaktoren und l-glutamin enthaltendes zellkulturmedium |
US20020142457A1 (en) | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
US20020063763A1 (en) | 2000-11-29 | 2002-05-30 | Mantell David Allen | Apparatus and method for removing air bubbles from an ink jet printhead |
US6368859B1 (en) | 1999-12-29 | 2002-04-09 | Children's Medical Center Corporation | Methods and compositions for producing a fascial sling |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
US6428802B1 (en) | 1999-12-29 | 2002-08-06 | Children's Medical Center Corp. | Preparing artificial organs by forming polylayers of different cell populations on a substrate |
JP2003521900A (ja) | 1999-12-30 | 2003-07-22 | ファイロジックス・エルエルシー | 前駆細胞保存因子、並びに関連する方法および産物 |
US6544506B2 (en) | 2000-01-05 | 2003-04-08 | Yeda Research & Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
US7455983B2 (en) | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
WO2001052649A1 (en) | 2000-01-18 | 2001-07-26 | The Board Of Trustees Of The Leland Stanford Junior University | Expansion of stem and progenitor cells by beta-catenin |
AU2001232917A1 (en) | 2000-01-24 | 2001-07-31 | Jozef S. Mruk | Use of flavone 8-acetic acid in vascular and cardiovascular interventions and acute coronary syndromes |
WO2001054706A2 (en) | 2000-01-31 | 2001-08-02 | Uwe Waldemar Rothenpieler | Method for treating kidney disorders |
US6610535B1 (en) | 2000-02-10 | 2003-08-26 | Es Cell International Pte Ltd. | Progenitor cells and methods and uses related thereto |
US6770478B2 (en) | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
PT1261694E (pt) | 2000-02-26 | 2008-04-03 | Artecel Inc | Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações. |
AU2001239947A1 (en) | 2000-02-29 | 2001-09-12 | Curis, Inc. | Methods and compositions for regulating adipocytes |
US6630153B2 (en) | 2001-02-23 | 2003-10-07 | Smith & Nephew, Inc. | Manufacture of bone graft substitutes |
US6849454B2 (en) | 2000-03-07 | 2005-02-01 | St. Jude Children's Research Hospital | Highly efficient gene transfer into human repopulating stem cells by RD114 pseudotyped retroviral vector particles |
AU4346401A (en) | 2000-03-09 | 2001-09-17 | Cryo Cell Int | Human cord blood as a source of neural tissue for repair of the brain and spinalcord |
US6607522B1 (en) | 2000-03-16 | 2003-08-19 | General Hospital Corporation | Methods for tissue welding using laser-activated protein solders |
US20010049139A1 (en) | 2000-03-23 | 2001-12-06 | Eric Lagasse | Hepatic regeneration from hematopoietic stem cells |
GB2362752B (en) | 2000-03-24 | 2002-06-05 | Innogy Ltd | Method of operating a fuel cell |
GB2365964B (en) | 2000-03-24 | 2002-07-10 | Innogy Ltd | Membrane moisture measurement |
US7008394B2 (en) | 2000-03-29 | 2006-03-07 | Bioaccess, Inc. | System and method for processing bone marrow |
GB2360789A (en) | 2000-03-30 | 2001-10-03 | Christopher Mason | Method of producing tissue structures |
US6613798B1 (en) | 2000-03-30 | 2003-09-02 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US6683192B2 (en) | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
US7572374B2 (en) | 2000-04-13 | 2009-08-11 | Transvivo, Inc. | Anticoagulant and thrombo-resistant hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration |
US7195711B2 (en) | 2000-04-13 | 2007-03-27 | Transvivo Inc. | Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration |
US6802820B1 (en) | 2000-04-13 | 2004-10-12 | Transvivo, Inc. | Specialized hollow fiber membranes for in-vivo plasmapheresis and ultrafiltration |
US7585412B2 (en) | 2000-04-13 | 2009-09-08 | Transvivo, Inc. | Specialized hollow fiber membranes for plasmapheresis and ultrafiltration |
GB0009506D0 (en) | 2000-04-17 | 2000-06-07 | Innogy Ltd | Ion exchange membrane |
US7473555B2 (en) | 2000-04-27 | 2009-01-06 | Geron Corporation | Protocols for making hepatocytes from embryonic stem cells |
US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
ATE328067T1 (de) | 2000-04-28 | 2006-06-15 | Childrens Medical Center | Isolierung von mesenchymalen stammzellen und deren verwendung |
US6828145B2 (en) | 2000-05-10 | 2004-12-07 | Cedars-Sinai Medical Center | Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker |
US20040087016A1 (en) | 2000-05-12 | 2004-05-06 | University Of Utah Research Foundation | Compositions and methods for cell dedifferentiation and tissue regeneration |
US6988004B2 (en) | 2000-05-16 | 2006-01-17 | Bioheart, Inc. | Method for inducing angiogenesis by electrical stimulation of muscles |
US8273570B2 (en) | 2000-05-16 | 2012-09-25 | Riken | Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells |
WO2001088104A2 (en) | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
US6645727B2 (en) | 2000-05-26 | 2003-11-11 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched mesenchymal progenitor preparations |
DE10026482A1 (de) | 2000-05-29 | 2001-12-13 | Augustinus Bader | Verfahren zur Herstellung eines bioartifiziellen Transplantats |
ES2312447T3 (es) | 2000-05-31 | 2009-03-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento para la purificacion de particulas de replicon alfavirus. |
US7049072B2 (en) | 2000-06-05 | 2006-05-23 | University Of South Florida | Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state |
WO2001094541A2 (en) | 2000-06-05 | 2001-12-13 | University Of South Florida | Human mesenchymal progenitor cell |
CA2412377A1 (en) | 2000-06-06 | 2001-12-13 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
EP1294855A4 (en) | 2000-06-20 | 2004-09-15 | Es Cell Int Pte Ltd | METHOD FOR CONTROLLING THE DIFFERENTIATION OF EMBRYONIC STEM CELLS (ES CELLS) BY CULTURE OF ES CELLS IN THE PRESENCE OF BMP-2 TRACK ANTAGONISTS |
WO2001097872A1 (en) | 2000-06-22 | 2001-12-27 | Austin Sam L | Bioadhesive compositions and methods of preparation and use |
US6632620B1 (en) | 2000-06-22 | 2003-10-14 | Andrew N. Makarovskiy | Compositions for identification and isolation of stem cells |
AU2001273041A1 (en) | 2000-06-26 | 2002-01-08 | Board Of Regents Of The University Of Nebraska | Methods for use of delivery composition for expanding, activating, committing ormobilizing one or more pluripotent, self-renewing and committed stem cells |
EP2295539A1 (en) | 2000-06-26 | 2011-03-16 | Nc Medical Research Inc. | Cell fractions containing cells capable of differentiating into neural cells |
US6759039B2 (en) | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
AU2001271873A1 (en) | 2000-07-06 | 2002-01-21 | Avi Biopharma, Inc. | Transforming growth factor beta (TGF-beta) blocking agent-treated stem cell composition and method |
US6719970B1 (en) | 2000-07-10 | 2004-04-13 | Alkermes Controlled Therapeutics, Inc. | Method of generating cartilage |
DE20012003U1 (de) | 2000-07-11 | 2000-10-12 | Geis John S | Vorrichtung zum Einbringen von Partikeln in ein Körpergewebe, insbesondere Muskelgewebe |
ES2309079T3 (es) | 2000-07-13 | 2008-12-16 | Abbott Cardiovascular Systems Inc. | Sistema de despliegue para material celular miocardico. |
US20030032143A1 (en) | 2000-07-24 | 2003-02-13 | Neff Thomas B. | Collagen type I and type III compositions for use as an adhesive and sealant |
EP1303588B1 (en) | 2000-07-26 | 2012-10-24 | Boston Scientific Limited | Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue |
EP1315835A2 (en) | 2000-08-01 | 2003-06-04 | Yissum Research Development Company of the Hebrew University of Jerusalem | Directed differentiation of embryonic cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US6673532B2 (en) | 2000-08-14 | 2004-01-06 | University Of Maryland, Baltimore County | Bioreactor and bioprocessing technique |
AU2001284160A1 (en) | 2000-08-19 | 2002-03-04 | Axordia Limited | Modulation of stem cell differentiation |
WO2002016556A1 (fr) | 2000-08-25 | 2002-02-28 | Asahi Kasei Kabushiki Kaisha | Milieu de culture de cellule souche et procede de culture utilisant ce milieu |
DE10042484A1 (de) | 2000-08-29 | 2002-03-28 | Merck Patent Gmbh | Verfahren zur Herstellung von humanen Knorpelimplantaten mittels in vitro gezüchteter Chondrozyten |
US6673603B2 (en) | 2000-09-01 | 2004-01-06 | Modex Therapeutiques, S.A. | Cell paste comprising keratinocytes and fibroblasts |
CN1452655A (zh) | 2000-09-12 | 2003-10-29 | 加藤幸夫 | 间充质类干细胞的培养方法 |
US7597712B2 (en) | 2000-09-18 | 2009-10-06 | Organogenesis, Inc. | Method for treating a patient using a cultured connective tissue construct |
WO2002024874A2 (en) | 2000-09-21 | 2002-03-28 | Schering Corporation | Methods for preparing interferon producing dentitric cells |
US20070122904A1 (en) | 2000-09-29 | 2007-05-31 | Unisearch Limited | Method and apparatus for culturing cells |
US20020146817A1 (en) | 2000-10-02 | 2002-10-10 | Cannon Thomas F. | Automated bioculture and bioculture experiments system |
JP4195287B2 (ja) | 2000-10-02 | 2008-12-10 | エフ.キャノン トーマス | 自動化されたバイオカルチャー及びバイオカルチャー実験システム |
US6734000B2 (en) | 2000-10-12 | 2004-05-11 | Regents Of The University Of California | Nanoporous silicon support containing macropores for use as a bioreactor |
DE60127983T2 (de) | 2000-10-12 | 2008-01-17 | National University Of Singapore | Nicht störendes, dreidimensionales system für die kultivierung und ernte verankerungsabhängiger zellen |
US20020045260A1 (en) | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
US8383806B2 (en) | 2000-10-20 | 2013-02-26 | University Of Medicine And Dentistry Of New Jersey | Method of reversing carboplatin resistance by inhibition of HGFIN |
AU2002255458A1 (en) | 2000-10-20 | 2002-08-19 | University Of Medicine And Dentistry New Jersey Medical School | Hematopoietic growth factor inducible neurokinin-1 gene |
US20030202938A1 (en) | 2000-10-20 | 2003-10-30 | Pranela Rameshwar | Hematopoietic growth factor inducible neurokinin-1 gene |
US7052517B2 (en) | 2000-10-24 | 2006-05-30 | Vita Special Purpose Corporation | Delivery device for biological composites and method of preparation thereof |
US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
WO2002055095A2 (en) | 2000-11-06 | 2002-07-18 | Vi Technologies Inc | Use of aziridino-compounds in the treatment of immune dysfunctions |
EP1387692A4 (en) | 2000-11-11 | 2004-07-21 | Arbor Vita Corp | MOLECULAR INTERACTIONS IN HEMATOPOETIC CELLS |
US6642019B1 (en) | 2000-11-22 | 2003-11-04 | Synthecan, Inc. | Vessel, preferably spherical or oblate spherical for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same |
US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US20030027331A1 (en) | 2000-11-30 | 2003-02-06 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
US20040072259A1 (en) | 2001-11-29 | 2004-04-15 | Scadden David T. | Methods and products for manipulating hematopoietic stem cells |
US20020136709A1 (en) | 2000-12-12 | 2002-09-26 | Nucleus Remodeling, Inc. | In vitro-derived adult pluripotent stem cells and uses therefor |
US20020077687A1 (en) | 2000-12-14 | 2002-06-20 | Ahn Samuel S. | Catheter assembly for treating ischemic tissue |
AU2002239810A1 (en) | 2001-01-02 | 2002-07-16 | The Charles Stark Draper Laboratory, Inc. | Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology |
WO2002060426A2 (en) | 2001-01-03 | 2002-08-08 | President And Fellows Of Harvard College | Compounds regulating cell proliferation and differentiation |
US6616912B2 (en) | 2001-01-05 | 2003-09-09 | Spectrum Laboratories, Inc. | Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells |
US20040079248A1 (en) | 2001-01-10 | 2004-04-29 | Yaron Mayer | Printer capable of printing simultaneously on both sides of the page |
CA2434362A1 (en) | 2001-01-20 | 2002-07-25 | Cardion Ag | Pluripotent adult stem cells derived from regenerative tissue |
WO2002061052A2 (en) | 2001-01-31 | 2002-08-08 | Interface Biotech A/S | An improved in vitro method of culturing mammalian cells for autologous cell implantation/transplantation methods |
US7045098B2 (en) | 2001-02-02 | 2006-05-16 | James Matthew Stephens | Apparatus and method for removing interfering substances from a urine sample using a chemical oxidant |
CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
EP3246396B1 (en) | 2001-02-14 | 2020-01-29 | Celularity, Inc. | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
US7326564B2 (en) | 2001-02-20 | 2008-02-05 | St. Jude Medical, Inc. | Flow system for medical device evaluation and production |
GB2372875B (en) | 2001-03-02 | 2003-04-16 | Innogy Ltd | Process for operating a regenerative fuel cell |
US6808503B2 (en) | 2001-03-06 | 2004-10-26 | Baxter International Inc. | Automated system and method for pre-surgical blood donation and fluid replacement |
US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
EP1409473A2 (en) | 2001-03-07 | 2004-04-21 | Websar Innovations Inc. | CONVERSION OF CBD TO $g(D)?8 -THC AND $g(D)?9 -THC |
US7341062B2 (en) | 2001-03-12 | 2008-03-11 | Bioheart, Inc. | Method of providing a dynamic cellular cardiac support |
US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
US20040234972A1 (en) | 2001-03-20 | 2004-11-25 | Owens Gary K. | Method for identifying and purifying smooth muscle progenitor cells |
US6949252B2 (en) | 2001-03-23 | 2005-09-27 | Histogenics, Corp. | Method for preparing an implantable multilayer tissue construct |
US7056738B2 (en) | 2001-03-23 | 2006-06-06 | Tulane University | Early stage multipotential stem cells in colonies of bone marrow stromal cells |
WO2002076288A2 (en) | 2001-03-27 | 2002-10-03 | Board Of Regents The University Of Texas System | Biodegradable, electrically conductiong polymer for tissue engineering applications |
US6629612B2 (en) | 2001-03-30 | 2003-10-07 | Carl H. Critz | Biological filtration station |
US20030027330A1 (en) | 2001-04-02 | 2003-02-06 | Robert Lanza | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
JP2004536794A (ja) | 2001-04-09 | 2004-12-09 | メドトロニック、インコーポレイテッド | マイクロ遠心機を用いる血液成分の分離方法及びその使用法 |
US6841386B2 (en) | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
CA2367636C (en) | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Fusion proteins |
KR100449141B1 (ko) | 2001-04-19 | 2004-09-21 | (주)라이프코드 | 간엽 간세포를 신경세포로 분화시키는 방법 |
GB2374722B (en) | 2001-04-20 | 2003-05-28 | Innogy Technology Ventures Ltd | Regenerative fuel cell with pH control |
WO2002086104A1 (en) | 2001-04-24 | 2002-10-31 | Dolores Baksh | Progenitor cell populations, expansion thereof, and growth of non-hematopoietic cell types and tissues therefrom |
JP2003284570A (ja) | 2001-04-25 | 2003-10-07 | Chemo Sero Therapeut Res Inst | フォンビルブラント因子(vWF)切断酵素 |
DK1392814T3 (da) | 2001-04-25 | 2007-09-24 | Cornell Res Foundation Inc | Indretninger og fremgangsmåder til farmakokinetisk baseret cellekultursystem |
US20050130297A1 (en) | 2001-04-26 | 2005-06-16 | Societe Nouvelle Cell Tissue Progress | Cell and tissue culture device with temperature regulation |
EP1389232B1 (en) | 2001-05-09 | 2009-09-23 | Bayer Pharmaceuticals Corporation | A cryopreservation bag assembly for mammalian cell lines |
US6582955B2 (en) | 2001-05-11 | 2003-06-24 | Spectrum Laboratories, Inc. | Bioreactor with application as blood therapy device |
US6814961B1 (en) | 2001-05-14 | 2004-11-09 | Gitte S. Jensen | Method for enhancing stem cell trafficking |
US20020197240A1 (en) | 2001-05-15 | 2002-12-26 | Chiu Ray C. | Marrow stem cell (MSC) transplantation for use in tissue and/or organ repair |
US6461853B1 (en) | 2001-05-17 | 2002-10-08 | Hong Zhu | Method for surface culture of microorganisms and cells in flexible culture bags |
WO2002092794A2 (en) | 2001-05-17 | 2002-11-21 | Isotis N.V. | Isolation method of mesenchymal cells |
JPWO2002101029A1 (ja) | 2001-05-31 | 2004-09-24 | 旭化成株式会社 | 腎再生用細胞の分離濃縮方法 |
AUPR540301A0 (en) | 2001-06-01 | 2001-06-28 | Walter And Eliza Hall Institute Of Medical Research, The | A method of purification of cells |
EP1407261A4 (en) | 2001-06-13 | 2006-11-22 | Massachusetts Inst Technology | BIOREACTORS FOR IN VIVO REACTIONS |
US6566126B2 (en) | 2001-06-22 | 2003-05-20 | Fibercell Systems, Inc. | Apparatus and method for growing cells |
DE10130512B4 (de) | 2001-06-25 | 2007-08-16 | Bionethos Holding Gmbh | Vorrichtung zur Druckperfusion für das Züchten und/oder für das Behandeln von Zellen |
DE10130657A1 (de) | 2001-06-27 | 2003-01-16 | Axaron Bioscience Ag | Neues endothetial exprimiertes Protein und seine Verwendung |
CN1827766B (zh) | 2001-06-28 | 2010-08-25 | 徐荣祥 | 体外细胞的培养方法 |
US6685971B2 (en) | 2001-06-28 | 2004-02-03 | Rongxiang Xu | Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract |
US6626950B2 (en) | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
US6972195B2 (en) | 2002-09-27 | 2005-12-06 | Rongxiang Xu | Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro |
WO2003006613A2 (en) | 2001-07-10 | 2003-01-23 | Massachusetts Institute Of Technology | Methods for ex vivo propagation of somatic stem cells |
WO2003029402A2 (en) | 2001-07-17 | 2003-04-10 | Massachusetts Institute Of Technology | Unique properties of stem cells |
US20030017587A1 (en) | 2001-07-18 | 2003-01-23 | Rader William C. | Embryonic stem cells, clinical applications and methods for expanding in vitro |
DE10134667A1 (de) | 2001-07-20 | 2003-02-06 | Neuroprogen Gmbh Leipzig | Verfahren zur Herstellung isolierter Zellkulturen, Kulturmedium zur Kultivierung von Zellkulturen und Zellkultur |
HUP0501108A3 (en) | 2001-07-23 | 2006-11-28 | Gen Hospital Corp Boston | Treatment of muscular dystrophy with cord blood cells |
AU2002317039B2 (en) | 2001-07-24 | 2007-10-04 | Es Cell International Pte Ltd | Methods of inducing differentiation of stem cells |
US20030049236A1 (en) | 2001-07-27 | 2003-03-13 | Arhus Amt | Immortalized stem cells |
WO2003013336A2 (en) | 2001-08-03 | 2003-02-20 | Stemsource Llc | Devices and method for extraction of bone marrow |
US7432104B2 (en) | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
WO2003014336A1 (fr) | 2001-08-07 | 2003-02-20 | Kirin Beer Kabushiki Kaisha | Procede de preparation de cellules souches hematopoietiques multipotentes |
ATE421574T1 (de) | 2001-08-09 | 2009-02-15 | Procure Therapeutics Ltd | Zellkulturmethode zur erzeugung von prostata- ähnlichen acini |
US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
AUPR703601A0 (en) | 2001-08-15 | 2001-09-06 | Peter Maccallum Cancer Institute, The | Identification and isolation of somatic stem cells and uses thereof |
JP2003052360A (ja) | 2001-08-20 | 2003-02-25 | Japan Science & Technology Corp | 基底膜細胞外基質を用いた間葉系幹細胞の培養方法 |
KR20040030161A (ko) | 2001-08-23 | 2004-04-08 | 리라이언스 라이프 사이언시스 프라이빗. 리미티드 | 인간 배 줄기 세포(hESC)주를 확립하기 위한 내부세포 덩어리의 분리 방법 |
AU2002313817A1 (en) | 2001-08-27 | 2003-03-10 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
JP2003070464A (ja) | 2001-09-04 | 2003-03-11 | Mitsubishi Heavy Ind Ltd | 細胞培養方法、人工臓器製造方法、及び人工臓器 |
US6617152B2 (en) | 2001-09-04 | 2003-09-09 | Corning Inc | Method for creating a cell growth surface on a polymeric substrate |
US20030104997A1 (en) | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
US8802432B2 (en) | 2001-09-07 | 2014-08-12 | Fox Chase Cancer Center | Methods and cell cultures for promoting organogenesis and tissue development |
EP1425388A2 (en) | 2001-09-12 | 2004-06-09 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use |
US20030054331A1 (en) | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
US6790455B2 (en) | 2001-09-14 | 2004-09-14 | The Research Foundation At State University Of New York | Cell delivery system comprising a fibrous matrix and cells |
CA2461121A1 (en) | 2001-09-20 | 2003-04-03 | Kyowa Hakko Kogyo Co., Ltd. | Multipotent stem cell in the interstitial tissues of skeletal muscle |
AU2002325758A1 (en) | 2001-09-20 | 2003-04-01 | Centre For Translational Research In Cancer | Cultured stromal cells and uses thereof |
US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
JP2004248505A (ja) | 2001-09-21 | 2004-09-09 | Norio Nakatsuji | 移植抗原の一部または全てを欠除したes細胞由来の未分化な体細胞融合細胞およびその製造 |
US6805860B1 (en) | 2001-09-30 | 2004-10-19 | Eckhard Alt | Method of transluminal application of myogenic cells for repair or replacement of heart tissue |
US6767740B2 (en) | 2001-10-09 | 2004-07-27 | Roger Anton Sramek | Stem cell and dental pulp harvesting method and apparatus |
US6645763B2 (en) | 2001-10-12 | 2003-11-11 | Naoya Kobayashi | Immortalized bone marrow mesenchymal stem cell |
AU2002363322A1 (en) | 2001-10-26 | 2003-05-19 | Large Scale Biology Corporation | Endothelial cell derived hemotopoietic growth factor |
EP1452586B1 (en) | 2001-10-30 | 2012-05-30 | Nc Medical Research Inc. | Method of inducing differentiation of mesodermal stem cells into nervous system cells |
AUPR856501A0 (en) | 2001-10-30 | 2001-11-29 | Peter Maccallum Cancer Institute, The | Detection of haematopoietic stem cells and progeny and uses thereof |
WO2003038048A2 (en) | 2001-10-30 | 2003-05-08 | The United States Of America As Represented By The Secretary Of The Navy | Ex-vivo rescue of transplantable hematopoietic stem cells following myeloablative injury |
US20050084959A1 (en) | 2001-10-31 | 2005-04-21 | Hirofumi Hamada | Immortalized mesenchymal cells and utilization thereof |
US20040214314A1 (en) | 2001-11-02 | 2004-10-28 | Friedrich Srienc | High throughput bioreactor |
US20050260179A1 (en) | 2001-11-06 | 2005-11-24 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Stem and progenitor cell capture for tissue regeneration |
CA2465476A1 (en) | 2001-11-08 | 2003-05-15 | The Regents Of The University Of California | Methods and compositions for correction of cardiac conduction disturbances |
JP2005508393A (ja) | 2001-11-09 | 2005-03-31 | アーテセル・サイエンシズ・インコーポレーテツド | 胚および成人幹細胞をサポートするための間質細胞の使用の方法および組成物 |
CZ2004696A3 (cs) | 2001-11-09 | 2005-02-16 | Artecel Sciences, Inc. | Endokrinní pankreatická diferenciace buněk stromatu odvozených z adipózní tkáně a její použití |
ATE335808T1 (de) | 2001-11-09 | 2006-09-15 | Viacell Inc | Herstellung von zellsuspensionen |
ATE438708T1 (de) | 2001-11-15 | 2009-08-15 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
EP1452594A4 (en) | 2001-11-15 | 2007-01-10 | Kyowa Hakko Kogyo Kk | INDUCTOR FOR DIFFERENTIATING EMBRYOONAL STEM CELLS TO EODODERMAL CELLS, METHOD FOR OBTAINING THEM AND USE THEREOF |
DE10156201C1 (de) | 2001-11-15 | 2002-10-17 | Voith Paper Patent Gmbh | Verfahren und Behälter zum Stapeln von hochkonsistentem Papierfaserstoff |
EP1444325A4 (en) | 2001-11-15 | 2006-02-15 | Becton Dickinson Co | METHODS AND DEVICES FOR INTEGRATED DISCOVERY OF CELL CULTURE ENVIRONMENTS |
DE10158680B4 (de) | 2001-11-30 | 2004-04-08 | Universitätsklinikum Hamburg-Eppendorf | Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen |
US6712850B2 (en) | 2001-11-30 | 2004-03-30 | Ethicon, Inc. | Porous tissue scaffolds for the repair and regeneration of dermal tissue |
US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US20050008626A1 (en) | 2001-12-07 | 2005-01-13 | Fraser John K. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US20040224403A1 (en) | 2001-12-07 | 2004-11-11 | Robarts Research Institute | Reconstituting hematopoietic cell function using human embryonic stem cells |
US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
AU2002364558A1 (en) | 2001-12-11 | 2003-06-23 | Cytograft Tissue Engineering, Inc. | Tissue engineered cellular sheets, methods of making and use thereof |
WO2003050273A1 (fr) | 2001-12-13 | 2003-06-19 | Japan Science And Technology Agency | Milieu de culture pour des cellules humaines et methode de culture |
US20030113910A1 (en) | 2001-12-18 | 2003-06-19 | Mike Levanduski | Pluripotent stem cells derived without the use of embryos or fetal tissue |
US20030180296A1 (en) | 2001-12-20 | 2003-09-25 | Theodora Salcedo | Antibodies that immunospecifically bind to trail receptors |
AU2002367057B2 (en) | 2001-12-21 | 2007-01-11 | Organogenesis Inc. | Chamber with adjustable volume for cell culture and organ assist |
US7625752B2 (en) | 2001-12-21 | 2009-12-01 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
US6703279B2 (en) | 2002-01-04 | 2004-03-09 | Promos Technologies, Inc. | Semiconductor device having contact of Si-Ge combined with cobalt silicide |
US6695791B2 (en) | 2002-01-04 | 2004-02-24 | Spiration, Inc. | System and method for capturing body tissue samples |
US6777227B2 (en) | 2002-01-09 | 2004-08-17 | John L. Ricci | Bio-reactor and cell culture surface with microgeometric surfaces |
WO2003060082A2 (en) | 2002-01-14 | 2003-07-24 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
FR2834898B1 (fr) | 2002-01-18 | 2005-06-10 | Didier Pourquier | Nouvelle application therapeutique du g-csf, du gm-csf et du scf |
FR2834899B1 (fr) | 2002-01-18 | 2005-06-10 | Didier Pourquier | Nouvelle application therapeutique des facteurs g-csf, gm-csf et scf |
US20040014209A1 (en) | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
IL152904A0 (en) | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
CA2473360A1 (en) | 2002-01-25 | 2003-08-07 | Genzyme Corporation | Serum-free media for chondrocytes and methods of use thereof |
US7033823B2 (en) | 2002-01-31 | 2006-04-25 | Cesco Bioengineering, Inc. | Cell-cultivating device |
US7145057B2 (en) | 2002-02-01 | 2006-12-05 | Origen Therapeutics, Inc. | Chimeric bird from embryonic stem cells |
US7416885B2 (en) | 2002-02-08 | 2008-08-26 | University Of South Florida | Proliferated cell lines and uses thereof |
US20050202428A1 (en) | 2002-02-13 | 2005-09-15 | Axordia Limited | Pluripotential stem cells |
ATE365793T1 (de) | 2002-02-19 | 2007-07-15 | Medipost Co Ltd | Verfahren zur isolierung und kulturexpansion mesenchymaler stamm-/vorläuferzellen aus nabelschnurblut sowie verfahren zur differenzierung von aus nabelschnurblut stammenden mesenchymalen stamm-/vorläuferzellen in unterschiedliche mesenchymgewebe |
US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
US7378246B2 (en) | 2002-02-28 | 2008-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for regulating adipogenesis |
AU2003224702A1 (en) | 2002-03-12 | 2003-09-29 | Oregon Health And Science University | Stem cell selection and differentiation |
AUPS112802A0 (en) | 2002-03-15 | 2002-04-18 | Monash University | Methods of inducing differentiation of stem cells into a specific cell lineage |
AU2003216822A1 (en) | 2002-03-19 | 2003-10-08 | University Of Sheffield | Stem cell culture |
WO2003080197A1 (en) | 2002-03-20 | 2003-10-02 | Sara Griffin | Sports training device |
US20040009589A1 (en) | 2002-03-26 | 2004-01-15 | Shulamit Levenberg | Endothelial cells derived from human embryonic stem cells |
GB0207214D0 (en) | 2002-03-27 | 2002-05-08 | Univ Loughborough | A catalyst for lowering the reduction overpotential of polysulfide species |
AU2003234688A1 (en) | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
EP1495108A2 (en) | 2002-04-08 | 2005-01-12 | Millenium Biologix Inc. | Automated tissue engineering system |
US7060494B2 (en) | 2002-04-09 | 2006-06-13 | Reliance Life Sciences Pvt. Ltd. | Growth of human Mesenchymal Stem Cells (hMSC) using umbilical cord blood serum and the method for the preparation thereof |
ITTO20020311A1 (it) | 2002-04-10 | 2003-10-10 | Medestea Int Spa | Procedimento per la preparazione di cellule staminali da tessuto muscolare e tessuto adiposo umano e cellule staminali ottenibili mediante t |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
US20050208029A1 (en) | 2002-04-17 | 2005-09-22 | Akihiro Umezawa | Method of forming pancreatic beta cells from mesenchymal cells |
US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
AUPS187202A0 (en) | 2002-04-22 | 2002-05-30 | Griffith University | Method for culturing stem cells |
AU2003241313A1 (en) | 2002-04-23 | 2003-11-10 | Roger Williams Hospital | Compositions and methods for stem cell delivery |
US7271234B2 (en) | 2002-04-24 | 2007-09-18 | Rutgers, The State University Of New Jersey | Polyarylates for drug delivery and tissue engineering |
NZ535600A (en) | 2002-04-24 | 2008-03-28 | Queensland Inst Med Res | MASP-depleted MBL compositions are superior at activating the complement cascade when compared with MBL purified in complex with its associated MASPs |
US20040242469A1 (en) | 2002-05-13 | 2004-12-02 | Lee Richard T. | Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof |
ITMI20021008A1 (it) | 2002-05-13 | 2003-11-13 | San Raffaele Centro Fond | Metodo per stabilire ed espandere cellule staminali pluripotenti di tipo mesoangioblastico |
JP2003332274A (ja) | 2002-05-17 | 2003-11-21 | Tokyo Seimitsu Co Ltd | 化学的機械研磨方法及び化学的機械研磨装置 |
US7119071B2 (en) | 2002-05-21 | 2006-10-10 | University Of Medicine And Dentistry Of New Jersey | Amino terminal substance P compositions and methods for using the same |
US20040091936A1 (en) | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
EP1367119B1 (en) | 2002-05-28 | 2008-09-17 | Toyo Boseki Kabushiki Kaisha | Methods of culturing, storing, and inducing differentiation in cells, instrument for use in the methods and method of using the instrument. |
US7048922B2 (en) | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
US20030022390A1 (en) | 2002-05-30 | 2003-01-30 | Stephens James Matthew | Method and kit for making interfering substances in urine undetectable |
WO2003105663A2 (en) | 2002-06-01 | 2003-12-24 | Stelsys Llc | Liver assist system based on hollow fiber cartridges or rotating bioreactor |
US6914279B2 (en) | 2002-06-06 | 2005-07-05 | Rutgers, The State University Of New Jersey | Multifunctional biosensor based on ZnO nanostructures |
US8377683B2 (en) | 2002-06-06 | 2013-02-19 | Rutgers, The State University Of New Jersey | Zinc oxide-based nanostructure modified QCM for dynamic monitoring of cell adhesion and proliferation |
US7989851B2 (en) | 2002-06-06 | 2011-08-02 | Rutgers, The State University Of New Jersey | Multifunctional biosensor based on ZnO nanostructures |
US7160719B2 (en) | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
FI113099B (fi) | 2002-06-25 | 2004-02-27 | Ensto Electric Oy | Järjestely toiminnanohjausjärjestelmän yhteydessä |
US20050282733A1 (en) | 2002-06-27 | 2005-12-22 | Prins Johannes B | Differentiation modulating agents and uses therefor |
AU2003304396A1 (en) | 2002-06-28 | 2005-02-25 | University Of Florida Research Foundation, Inc. | Raav compositions and methods for delivery of human factor vii polypeptides and treatment of hemophilia a |
US6730510B2 (en) | 2002-07-02 | 2004-05-04 | Organogenesis, Inc. | Culture dish and bioreactor system |
US20050136093A1 (en) | 2002-07-05 | 2005-06-23 | Polyzenix Gmbh | Implant for transport and release for pharmacologically active agents as well as a process for producing the same |
WO2004006657A1 (en) | 2002-07-11 | 2004-01-22 | Bureau Of Sugar Experiment Stations | Transgenic plants used as a bioreactor system |
US20040009158A1 (en) | 2002-07-11 | 2004-01-15 | Washington University | Promotion of neovascularization using bone marrow-derived endothelial-progenitor cells |
AU2003242976A1 (en) | 2002-07-16 | 2004-02-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of implanting mesenchymal stem cells for tissue repair and formation |
AU2003251992A1 (en) | 2002-07-17 | 2004-02-02 | Rutgers, The State University | Therapeutic devices for patterned cell growth |
US20040018174A1 (en) | 2002-07-23 | 2004-01-29 | Boston Scientific Corporation | Cell therapy for regeneration |
FR2842943B1 (fr) | 2002-07-24 | 2005-07-01 | Commissariat Energie Atomique | Procede de fabrication de film polymere conducteur anisotrope sur tranche de semi-conducteur |
US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
ES2560847T3 (es) | 2002-07-31 | 2016-02-23 | Yves Saint-Laurent Parfums | Células madre procedentes de tejido adiposo y células diferenciadas procedentes de estas células |
US20040027914A1 (en) | 2002-08-08 | 2004-02-12 | Vrane David R. | Method and system for maintaining particles in suspension in a fluid |
AU2003252559A1 (en) | 2002-08-17 | 2004-03-03 | Hae-Young Suh | A method for transdifferentiating mesenchymal stem cells into neuronal cells |
US6943008B1 (en) | 2002-08-21 | 2005-09-13 | Florida State University Research Foundation, Inc. | Bioreactor for cell culture |
GB2393726A (en) | 2002-08-21 | 2004-04-07 | Regenesys Tech Ltd | Ion exchange membranes formed from hydrolysed polymers |
US20050271639A1 (en) | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
US20040037811A1 (en) | 2002-08-22 | 2004-02-26 | The Cleveland Clinic Foundation | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
US20040161412A1 (en) | 2002-08-22 | 2004-08-19 | The Cleveland Clinic Foundation | Cell-based VEGF delivery |
WO2004018655A2 (en) | 2002-08-26 | 2004-03-04 | Neuronova Ab | Method for culturing stem cells |
GB0221481D0 (en) | 2002-09-16 | 2002-10-23 | Richards John M | Grip for hand held instruments |
DE10244859B4 (de) | 2002-09-20 | 2007-01-11 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Bioreaktor mit modularem Aufbau, insbesondere zur ex-vivo Zellvermehrung |
WO2004026115A2 (en) | 2002-09-23 | 2004-04-01 | The General Hospital Corporation | Theree-dimensional construct for the design and fabrication of physiological fluidic networks |
WO2004029231A1 (en) | 2002-09-26 | 2004-04-08 | Institut National De La Sante Et De La Recherche Medicale | Compositions and methods for amplification of human stem cells |
US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
US20050031587A1 (en) | 2002-10-04 | 2005-02-10 | Yamanouchi Pharmaceutical Co., Ltd. | Immune response induction method |
US20040121464A1 (en) | 2002-09-30 | 2004-06-24 | Rathjen Peter David | Method for the preparation of cells of mesodermal lineage |
AU2003279132A1 (en) | 2002-10-04 | 2004-05-04 | Tissuetech, Inc. | Retinal pigment epithelial cell cultures on amniotic membrane and transplantation |
US20040067585A1 (en) | 2002-10-07 | 2004-04-08 | Yu-Chi Wang | Cell cultivation surface and method of making the same |
US7776594B2 (en) | 2002-10-10 | 2010-08-17 | Wright Medical Technology, Inc. | Bone marrow infusion chamber and method |
WO2004035748A2 (en) | 2002-10-16 | 2004-04-29 | Advanced Cell Technology, Inc. | Methods using gene trapped stem cells for marking pathways of stem cell differentiation and making and isolating differentiated cells |
WO2004034890A2 (en) | 2002-10-17 | 2004-04-29 | Vacanti, Joseph, P. | Biological scaffolding material |
US20040151729A1 (en) | 2002-10-28 | 2004-08-05 | George Michalopoulos | Novel long-term three-dimensional culture system |
AU2003287429A1 (en) | 2002-11-01 | 2004-06-07 | Five Prime Therapeutics, Inc. | Stem cell libraries |
WO2004042033A2 (en) | 2002-11-01 | 2004-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating stem cells and uses related thereto |
US20040258669A1 (en) | 2002-11-05 | 2004-12-23 | Dzau Victor J. | Mesenchymal stem cells and methods of use thereof |
US20050003534A1 (en) | 2002-11-07 | 2005-01-06 | Eliezer Huberman | Human stem cell materials and methods |
AU2003284314A1 (en) | 2002-11-08 | 2004-06-03 | Viacell, Inc. | Stem cell populations |
US20060252150A1 (en) | 2002-11-08 | 2006-11-09 | Linzhao Cheng | Human embryonic stem cell cultures, and compositions and methods for growing same |
AU2003274748A1 (en) | 2002-11-08 | 2004-06-07 | Reprocell Inc. | Expansion agents for stem cells |
KR100452403B1 (ko) | 2002-11-19 | 2004-10-12 | 한국과학기술연구원 | 세포배양용 복합 생물반응기 |
US20040101959A1 (en) | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
US20050112762A1 (en) | 2002-11-26 | 2005-05-26 | The Corporation Of The Trustees Of The Sisters Of Mercy In Queensland | Method for culturing dendritic cells |
AU2003298016A1 (en) | 2002-11-27 | 2004-06-23 | Regents Of The University Of Minnesota | Homologous recombination in multipotent adult progenitor cells |
US7947499B2 (en) | 2002-11-29 | 2011-05-24 | Technion Research & Development Foundation Ltd. | Method of dynamically culturing embryonic stem cells |
US20040110286A1 (en) | 2002-12-06 | 2004-06-10 | The John P. Robarts Research Institute | Method for making hematopoietic cells |
US20050031598A1 (en) | 2002-12-10 | 2005-02-10 | Shulamit Levenberg | Engineering three-dimensional tissue structures using differentiating embryonic stem cells |
US20040115804A1 (en) | 2002-12-13 | 2004-06-17 | Yu-Show Fu | Cell system for generating somatic cells |
US7252995B2 (en) | 2002-12-13 | 2007-08-07 | Yu-Show Fu | Method of generating neurons from stem cells and medium for culturing stem cells |
DK1572984T3 (en) | 2002-12-16 | 2016-06-13 | Technion Res & Dev Foundation | FEEDER CELL-FREE, XENOPHRIC CULTIVATION SYSTEM FOR HUMAN EMBRYONAL STEM CELLS |
DE10327988B4 (de) | 2002-12-18 | 2009-05-14 | Alpha Plan Gmbh | Filtermodul zur Aufbereitung von Flüssigkeiten |
US20040128077A1 (en) | 2002-12-27 | 2004-07-01 | Automated Cell, Inc. | Method and apparatus for following cells |
US20040126405A1 (en) | 2002-12-30 | 2004-07-01 | Scimed Life Systems, Inc. | Engineered scaffolds for promoting growth of cells |
US7071001B2 (en) | 2003-01-10 | 2006-07-04 | Dnk Associates, Inc. | System and method for in vitro bleeding time testing |
US20040143863A1 (en) | 2003-01-10 | 2004-07-22 | Linheng Li | Hematopoietic stem cell niche cells |
US20050002914A1 (en) | 2003-01-15 | 2005-01-06 | Rosen Michael R. | Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
EP1589814B1 (en) | 2003-01-16 | 2009-08-12 | The General Hospital Corporation | Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications |
US20040151706A1 (en) | 2003-01-27 | 2004-08-05 | Alex Shakhov | Collection and storage of biological specimens containing stem cells from healthy individuals for future use in treatment of their own cytopathological illnesses or other medical conditions |
BRPI0406931A (pt) | 2003-01-27 | 2006-01-03 | Harvest Technologies Inc | Método para a produção de um coagulante a partir de sangue total anticoagulado, kit para a preparação de um coagulante a partir de sangue total anticoagulado, e, fração de sangue humano |
US7186554B2 (en) | 2003-01-28 | 2007-03-06 | Stanford University | Methods and compositions for human bladder epithelial cell culture |
US7807458B2 (en) | 2003-01-30 | 2010-10-05 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Multilineage-inducible cells and uses thereof |
EP1592373B1 (en) | 2003-01-30 | 2013-04-24 | ProChon Biotech Ltd. | Freeze-dried fibrin matrices and methods for preparation thereof |
AU2004209645B2 (en) | 2003-01-31 | 2008-10-09 | The Regents Of The University Of California | Use of islet 1 as a marker for isolating or generating stem cells |
US7604987B2 (en) | 2003-02-06 | 2009-10-20 | National University Of Singapore | Bioreactor for growing cell or tissue cultures |
WO2004072264A2 (en) | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Fate determination by hes 1 in hematopoietic stem-progenitor cells and uses thereof |
US20040197310A1 (en) | 2003-02-12 | 2004-10-07 | Sanberg Paul R. | Compositions and methods for using umbilical cord progenitor cells in the treatment of myocardial infarction |
US7175763B2 (en) | 2003-02-13 | 2007-02-13 | Zenon Technology Partnership | Membrane supported biofilm process for autotrophic reduction |
WO2004071973A1 (en) | 2003-02-13 | 2004-08-26 | Zenon Environmental Inc. | Supported biofilm apparatus and process |
JP2006517975A (ja) | 2003-02-13 | 2006-08-03 | アンスロジェネシス コーポレーション | 疾患、障害または症状を患っている個体を治療するための臍帯血の使用 |
CN100361907C (zh) | 2003-02-13 | 2008-01-16 | 泽农技术合伙公司 | 受支撑的生物薄膜设备和反应器及处理液体方法 |
US7294259B2 (en) | 2003-02-13 | 2007-11-13 | Zenon Technology Partnership | Membrane module for gas transfer |
US7300571B2 (en) | 2003-02-13 | 2007-11-27 | Zenon Technology Partnership | Supported biofilm apparatus |
US7303676B2 (en) | 2003-02-13 | 2007-12-04 | Zenon Technology Partnership | Supported biofilm apparatus and process |
WO2004073633A2 (en) | 2003-02-14 | 2004-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for modulating the development of stem cells |
GB0304030D0 (en) | 2003-02-21 | 2003-03-26 | King S College London | Teeth |
US7416884B2 (en) | 2003-02-26 | 2008-08-26 | Georgia Tech Research Corporation | Bioreactor and methods for tissue growth and conditioning |
WO2004076642A2 (en) | 2003-02-27 | 2004-09-10 | The Rockefeller University | Method for modulating epithelial stem cell lineage |
AU2003900944A0 (en) | 2003-02-28 | 2003-03-13 | The University Of Queensland | Cell isolation & enrichment |
ATE488588T1 (de) | 2003-03-10 | 2010-12-15 | Japan Science & Tech Agency | Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker |
US7153650B2 (en) | 2003-03-13 | 2006-12-26 | Geron Corporation | Marker system for preparing and characterizing high-quality human embryonic stem cells |
WO2004087870A2 (en) | 2003-03-25 | 2004-10-14 | The Johns Hopkins University | Neuronal cell lineages and methods of production thereof |
WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
EP2335738A1 (en) | 2003-04-01 | 2011-06-22 | United States Government as represented by the Department of Veteran's Affaires | Stem-cell, precursor cell or target cell-based treatment of wound healing |
US20040197375A1 (en) | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
EP1619949B1 (en) | 2003-04-19 | 2011-06-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Postnatal stem cells and uses thereof |
US7494811B2 (en) | 2003-05-01 | 2009-02-24 | Lifenet Health | In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby |
US7795024B2 (en) | 2003-05-02 | 2010-09-14 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
CA2524950A1 (en) | 2003-05-07 | 2004-12-02 | La Jolla Institute For Molecular Medicine | Methods for facilitating recovery of functions of endogenous or implanted or transplanted stem cells using high molecular weight hyaluronic acid |
US7485460B2 (en) | 2003-05-21 | 2009-02-03 | Tulane University Health Sciences Center | Enhanced growth of adult stem cells with Dkk-1 |
WO2005001033A2 (en) | 2003-05-22 | 2005-01-06 | The Cleveland Clinic Foundation | Tolerance induction and maintenance in hematopoietic stem cell allografts |
EP1653865A2 (en) | 2003-05-23 | 2006-05-10 | Angiotech International Ag | Anastomotic connector devices |
US20050014255A1 (en) | 2003-05-29 | 2005-01-20 | Board Of Regents, The University Of Texas System | Stem cells for clinical and commercial uses |
AU2003902776A0 (en) | 2003-06-03 | 2003-06-19 | Monash University | Method for expanding cells |
WO2005010524A1 (en) | 2003-06-04 | 2005-02-03 | Curis, Inc. | Stem cell-based methods for identifying and characterizing agents |
US7338517B2 (en) | 2003-06-04 | 2008-03-04 | University Of South Carolina | Tissue scaffold having aligned fibrils and artificial tissue comprising the same |
US7425440B2 (en) | 2003-06-10 | 2008-09-16 | The Automation Partnership (Cambridge) Limited | Culture flask |
DE10326748B4 (de) | 2003-06-13 | 2006-11-23 | Gerlach, Jörg, Dr.med. | Nervenzellkulturbioreaktor und hybrides Nervenzellsystem |
DE10326750B4 (de) | 2003-06-13 | 2006-07-27 | Gerlach, Jörg, Dr.med. | Verfahren zur Herstellung einer Zellpräparation und derart hergestellte Zellpräparationen |
DE10326764A1 (de) | 2003-06-13 | 2004-12-30 | Biotest Ag | Endothel-protektive Perfusionslösung, eine Apparatur und Verfahren zur Konservierung des Endothels in isolierten Hohlorganen und biologischen Gefäßen |
DE10362002B4 (de) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adulte pluripotente Stammzellen |
CN1842589B (zh) | 2003-06-25 | 2012-04-25 | 马克罗珀尔生物外科公司 | 用于从组织分离并且浓缩再生细胞的系统和方法 |
JP4750697B2 (ja) | 2003-06-25 | 2011-08-17 | オタワ ヘルス リサーチ インスティテュート | 幹細胞の成長及び分化を調節する方法及び組成物 |
CA2529718C (en) | 2003-06-27 | 2012-10-23 | Universite Laval | Method of isolating cells from umbilical cord |
PL1641914T3 (pl) | 2003-06-27 | 2017-01-31 | DePuy Synthes Products, Inc. | Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek |
US8426200B2 (en) | 2003-07-02 | 2013-04-23 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
WO2005010172A2 (en) | 2003-07-16 | 2005-02-03 | Boston Scientific Limited | Aligned scaffolds for improved myocardial regeneration |
WO2005007799A2 (en) | 2003-07-17 | 2005-01-27 | Gamida-Cell Ltd. | Methods for ex-vivo expanding stem/progenitor cells |
AU2004257939B2 (en) | 2003-07-22 | 2008-06-05 | Valneva | Production of poxviruses with adherent or non adherent avian cell lines |
ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
WO2005012512A1 (en) | 2003-08-01 | 2005-02-10 | Norimasa Nakamura | Scaffold-free self-organized 3d synthetic tissue |
EP2266500B1 (en) | 2003-08-01 | 2015-04-01 | CellSeed Inc. | Three-dimensional tissue structure |
DE10336152B4 (de) | 2003-08-06 | 2007-02-15 | Nephrogen LLC, Salt Lake City | Aufreinigungsverfahren für humane mesenchymale Stammzellen |
US20050032122A1 (en) | 2003-08-06 | 2005-02-10 | Shiaw-Min Hwang | Optimizing culture medium for CD34<+> hematopoietic cell expansion |
US7074615B2 (en) | 2003-08-15 | 2006-07-11 | Becton, Dickinson And Company | Peptides for enhanced cell attachment and cell growth |
WO2005029224A2 (en) | 2003-09-12 | 2005-03-31 | Arkados, Inc. | Method and system for distributed content management and delivery |
ATE437950T1 (de) | 2003-09-15 | 2009-08-15 | Res Dev Foundation | Cripto-antagonismus von activin und tgf-b signalisierung |
CA2531894C (en) | 2003-09-25 | 2014-02-11 | Rutgers, The State University | Inherently radiopaque polymeric products for embolotherapy |
WO2005044972A2 (en) | 2003-11-06 | 2005-05-19 | Nunc A/S | A three-dimensional carrier for culturing microbiological material |
AU2004289287A1 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
US20050208095A1 (en) | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
CA2536181A1 (en) | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Polymer compositions and methods for their use |
JP2007513650A (ja) | 2003-11-20 | 2007-05-31 | アンジオテック インターナショナル アーゲー | 移植可能なセンサーおよび移植可能なポンプならびに瘢痕化抑制剤 |
US7368169B2 (en) | 2003-12-01 | 2008-05-06 | Rutgers, The State University Of New Jersey | Hydrazide compounds with angiogenic activity |
TWI338714B (en) | 2003-12-02 | 2011-03-11 | Cathay General Hospital | Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid |
EP1694345A1 (en) | 2003-12-04 | 2006-08-30 | Regents Of The University Of Minnesota | Compositions and methods for the treatment of lysosomal storage disorders |
WO2005056747A2 (en) | 2003-12-09 | 2005-06-23 | Ben-Gurion University Of The Negev Research And Development Authority | Pulse-medium perfusion bioreactor with improved mass transport for multiple 3-d cell constructs |
US20050137517A1 (en) | 2003-12-19 | 2005-06-23 | Baxter International Inc. | Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation |
JP2007520462A (ja) | 2003-12-19 | 2007-07-26 | バイアセル インコーポレーティッド | ヒト臍帯血由来多能性細胞の疾患の処置のための使用方法 |
GB0329449D0 (en) | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
US7172696B1 (en) | 2004-01-02 | 2007-02-06 | Spectrum Laboratories, Inc. | Radial dispersion mass transfer device having a semi-permeable tubular hollow fiber membrane wound around a porous core |
US20050180957A1 (en) | 2004-01-16 | 2005-08-18 | Scharp David W. | Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells |
US7192776B2 (en) | 2004-01-28 | 2007-03-20 | James Matthew Stephens | Synthetic urine and method of manufacturing same |
EP1718310A4 (en) | 2004-02-06 | 2009-05-06 | Elan Pharm Inc | METHODS AND COMPOSITIONS FOR TREATING TUMORS AND METASTATIC DISEASE |
WO2005075636A1 (en) | 2004-02-09 | 2005-08-18 | The University Of Queensland | Molecular markers associated with metanephric development and renal progenitors |
WO2005087915A2 (en) | 2004-03-08 | 2005-09-22 | Biovest International, Inc. | Use of ethanolamine for enhancing cell growth in membrane systems |
JP2005278564A (ja) | 2004-03-30 | 2005-10-13 | Hitachi Medical Corp | 細胞培養装置 |
RU2252252C1 (ru) | 2004-04-09 | 2005-05-20 | Тепляшин Александр Сергеевич | Способ выделения мезенхимальных стволовых клеток |
US20070298015A1 (en) | 2004-04-28 | 2007-12-27 | Viacell, Inc. | Treatment of Muscular Dystrophy with Mobilized Peripheral Blood Pluripotent Cells |
US7855074B2 (en) | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
US7785883B2 (en) | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
WO2005107760A1 (en) | 2004-04-30 | 2005-11-17 | Irm Llc | Compounds and compositions as inducers of keratinocyte differentiation |
WO2006073461A2 (en) | 2004-05-05 | 2006-07-13 | Clearant Inc. | Methods of sterilizing biological mixtures using alpha-keto acids |
US7658738B2 (en) | 2004-05-14 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | Medical devices for use with endoscope |
AU2005247967B2 (en) | 2004-05-26 | 2011-09-01 | Octane Biotech, Inc. | Advanced tissue engineering system |
US7361493B1 (en) | 2004-05-26 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Production of urokinase in a three-dimensional cell culture |
JP2005333945A (ja) | 2004-05-31 | 2005-12-08 | Toray Ind Inc | 培養用中空糸モジュール及び培養装置及び細胞製剤の製造方法 |
ES2299837T3 (es) * | 2004-06-14 | 2008-06-01 | Probiogen Ag | Reactor de exposicion a fases liquida y gaseosa para el cultivo de celulas. |
US7531351B2 (en) | 2004-06-14 | 2009-05-12 | Probiogen Ag | Liquid-gas-phase exposure reactor for cell culturing |
US7335508B2 (en) | 2004-07-22 | 2008-02-26 | Prochon Biotech Ltd. | Porous plasma protein matrices and methods for preparation thereof |
JP4831687B2 (ja) | 2004-07-23 | 2011-12-07 | 株式会社カネカ | 間葉系幹細胞から象牙芽細胞への分化誘導方法 |
CH697191A5 (de) | 2004-07-29 | 2008-06-25 | Biospectra Ag | Mehrfach-Bioreaktorvorrichtung. |
US7588938B2 (en) | 2004-08-04 | 2009-09-15 | The United States Of America As Represented By The Secretary Of The Navy | Neural stem cell-collagen-bioreactor system to construct a functional embryonic brain-like tissue |
DK1789534T3 (en) | 2004-08-16 | 2014-11-17 | Cellres Corp Pte Ltd | ISOLATION OF stem / progenitor cells FOSTER HINDE FROM an umbilical cord |
EP1788073B1 (en) | 2004-08-17 | 2013-11-06 | Kyushu Institute of Technology | Porous sheet member for cell culture and, utilizing the same, bioreactor and culturing method |
DE102004044429B4 (de) | 2004-09-14 | 2009-04-30 | Biotest Ag | Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor |
CN102391981B (zh) | 2004-09-24 | 2014-08-20 | 麦索布莱斯特公司 | 多能扩增间充质前体细胞子代(memp)及其应用 |
CA2581237C (en) | 2004-09-24 | 2018-11-06 | Angioblast Systems, Inc. | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc) |
JP4678882B2 (ja) | 2004-10-14 | 2011-04-27 | ジェネンテック, インコーポレイテッド | Cop1分子およびその使用 |
AU2005302258B2 (en) | 2004-11-01 | 2010-10-21 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
US7439057B2 (en) | 2004-11-16 | 2008-10-21 | La Jolla Bioengineering Institute | Convective flow tissue assembly |
PL1819230T3 (pl) | 2004-12-07 | 2013-02-28 | Univ Miami | Makrocząstki pochodzące z czerwonych krwinek jako czynniki hemostatyczne do kontrolowania krwotoku i do leczenia zaburzeń krwawienia |
US20060166364A1 (en) | 2004-12-22 | 2006-07-27 | Introgen, Inc. | Use of flexible bag containers for viral production |
US7682823B1 (en) | 2005-01-04 | 2010-03-23 | Larry Runyon | Bioreactor systems |
US9163208B2 (en) | 2005-01-04 | 2015-10-20 | Larry Runyon | Method and system for bioreaction |
US20080206733A1 (en) | 2005-02-03 | 2008-08-28 | National University Corporation Okayama University | Method of Inducing Differentiation of Embryo-Stem Cell Into Hepatocyte and Hepatocyte Induced by the Method |
US20070269486A1 (en) | 2005-03-14 | 2007-11-22 | Conor Medsystems, Llc. | Methods and Devices for Reducing Tissue Damage After Ischemic Injury |
WO2006102488A1 (en) | 2005-03-22 | 2006-09-28 | Cascade Medical Enterprises, Llc | Systems and methods of producing membranes |
EP3354265A1 (en) | 2005-03-22 | 2018-08-01 | President and Fellows of Harvard College | Treatment of solid tumors |
US8367405B2 (en) | 2005-04-12 | 2013-02-05 | Mesoblast, Inc. | Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase |
US20100034793A1 (en) | 2005-04-19 | 2010-02-11 | The John Hopkins University | Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood |
US20060280748A1 (en) | 2005-04-22 | 2006-12-14 | Buckheit Robert W Jr | Plasma or serum fraction for treatment or prevention of abnormal cell proliferation |
US20070011752A1 (en) | 2005-05-06 | 2007-01-11 | American Integrated Biologics, Inc. | Production of human proteins in transgenic animal saliva |
US20060258586A1 (en) | 2005-05-06 | 2006-11-16 | Sheppard Paul O | Compositions and uses of secreted polypeptide, Zsig98 |
CN101321856A (zh) | 2005-05-09 | 2008-12-10 | 萨克松尼亚生物科技有限责任公司 | 用于细胞培养模块的供应系统 |
US20090280153A1 (en) | 2005-05-10 | 2009-11-12 | Angiotech International Ag | electrical devices, anti-scarring agents, and therapeutic compositions |
CA2608048A1 (en) | 2005-05-10 | 2006-11-16 | United States Of America Department Of Veteran's Affairs | Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media |
US7831293B2 (en) | 2005-05-10 | 2010-11-09 | Advanced Clinical Solutions, Inc. | Method of defining a biological target for treatment |
JP2008540521A (ja) | 2005-05-12 | 2008-11-20 | アンジオテック インターナショナル アーゲー | 憩室疾患の治療のための組成物と方法 |
EP1888741B1 (en) | 2005-05-27 | 2013-04-17 | Viacell, Inc. | Treatment of ischemia using stem cells |
US20110206643A1 (en) | 2005-06-02 | 2011-08-25 | In Motion Investment, Ltd. | Automated Cell Therapy System |
JP4938768B2 (ja) | 2005-06-10 | 2012-05-23 | ヌンク エー/エス | 培養挿入具キャリア、培養挿入具及び培養挿入具システム |
JP2007000038A (ja) | 2005-06-22 | 2007-01-11 | Toray Ind Inc | 閉鎖系循環回路型培養装置 |
EP1739165A1 (en) | 2005-06-29 | 2007-01-03 | Cellution Biotech B.V. | Method and apparatus for cultivating cells utilizing wave motion |
GB2443370A (en) | 2005-07-29 | 2008-04-30 | Australian Stem Cell Ct Ltd | Compositions and methods for growth of pluripotent cells |
WO2007015782A1 (en) | 2005-07-29 | 2007-02-08 | Ecole Polytechnique Federale De Lausanne | Molecular variant fibrinogen fusion proteins |
US8486621B2 (en) | 2005-08-11 | 2013-07-16 | Cornell Research Foundation, Inc. | Nucleic acid-based matrixes |
US7943374B2 (en) | 2005-08-21 | 2011-05-17 | Markus Hildinger | Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb |
EP1940423B1 (en) | 2005-09-09 | 2014-04-16 | Duke University | Tissue engineering methods and compositions |
JP2007097407A (ja) * | 2005-09-30 | 2007-04-19 | Espec Corp | 細胞製造方法及び細胞培養装置 |
US20070198063A1 (en) | 2005-10-03 | 2007-08-23 | Hunter William L | Electrical devices and anti-scarring drug combinations |
US20070208134A1 (en) | 2005-10-03 | 2007-09-06 | Hunter William L | Anti-scarring drug combinations and use thereof |
WO2007041677A2 (en) | 2005-10-03 | 2007-04-12 | Combinatorx, Incorporated | Soft tissue implants and drug combination compositions, and use thereof |
US20070197957A1 (en) | 2005-10-03 | 2007-08-23 | Hunter William L | Implantable sensors, implantable pumps and anti-scarring drug combinations |
US7888119B2 (en) | 2005-10-14 | 2011-02-15 | University Of Central Florida Research Foundation, Inc. | Tissue substitutes comprising stem cells and reduced ceria |
US20070116612A1 (en) | 2005-11-02 | 2007-05-24 | Biopath Automation, L.L.C. | Prefix tissue cassette |
WO2007071072A1 (en) | 2005-12-22 | 2007-06-28 | Corporation De L'ecole Polytechnique De Montreal | High-rate perfusion bioreactor |
MX348735B (es) | 2006-01-13 | 2017-06-27 | Mesoblast Int Sarl | Celulas madre mesenquimales que expresan los receptores tnf-alfa. |
US8492150B2 (en) | 2006-02-03 | 2013-07-23 | President And Fellows Of Harvard College | Engineered cell growth on polymeric films and biotechnological applications thereof |
WO2007091255A2 (en) | 2006-02-06 | 2007-08-16 | Pluristem Ltd. | Method and apparatus for maintenance and expansion of hematopoietic stem cells from mononuclear cells |
US20110171182A1 (en) | 2006-03-23 | 2011-07-14 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
US20110293583A1 (en) | 2006-03-23 | 2011-12-01 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
RU2433177C2 (ru) | 2006-03-23 | 2011-11-10 | Плуристем Лтд. | Способ экспансии клеток, способ получения кондиционной среды, популяция адгезивных мезенхимальных стромальных клеток плаценты или жировой ткани, фармацевтическая композиция и применение адгезивных мезенхимальных стромальных клеток плаценты или жировой ткани в трансплантации |
US7682822B2 (en) | 2006-03-31 | 2010-03-23 | Aastrom Biosciences, Inc. | Ex vivo generated tissue system |
AU2007236550B2 (en) | 2006-04-07 | 2012-09-13 | The University Of Melbourne | Porous polymer structures |
WO2007115367A1 (en) | 2006-04-07 | 2007-10-18 | The University Of Queensland | Porous polymer blend structures |
EP2010641A1 (en) | 2006-04-12 | 2009-01-07 | Synexa Life Sciences (Proprietary) Ltd | High throughput bioprocess apparatus |
US8758991B2 (en) | 2006-04-26 | 2014-06-24 | University Of Louisville Research Foundation, Inc. | Isolation of membrane vesicles from biological fluids and methods of using same |
EP2029722B1 (en) | 2006-05-22 | 2019-10-16 | Biovest International, Inc. | Method and system for the production of cells |
US8642307B2 (en) | 2006-05-25 | 2014-02-04 | Nalge Nunc International Corporation | Cell culture surface chemistries |
US8361453B2 (en) | 2006-06-06 | 2013-01-29 | Rutgers, The State University Of New Jersey | Iodinated polymers |
US20080153077A1 (en) | 2006-06-12 | 2008-06-26 | David Henry | Substrates for immobilizing cells and tissues and methods of use thereof |
US20070295651A1 (en) | 2006-06-26 | 2007-12-27 | Martinez F Jesus | Dialysis bag system |
US20070298497A1 (en) | 2006-06-26 | 2007-12-27 | Gambro Bct, Inc. | Method of Culturing Mesenchymal Stem Cells |
US8497126B2 (en) | 2006-06-30 | 2013-07-30 | Corning Incorporated | Method of making enhanced cell growth surface |
DE102006031871B4 (de) | 2006-07-10 | 2008-10-23 | Gerlach, Jörg, Dr.med. | 3-D Petri-Schale zur Züchtung und Untersuchung von Zellen |
WO2008008846A2 (en) | 2006-07-11 | 2008-01-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differential expression of molecules associated with intra-cerebral hemorrhage |
DK2046349T3 (en) | 2006-07-12 | 2015-12-21 | Mesoblast Inc | TREATMENT OF EXCESSIVE NEOVASCULARIZATION |
US8715718B2 (en) | 2006-07-14 | 2014-05-06 | Rutgers, The State University Of New Jersey | Extracellular matrix production from nanoscale substrate |
WO2008011664A1 (en) | 2006-07-24 | 2008-01-31 | The University Of Queensland | Method of producing a population of cells |
HU3285U (en) | 2006-07-24 | 2007-05-29 | Tamas Dr Molnar | Tissue sample container |
EP2049159A4 (en) | 2006-08-11 | 2011-08-17 | Univ Queensland | SCAFFOLD TREATMENT DEVICE AND METHOD |
WO2008028241A1 (en) | 2006-09-06 | 2008-03-13 | The University Of Queensland | Microbioreactor |
US20080113440A1 (en) | 2006-10-06 | 2008-05-15 | Leica Biosystems Melbourne Pty Ltd | Method and Apparatus for Tissue Sample Processing |
EP2343014B1 (en) | 2006-10-06 | 2018-02-14 | Bard Peripheral Vascular, Inc. | Tissue handling system with reduced operator exposure |
WO2010033640A1 (en) | 2008-09-16 | 2010-03-25 | Rutgers, The State University Of New Jersey | Bioresorbable polymers synthesized from monomer analogs of natural metabolites |
WO2008082738A2 (en) | 2006-10-17 | 2008-07-10 | Rutgers, The State University | N-substituted monomers and polymers |
WO2008049056A2 (en) | 2006-10-18 | 2008-04-24 | Baylor College Of Medicine | Treatment of medical condition with a2 domain of von willebrand factor |
US20080095690A1 (en) | 2006-10-24 | 2008-04-24 | Wei Liu | Nano-sized needle crystal mullite film and method of making |
US20080103412A1 (en) | 2006-11-01 | 2008-05-01 | Yem Chin | Removing Tissue |
EP1935429A1 (en) | 2006-12-22 | 2008-06-25 | CSL Behring GmbH | Synergistic therapeutic use of prothrombin complex concentrates with FVIII concentrates |
KR20090111843A (ko) | 2007-01-18 | 2009-10-27 | 백스터 인터내셔널 인코포레이티드 | Tgf-베타의 제어 방출용 피브린 겔 및 이의 용도 |
US20100291180A1 (en) | 2007-02-20 | 2010-11-18 | Uhrich Kathryn E | Nerve guidance tubes |
WO2008103339A2 (en) | 2007-02-22 | 2008-08-28 | Corning Incorporated | Substrates useful for cell culture and methods for making and using same |
EP2115117A1 (en) | 2007-03-01 | 2009-11-11 | CaridianBCT, Inc. | Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling |
JP2010519937A (ja) * | 2007-03-05 | 2010-06-10 | カリディアンビーシーティー、インコーポレーテッド | 細胞増殖システムおよび使用方法 |
ES2665024T3 (es) | 2007-03-05 | 2018-04-24 | Terumo Bct, Inc. | Métodos para controlar el movimiento celular en biorreactores de fibra hueca |
US20080221444A1 (en) | 2007-03-07 | 2008-09-11 | Ritchie Paul G | Integrated Imaging and Biopsy System with Integrated Surgical, Therapy, and Diagnostic Devices |
JP2010520765A (ja) | 2007-03-09 | 2010-06-17 | コーニング インコーポレイテッド | 細胞培養用ガムコーティング、製造方法および使用方法 |
US8080418B2 (en) | 2007-03-09 | 2011-12-20 | Corning Incorporated | Method of making a three dimensional cell culture matrix |
EP2118263A2 (en) | 2007-03-14 | 2009-11-18 | CaridianBCT, Inc. | Cell expansion apparatus with plate bioreactor |
WO2008116261A1 (en) | 2007-03-27 | 2008-10-02 | The University Of Queensland | Production of particles |
US8983570B2 (en) | 2007-03-27 | 2015-03-17 | Cardiovascular Biotherapeutics, Inc. | Therapeutic angiogenesis for treatment of the spine |
AU2008236529B2 (en) | 2007-04-06 | 2013-09-05 | Terumo Bct, Inc. | Improved bioreactor surfaces |
WO2008128165A2 (en) | 2007-04-13 | 2008-10-23 | Caridianbct, Inc. | Cell expansion system and methods of use |
EP2147096B1 (en) | 2007-04-13 | 2015-03-25 | Catalyst Biosciences, Inc. | Modified factor VII polypeptides and uses thereof |
US20080268165A1 (en) | 2007-04-26 | 2008-10-30 | Curtis Robert Fekety | Process for making a porous substrate of glass powder formed through flame spray pyrolysis |
AU2008259839A1 (en) | 2007-05-31 | 2008-12-11 | The Children's Hospital Of Philadelphia | Compositions and methods for modulation of ADAMTS13 activity |
EP2000956B1 (en) | 2007-05-31 | 2010-12-15 | Semiconductor Energy Laboratory Co., Ltd. | power supply for RFID transponder |
US8367078B2 (en) | 2007-06-06 | 2013-02-05 | University Of Florida Research Foundation, Inc. | Kinase inhibitor compounds |
LT2883545T (lt) | 2007-06-07 | 2018-10-25 | Bayer Animal Health Gmbh | Kova su ektoparazitais |
TW200916583A (en) | 2007-06-08 | 2009-04-16 | Novathera Ltd | Cell expansion |
CN101772350A (zh) | 2007-06-19 | 2010-07-07 | 巴克斯特国际公司 | 用于pdgf受控释放的纤维蛋白凝胶及其应用 |
US7906076B2 (en) | 2007-07-02 | 2011-03-15 | University Of Massachusetts | Method and apparatus for biopsy sample processing |
US9109193B2 (en) | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
KR20170045382A (ko) | 2007-08-06 | 2017-04-26 | 메소블라스트, 아이엔씨. | 생체 내에서 결합 조직을 생성, 복구 및/또는 유지하는 방법 |
EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
AU2008291695A1 (en) | 2007-08-31 | 2009-03-05 | Sugar Industry Innovation Pty Ltd | Production of hyaluronic acid |
WO2009032117A2 (en) | 2007-08-31 | 2009-03-12 | Corning Incorporated | Reactive surface on a polymeric substrate |
WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
PT2200622E (pt) | 2007-09-19 | 2012-11-06 | Pluristem Ltd | Células aderentes provenientes de tecido adiposo ou placentário e respetiva utilização terapêutica |
US8105822B2 (en) | 2007-10-10 | 2012-01-31 | Corning Incorporated | Biosensor article and methods thereof |
US7923241B2 (en) | 2007-10-10 | 2011-04-12 | Corning Incorporated | Cell culture article and methods thereof |
US20120219737A1 (en) | 2007-10-19 | 2012-08-30 | University Of Medicine And Dentistry Of New Jersey | Production of extracellular matrix, conditioned media and uses thereof |
WO2009052459A1 (en) | 2007-10-19 | 2009-04-23 | University Of Medicine And Dentistry Of New Jersey | A method of using an extracellular matrix to enhance cell transplant survival and differentiation |
MX2010004425A (es) | 2007-10-23 | 2010-05-03 | Becton Dickinson Co | Recipiente para tejidos de desplazamiento de fluidos para diagnosticos moleculares e histologicos. |
CA2702841C (en) | 2007-10-23 | 2016-01-19 | C. Mark Newby | Container system for tissue stabilization for molecular and histopathology diagnostics |
ES2805503T3 (es) | 2007-10-23 | 2021-02-12 | Becton Dickinson Co | Recipiente para tejidos para diagnóstico molecular e histológico que incorpora una membrana rompible |
CA2816874C (en) | 2007-10-23 | 2016-03-15 | Becton, Dickinson And Company | Multi-chambered tissue containment system for molecular and histology diagnostics |
US20100021954A1 (en) | 2008-07-23 | 2010-01-28 | Sophie Deshayes | High capacity nanoparticulate immobilization surface |
WO2009058146A1 (en) | 2007-10-31 | 2009-05-07 | Celonova Bioscience, Inc. | Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use |
EP2231702A1 (en) | 2007-12-21 | 2010-09-29 | Ifxa A/s | Protease inhibitor |
EP2237806A2 (en) | 2007-12-26 | 2010-10-13 | Metamorefix | Pulverrized fibrin clots and pharmaceutical compositions containing them |
JP5501981B2 (ja) | 2008-01-30 | 2014-05-28 | ジェロン・コーポレーション | 既知組成培地中で細胞を培養するための合成表面 |
WO2009099539A2 (en) | 2008-01-30 | 2009-08-13 | Corning Incorporated | (meth)acrylate surfaces for cell culture, methods of making and using the surfaces |
US8329469B2 (en) | 2008-01-30 | 2012-12-11 | Geron Corporation | Swellable (meth)acrylate surfaces for culturing cells in chemically defined media |
US20090227027A1 (en) | 2008-03-07 | 2009-09-10 | Baker Wendy A | Coated cell culture surfaces and methods thereof |
US8932858B2 (en) | 2008-03-07 | 2015-01-13 | Corning Incorporated | Modified polysaccharide for cell culture and release |
US20090233334A1 (en) | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
NO329287B1 (no) | 2008-03-17 | 2010-09-27 | Med Storm Innovation As | Fremgangsmate og apparat for a overvake det autonome nervesystemet til en sedert pasient |
US8828720B2 (en) | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US20120028352A1 (en) | 2008-03-17 | 2012-02-02 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
US20110143433A1 (en) | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
US20120219531A1 (en) | 2008-03-17 | 2012-08-30 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
TWI465247B (zh) | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子vii多肽和其用途 |
US8532748B2 (en) | 2008-04-23 | 2013-09-10 | Devicor Medical Products, Inc. | Devices useful in imaging |
US8623820B2 (en) | 2008-05-02 | 2014-01-07 | University Of Western Ontario | FGF-9 and its use relating to blood vessels |
US20110182866A1 (en) | 2008-05-15 | 2011-07-28 | University Of Miami | Isolation of stem cell precursors and expansion in non-adherent conditions |
BRPI0909541A2 (pt) | 2008-05-27 | 2016-10-11 | Pluristem Ltd | ''método para tratamento de doenças inflamatórias do cólon'' |
WO2010005527A1 (en) | 2008-06-30 | 2010-01-14 | Angioblast Systems, Inc. | Treatment of eye diseases and excessive neovascularization using a combined therapy |
WO2010005557A2 (en) | 2008-07-07 | 2010-01-14 | Arteriocyte Medical Systems, Inc. | Biological therapeutic compositions and methods thereof |
WO2010006219A2 (en) | 2008-07-09 | 2010-01-14 | Baxter International Inc. | Use of scaffold comprising fibrin for delivery of stem cells |
WO2010014253A2 (en) | 2008-08-01 | 2010-02-04 | University Of Florida Research Foundation, Inc. | Ant4 inhibitor compounds and methods of use thereof |
US8321145B2 (en) | 2008-08-12 | 2012-11-27 | Terumo Bct, Inc. | Predictor of when to harvest cells grown in a bioreactor |
CA2733985C (en) | 2008-08-14 | 2016-07-12 | Osiris Therapeutics, Inc. | Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions |
CN104678106B (zh) | 2008-08-18 | 2016-12-07 | 中胚有限公司 | 单克隆抗体stro-4 |
WO2010026574A2 (en) | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
WO2010026573A1 (en) | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Methods of selection of cells for transplantation |
SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
US20100075410A1 (en) | 2008-09-20 | 2010-03-25 | Virendra Desai | Reusable Tissue Biopsy Kit with Padded Cassette |
EP2334328A4 (en) | 2008-09-24 | 2012-08-29 | Medimmune Llc | METHOD FOR CLEANING VIRUSES |
RU2547587C2 (ru) | 2008-09-24 | 2015-04-10 | Медиммун, Ллк | Способы культивирования клеток, размножения и очистки вирусов |
EP2168668A1 (en) | 2008-09-25 | 2010-03-31 | Gambro Lundia AB | Membrane for cell expansion |
US8551511B2 (en) | 2008-10-11 | 2013-10-08 | Rutgers, The State University Of New Jersey | Phase-separated biocompatible polymer compositions for medical uses |
US8673637B2 (en) | 2008-10-16 | 2014-03-18 | The Board Of Trustees Of The Leland Stanford Junior University | Human multipotent germ line stem cells expressing a germ line marker and a pluripotency marker produced by co-culture of testicular tissue |
JP2012506257A (ja) | 2008-10-22 | 2012-03-15 | バイオベスト インターナショナル インコーポレイテッド | 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法 |
US9284523B2 (en) | 2008-10-27 | 2016-03-15 | Terumo Bct, Inc. | Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith |
US20100183585A1 (en) | 2008-10-30 | 2010-07-22 | University Of Kentucky Research Foundation | Methods and compositions for treating tumors and metastases through the modulation of latexin |
WO2010061377A2 (en) | 2008-11-03 | 2010-06-03 | Metamorefix | Tissue adhesive |
WO2010059902A2 (en) | 2008-11-24 | 2010-05-27 | Corning Incorporated | 3d cell-culture article and methods thereof |
EP2376425A4 (en) | 2008-12-09 | 2012-12-26 | Univ Florida | KINASE INHIBITORS COMPOUNDS |
WO2010071826A2 (en) | 2008-12-19 | 2010-06-24 | University Of Florida Research Foundation, Inc. | Methods for treating osteoclast-related disease, compounds and compositions thereof |
US9156037B2 (en) | 2009-01-15 | 2015-10-13 | Children's Medical Center Corporation | Microfluidic device and uses thereof |
WO2010083385A2 (en) | 2009-01-15 | 2010-07-22 | The General Hospital Corporation | Compounds for reducing drug resistance and uses thereof |
US8399245B2 (en) | 2009-02-18 | 2013-03-19 | Terumo Bct, Inc. | Rotation system for cell growth chamber of a cell expansion system and method of use therefor |
US8051947B2 (en) | 2009-03-12 | 2011-11-08 | E.I. Du Pont De Nemours And Company | Energy absorbing thermoplastic elastomer |
WO2010111255A1 (en) | 2009-03-23 | 2010-09-30 | Hememics Biotechnologies, Inc. | Desiccated biologics and methods of preparing the same |
WO2010119036A1 (en) | 2009-04-14 | 2010-10-21 | Humagene Inc. | Novel post-translational fibrinogen variants |
USD620732S1 (en) | 2009-04-15 | 2010-08-03 | Spectrum Laboratories, Llc | Beverage container holder |
WO2010138687A1 (en) | 2009-05-28 | 2010-12-02 | Corning Incorporated | Synthetic microcarriers for culturing cells |
WO2010138486A1 (en) | 2009-05-29 | 2010-12-02 | Corning Incorporated | Substrates for adhering, culturing and assaying cells |
EP2443230B1 (en) | 2009-06-18 | 2017-07-26 | Takara Bio Europe AB | 3D CULTURING SYSTEMS FOR GROWTH AND DIFFERENTIATION OF HUMAN PLURIPOTENT STEM (hPS) CELLS |
WO2011011035A2 (en) | 2009-07-24 | 2011-01-27 | Millipore Corporation | Feed bag construction |
EP2361968B1 (en) | 2010-02-26 | 2014-11-19 | Corning Incorporated | Synthetic polysaccharide microcarriers for culturing cells |
US9068182B2 (en) | 2009-07-28 | 2015-06-30 | Corning Incorporated | Synthetic polysaccharide microcarriers for culturing cells |
US9080015B2 (en) | 2009-07-31 | 2015-07-14 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
FR2949195B1 (fr) | 2009-08-24 | 2011-10-14 | Lfb Biomedicaments | Poche de stockage de solution therapeutique |
EP2470642A4 (en) | 2009-08-27 | 2013-03-20 | Ge Healthcare Bio Sciences Ab | CELL EXPANSION METHOD |
CA3029961C (en) | 2009-10-11 | 2021-06-22 | Rutgers, The State Of University Of New Jersey | Biocompatible polymers for medical devices |
WO2011047289A1 (en) | 2009-10-16 | 2011-04-21 | University Of Medicine And Dentistry Of New Jersey | Closed system separation of adherent bone marrow stem cells for regenerative medicine applications |
FR2952041B1 (fr) | 2009-10-29 | 2012-02-03 | Sartorius Stedim Biotech Sa | Film multicouche de paroi de poche a soudures destinee a un produit biopharmaceutique. |
EP2977445B1 (en) | 2009-11-30 | 2018-07-25 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
WO2011090605A2 (en) * | 2009-12-29 | 2011-07-28 | Caridianbct, Inc. | Method of loading and distributing cells in a bioreactor of a cell expansion system |
US20120315696A1 (en) | 2010-02-15 | 2012-12-13 | Alfred Luitjens | METHOD FOR THE PRODUCTION OF Ad26 ADENOVIRAL VECTORS |
US8678638B2 (en) | 2010-03-09 | 2014-03-25 | Emd Millipore Corporation | Process bag container with sensors |
US20130039892A1 (en) | 2010-04-23 | 2013-02-14 | Pluristem Ltd. | Adherent stromal cells derived from plancentas of multiple donors and uses thereof |
JP6039547B2 (ja) * | 2010-05-05 | 2016-12-07 | テルモ ビーシーティー、インコーポレーテッド | 中空糸型バイオリアクターシステムにおいて成長させた接着細胞を再播種する方法 |
WO2011142670A1 (en) | 2010-05-12 | 2011-11-17 | Xpand Biotechnology B.V. | Cell-culture-bag |
AU2011251055B2 (en) | 2010-05-12 | 2014-12-04 | Scinus Cell Expansion B.V. | Cell - culture - bag |
EP2575831B1 (en) | 2010-05-27 | 2016-04-20 | Pluristem Ltd. | Skeletal muscle regeneration using mesenchymal stem cells |
EP3679939A1 (en) | 2010-10-08 | 2020-07-15 | Mesoblast International Sàrl | Enhanced msc preparations |
WO2012048276A2 (en) * | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
US20120118919A1 (en) | 2010-11-17 | 2012-05-17 | Millipore Corporation | Feed bag construction |
US20120237557A1 (en) | 2010-11-30 | 2012-09-20 | Rutgers, The State University Of New Jersey | Bioactive carbon-nanotube agarose composites for neural engineering |
FR2968197B1 (fr) | 2010-12-01 | 2013-12-20 | Sartorius Stedim Biotech Sa | Poche flexible a usage biopharmaceutique ayant une pluralite de ports de sortie. |
US9220810B2 (en) | 2010-12-10 | 2015-12-29 | Florida State University Research Foundation, Inc. | Mesenchymal stem cells (MSC) expansion methods and materials |
US8961948B2 (en) | 2011-01-17 | 2015-02-24 | Rutgers, The State University Of New Jersey | Molecular surface design of tyrosine-derived polycarbonates for attachment of biomolecules |
US20140017209A1 (en) | 2011-03-22 | 2014-01-16 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
KR101835917B1 (ko) | 2011-03-22 | 2018-03-07 | 플루리스템 리미티드 | 방사선 또는 화학적 손상을 치료하는 방법들 |
US9701939B2 (en) | 2011-04-08 | 2017-07-11 | The University Of Akron | Thermoresponsive cell culture supports |
CN108342350A (zh) | 2011-04-15 | 2018-07-31 | 普拉里斯坦有限公司 | 收获细胞的方法和系统 |
US8668886B2 (en) | 2011-04-24 | 2014-03-11 | Therapeutic Proteins International, LLC | Separative bioreactor |
EP2710118B1 (en) | 2011-05-17 | 2018-02-07 | Terumo BCT, Inc. | Systems and methods for expanding high density non-adherent cells |
SG10201914092XA (en) | 2011-06-06 | 2020-03-30 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
WO2012171026A2 (en) | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Methods for high yield virus production |
WO2012171030A2 (en) | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Method and apparatus for antibody production and purification |
DE102012200938B4 (de) | 2012-01-23 | 2016-08-18 | Alpha Plan Gmbh | Bio- und medizintechnisches Baukastensystem |
DE102012200939B4 (de) | 2012-01-23 | 2016-05-12 | Alpha Plan Gmbh | Bioreaktor zur Kultivierung von Zellen und Gewebekulturen sowie Hefen und Bakterien als Objekte |
WO2014031690A1 (en) | 2012-08-20 | 2014-02-27 | Terumo Bct, Inc. | Concentrating components of fluid circulated through a cell growth chamber |
EP2885393A1 (en) * | 2012-08-20 | 2015-06-24 | Terumo BCT, Inc. | Method of loading and distributing cells in a bioreactor of a cell expansion system |
EP2909302A4 (en) | 2012-08-28 | 2016-07-27 | Biovest Int Inc | BIOFABRICATION FILAMENT AND METHOD FOR LARGE-SCALE PRODUCTION OF CELLS, VIRUSES AND BIOMOLECULES |
US9725768B2 (en) | 2012-08-31 | 2017-08-08 | Biovest International, Inc. | Methods for producing high-fidelity autologous idiotype vaccines |
KR101921787B1 (ko) | 2012-09-04 | 2018-11-23 | 플루리스템 리미티드 | 자간전증의 예방 및 치료 방법 |
US9512393B2 (en) | 2012-09-06 | 2016-12-06 | Pluristem Ltd. | Devices and methods for culture of cells |
JP6506693B2 (ja) | 2012-10-31 | 2019-04-24 | プルリステム リミテッド | 生物由来材料を解凍するための方法および装置 |
US10351910B2 (en) | 2013-02-20 | 2019-07-16 | Pluristem Ltd | Gene and protein expression properties of adherent stromal cells cultured in 3D |
DE102013203082B4 (de) | 2013-02-25 | 2014-10-09 | Alpha Plan Gmbh | Prüf- und Trocknungseinrichtung zur Funktionsprüfung von Dialysatoren |
DE102013203306B4 (de) | 2013-02-27 | 2015-10-22 | Alpha Plan Gmbh | Einsatz zur beidseitigen Kultivierung einer Poren aufweisenden Membran für Zellen und Gewebekulturen sowie Hefen und Bakterien als Objekte |
WO2014141111A1 (en) | 2013-03-14 | 2014-09-18 | Pluristem Ltd. | Methods for prevention and treatment of graft-versus-host disease |
WO2015004609A2 (en) | 2013-07-09 | 2015-01-15 | Pluristem Ltd. | Adherent cells from placenta and use thereof in treatment of injured tendons |
WO2015073918A1 (en) * | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
WO2015118146A1 (en) | 2014-02-10 | 2015-08-13 | Univercells Nv | System, apparatus and method for biomolecules production |
WO2015118149A1 (en) | 2014-02-10 | 2015-08-13 | Univercells Nv | System, apparatus and method for anti-rsv antibodies and formulations |
BE1022439B1 (fr) | 2014-02-10 | 2016-03-30 | Univercells Sa | Systeme appareil et procede pour production de biomolecules |
US20170081638A1 (en) | 2014-02-28 | 2017-03-23 | Florida State University Research Foundation, Inc. | Materials and methods for expansion of stem cells |
MX2017010217A (es) | 2015-02-09 | 2017-11-10 | Univercells Nv | Sistema, aparato y metodo para la produccion de celulas y/o productos de celulas. |
US10760053B2 (en) | 2015-10-15 | 2020-09-01 | StemoniX Inc. | Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor |
KR20180074775A (ko) | 2015-10-26 | 2018-07-03 | 론자 리미티드 | 생물약제의 생산을 위한 제조 설비 |
US20180010082A1 (en) | 2016-06-03 | 2018-01-11 | Lonza Ltd | Bioreactor With Higher Agitation Rates |
SG11201901518WA (en) | 2016-09-01 | 2019-03-28 | Takeda Vaccines Inc | Methods for producing virus for vaccine production |
-
2014
- 2014-11-14 WO PCT/US2014/065829 patent/WO2015073918A1/en active Application Filing
- 2014-11-14 CN CN201480065645.1A patent/CN105793411B/zh active Active
- 2014-11-14 CN CN201480065648.5A patent/CN105992816B/zh active Active
- 2014-11-14 US US14/542,304 patent/US10633625B2/en active Active
- 2014-11-14 EP EP14806151.8A patent/EP3068866B1/en active Active
- 2014-11-14 WO PCT/US2014/065823 patent/WO2015073913A1/en active Application Filing
- 2014-11-14 JP JP2016530921A patent/JP6633522B2/ja active Active
- 2014-11-14 EP EP14806152.6A patent/EP3068867B1/en active Active
- 2014-11-14 JP JP2016531019A patent/JP6612227B2/ja active Active
- 2014-11-14 US US14/542,276 patent/US9617506B2/en active Active
-
2017
- 2017-04-07 US US15/482,168 patent/US10557112B2/en active Active
-
2020
- 2020-04-24 US US16/858,058 patent/US11708554B2/en active Active
- 2020-04-27 US US16/859,849 patent/US11667876B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN105793411B (zh) | 2018-04-17 |
CN105793411A (zh) | 2016-07-20 |
EP3068867A1 (en) | 2016-09-21 |
WO2015073913A1 (en) | 2015-05-21 |
JP2016536998A (ja) | 2016-12-01 |
US11708554B2 (en) | 2023-07-25 |
US20150140653A1 (en) | 2015-05-21 |
US20170275580A1 (en) | 2017-09-28 |
CN105992816A (zh) | 2016-10-05 |
US20150140654A1 (en) | 2015-05-21 |
EP3068866A1 (en) | 2016-09-21 |
EP3068867B1 (en) | 2018-04-18 |
JP2016537001A (ja) | 2016-12-01 |
EP3068866B1 (en) | 2018-04-25 |
US9617506B2 (en) | 2017-04-11 |
US11667876B2 (en) | 2023-06-06 |
US20200248126A1 (en) | 2020-08-06 |
US10633625B2 (en) | 2020-04-28 |
WO2015073918A1 (en) | 2015-05-21 |
JP6612227B2 (ja) | 2019-11-27 |
US20200255786A1 (en) | 2020-08-13 |
CN105992816B (zh) | 2018-04-17 |
US10557112B2 (en) | 2020-02-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6633522B2 (ja) | バイオリアクターにおける細胞増殖 | |
US10577576B2 (en) | System for expanding cells | |
JP6633143B2 (ja) | 細胞成長チャンバーを循環する流体の成分を濃縮する方法 | |
US8785181B2 (en) | Cell expansion system and methods of use | |
US11634677B2 (en) | Coating a bioreactor in a cell expansion system | |
US20230174917A1 (en) | Cell Growth With Mechanical Stimuli | |
US10577575B2 (en) | Coating a bioreactor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171109 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171109 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180815 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180828 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20181116 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190125 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190226 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190523 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190711 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190806 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20191119 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20191212 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6633522 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |