ITRM20030376A1 - Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. - Google Patents

Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.

Info

Publication number
ITRM20030376A1
ITRM20030376A1 IT000376A ITRM20030376A ITRM20030376A1 IT RM20030376 A1 ITRM20030376 A1 IT RM20030376A1 IT 000376 A IT000376 A IT 000376A IT RM20030376 A ITRM20030376 A IT RM20030376A IT RM20030376 A1 ITRM20030376 A1 IT RM20030376A1
Authority
IT
Italy
Prior art keywords
cardioc
biopsia
stamin
isolation
expansion
Prior art date
Application number
IT000376A
Other languages
English (en)
Inventor
Massimo Battaglia
Giacomo Frati
Alessandro Giacomello
Elisa Messina
Original Assignee
Univ Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Roma filed Critical Univ Roma
Priority to IT000376A priority Critical patent/ITRM20030376A1/it
Publication of ITRM20030376A0 publication Critical patent/ITRM20030376A0/it
Priority to EP11186852.7A priority patent/EP2465921A3/en
Priority to PCT/IT2004/000421 priority patent/WO2005012510A1/en
Priority to CA2534378A priority patent/CA2534378C/en
Priority to US10/567,008 priority patent/US8268619B2/en
Priority to CA2793046A priority patent/CA2793046C/en
Priority to EP04770731.0A priority patent/EP1649012B1/en
Priority to CNA200480026720XA priority patent/CN1852973A/zh
Publication of ITRM20030376A1 publication Critical patent/ITRM20030376A1/it
Priority to US13/214,680 priority patent/US8846396B2/en
Priority to US13/214,742 priority patent/US20120093879A1/en
Priority to US13/245,787 priority patent/US20120021019A1/en
Priority to US13/245,788 priority patent/US8772030B2/en
Priority to US14/990,592 priority patent/US20160244723A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/175—Cardiotrophin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT000376A 2003-07-31 2003-07-31 Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. ITRM20030376A1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT000376A ITRM20030376A1 (it) 2003-07-31 2003-07-31 Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
CNA200480026720XA CN1852973A (zh) 2003-07-31 2004-07-29 从活检分离和扩充心脏干细胞的方法
EP04770731.0A EP1649012B1 (en) 2003-07-31 2004-07-29 Method for the isolation and expansion of cardiac stem cells from biopsy
PCT/IT2004/000421 WO2005012510A1 (en) 2003-07-31 2004-07-29 Method for the isolation and expansion of cardiac stem cells from biopsy
CA2534378A CA2534378C (en) 2003-07-31 2004-07-29 Method for the isolation and expansion of cardiac stem cells from biopsy
US10/567,008 US8268619B2 (en) 2003-07-31 2004-07-29 Method for the isolation and expansion of cardiac stem cells from biopsy
CA2793046A CA2793046C (en) 2003-07-31 2004-07-29 Method for the isolation and expansion of cardiac stem cells from biopsy
EP11186852.7A EP2465921A3 (en) 2003-07-31 2004-07-29 Cardiac stem cells from biopsy
US13/214,680 US8846396B2 (en) 2003-07-31 2011-08-22 Methods for the isolation of cardiac stem cells
US13/214,742 US20120093879A1 (en) 2003-07-31 2011-08-22 Cardiac stem cells and uses of same in cardiac repair
US13/245,787 US20120021019A1 (en) 2003-07-31 2011-09-26 Cardiac stem cell populations for repair of cardiac tissue
US13/245,788 US8772030B2 (en) 2003-07-31 2011-09-26 Cardiac stem cells and methods for isolation of same
US14/990,592 US20160244723A1 (en) 2003-07-31 2016-01-07 Cardiac stem cells and uses of same in cardiac repair

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000376A ITRM20030376A1 (it) 2003-07-31 2003-07-31 Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.

Publications (2)

Publication Number Publication Date
ITRM20030376A0 ITRM20030376A0 (it) 2003-07-31
ITRM20030376A1 true ITRM20030376A1 (it) 2005-02-01

Family

ID=29765944

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000376A ITRM20030376A1 (it) 2003-07-31 2003-07-31 Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.

Country Status (6)

Country Link
US (6) US8268619B2 (it)
EP (2) EP2465921A3 (it)
CN (1) CN1852973A (it)
CA (2) CA2793046C (it)
IT (1) ITRM20030376A1 (it)
WO (1) WO2005012510A1 (it)

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US8075881B2 (en) * 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
CN101087563A (zh) * 2004-11-08 2007-12-12 约翰霍普金斯大学 活检钳
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
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US20140329314A1 (en) 2011-03-29 2014-11-06 Christopher O'Sullivan Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
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US8772030B2 (en) 2014-07-08
EP2465921A2 (en) 2012-06-20
US8268619B2 (en) 2012-09-18
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EP2465921A3 (en) 2013-06-05
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CA2534378A1 (en) 2005-02-10
US8846396B2 (en) 2014-09-30
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