IT1282207B1 - Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico - Google Patents

Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico

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Publication number
IT1282207B1
IT1282207B1 IT95PD000225A ITPD950225A IT1282207B1 IT 1282207 B1 IT1282207 B1 IT 1282207B1 IT 95PD000225 A IT95PD000225 A IT 95PD000225A IT PD950225 A ITPD950225 A IT PD950225A IT 1282207 B1 IT1282207 B1 IT 1282207B1
Authority
IT
Italy
Prior art keywords
bone marrow
hyaluronic acid
marrow stem
connective tissue
cell culture
Prior art date
Application number
IT95PD000225A
Other languages
English (en)
Inventor
Giovanni Abatangelo
Lanfranco Callegaro
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of ITPD950225A0 publication Critical patent/ITPD950225A0/it
Priority to IT95PD000225A priority Critical patent/IT1282207B1/it
Priority to AU76934/96A priority patent/AU709236B2/en
Priority to CA002238011A priority patent/CA2238011C/en
Priority to EP96939845A priority patent/EP0863776B1/en
Priority to PT96939845T priority patent/PT863776E/pt
Priority to DE69626035T priority patent/DE69626035T2/de
Priority to ES96939845T priority patent/ES2189890T3/es
Priority to PCT/EP1996/005093 priority patent/WO1997018842A1/en
Priority to DK96939845T priority patent/DK0863776T3/da
Priority to JP51938597A priority patent/JP3808900B2/ja
Priority to US09/041,287 priority patent/US6596274B1/en
Priority to AT96939845T priority patent/ATE231730T1/de
Priority to IL12445096A priority patent/IL124450A/en
Publication of ITPD950225A1 publication Critical patent/ITPD950225A1/it
Application granted granted Critical
Publication of IT1282207B1 publication Critical patent/IT1282207B1/it
Priority to US09/602,033 priority patent/US6482231B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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IT95PD000225A 1995-11-20 1995-11-20 Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico IT1282207B1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT95PD000225A IT1282207B1 (it) 1995-11-20 1995-11-20 Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
ES96939845T ES2189890T3 (es) 1995-11-20 1996-11-19 Un material biologico comprendiendo un cultivo eficaz de celulas madre de medula osea parcialmente o complemtamente diferenciadas en celulas de tejido conectivo y una matriz tridimensional biocompatible y biodegradable consistente en un derivado del acido hialuronico.
DK96939845T DK0863776T3 (da) 1995-11-20 1996-11-19 Et biologisk materiale, der omfatter en effektiv kultur af knoglemarvsstamceller, der er differentieret delvist eller fuldstændigt til bindevævsceller og en tredimensionel biokompatibel og biologisk nedbrydelig matrix bestående af en hyaluronsyrederivat
EP96939845A EP0863776B1 (en) 1995-11-20 1996-11-19 A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
PT96939845T PT863776E (pt) 1995-11-20 1996-11-19 Material biologico compreendendo uma cultura eficiente de celulas estaminais de medula ossea parcialmente ou completamente diferenciadas em celulas detecido conjuntivo e uma matriz tridimensional biocompativel e biodegradavel consistindo num derivado de acido hialuronico
DE69626035T DE69626035T2 (de) 1995-11-20 1996-11-19 Ein biologisches material, das eine wirksame kultur von knochenmarkstammzellen, die teilweise oder vollständing in bindegewebszellen differenziert sind, enthält, und eine dreidimensionale, bioverträgliche und biologische abbaubare matrix, die aus einen hyaluronsäurederivat besteht
AU76934/96A AU709236B2 (en) 1995-11-20 1996-11-19 A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of hyaluronic acid derivative
PCT/EP1996/005093 WO1997018842A1 (en) 1995-11-20 1996-11-19 A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
CA002238011A CA2238011C (en) 1995-11-20 1996-11-19 A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
JP51938597A JP3808900B2 (ja) 1995-11-20 1996-11-19 結合組織細胞に部分的又は完全に分化した骨髄幹細胞の有効培養物及びヒアルロン酸誘導体より成る三次元の生体親和性で且つ生分解性のマトリックスから構成される生物学的物質
US09/041,287 US6596274B1 (en) 1995-11-20 1996-11-19 Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix
AT96939845T ATE231730T1 (de) 1995-11-20 1996-11-19 Ein biologisches material, das eine wirksame kultur von knochenmarkstammzellen, die teilweise oder vollständing in bindegewebszellen differenziert sind, enthält, und eine dreidimensionale, bioverträgliche und biologische abbaubare matrix, die aus einen hyaluronsäurederivat besteht
IL12445096A IL124450A (en) 1995-11-20 1996-11-19 Biological material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
US09/602,033 US6482231B1 (en) 1995-11-20 2000-06-23 Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

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CA2238011A1 (en) 1997-05-29
IL124450A0 (en) 1998-12-06
ITPD950225A0 (it) 1995-11-20
PT863776E (pt) 2003-06-30
IL124450A (en) 2004-02-19
ITPD950225A1 (it) 1997-05-20
EP0863776B1 (en) 2003-01-29
DE69626035T2 (de) 2004-01-22
ATE231730T1 (de) 2003-02-15
CA2238011C (en) 2007-01-09
AU7693496A (en) 1997-06-11
AU709236B2 (en) 1999-08-26
US6596274B1 (en) 2003-07-22
JP2000500372A (ja) 2000-01-18
JP3808900B2 (ja) 2006-08-16
ES2189890T3 (es) 2003-07-16
EP0863776A1 (en) 1998-09-16
DK0863776T3 (da) 2003-05-26
DE69626035D1 (de) 2003-03-06

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