ATE92107T1 - N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. - Google Patents
N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.Info
- Publication number
- ATE92107T1 ATE92107T1 AT90304575T AT90304575T ATE92107T1 AT E92107 T1 ATE92107 T1 AT E92107T1 AT 90304575 T AT90304575 T AT 90304575T AT 90304575 T AT90304575 T AT 90304575T AT E92107 T1 ATE92107 T1 AT E92107T1
- Authority
- AT
- Austria
- Prior art keywords
- fusion proteins
- serum albumin
- human serum
- terminal fragments
- containing fusion
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 210000002966 serum Anatomy 0.000 title 1
- 102000003908 Cathepsin D Human genes 0.000 abstract 1
- 108090000258 Cathepsin D Proteins 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 210000004087 cornea Anatomy 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898909919A GB8909919D0 (en) | 1989-04-29 | 1989-04-29 | Small polypeptides |
EP90304575A EP0399666B1 (de) | 1989-04-29 | 1990-04-26 | N-terminale Fragmente von menschliches Serumalbumin enthaltenden Fusionsproteinen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE92107T1 true ATE92107T1 (de) | 1993-08-15 |
Family
ID=10656003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90304575T ATE92107T1 (de) | 1989-04-29 | 1989-04-26 | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP0407008A3 (de) |
AT (1) | ATE92107T1 (de) |
DE (1) | DE69002395T2 (de) |
DK (1) | DK0399666T3 (de) |
ES (1) | ES2060033T3 (de) |
GB (1) | GB8909919D0 (de) |
WO (1) | WO1990013306A2 (de) |
Families Citing this family (79)
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US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
DE69012950T2 (de) * | 1989-10-13 | 1995-03-16 | Takara Shuzo Co | Antikrebsmittel. |
US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
FR2719593B1 (fr) * | 1994-05-06 | 1996-05-31 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur préparation et composition pharmaceutique les contenant. |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
JP3192067B2 (ja) * | 1995-10-09 | 2001-07-23 | 科学技術振興事業団 | ペプチドとコラーゲン収縮阻害剤 |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
US5922676A (en) * | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
US20040010134A1 (en) | 2000-04-12 | 2004-01-15 | Rosen Craig A. | Albumin fusion proteins |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1322667A4 (de) * | 2000-08-25 | 2004-08-18 | Human Genome Sciences Inc | Tumor-nekrose-faktor rezeptoren 6-alpha und 6-beta |
SI1355942T1 (sl) | 2000-12-07 | 2009-02-28 | Lilly Co Eli | Glp-1 fuzijski proteini |
DK1463751T3 (da) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albuminfusionsproteiner. |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
RU2401842C2 (ru) | 2004-10-08 | 2010-10-20 | Домантис Лимитед | Антагонисты и способы их применения |
AU2006344395B2 (en) | 2005-10-13 | 2013-05-02 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive diseases |
EP3058972A1 (de) | 2005-11-17 | 2016-08-24 | Zogenix, Inc. | Abgabe von viskosen formulierungen durch nadellose injektion |
EP1816201A1 (de) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät |
US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
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CA2688434A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
ES2632504T3 (es) | 2007-11-20 | 2017-09-13 | Ambrx, Inc. | Polipéptidos de insulina modificados y sus usos |
ES2563061T3 (es) | 2008-04-28 | 2016-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
BRPI0913007A2 (pt) | 2008-05-02 | 2019-09-24 | Novartis Ag | moléculas de ligação aprimoradas à base de fibronectina e usos das mesmas |
NZ600382A (en) | 2008-07-23 | 2013-11-29 | Ambrx Inc | Modified bovine G-CSF polypeptides and their uses |
BRPI0921586A2 (pt) | 2008-11-18 | 2019-09-24 | Merrimack Pharmaceuticals Inc | articuladores de albumina de soro humana e conjugados destes |
CN102307897B (zh) | 2008-12-05 | 2016-01-20 | 葛兰素集团有限公司 | 选出蛋白酶抗性多肽的方法 |
EA022925B1 (ru) | 2009-02-19 | 2016-03-31 | Глаксо Груп Лимитед | Улучшенные полипептиды, вариабельные домены антител и антагонисты против tnfr1 |
WO2010138555A2 (en) | 2009-05-26 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Small peptide expression system in mammalian cells |
WO2011006914A2 (en) | 2009-07-16 | 2011-01-20 | Glaxo Group Limited | Antagonists, uses & methods for partially inhibiting tnfr1 |
PE20121564A1 (es) | 2009-10-27 | 2012-11-29 | Glaxo Group Ltd | Polipeptidos anti-tnfr1 estables, dominios variables de anticuerpos y antagonistas |
WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
CN102753573A (zh) | 2009-12-21 | 2012-10-24 | Ambrx公司 | 经过修饰的牛促生长素多肽和其用途 |
EP2805965A1 (de) | 2009-12-21 | 2014-11-26 | Ambrx, Inc. | Modifizierte Schweine-Somatotropin-Polypeptide und deren Verwendungen |
WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
ES2659406T3 (es) | 2010-05-06 | 2018-03-15 | Novartis Ag | Composiciones y procedimientos de uso para anticuerpos terapéuticos contra la proteína 6 relacionada con las lipoproteínas de baja densidad (LRP6) |
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WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
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EP2726502A1 (de) | 2011-07-01 | 2014-05-07 | Bayer Intellectual Property GmbH | Relaxin-fusionspolypeptide und ihre verwendung |
AU2012283235A1 (en) | 2011-07-08 | 2014-01-09 | Bayer Intellectual Property Gmbh | Fusion proteins releasing Relaxin and uses thereof |
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CN107739409A (zh) | 2012-05-18 | 2018-02-27 | 爱德迪安(北京)生物技术有限公司 | 用于糖尿病治疗的蛋白、蛋白缀合物及其应用 |
US9345766B2 (en) | 2012-08-30 | 2016-05-24 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-ERBB3 agents |
WO2014164703A1 (en) | 2013-03-11 | 2014-10-09 | University Of Florida Research Foundation, Inc. | Delivery of card protein as therapy for occular inflammation |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8516421D0 (en) * | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
SE459586B (sv) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
GB8725529D0 (en) * | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
AU2719088A (en) * | 1987-11-09 | 1989-06-01 | Chiron Ophthalmics Inc. | Wound healing composition and method |
-
1989
- 1989-04-26 AT AT90304575T patent/ATE92107T1/de not_active IP Right Cessation
- 1989-04-29 GB GB898909919A patent/GB8909919D0/en active Pending
-
1990
- 1990-04-26 ES ES90304575T patent/ES2060033T3/es not_active Expired - Lifetime
- 1990-04-26 WO PCT/GB1990/000651 patent/WO1990013306A2/en unknown
- 1990-04-26 DK DK90304575.5T patent/DK0399666T3/da active
- 1990-04-26 EP EP19900304574 patent/EP0407008A3/en not_active Withdrawn
- 1990-04-26 EP EP90304575A patent/EP0399666B1/de not_active Expired - Lifetime
- 1990-04-26 DE DE90304575T patent/DE69002395T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0407008A2 (de) | 1991-01-09 |
EP0399666B1 (de) | 1993-07-28 |
GB8909919D0 (en) | 1989-06-14 |
EP0407008A3 (en) | 1991-07-17 |
DK0399666T3 (da) | 1993-08-30 |
WO1990013306A3 (en) | 1991-05-02 |
DE69002395D1 (de) | 1993-09-02 |
EP0399666A1 (de) | 1990-11-28 |
DE69002395T2 (de) | 1993-11-25 |
WO1990013306A2 (en) | 1990-11-15 |
ES2060033T3 (es) | 1994-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEFA | Change of the company name | ||
EELA | Cancelled due to lapse of time |