ZA9810490B - 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor - Google Patents
2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate thereforInfo
- Publication number
- ZA9810490B ZA9810490B ZA9810490A ZA9810490A ZA9810490B ZA 9810490 B ZA9810490 B ZA 9810490B ZA 9810490 A ZA9810490 A ZA 9810490A ZA 9810490 A ZA9810490 A ZA 9810490A ZA 9810490 B ZA9810490 B ZA 9810490B
- Authority
- ZA
- South Africa
- Prior art keywords
- aryl
- preparation
- pharmaceutical composition
- composition containing
- same
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35000097 | 1997-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9810490B true ZA9810490B (en) | 1999-05-20 |
Family
ID=18407561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9810490A ZA9810490B (en) | 1997-12-03 | 1998-11-17 | 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor |
Country Status (27)
Country | Link |
---|---|
US (1) | US6372740B1 (ko) |
EP (1) | EP1036794B1 (ko) |
JP (1) | JP3815966B2 (ko) |
KR (1) | KR100494347B1 (ko) |
CN (1) | CN1146566C (ko) |
AR (1) | AR017796A1 (ko) |
AT (1) | ATE248169T1 (ko) |
AU (1) | AU744014B2 (ko) |
BR (1) | BR9815140A (ko) |
CA (1) | CA2312885C (ko) |
DE (1) | DE69817611T2 (ko) |
DK (1) | DK1036794T3 (ko) |
ES (1) | ES2205574T3 (ko) |
HK (1) | HK1028769A1 (ko) |
HU (1) | HUP0004422A3 (ko) |
ID (1) | ID24929A (ko) |
IL (1) | IL135920A0 (ko) |
NO (1) | NO20002835L (ko) |
NZ (1) | NZ504457A (ko) |
PL (1) | PL191489B1 (ko) |
PT (1) | PT1036794E (ko) |
RU (1) | RU2223272C2 (ko) |
SK (1) | SK285703B6 (ko) |
TR (1) | TR200001600T2 (ko) |
TW (1) | TW502034B (ko) |
WO (1) | WO1999028320A1 (ko) |
ZA (1) | ZA9810490B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073306A1 (fr) * | 1999-05-31 | 2000-12-07 | Dainippon Pharmaceutical Co., Ltd. | Derives de 2-arylpurine-9-acetamide, leur procede de preparation, compositions medicinales les contenant et intermediaires des derives |
Families Citing this family (49)
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---|---|---|---|---|
GB9913932D0 (en) | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
KR20020028232A (ko) * | 1999-09-27 | 2002-04-16 | 우에노 도시오 | 피리미딘 유도체 화합물, 그 제조 방법 및 그 화합물을유효성분으로 하는 의약 |
HUP0303714A3 (en) * | 2000-07-31 | 2007-03-28 | Dainippon Sumitomo Pharma Co | Pharmaceutical compositions for dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient |
CN1894222A (zh) * | 2003-08-05 | 2007-01-10 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道抑制剂的稠合嘧啶化合物 |
CN1922141A (zh) * | 2004-02-23 | 2007-02-28 | 大日本住友制药株式会社 | 新的杂环化合物 |
US20080015196A1 (en) * | 2004-04-16 | 2008-01-17 | Neurogen Corporation | Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands |
FR2870239B1 (fr) * | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
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US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
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EP1991547A2 (en) * | 2006-03-09 | 2008-11-19 | Pharmacopeia, Inc. | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders |
US7915268B2 (en) * | 2006-10-04 | 2011-03-29 | Wyeth Llc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
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US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
JP2009007273A (ja) | 2007-06-27 | 2009-01-15 | Ajinomoto Co Inc | ジアミノピリミジン化合物の製造方法 |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
US8473571B2 (en) | 2009-01-08 | 2013-06-25 | Microsoft Corporation | Synchronizing presentation states between multiple applications |
WO2011030798A1 (ja) * | 2009-09-09 | 2011-03-17 | 大日本住友製薬株式会社 | 8-オキソジヒドロプリン誘導体 |
ES2751705T3 (es) | 2009-10-26 | 2020-04-01 | Signal Pharm Llc | Métodos de síntesis y purificación de compuestos heteroarilo |
JP2014076947A (ja) * | 2011-02-03 | 2014-05-01 | Dainippon Sumitomo Pharma Co Ltd | 2−オキシ置換8−オキソジヒドロプリン誘導体 |
WO2012168697A1 (en) | 2011-06-06 | 2012-12-13 | Imperial Innovations Limited | Methods to predict binding affinity of tspo imaging agents to tspo |
UA115319C2 (uk) | 2011-10-19 | 2017-10-25 | Сігнал Фармасьютікалз, Елелсі | Лікування злоякісної пухлини інгібітором тоr-кінази |
CA3125862A1 (en) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
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CN105339008A (zh) | 2013-04-17 | 2016-02-17 | 西格诺药品有限公司 | 用于治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯酰胺的组合疗法 |
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EA030808B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ |
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MX2015015880A (es) | 2013-05-29 | 2016-05-31 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il)piridin- 3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pi razin-2(1h)-ona, una forma solida del mismo y metodos de su uso. |
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MX2021001186A (es) | 2015-11-20 | 2022-10-11 | Forma Therapeutics Inc | Purinonas como inhibidores de proteasa especifica de ubiquitina 1. |
CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
JP7328977B2 (ja) | 2018-02-12 | 2023-08-17 | エフ. ホフマン-ラ ロシュ アーゲー | ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2525595A1 (fr) | 1982-04-27 | 1983-10-28 | Pharmuka Lab | Nouveaux derives d'arene et d'heteroarenecarboxamides et leur utilisation comme medicaments |
FR2582514B1 (fr) | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
DK273689A (da) | 1988-06-06 | 1989-12-07 | Sanofi Sa | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler |
FR2632639B1 (fr) | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
US5856481A (en) | 1994-07-28 | 1999-01-05 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
AU698419B2 (en) * | 1996-07-03 | 1998-10-29 | Dainippon Sumitomo Pharma Co., Ltd. | A novel purine derivative |
JP2002501493A (ja) * | 1997-04-22 | 2002-01-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Crfアンタゴニストのチオフェノピリジン類 |
JP3814125B2 (ja) * | 1999-06-02 | 2006-08-23 | 大日本住友製薬株式会社 | 2−アリール−8−オキソジヒドロプリン誘導体からなる医薬 |
-
1998
- 1998-11-17 ZA ZA9810490A patent/ZA9810490B/xx unknown
- 1998-11-25 TW TW087119571A patent/TW502034B/zh not_active IP Right Cessation
- 1998-11-26 RU RU2000117278/04A patent/RU2223272C2/ru not_active IP Right Cessation
- 1998-11-26 EP EP98955937A patent/EP1036794B1/en not_active Expired - Lifetime
- 1998-11-26 HU HU0004422A patent/HUP0004422A3/hu unknown
- 1998-11-26 US US09/555,490 patent/US6372740B1/en not_active Expired - Fee Related
- 1998-11-26 SK SK797-2000A patent/SK285703B6/sk unknown
- 1998-11-26 DK DK98955937T patent/DK1036794T3/da active
- 1998-11-26 PT PT98955937T patent/PT1036794E/pt unknown
- 1998-11-26 PL PL340925A patent/PL191489B1/pl unknown
- 1998-11-26 AT AT98955937T patent/ATE248169T1/de not_active IP Right Cessation
- 1998-11-26 TR TR2000/01600T patent/TR200001600T2/xx unknown
- 1998-11-26 NZ NZ504457A patent/NZ504457A/en unknown
- 1998-11-26 DE DE69817611T patent/DE69817611T2/de not_active Expired - Fee Related
- 1998-11-26 JP JP2000523212A patent/JP3815966B2/ja not_active Expired - Fee Related
- 1998-11-26 ES ES98955937T patent/ES2205574T3/es not_active Expired - Lifetime
- 1998-11-26 WO PCT/JP1998/005320 patent/WO1999028320A1/ja active IP Right Grant
- 1998-11-26 KR KR10-2000-7005968A patent/KR100494347B1/ko not_active IP Right Cessation
- 1998-11-26 CN CNB988134519A patent/CN1146566C/zh not_active Expired - Fee Related
- 1998-11-26 CA CA002312885A patent/CA2312885C/en not_active Expired - Fee Related
- 1998-11-26 AU AU12604/99A patent/AU744014B2/en not_active Ceased
- 1998-11-26 BR BR9815140-1A patent/BR9815140A/pt not_active Application Discontinuation
- 1998-11-26 ID IDW20000990A patent/ID24929A/id unknown
- 1998-11-26 IL IL13592098A patent/IL135920A0/xx not_active IP Right Cessation
- 1998-12-03 AR ARP980106147A patent/AR017796A1/es active IP Right Grant
-
2000
- 2000-06-02 NO NO20002835A patent/NO20002835L/no unknown
- 2000-12-15 HK HK00108107A patent/HK1028769A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073306A1 (fr) * | 1999-05-31 | 2000-12-07 | Dainippon Pharmaceutical Co., Ltd. | Derives de 2-arylpurine-9-acetamide, leur procede de preparation, compositions medicinales les contenant et intermediaires des derives |
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