ZA959679B - Acylated insulin analogs - Google Patents

Acylated insulin analogs

Info

Publication number
ZA959679B
ZA959679B ZA959679A ZA959679A ZA959679B ZA 959679 B ZA959679 B ZA 959679B ZA 959679 A ZA959679 A ZA 959679A ZA 959679 A ZA959679 A ZA 959679A ZA 959679 B ZA959679 B ZA 959679B
Authority
ZA
South Africa
Prior art keywords
insulin analogs
acylated insulin
acylated
analogs
insulin
Prior art date
Application number
ZA959679A
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Jose Michael Hanquier
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA959679B publication Critical patent/ZA959679B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA959679A 1994-11-17 1995-11-14 Acylated insulin analogs ZA959679B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/342,931 US5693609A (en) 1994-11-17 1994-11-17 Acylated insulin analogs

Publications (1)

Publication Number Publication Date
ZA959679B true ZA959679B (en) 1997-05-14

Family

ID=23343907

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA959679A ZA959679B (en) 1994-11-17 1995-11-14 Acylated insulin analogs

Country Status (25)

Country Link
US (2) US5693609A (no)
EP (1) EP0712861B1 (no)
JP (1) JPH10511644A (no)
KR (1) KR970706842A (no)
AR (1) AR002700A1 (no)
AT (1) ATE237635T1 (no)
AU (1) AU711282B2 (no)
BR (1) BR9509653A (no)
CA (1) CA2205060A1 (no)
CO (1) CO4520284A1 (no)
CZ (1) CZ145797A3 (no)
DE (1) DE69530353T2 (no)
ES (1) ES2194890T3 (no)
FI (1) FI972031A (no)
HU (1) HUT77030A (no)
IL (1) IL115973A (no)
NO (1) NO972169D0 (no)
NZ (1) NZ297257A (no)
PL (1) PL320644A1 (no)
RU (1) RU2160118C2 (no)
TR (1) TR199501420A2 (no)
TW (1) TW434259B (no)
WO (1) WO1996015804A1 (no)
YU (1) YU71395A (no)
ZA (1) ZA959679B (no)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0537524A1 (en) * 1991-10-17 1993-04-21 Shipley Company Inc. Radiation sensitive compositions and methods
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US20010041786A1 (en) * 1995-06-07 2001-11-15 Mark L. Brader Stabilized acylated insulin formulations
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
CA2252055C (en) * 1996-04-11 2007-01-16 The University Of British Columbia Fusogenic liposomes
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
JP3300368B2 (ja) * 1996-07-11 2002-07-08 ノボ ノルディスク アクティーゼルスカブ 選択的アシル化方法
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
EP2016950B1 (en) 1996-08-08 2011-01-05 Amylin Pharmaceuticals, Inc. Pharmaceutical composition comprising an exendin-4 peptide
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
AU1111799A (en) * 1997-10-24 1999-05-17 Eli Lilly And Company Fatty acid-acylated insulin analogs
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
US6159931A (en) * 1998-09-29 2000-12-12 The Ohio State University Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells
WO2000073793A2 (en) * 1999-05-27 2000-12-07 Cecil Yip Identification of compounds modulating insulin receptor activity
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
ES2343124T3 (es) * 1999-10-29 2010-07-23 Novartis Ag Composiciones de polvo seco con dispersabilidad mejorada.
WO2002051428A1 (fr) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Composition de parfum stimulant le systeme sympathique
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7905230B2 (en) * 2001-05-09 2011-03-15 Novartis Ag Metered dose inhaler with lockout
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
TW553752B (en) * 2001-06-20 2003-09-21 Inhale Therapeutic Syst Powder aerosolization apparatus and method
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
DK1436012T3 (en) * 2001-10-18 2018-01-22 Nektar Therapeutics Polymer Conjugates of Opioid Antagonists
WO2003057564A1 (en) * 2001-12-21 2003-07-17 Nektar Therapeutics Apparatus and method for sealing cavities
WO2003057593A1 (en) 2001-12-21 2003-07-17 Nektar Therapeutics Capsule package with moisture barrier
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US6941980B2 (en) * 2002-06-27 2005-09-13 Nektar Therapeutics Apparatus and method for filling a receptacle with powder
CA2503247A1 (en) * 2002-10-23 2004-05-06 Intronn, Inc. Screening methods for identification of efficient pre-trans-splicing molecules
US7516741B2 (en) * 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
JP4808970B2 (ja) 2002-12-30 2011-11-02 ネクター セラピューティクス 噴霧乾燥システム
US20050236296A1 (en) * 2002-12-30 2005-10-27 Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) Carry case for aerosolization apparatus
CN1744918A (zh) 2002-12-31 2006-03-08 尼克塔治疗亚拉巴马公司 含有酮或相关官能团的聚合物试剂
US7669596B2 (en) * 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
US8869794B1 (en) 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
PL1615689T3 (pl) * 2003-04-09 2016-06-30 Novartis Ag Urządzenie do aerozolizacji z prowadnicą wyrównującą do przebijania kapsułki
PT1610850E (pt) * 2003-04-09 2012-06-15 Novartis Ag Dispositivo para gerar um aerossol com protecção da entrada de ar
ES2725808T3 (es) 2003-05-23 2019-09-27 Nektar Therapeutics Derivados de PEG que contienen dos cadenas de PEG
SI1648933T1 (sl) * 2003-07-25 2010-01-29 Conjuchem Biotechnologies Inc Dolgo delujoäś inzulinski derivat in metoda zanj
US7744861B2 (en) 2003-09-17 2010-06-29 Nektar Therapeutics Multi-arm polymer prodrugs
WO2005044226A2 (en) * 2003-11-04 2005-05-19 Nectar Therapeutics Lipid formulations for spontaneous drug encapsulation
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
EP1687428A1 (en) * 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
AU2004297228A1 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
EA015333B1 (ru) 2003-12-16 2011-06-30 Нектар Терапьютикс Композиции, содержащие конъюгаты, способы их получения и применение
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
EP1701714A2 (en) * 2004-01-07 2006-09-20 Nektar Therapeutics Improved sustained release compositions for pulmonary administration of insulin
US8562965B2 (en) * 2004-05-03 2013-10-22 Nektar Therapeutics Polymer derivatives comprising an acetal or ketal branching point
US9085659B2 (en) * 2004-05-03 2015-07-21 Nektar Therapeutics Polymer derivatives comprising an imide branching point
ES2564167T3 (es) 2004-07-08 2016-03-18 Novo Nordisk A/S Conjugados de polipéptidos de acción prolongada que contienen una fracción tetrazol
PL1773878T3 (pl) 2004-07-19 2015-07-31 Biocon Ltd Koniugaty insulina-oligomer, ich formulacje i zastosowania
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP1846447B1 (en) 2005-02-02 2013-08-21 Novo Nordisk A/S Insulin derivatives
US20070083677A1 (en) * 2005-05-18 2007-04-12 Nektar Therapeutics Valves, devices, and methods for endobronchial therapy
JP5600240B2 (ja) * 2005-07-19 2014-10-01 ウェルズ ファーゴ バンク ナショナル アソシエイション 重合体マレイミド類を調製する方法
CA2615627C (en) * 2005-07-29 2014-10-21 Nektar Therapeutics Al, Corporation Methods for preparing polymeric reagents and compositions of polymeric reagents
ES2368500T3 (es) 2005-08-16 2011-11-17 Novo Nordisk A/S Método para producir polipéptidos de insulina maduros.
US20090032427A1 (en) * 2005-09-29 2009-02-05 Nektar Therapeutics Receptacles and Kits, Such as for Dry Powder Packaging
CN104586868A (zh) 2005-09-29 2015-05-06 尼克塔治疗公司 抗生素制剂、单位剂量、试剂盒以及方法
ATE519780T1 (de) 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
KR101728868B1 (ko) 2006-01-18 2017-05-02 포시 파마슈티컬스 컴퍼니 리미티드 안정성이 강화된 약학 조성물
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US8933021B2 (en) * 2006-05-09 2015-01-13 Novo Nordisk A/S Insulin derivative
DK2054073T3 (da) * 2006-07-11 2015-03-02 Foresee Pharmaceuticals Inc Farmaceutiske præparater til fremføring med langvarig frigivelse af peptider
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
EP2074141B1 (en) 2006-09-22 2016-08-10 Novo Nordisk A/S Protease resistant insulin analogues
JP5503968B2 (ja) 2006-09-27 2014-05-28 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
JP2010508069A (ja) * 2006-10-25 2010-03-18 ノバルティス アーゲー パウダー分散装置、その装置の製造方法および使用方法、その装置および他の装置に使用される構成要素
ES2538082T3 (es) 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Método de administración terapéutica de DHE para permitir el rápido alivio de migraña mientras que se minimiza el perfil de efectos secundarios
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
KR20100017667A (ko) * 2007-06-01 2010-02-16 노보 노르디스크 에이/에스 안정한 비-수성의 약학 조성물
EP2167032B1 (en) 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
JP5730569B2 (ja) 2007-08-15 2015-06-10 ノボ・ノルデイスク・エー／エス アシル及びアルキレングリコール部分を有するインスリンアナログ
KR101234540B1 (ko) 2007-10-16 2013-02-19 바이오콘 리미티드 경구 투여가능한 고형 약제학적 조성물 및 그 제조방법
AU2008317307A1 (en) * 2007-10-25 2009-04-30 Novartis Ag Powder conditioning of unit dose drug packages
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
ES2452935T3 (es) 2008-04-04 2014-04-03 Nektar Therapeutics Dispositivo de aerosolización
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
WO2010014258A2 (en) * 2008-08-01 2010-02-04 Nektar Therapeutics Al, Corporation Conjugates having a releasable linkage
JP5588983B2 (ja) 2008-08-11 2014-09-10 ウェルズ ファーゴ バンク ナショナル アソシエイション マルチアームポリマーアルカノエートコンジュゲート
US8354435B2 (en) 2008-09-08 2013-01-15 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
WO2010030366A2 (en) 2008-09-11 2010-03-18 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
JP5765813B2 (ja) * 2008-09-19 2015-08-19 ウェルズ ファーゴ バンク ナショナル アソシエイション 治療用ペプチドのポリマーコンジュゲート
CN102202669A (zh) 2008-10-28 2011-09-28 利兰·斯坦福青年大学托管委员会 醛脱氢酶调节剂及其使用方法
CN102202683A (zh) 2008-10-30 2011-09-28 诺沃-诺迪斯克有限公司 用少于每日一次的注射频率注射胰岛素来治疗糖尿病
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
AU2010208381A1 (en) 2009-01-28 2011-08-04 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
KR20110110253A (ko) 2009-01-28 2011-10-06 스마트쎌스, 인크. 결정질 인슐린-접합체
MX2011007929A (es) 2009-01-28 2011-08-17 Smartcells Inc Sistemas basados en conjugados para entrega farmacologica controlada.
EP2397152B1 (en) 2009-02-12 2014-05-28 Proyecto de Biomedicina Cima, S.L. Use of cardiotrophin- 1 for the treatment of metabolic diseases
AU2010226613B2 (en) 2009-03-18 2013-07-25 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
JP2012520879A (ja) 2009-03-20 2012-09-10 スマートセルズ・インコーポレイテツド 末端官能基化コンジュゲートおよびその用途
KR101740624B1 (ko) 2009-07-17 2017-05-26 넥타르 테라퓨틱스 네거티브하게 바이어싱된 밀봉된 분무기 시스템들 및 방법들
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
CN102905748B (zh) 2010-01-19 2016-03-23 内克塔医疗公司 识别干喷雾器元件
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
EP2598522A4 (en) 2010-07-28 2014-11-12 Smartcells Inc RECOMBINANT LECTINES, LECTINES WITH MODIFIED BINDING SITE AND USES THEREOF
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
US20140088021A1 (en) 2011-05-27 2014-03-27 Nektar Therapeutics Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
KR20140103939A (ko) 2011-12-16 2014-08-27 노파르티스 아게 흡입 프로파일-비의존적 약물 전달을 위한 에어로졸화 장치
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
EA033469B1 (ru) 2012-04-16 2019-10-31 Cantab Biopharmaceuticals Patents Ltd Подкожное введение конъюгатов факторов крови с полиэтиленгликолем
JP6735561B2 (ja) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
AR097893A1 (es) 2013-10-04 2016-04-20 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa
HUE036702T2 (hu) 2013-10-07 2018-07-30 Novo Nordisk As Inzulinanalóg új származéka
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2015196174A1 (en) 2014-06-20 2015-12-23 Greene Howard E Infusion delivery devices and methods
WO2017127420A1 (en) 2016-01-19 2017-07-27 Nektar Therapeutics Sealed liquid reservoir for a nebulizer
CN114847965A (zh) 2016-02-01 2022-08-05 英凯达治疗公司 电子监测联合吸入药理学疗法管理心律失常
CN115154591B (zh) 2016-12-16 2023-04-14 诺和诺德股份有限公司 含胰岛素的药物组合物
WO2018209107A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
TW201917134A (zh) 2017-08-17 2019-05-01 丹麥商諾佛 儂迪克股份有限公司 新穎的醯基化胰島素類似物及其用途
US11413352B2 (en) 2017-12-18 2022-08-16 Merck, Sharp & Dohme LLC Conjugate based systems for controlled insulin delivery
WO2019125878A1 (en) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
MX2021015096A (es) 2019-06-10 2022-03-22 Respira Therapeutics Inc Formulaciones a base de portadores y metodos relacionados.
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
CA3173417A1 (en) 2020-03-31 2021-10-07 Alborz Mahdavi Conjugates for selective responsiveness to vicinal diols
KR20230009499A (ko) * 2020-05-15 2023-01-17 일라이 릴리 앤드 캄파니 연장된 시간 작용 아실화된 인슐린 화합물
CA3198757A1 (en) 2020-11-19 2022-05-27 Protomer Technologies Inc. Aromatic boron-containing compounds and insulin analogs
WO2023225534A1 (en) 2022-05-18 2023-11-23 Protomer Technologies Inc. Aromatic boron-containing compounds and related insulin analogs

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3896437A (en) * 1973-10-11 1975-07-22 Sperry Rand Corp Apparatus for generating precise crossover frequency of two independent equal bandwidth spectra
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
WO1992001476A1 (en) * 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
RO112873B1 (ro) * 1993-09-17 1998-01-30 Novo Nordisk As Derivati de insulina
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
KR19980703039A (ko) * 1995-03-17 1998-09-05 켈스버그 라아스 인슐린 유도체

Also Published As

Publication number Publication date
HUT77030A (hu) 1998-03-02
FI972031A0 (fi) 1997-05-13
CO4520284A1 (es) 1997-10-15
BR9509653A (pt) 1997-09-16
AU711282B2 (en) 1999-10-07
US5693609A (en) 1997-12-02
RU2160118C2 (ru) 2000-12-10
DE69530353D1 (de) 2003-05-22
ATE237635T1 (de) 2003-05-15
DE69530353T2 (de) 2004-02-19
TW434259B (en) 2001-05-16
TR199501420A2 (tr) 1996-06-21
US5922675A (en) 1999-07-13
CZ145797A3 (en) 1997-12-17
EP0712861B1 (en) 2003-04-16
MX9703508A (es) 1997-07-31
NO972169L (no) 1997-05-12
CA2205060A1 (en) 1996-05-30
EP0712861A3 (en) 1998-03-11
ES2194890T3 (es) 2003-12-01
FI972031A (fi) 1997-05-14
KR970706842A (ko) 1997-12-01
NO972169D0 (no) 1997-05-12
NZ297257A (en) 1999-05-28
AU4237396A (en) 1996-06-17
WO1996015804A1 (en) 1996-05-30
IL115973A0 (en) 1996-01-31
PL320644A1 (en) 1997-10-13
AR002700A1 (es) 1998-04-29
IL115973A (en) 2001-08-26
EP0712861A2 (en) 1996-05-22
JPH10511644A (ja) 1998-11-10
YU71395A (sh) 1998-07-10

Similar Documents

Publication Publication Date Title
IL115973A0 (en) Acylated insulin analogs
GB9419536D0 (en) Medicaments
AU3236895A (en) Aspb1 insulin analogs
AU128844S (en) Ampoule
GB9406573D0 (en) Medicaments
ZA939477B (en) Insulin analogs
ZA959517B (en) Leutherobin and analogs thereof
EP0689052A3 (en) Standard insulin solution
GB9513967D0 (en) Insulin
GB9418530D0 (en) Medicaments
GB9411052D0 (en) Medicaments
GB9416365D0 (en) Medicaments
ZA947187B (en) Acylated insulin
EP0790829A4 (en) DRUG
IL120356A0 (en) Hydantocidin analogs
GB9400159D0 (en) Medicament solution
ZA945617B (en) Syringes
GB9416710D0 (en) Syringes
GB9418563D0 (en) Syringes
GB9408693D0 (en) Medicament
GB9419954D0 (en) Medicament
GB9420703D0 (en) Medicament
GB9403442D0 (en) Syringe
GB9306628D0 (en) Constructional units-projectional spacing
HU9401934D0 (en) Anti-freele solution