DE69530353D1 - Acylierte Insulinanalogen - Google Patents

Acylierte Insulinanalogen

Info

Publication number
DE69530353D1
DE69530353D1 DE69530353T DE69530353T DE69530353D1 DE 69530353 D1 DE69530353 D1 DE 69530353D1 DE 69530353 T DE69530353 T DE 69530353T DE 69530353 T DE69530353 T DE 69530353T DE 69530353 D1 DE69530353 D1 DE 69530353D1
Authority
DE
Germany
Prior art keywords
insulin analogs
acylated insulin
acylated
analogs
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530353T
Other languages
English (en)
Other versions
DE69530353T2 (de
Inventor
Jeffrey Clayton Baker
Jose Michael Hanquier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69530353D1 publication Critical patent/DE69530353D1/de
Publication of DE69530353T2 publication Critical patent/DE69530353T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DE69530353T 1994-11-17 1995-11-14 Acylierte Insulinanalogen Expired - Fee Related DE69530353T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US342931 1994-11-17
US08/342,931 US5693609A (en) 1994-11-17 1994-11-17 Acylated insulin analogs

Publications (2)

Publication Number Publication Date
DE69530353D1 true DE69530353D1 (de) 2003-05-22
DE69530353T2 DE69530353T2 (de) 2004-02-19

Family

ID=23343907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530353T Expired - Fee Related DE69530353T2 (de) 1994-11-17 1995-11-14 Acylierte Insulinanalogen

Country Status (25)

Country Link
US (2) US5693609A (de)
EP (1) EP0712861B1 (de)
JP (1) JPH10511644A (de)
KR (1) KR970706842A (de)
AR (1) AR002700A1 (de)
AT (1) ATE237635T1 (de)
AU (1) AU711282B2 (de)
BR (1) BR9509653A (de)
CA (1) CA2205060A1 (de)
CO (1) CO4520284A1 (de)
CZ (1) CZ145797A3 (de)
DE (1) DE69530353T2 (de)
ES (1) ES2194890T3 (de)
FI (1) FI972031A (de)
HU (1) HUT77030A (de)
IL (1) IL115973A (de)
NO (1) NO972169D0 (de)
NZ (1) NZ297257A (de)
PL (1) PL320644A1 (de)
RU (1) RU2160118C2 (de)
TR (1) TR199501420A2 (de)
TW (1) TW434259B (de)
WO (1) WO1996015804A1 (de)
YU (1) YU71395A (de)
ZA (1) ZA959679B (de)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0537524A1 (de) * 1991-10-17 1993-04-21 Shipley Company Inc. Strahlungsempfindliche Zusammensetzungen und Verfahren
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US20010041786A1 (en) * 1995-06-07 2001-11-15 Mark L. Brader Stabilized acylated insulin formulations
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
EP0910576B1 (de) * 1996-04-11 2004-08-11 University Of British Columbia Fusogene liposomen
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
DE69731105T2 (de) * 1996-07-11 2005-11-17 Novo Nordisk A/S Verfahren zur selektiven acetylierung
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
DE69739172D1 (de) 1996-08-08 2009-01-29 Amylin Pharmaceuticals Inc Regulation gastrointestinaler beweglichkeit
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
CA2306877A1 (en) * 1997-10-24 1999-05-06 Eli Lilly And Company Insoluble insulin compositions
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
US6159931A (en) * 1998-09-29 2000-12-12 The Ohio State University Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells
WO2000073793A2 (en) * 1999-05-27 2000-12-07 Cecil Yip Identification of compounds modulating insulin receptor activity
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
DE60044070D1 (de) * 1999-10-29 2010-05-06 Novartis Ag Trockenpulverzusammensetzungen mit verbesserter Dispersität
KR20030005204A (ko) * 2000-12-25 2003-01-17 가부시키가이샤 시세이도 교감신경 활성화 향료 조성물
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7905230B2 (en) * 2001-05-09 2011-03-15 Novartis Ag Metered dose inhaler with lockout
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
WO2003000326A1 (en) * 2001-06-20 2003-01-03 Nektar Therapeutics Powder aerosolization apparatus and method
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
WO2003032990A2 (en) * 2001-10-18 2003-04-24 Nektar Therapeutics Al, Corporation Polymer conjugates of opioid antagonists
US8777011B2 (en) * 2001-12-21 2014-07-15 Novartis Ag Capsule package with moisture barrier
EP1472140A1 (de) * 2001-12-21 2004-11-03 Nektar Therapeutics Verfahren und vorrichtung zum versiegeln von hohlräumen
ES2360182T3 (es) * 2002-05-07 2011-06-01 Novo Nordisk A/S Formulaciones solubles que comprenden insulina monomérica e insulina acilada.
US6941980B2 (en) * 2002-06-27 2005-09-13 Nektar Therapeutics Apparatus and method for filling a receptacle with powder
WO2004038380A2 (en) * 2002-10-23 2004-05-06 Intronn, Inc. Screening methods for identification of efficient pre-trans-splicing molecules
US7516741B2 (en) * 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050236296A1 (en) * 2002-12-30 2005-10-27 Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) Carry case for aerosolization apparatus
MXPA05007154A (es) 2002-12-30 2005-09-21 Nektar Therapeutics Atomizador prepeliculizacion.
AU2003303519C1 (en) 2002-12-31 2010-08-12 Nektar Therapeutics Polymeric reagents comprising a ketone or a related functional group
US7669596B2 (en) * 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
HUE026950T2 (en) 2003-04-09 2016-08-29 Novartis Ag Nozzle with guide wire for puncturing the capsule
US7559325B2 (en) * 2003-04-09 2009-07-14 Novartis Pharma Ag Aerosolization apparatus with air inlet shield
US8869794B1 (en) 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
EP1626741A2 (de) 2003-05-23 2006-02-22 Nektar Therapeutics Al, Corporation Peg-derivative mit einer amidocarbonat-bindung
ES2328579T3 (es) * 2003-07-25 2009-11-16 Conjuchem Biotechnologies Inc. Derivados de insulina de larga duracion y procedimientos asociados.
PL1675622T3 (pl) 2003-09-17 2017-11-30 Nektar Therapeutics Proleki na bazie wieloramiennego polimeru
WO2005044226A2 (en) * 2003-11-04 2005-05-19 Nectar Therapeutics Lipid formulations for spontaneous drug encapsulation
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
JP2007532096A (ja) * 2003-11-14 2007-11-15 ノボ ノルディスク アクティーゼルスカブ アシル化されたインスリンの製造方法
US7790835B2 (en) * 2003-12-03 2010-09-07 Nektar Therapeutics Method of preparing maleimide functionalized polymers
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
CN102895666B (zh) 2003-12-16 2015-08-19 尼克塔治疗公司 化学改性的小分子
EP1701714A2 (de) * 2004-01-07 2006-09-20 Nektar Therapeutics Verbesserte zusammensetzungen mit verzögerter freisetzung für die pulmonale verabreichung von insulin
WO2005108463A2 (en) 2004-05-03 2005-11-17 Nektar Therapeutics Al, Corporation Branched polyethylen glycol derivates comprising an acetal or ketal branching point
WO2005107815A2 (en) * 2004-05-03 2005-11-17 Nektar Therapeutics Al, Corporation Polymer derivatives comprising an imide branching point
KR20070029247A (ko) 2004-07-08 2007-03-13 노보 노르디스크 에이/에스 폴리펩티드 연장 태그
AU2005269753B2 (en) 2004-07-19 2011-08-18 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
MX2007001589A (es) * 2004-08-09 2007-08-02 Alios Biopharma Inc Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas.
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP2292653B1 (de) 2005-02-02 2014-05-21 Novo Nordisk A/S Neuartige Insulinderivate
AU2006287934B2 (en) * 2005-05-18 2012-12-13 Nektar Therapeutics Valves, devices, and methods for endobronchial therapy
AU2006269845B2 (en) * 2005-07-19 2012-03-22 Nektar Therapeutics Method for preparing polymer maleimides
PT1922350E (pt) * 2005-07-29 2015-03-09 Nektar Therapeutics Métodos para preparação de reagentes poliméricos
US9056921B2 (en) 2005-08-16 2015-06-16 Novo Nordisk A/S Method for making mature insulin polypeptides
CA2623256A1 (en) * 2005-09-29 2007-04-12 Nektar Therapeutics Receptacles and kits, such as for dry powder packaging
EP1928410A2 (de) 2005-09-29 2008-06-11 Nektar Therapeutics Antibiotische formulierungen, einheitsdosen, kits und verfahren
JP4808785B2 (ja) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー/エス インスリン組成物および組成物の製造方法
SI1984009T1 (sl) * 2006-01-18 2013-02-28 Qps, Llc Farmacevtski sestavki z izboljĺ ano stabilnostjo
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
ES2548393T3 (es) 2006-05-09 2015-10-16 Novo Nordisk A/S Derivado de insulina
MX2009000434A (es) * 2006-07-11 2009-01-29 Qps Llc Composiciones farmaceuticas para la distribucion de liberacion sostenida de peptidos.
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
KR101729986B1 (ko) 2006-09-22 2017-04-25 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
JP5503968B2 (ja) 2006-09-27 2014-05-28 ノボ・ノルデイスク・エー/エス 成熟インスリンポリペプチドの作製方法
JP2010508069A (ja) * 2006-10-25 2010-03-18 ノバルティス アーゲー パウダー分散装置、その装置の製造方法および使用方法、その装置および他の装置に使用される構成要素
PL2425820T3 (pl) 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2164458A1 (de) * 2007-06-01 2010-03-24 Novo Nordisk A/S Stabile nichtwässrige pharmazeutische zusammensetzungen
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
KR20100053561A (ko) 2007-08-15 2010-05-20 노보 노르디스크 에이/에스 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
MX2010003979A (es) 2007-10-16 2010-06-02 Biocon Ltd Composicion farmaceutica oralmente administrable y proceso para su preparacion.
BRPI0818818A2 (pt) * 2007-10-25 2015-04-22 Novartis Ag Condicionamento de pó
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910569B1 (de) 2008-03-18 2016-10-05 Novo Nordisk A/S Proteasestabilisierte, acylierte Insulinanaloga
WO2010008424A2 (en) 2008-04-04 2010-01-21 Novartis Ag Aerosolization device
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
WO2010014258A2 (en) * 2008-08-01 2010-02-04 Nektar Therapeutics Al, Corporation Conjugates having a releasable linkage
CA2732508C (en) 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
JP2012502048A (ja) 2008-09-08 2012-01-26 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法
WO2010030366A2 (en) 2008-09-11 2010-03-18 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
CA2737040C (en) 2008-09-19 2017-05-02 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US8389522B2 (en) 2008-10-28 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase and methods of use thereof
US9603904B2 (en) 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
BRPI1007466A2 (pt) 2009-01-28 2018-06-12 Smartcells Inc conjugado de insulina cristalina, formulação de liberação prolongada, e, sistema de distribuição de bomba
EA027757B1 (ru) 2009-01-28 2017-08-31 Смартселлз, Инк. Конъюгат для контролируемой доставки инсулина
JP2012516340A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 合成コンジュゲートおよびその使用
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
CN102316892B (zh) 2009-02-12 2014-06-04 西马生物医学计划公司 心肌营养素-1用于治疗代谢病的用途
EP3552602A1 (de) 2009-03-18 2019-10-16 Incarda Therapeutics, Inc. Einheitsdosen, aerosole, kits und verfahren zur behandlung von herzleiden mittels pulmonaler verabreichung
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
EP2408808A4 (de) 2009-03-20 2015-05-06 Smartcells Inc Terminal-funktionalisierte konjugate und ihre verwendung
JP5841052B2 (ja) 2009-07-17 2016-01-06 ウェルズ ファーゴ バンク ナショナル アソシエイション 負圧により付勢され、且つシールされた噴霧器システムおよび方法
BR112012012945A2 (pt) 2009-11-25 2020-12-29 Arisgen Sa Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo
IN2012DN06298A (de) 2010-01-19 2015-09-25 Nektar Therapeutics
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
JP2013542915A (ja) 2010-07-28 2013-11-28 スマートセルズ・インコーポレイテツド 薬物−リガンドコンジュゲート、その合成およびその中間体
CA2806399A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
AU2012351947B2 (en) 2011-12-16 2017-08-17 Novartis Ag Aerosolization apparatus for inhalation profile-independent drug delivery
EP2836508B1 (de) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulinformulierungen
EP2838566A2 (de) 2012-04-16 2015-02-25 Cantab Biopharmaceuticals Patents Limited Optimierter subkutane therapeutika
WO2014088836A1 (en) 2012-12-03 2014-06-12 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
CN105358531B (zh) 2013-03-14 2017-11-14 利兰-斯坦福大学初级学院的董事会 线粒体醛脱氢酶‑2调节剂和其使用方法
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
TW201605470A (zh) 2013-10-04 2016-02-16 默沙東藥廠 葡萄糖反應性胰島素結合物
MX366636B (es) 2013-10-07 2019-07-17 Novo Nordisk As Nuevo derivado de un análogo de insulina.
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
US9656017B2 (en) 2014-06-20 2017-05-23 Howard E. Greene Infusion delivery devices and methods
WO2017127420A1 (en) 2016-01-19 2017-07-27 Nektar Therapeutics Sealed liquid reservoir for a nebulizer
US10010294B2 (en) 2016-02-01 2018-07-03 Incarda Therapeutics, Inc. Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
RU2758367C2 (ru) 2016-12-16 2021-10-28 Ново Нордиск А/С Фармацевтические композиции, содержащие инсулин
CA3060702A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
MA49896A (fr) 2017-08-17 2020-06-24 Novo Nordisk As Nouveaux analogues d'insuline acylés et leurs utilisations
US11820805B2 (en) 2017-12-18 2023-11-21 Merck Sharp & Dohme Llc Conjugate based systems for controlled insulin delivery
WO2019125879A2 (en) 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN114206322A (zh) 2019-06-10 2022-03-18 瑞必治公司 载体基制剂及相关方法
US11020384B2 (en) 2019-08-01 2021-06-01 Incarda Therapeutics, Inc. Antiarrhythmic formulation
BR112022019687A2 (pt) 2020-03-31 2022-12-20 Protomer Tech Inc Conjugados para responsividade seletiva a dióis vicinais
KR20230009499A (ko) * 2020-05-15 2023-01-17 일라이 릴리 앤드 캄파니 연장된 시간 작용 아실화된 인슐린 화합물
WO2022109078A1 (en) 2020-11-19 2022-05-27 Protomer Technologies Inc. Aromatic boron-containing compounds and insulin analogs
WO2023225534A1 (en) 2022-05-18 2023-11-23 Protomer Technologies Inc. Aromatic boron-containing compounds and related insulin analogs

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3896437A (en) * 1973-10-11 1975-07-22 Sperry Rand Corp Apparatus for generating precise crossover frequency of two independent equal bandwidth spectra
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
AU8091091A (en) * 1990-07-26 1992-02-18 University Of Iowa Research Foundation, The Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
WO1996029344A1 (en) * 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives

Also Published As

Publication number Publication date
CZ145797A3 (en) 1997-12-17
JPH10511644A (ja) 1998-11-10
US5922675A (en) 1999-07-13
RU2160118C2 (ru) 2000-12-10
EP0712861A2 (de) 1996-05-22
MX9703508A (es) 1997-07-31
FI972031A (fi) 1997-05-14
IL115973A (en) 2001-08-26
NO972169L (no) 1997-05-12
FI972031A0 (fi) 1997-05-13
KR970706842A (ko) 1997-12-01
ES2194890T3 (es) 2003-12-01
DE69530353T2 (de) 2004-02-19
TR199501420A2 (tr) 1996-06-21
NO972169D0 (no) 1997-05-12
WO1996015804A1 (en) 1996-05-30
US5693609A (en) 1997-12-02
CA2205060A1 (en) 1996-05-30
EP0712861B1 (de) 2003-04-16
AU4237396A (en) 1996-06-17
AR002700A1 (es) 1998-04-29
YU71395A (sh) 1998-07-10
IL115973A0 (en) 1996-01-31
BR9509653A (pt) 1997-09-16
NZ297257A (en) 1999-05-28
ATE237635T1 (de) 2003-05-15
TW434259B (en) 2001-05-16
HUT77030A (hu) 1998-03-02
EP0712861A3 (de) 1998-03-11
ZA959679B (en) 1997-05-14
PL320644A1 (en) 1997-10-13
AU711282B2 (en) 1999-10-07
CO4520284A1 (es) 1997-10-15

Similar Documents

Publication Publication Date Title
DE69530353D1 (de) Acylierte Insulinanalogen
NO964106D0 (no) Spröyte
FR04C0020I2 (fr) Insuline acylee
FI952931A0 (fi) Insuliinianalogiformulaatioita
NO2001027I1 (no) Telitromycin
FI971279A (fi) Lääkkeitä
BR9508339A (pt) Medicamento
DE69522857T2 (de) Insulinstandardlösung
DE9317847U1 (de) Kanüle
IT230757Y1 (it) Cannula per fleboipodermoclisi
IT230756Y1 (it) Cannula per fleboipodermoclisi
KR950022733U (ko) 세척기
KR960016384U (ko) 주사기
KR950026744U (ko) 주사기
SE9402131D0 (sv) Läkemedel
NO944330D0 (no) Legemiddel
SE9401674L (sv) Läkemedel
FI1583U1 (fi) Faestanordning foer ett fordon
FI1373U1 (fi) Laoskonstruktion foer ett skjutvapen
FI1471U1 (fi) Stoedanordning foer ett fordons passagerar saete
SE9303326D0 (sv) Kanyl II
DE9407403U1 (de) Kopfbedeckung
FI943002A0 (fi) Hjaelpanordning foer ett sekretunderlag
FI945005A0 (fi) Ett El-drag
FI944450A0 (fi) Handbroms foer ett fordon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee