MX9703508A - Analogos de insulina acilados. - Google Patents
Analogos de insulina acilados.Info
- Publication number
- MX9703508A MX9703508A MX9703508A MX9703508A MX9703508A MX 9703508 A MX9703508 A MX 9703508A MX 9703508 A MX9703508 A MX 9703508A MX 9703508 A MX9703508 A MX 9703508A MX 9703508 A MX9703508 A MX 9703508A
- Authority
- MX
- Mexico
- Prior art keywords
- chain
- insulin analogs
- acylated insulin
- acylated
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere al campo de la diabetes. Más particularmente, la invencion se refiere a un análogo de insulina monomérico en donde la cadena A es la secuencia que ocurre naturalmente de la cadena A de insulina de humano y la cadena B se modifica ya sea en la posicion B28 y B29 o ambas. El análogo es monoacilado en la N-terminacion de la cadena A o la cadena B o en la lisina. Los análogos de insulina acilados tienen una duracion extendida de accion.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/342,931 US5693609A (en) | 1994-11-17 | 1994-11-17 | Acylated insulin analogs |
| US08342931 | 1994-11-17 | ||
| PCT/US1995/014873 WO1996015804A1 (en) | 1994-11-17 | 1995-11-14 | Acylated insulin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9703508A true MX9703508A (es) | 1997-07-31 |
| MXPA97003508A MXPA97003508A (es) | 1997-12-01 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| IL115973A (en) | 2001-08-26 |
| TW434259B (en) | 2001-05-16 |
| JPH10511644A (ja) | 1998-11-10 |
| ZA959679B (en) | 1997-05-14 |
| ES2194890T3 (es) | 2003-12-01 |
| TR199501420A2 (tr) | 1996-06-21 |
| FI972031A0 (fi) | 1997-05-13 |
| BR9509653A (pt) | 1997-09-16 |
| CA2205060A1 (en) | 1996-05-30 |
| EP0712861A2 (en) | 1996-05-22 |
| CO4520284A1 (es) | 1997-10-15 |
| US5693609A (en) | 1997-12-02 |
| NO972169L (no) | 1997-05-12 |
| IL115973A0 (en) | 1996-01-31 |
| ATE237635T1 (de) | 2003-05-15 |
| WO1996015804A1 (en) | 1996-05-30 |
| AU711282B2 (en) | 1999-10-07 |
| HUT77030A (hu) | 1998-03-02 |
| YU71395A (sh) | 1998-07-10 |
| DE69530353T2 (de) | 2004-02-19 |
| FI972031A (fi) | 1997-05-14 |
| AU4237396A (en) | 1996-06-17 |
| CZ145797A3 (en) | 1997-12-17 |
| NO972169D0 (no) | 1997-05-12 |
| US5922675A (en) | 1999-07-13 |
| DE69530353D1 (de) | 2003-05-22 |
| PL320644A1 (en) | 1997-10-13 |
| AR002700A1 (es) | 1998-04-29 |
| NZ297257A (en) | 1999-05-28 |
| KR970706842A (ko) | 1997-12-01 |
| EP0712861A3 (en) | 1998-03-11 |
| RU2160118C2 (ru) | 2000-12-10 |
| EP0712861B1 (en) | 2003-04-16 |
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