HUP0100391A2 - Monomer inzulinanalógokat tartalmazó gyógyászati készítmény és alkalmazása - Google Patents

Monomer inzulinanalógokat tartalmazó gyógyászati készítmény és alkalmazása

Info

Publication number
HUP0100391A2
HUP0100391A2 HU0100391A HUP0100391A HUP0100391A2 HU P0100391 A2 HUP0100391 A2 HU P0100391A2 HU 0100391 A HU0100391 A HU 0100391A HU P0100391 A HUP0100391 A HU P0100391A HU P0100391 A2 HUP0100391 A2 HU P0100391A2
Authority
HU
Hungary
Prior art keywords
monomeric insulin
pharmaceutical composition
composition containing
insulin analogs
use pharmaceutical
Prior art date
Application number
HU0100391A
Other languages
English (en)
Inventor
Richard Dennis Dimarchi
Roger Garrick Harrison
Ronald Keith Wolff
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0100391A2 publication Critical patent/HUP0100391A2/hu
Publication of HUP0100391A3 publication Critical patent/HUP0100391A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Abstract

A találmány tárgya monomer inzulinanalógot tartalmazóinhalációs készítmény az inhalációval beadott monomer inzulinanalógcukorbetegség és/vagy hiperglikémia kezelésében való alkalmazásáravonatkozik. Ó
HU0100391A 1998-01-08 1999-01-07 Monomeric insulin analogs and their use pharmaceutical composition containing HUP0100391A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7075298P 1998-01-08 1998-01-08
PCT/US1999/000324 WO1999034816A1 (en) 1998-01-08 1999-01-07 Method for administering monomeric insulin analogs

Publications (2)

Publication Number Publication Date
HUP0100391A2 true HUP0100391A2 (hu) 2001-08-28
HUP0100391A3 HUP0100391A3 (en) 2001-12-28

Family

ID=22097181

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0101293A HUP0101293A3 (en) 1998-01-08 1999-01-07 Aspb28-human insulin comprising pharmaceutical composition administered by inhalation and their use
HU0100391A HUP0100391A3 (en) 1998-01-08 1999-01-07 Monomeric insulin analogs and their use pharmaceutical composition containing

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0101293A HUP0101293A3 (en) 1998-01-08 1999-01-07 Aspb28-human insulin comprising pharmaceutical composition administered by inhalation and their use

Country Status (16)

Country Link
US (2) US20010007853A1 (hu)
EP (2) EP0951910A3 (hu)
JP (2) JP2002500193A (hu)
KR (2) KR20010033940A (hu)
CN (2) CN1287492A (hu)
AU (2) AU747619B2 (hu)
BR (2) BR9906796A (hu)
CA (2) CA2317733A1 (hu)
EA (2) EA200000747A1 (hu)
HU (2) HUP0101293A3 (hu)
IL (2) IL137105A0 (hu)
NO (2) NO20003051D0 (hu)
PL (2) PL341592A1 (hu)
TR (2) TR200001891T2 (hu)
WO (2) WO1999034816A1 (hu)
ZA (2) ZA99105B (hu)

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US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
WO2001000674A1 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Insulin crystals for pulmonary administration
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
DE60138641D1 (de) 2000-10-27 2009-06-18 Baxter Healthcare Sa Herstellung von mikrokügelchen
ATE395042T1 (de) * 2001-08-16 2008-05-15 Baxter Int Darreichungsformen welche mikropartikel und treibgas enthalten
EP1944016A1 (en) 2001-08-16 2008-07-16 Baxter International Inc. Propellant-based microparticle formulatons
CA2466525C (en) * 2001-12-07 2011-05-17 Eiffel Technologies Limited Synthesis of small particles
AU2002359730A1 (en) * 2001-12-21 2003-07-30 Smithkline Beecham Corporation Compositions and methods for altering glucose production
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
WO2004002395A2 (en) * 2002-06-27 2004-01-08 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders
WO2005041848A2 (en) 2003-10-27 2005-05-12 Oriel Therapeutics, Inc. Dry powder drug containment system packages with tabs, inhalers and associated methods
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
WO2005065756A2 (en) 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Dry powder nebulizers and associated methods of dispensing dry powders
US7624733B2 (en) 2004-02-09 2009-12-01 Oriel Therapeutics, Inc. Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
US8365725B2 (en) * 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
EP1934805A4 (en) * 2005-08-25 2017-01-11 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
EP1986722B1 (en) 2006-01-31 2018-10-24 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths for microcartridges with dry powder
EP2060268A1 (en) * 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
ES2550309T3 (es) 2008-09-26 2015-11-06 Oriel Therapeutics, Inc. Mecanismos inhaladores con perforadores predispuestos radialmente y métodos relacionados
WO2010036839A2 (en) 2008-09-26 2010-04-01 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods
CN102159269B (zh) 2008-09-26 2014-05-07 奥里尔治疗公司 一种带有双穿刺元件的干燥粉末吸入器以及相关装置和方法
WO2010039201A2 (en) * 2008-09-30 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods
US8991391B2 (en) * 2008-09-30 2015-03-31 Oriel Therapeutics, Inc. Dry powder inhalers with endless strips and cooperating piercers and related methods
MX2011003245A (es) * 2008-10-01 2011-04-26 Oriel Therapeutics Inc Inhaladores de polvo seco con mecanismos de perforacion giratorios y dispositivos y metodos relacionados.
JP5341532B2 (ja) * 2009-01-19 2013-11-13 第一電子工業株式会社 １対の誤嵌合防止キー及び該キーを用いた電気コネクタ
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
CA2786996A1 (en) 2010-01-27 2011-07-07 Dan Adler Dry powder inhaler
USD635246S1 (en) 2010-03-26 2011-03-29 Oriel Therapeutics, Inc. Dose disk for dry powder inhalers
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
US11491288B2 (en) 2014-01-08 2022-11-08 Seroton, Inc. Dispenser for dry-powder inhalation devices
US10238820B2 (en) 2014-01-08 2019-03-26 Seroton, Inc. Dry-powder inhalation device

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK179286D0 (da) * 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
WO1995000550A1 (en) * 1993-06-21 1995-01-05 Novo Nordisk A/S Aspb28 insulin crystals
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5451569A (en) * 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
EP0741188A3 (en) * 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity

Also Published As

Publication number Publication date
CN1195543C (zh) 2005-04-06
JP2002500193A (ja) 2002-01-08
AU2107399A (en) 1999-07-26
IL137150A0 (en) 2001-07-24
JP2002500192A (ja) 2002-01-08
HUP0100391A3 (en) 2001-12-28
CN1287492A (zh) 2001-03-14
PL342745A1 (en) 2001-07-02
ZA99105B (en) 2000-07-07
AU2312299A (en) 1999-07-26
BR9906796A (pt) 2000-11-14
NO20003050D0 (no) 2000-06-14
CN1287491A (zh) 2001-03-14
ZA99104B (en) 2000-07-07
EA200000747A1 (ru) 2000-12-25
PL341592A1 (en) 2001-04-23
BR9906813A (pt) 2001-03-20
AU747619B2 (en) 2002-05-16
NO20003050L (no) 2000-06-14
KR20010033941A (ko) 2001-04-25
WO1999034816A1 (en) 1999-07-15
HUP0101293A2 (hu) 2001-08-28
WO1999034815A1 (en) 1999-07-15
NO20003051L (no) 2000-06-14
TR200001891T2 (tr) 2000-11-21
TR200001892T2 (tr) 2000-11-21
AU754707B2 (en) 2002-11-21
CA2317733A1 (en) 1999-07-15
HUP0101293A3 (en) 2001-12-28
KR20010033940A (ko) 2001-04-25
EP0951911A2 (en) 1999-10-27
IL137105A0 (en) 2001-06-14
CA2317739A1 (en) 1999-07-15
EA200000748A1 (ru) 2000-12-25
EP0951911A3 (en) 2002-06-19
NO20003051D0 (no) 2000-06-14
US20010007853A1 (en) 2001-07-12
US20010053761A1 (en) 2001-12-20
EP0951910A3 (en) 2002-06-19
EP0951910A2 (en) 1999-10-27

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