HUP0002373A2 - Glükagon antagonisták/inverz agonisták és ezeket tartalmazó gyógyászati készítmények - Google Patents

Glükagon antagonisták/inverz agonisták és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0002373A2
HUP0002373A2 HU0002373A HUP0002373A HUP0002373A2 HU P0002373 A2 HUP0002373 A2 HU P0002373A2 HU 0002373 A HU0002373 A HU 0002373A HU P0002373 A HUP0002373 A HU P0002373A HU P0002373 A2 HUP0002373 A2 HU P0002373A2
Authority
HU
Hungary
Prior art keywords
compounds
inverse agonists
glucagon antagonists
general formula
type
Prior art date
Application number
HU0002373A
Other languages
English (en)
Inventor
Jun Feng
Javier Gonzales
Vlad Gregor
Yufeng Hong
Michael David Johnson
Dan Kiel
Lotte Bjerre Knudsen
Atsuo Kuki
Jesper Lau
Anthony Ling
Peter Madsen
Lars Naerum
Michael Bruno Plewe
Christian Sams
Shenghua Shi
Ulla Grove Sidelmann
Min Teng
Kimberly Ann Teston
Original Assignee
Agouron Pharmaceuticals Inc.
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals Inc., Novo Nordisk A/S filed Critical Agouron Pharmaceuticals Inc.
Publication of HUP0002373A2 publication Critical patent/HUP0002373A2/hu
Publication of HUP0002373A3 publication Critical patent/HUP0002373A3/hu

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
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    • C07C2601/14—The ring being saturated

Abstract

A találmány tárgyát az (I) általános képletű vegyületek, valamintezeket tartalmazó gyógyászati készítmények képezik. Ezen vegyületek ésgyógyászati készítmények eredményesen alkalmazhatók az 1-es vagy 2-estípusú diabetes, valamint hiperglikémia kezelésére, és adhatókemlősöknél a vércukorszint csökkentésére. Az (I) általános képletűvegyületekhez tartoznak ezek optikai vagy geometriai izomerjei vagytautomer alakjai, ideértve ezek elegyeit is, továbbá a vegyületekgyógyászatilag megfelelő sói. Ó
HU0002373A 1997-07-01 1998-07-01 Glucagon antagonists/inverse agonists HUP0002373A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88678597A 1997-07-01 1997-07-01
US3251698A 1998-02-27 1998-02-27
PCT/DK1998/000287 WO1999001423A1 (en) 1997-07-01 1998-06-30 Glucagon antagonists/inverse agonists

Publications (2)

Publication Number Publication Date
HUP0002373A2 true HUP0002373A2 (hu) 2000-10-28
HUP0002373A3 HUP0002373A3 (en) 2000-11-28

Family

ID=26708528

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002373A HUP0002373A3 (en) 1997-07-01 1998-07-01 Glucagon antagonists/inverse agonists

Country Status (11)

Country Link
EP (1) EP0994848A1 (hu)
JP (1) JP2003514508A (hu)
KR (1) KR20010020590A (hu)
CN (1) CN1267281A (hu)
AU (1) AU749271B2 (hu)
BR (1) BR9810378A (hu)
HU (1) HUP0002373A3 (hu)
IL (1) IL133377A0 (hu)
NO (1) NO996550L (hu)
PL (1) PL337781A1 (hu)
WO (1) WO1999001423A1 (hu)

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