EA200000748A1 - Способ введения мономерных аналогов инсулина - Google Patents

Способ введения мономерных аналогов инсулина

Info

Publication number
EA200000748A1
EA200000748A1 EA200000748A EA200000748A EA200000748A1 EA 200000748 A1 EA200000748 A1 EA 200000748A1 EA 200000748 A EA200000748 A EA 200000748A EA 200000748 A EA200000748 A EA 200000748A EA 200000748 A1 EA200000748 A1 EA 200000748A1
Authority
EA
Eurasian Patent Office
Prior art keywords
monomerial
introduction
insulin analogues
inhalation
administering
Prior art date
Application number
EA200000748A
Other languages
English (en)
Inventor
Ричард Деннис Димарчи
Роджер Гэррик Харрисон
Рональд Кейт Вольфф
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200000748A1 publication Critical patent/EA200000748A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Abstract

(57) Заявленное изобретение относится к способу введения аналога инсулина с помощью ингаляции, способу лечения диабета путем введения аналога инсулина с помощью ингаляции и способу лечения гипергликемии путем введения аналога инсулина с помощью ингаляции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000748A 1998-01-08 1999-01-07 Способ введения мономерных аналогов инсулина EA200000748A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7075298P 1998-01-08 1998-01-08
PCT/US1999/000324 WO1999034816A1 (en) 1998-01-08 1999-01-07 Method for administering monomeric insulin analogs

Publications (1)

Publication Number Publication Date
EA200000748A1 true EA200000748A1 (ru) 2000-12-25

Family

ID=22097181

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200000747A EA200000747A1 (ru) 1998-01-08 1999-01-07 СПОСОБ ВВЕДЕНИЯ AspB28-ИНСУЛИНА ЧЕЛОВЕКА
EA200000748A EA200000748A1 (ru) 1998-01-08 1999-01-07 Способ введения мономерных аналогов инсулина

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200000747A EA200000747A1 (ru) 1998-01-08 1999-01-07 СПОСОБ ВВЕДЕНИЯ AspB28-ИНСУЛИНА ЧЕЛОВЕКА

Country Status (16)

Country Link
US (2) US20010053761A1 (ru)
EP (2) EP0951911A3 (ru)
JP (2) JP2002500192A (ru)
KR (2) KR20010033941A (ru)
CN (2) CN1195543C (ru)
AU (2) AU754707B2 (ru)
BR (2) BR9906813A (ru)
CA (2) CA2317733A1 (ru)
EA (2) EA200000747A1 (ru)
HU (2) HUP0100391A3 (ru)
IL (2) IL137105A0 (ru)
NO (2) NO20003050D0 (ru)
PL (2) PL341592A1 (ru)
TR (2) TR200001892T2 (ru)
WO (2) WO1999034815A1 (ru)
ZA (2) ZA99105B (ru)

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US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
AU5453300A (en) * 1999-06-29 2001-01-31 Eli Lilly And Company Insulin crystals for pulmonary administration
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
DE60138641D1 (de) 2000-10-27 2009-06-18 Baxter Healthcare Sa Herstellung von mikrokügelchen
ES2307779T3 (es) * 2001-08-16 2008-12-01 Baxter International Inc. Formulaciones de microparticulas a base de propelentes.
EP1944016A1 (en) 2001-08-16 2008-07-16 Baxter International Inc. Propellant-based microparticle formulatons
WO2003047553A1 (en) * 2001-12-07 2003-06-12 Eiffel Technologies Limited Synthesis of small particles
JP2005539208A (ja) * 2001-12-21 2005-12-22 スミスクライン ビーチャム コーポレーション グルコース産生を変化させるための組成物および方法
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
SI1535349T1 (sl) * 2002-06-27 2014-10-30 Oriel Therapeutics, Inc. Naprave, sistemi in ustrezni postopki za predelavo, izdajo in/ali vrednotenje nefarmacevtskih suhih praškov
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
WO2005044173A1 (en) 2003-10-27 2005-05-19 Oriel Therapeutics, Inc. Blister packages and associated methods of fabricating dry powder drug containment systems
WO2005065756A2 (en) 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Dry powder nebulizers and associated methods of dispensing dry powders
US7624733B2 (en) 2004-02-09 2009-12-01 Oriel Therapeutics, Inc. Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
US8365725B2 (en) * 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
WO2007024953A1 (en) * 2005-08-25 2007-03-01 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
AU2007210177C1 (en) 2006-01-31 2012-11-01 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
EP2060268A1 (en) * 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
CA2732842C (en) 2008-09-26 2018-01-09 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods
EP2346554B1 (en) * 2008-09-26 2015-09-16 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
CN102159269B (zh) * 2008-09-26 2014-05-07 奥里尔治疗公司 一种带有双穿刺元件的干燥粉末吸入器以及相关装置和方法
WO2010039201A2 (en) * 2008-09-30 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods
US8991391B2 (en) * 2008-09-30 2015-03-31 Oriel Therapeutics, Inc. Dry powder inhalers with endless strips and cooperating piercers and related methods
US8646446B2 (en) * 2008-10-01 2014-02-11 Oriel Therapeutics, Inc. Dry powder inhalers with rotating piercing mechanisms and related devices and methods
JP5341532B2 (ja) * 2009-01-19 2013-11-13 第一電子工業株式会社 １対の誤嵌合防止キー及び該キーを用いた電気コネクタ
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
WO2011080747A2 (en) 2010-01-27 2011-07-07 Aespira Ltd. Dry powder inhaler
USD635246S1 (en) 2010-03-26 2011-03-29 Oriel Therapeutics, Inc. Dose disk for dry powder inhalers
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
US10238820B2 (en) 2014-01-08 2019-03-26 Seroton, Inc. Dry-powder inhalation device
US11491288B2 (en) 2014-01-08 2022-11-08 Seroton, Inc. Dispenser for dry-powder inhalation devices

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DK179286D0 (da) * 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
ES2130428T3 (es) * 1993-06-21 1999-07-01 Novo Nordisk As Cristales de insulina asp-b28.
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5451569A (en) * 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
IL118127A0 (en) * 1995-05-05 1996-09-12 Lilly Co Eli Single chain insulin with high bioactivity

Also Published As

Publication number Publication date
BR9906813A (pt) 2001-03-20
EA200000747A1 (ru) 2000-12-25
PL342745A1 (en) 2001-07-02
JP2002500193A (ja) 2002-01-08
EP0951911A3 (en) 2002-06-19
US20010007853A1 (en) 2001-07-12
WO1999034815A1 (en) 1999-07-15
US20010053761A1 (en) 2001-12-20
NO20003050L (no) 2000-06-14
CA2317739A1 (en) 1999-07-15
AU747619B2 (en) 2002-05-16
PL341592A1 (en) 2001-04-23
BR9906796A (pt) 2000-11-14
JP2002500192A (ja) 2002-01-08
TR200001892T2 (tr) 2000-11-21
NO20003050D0 (no) 2000-06-14
AU754707B2 (en) 2002-11-21
NO20003051L (no) 2000-06-14
HUP0100391A2 (hu) 2001-08-28
KR20010033941A (ko) 2001-04-25
CA2317733A1 (en) 1999-07-15
HUP0100391A3 (en) 2001-12-28
WO1999034816A1 (en) 1999-07-15
AU2107399A (en) 1999-07-26
ZA99105B (en) 2000-07-07
HUP0101293A2 (hu) 2001-08-28
EP0951910A3 (en) 2002-06-19
CN1287492A (zh) 2001-03-14
EP0951910A2 (en) 1999-10-27
CN1287491A (zh) 2001-03-14
IL137105A0 (en) 2001-06-14
HUP0101293A3 (en) 2001-12-28
ZA99104B (en) 2000-07-07
AU2312299A (en) 1999-07-26
NO20003051D0 (no) 2000-06-14
EP0951911A2 (en) 1999-10-27
CN1195543C (zh) 2005-04-06
IL137150A0 (en) 2001-07-24
KR20010033940A (ko) 2001-04-25
TR200001891T2 (tr) 2000-11-21

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