FR2730637B1
(fr)
|
1995-02-17 |
1997-03-28 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
|
CA2222328C
(en)
*
|
1995-06-07 |
2012-01-10 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
FR2739292B1
(fr)
*
|
1995-09-28 |
1997-10-31 |
Rhone Poulenc Rorer Sa |
Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
|
GB2324534B
(en)
*
|
1996-01-06 |
2000-05-10 |
Danbiosyst Uk |
Composition for delivery of nucleic acid to a cell
|
EP0934082B1
(de)
*
|
1996-10-23 |
2002-07-17 |
SKW Trostberg Aktiengesellschaft |
Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten
|
ES2392246T3
(es)
*
|
1996-11-12 |
2012-12-07 |
The Regents Of The University Of California |
Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo
|
US6884430B1
(en)
*
|
1997-02-10 |
2005-04-26 |
Aventis Pharma S.A. |
Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
|
ATE466948T1
(de)
*
|
1997-03-11 |
2010-05-15 |
Univ Minnesota |
Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle
|
US5912225A
(en)
|
1997-04-14 |
1999-06-15 |
Johns Hopkins Univ. School Of Medicine |
Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
|
US6524613B1
(en)
|
1997-04-30 |
2003-02-25 |
Regents Of The University Of Minnesota |
Hepatocellular chimeraplasty
|
DE19726186A1
(de)
*
|
1997-06-20 |
1998-12-24 |
Boehringer Ingelheim Int |
Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
|
US20020022034A1
(en)
*
|
1997-09-15 |
2002-02-21 |
Julianna Lisziewicz |
Therapeutic DNA vaccination
|
BR9813202B1
(pt)
*
|
1997-09-15 |
2011-11-01 |
|
complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes.
|
DE19743135A1
(de)
|
1997-09-30 |
1999-04-01 |
Hoechst Marion Roussel De Gmbh |
Biologisch verträgliche niedermolekular Polyethylenimine
|
WO1999065531A1
(en)
*
|
1998-06-18 |
1999-12-23 |
Johns Hopkins University School Of Medicine |
Polymers for delivery of nucleic acids
|
US6916490B1
(en)
|
1998-07-23 |
2005-07-12 |
UAB Research Center |
Controlled release of bioactive substances
|
US6562371B1
(en)
*
|
1998-11-02 |
2003-05-13 |
Terumo Kabushiki Kaisha |
Liposomes
|
US7160682B2
(en)
*
|
1998-11-13 |
2007-01-09 |
Regents Of The University Of Minnesota |
Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell
|
AU770090B2
(en)
*
|
1999-04-02 |
2004-02-12 |
Research Development Foundation |
Polyethyleneimine:dna formulations for aerosol delivery
|
US6770740B1
(en)
|
1999-07-13 |
2004-08-03 |
The Regents Of The University Of Michigan |
Crosslinked DNA condensate compositions and gene delivery methods
|
FR2797402B1
(fr)
|
1999-07-15 |
2004-03-12 |
Biomerieux Stelhys |
Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune
|
DE19960206A1
(de)
*
|
1999-12-14 |
2001-07-19 |
Frank Czubayko |
Komplexierung von RNS mit Polyethyleniminen zur deren Stabilisierung und zellulären Einschleusung
|
WO2001047563A1
(en)
|
1999-12-28 |
2001-07-05 |
Transgene S.A. |
Use of lithium (li+) for the preparation of a composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy
|
AU3366901A
(en)
*
|
1999-12-30 |
2001-07-16 |
Novartis Ag |
Novel colloid synthetic vectors for gene therapy
|
FR2805271B1
(fr)
*
|
2000-02-18 |
2002-04-26 |
Aventis Pharma Sa |
Procede de preparation de polyalkylenimines fonctionnalises, compositions les contenant et leurs utilisations
|
JP2004508364A
(ja)
*
|
2000-09-05 |
2004-03-18 |
ジヤンセル・エス・アー |
酸感受性化合物、該化合物の製造および使用
|
FR2813605B1
(fr)
*
|
2000-09-05 |
2002-10-18 |
Aventis Pharma Sa |
Composes acidosensibles, leur preparation et utilisations
|
FR2814370B1
(fr)
*
|
2000-09-22 |
2004-08-20 |
Centre Nat Rech Scient |
Utilisation d'un complexe acide nucleique/pei pour le ciblage de cellules souches du cerveau
|
DE10145134A1
(de)
*
|
2000-10-09 |
2002-05-16 |
Bayer Ag |
Komplexe zur Einführung von Nukleinsäuren in Zellen
|
AU2001289943A1
(en)
*
|
2000-10-09 |
2002-04-22 |
Bayer Aktiengesellschaft |
Complexes for transferring nucleic acids into cells
|
US20020091242A1
(en)
|
2000-10-11 |
2002-07-11 |
Michel Bessodes |
Acid-sensitive compounds, their preparation and uses
|
JP2004537501A
(ja)
*
|
2001-02-01 |
2004-12-16 |
ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム |
肺への遺伝子送達のための安定化ポリマーエアロゾル
|
US6652886B2
(en)
|
2001-02-16 |
2003-11-25 |
Expression Genetics |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
|
WO2002100435A1
(en)
*
|
2001-06-11 |
2002-12-19 |
Centre Hospitalier Universitaire De Montreal |
Compositions and methods for enhancing nucleic acid transfer into cells
|
ATE447967T1
(de)
|
2001-09-14 |
2009-11-15 |
Cytos Biotechnology Ag |
Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
|
EP1448586A4
(de)
*
|
2001-11-02 |
2006-03-01 |
Intradigm Corp |
Therapeutische verfahren für vehikel zur verabreichung von nukleinsäure
|
WO2003060411A1
(en)
|
2002-01-17 |
2003-07-24 |
York Refrigeration Aps |
Submerged evaporator with integrated heat exchanger
|
WO2003089618A2
(en)
*
|
2002-04-22 |
2003-10-30 |
Regents Of The University Of Minnesota |
Transposon system and methods of use
|
US7220400B2
(en)
|
2002-05-24 |
2007-05-22 |
Mirus Bio Corporation |
Compositions for delivering nucleic acids to cells
|
DE60334618D1
(de)
|
2002-06-28 |
2010-12-02 |
Protiva Biotherapeutics Inc |
Verfahren und vorrichtung zur herstellung von liposomen
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
BR0314236A
(pt)
*
|
2002-09-13 |
2005-08-09 |
Replicor Inc |
Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos
|
DK1816461T3
(da)
|
2002-10-16 |
2020-04-14 |
Streck Laboratories Inc |
Fremgangsmåde og indretning til indsamling og sikring af celler til brug for analyse
|
US7153905B2
(en)
*
|
2003-03-21 |
2006-12-26 |
The General Hospital Corporation |
Hyperbranched dendron and methods of synthesis and use thereof
|
US20050064595A1
(en)
|
2003-07-16 |
2005-03-24 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering RNA
|
AU2004272646B2
(en)
|
2003-09-15 |
2011-11-24 |
Arbutus Biopharma Corporation |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
JP2007527240A
(ja)
*
|
2004-03-01 |
2007-09-27 |
マサチューセッツ インスティテュート オブ テクノロジー |
アレルギー性鼻炎および喘息のためのRNAiベースの治療
|
US20050215507A1
(en)
*
|
2004-03-04 |
2005-09-29 |
Massachusetts Institute Of Technology |
Therapeutic anti-cancer DNA
|
US20060026699A1
(en)
*
|
2004-06-04 |
2006-02-02 |
Largaespada David A |
Methods and compositions for identification of genomic sequences
|
ATE536418T1
(de)
|
2004-06-07 |
2011-12-15 |
Protiva Biotherapeutics Inc |
Lipidverkapselte interferenz-rna
|
AU2005251403B2
(en)
|
2004-06-07 |
2011-09-01 |
Arbutus Biopharma Corporation |
Cationic lipids and methods of use
|
WO2006002538A1
(en)
|
2004-07-02 |
2006-01-12 |
Protiva Biotherapeutics, Inc. |
Immunostimulatory sirna molecules and uses therefor
|
EP2395012B8
(de)
|
2005-11-02 |
2018-06-06 |
Arbutus Biopharma Corporation |
Modifizierte siRNA-Moleküle und Verwendungen davon
|
US7915399B2
(en)
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
US20080312174A1
(en)
*
|
2007-06-05 |
2008-12-18 |
Nitto Denko Corporation |
Water soluble crosslinked polymers
|
JP2010539245A
(ja)
*
|
2007-09-14 |
2010-12-16 |
日東電工株式会社 |
薬物担体
|
EP2047858A1
(de)
|
2007-10-10 |
2009-04-15 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Kombinationsprodukte zur Krebsbehandlung
|
DE102008023913A1
(de)
|
2008-05-16 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Beeinflussung des angeborenen Immunsystems
|
DE102008016275A1
(de)
|
2008-03-28 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
DE102007056488A1
(de)
|
2007-11-22 |
2009-07-23 |
Biontex Laboratories Gmbh |
Steigerung von Transfektionseffizienzen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
WO2009065618A2
(de)
|
2007-11-22 |
2009-05-28 |
Biontex Laboratories Gmbh |
Verbesserung von transfektionsergebnissen nicht-viraler genliefersysteme durch beeinflussung des angeborenen immunsystems
|
GB0724253D0
(en)
|
2007-12-12 |
2008-01-30 |
Fermentas Uab |
Transfection reagent
|
JP5697988B2
(ja)
|
2007-12-27 |
2015-04-08 |
プロチバ バイオセラピューティクス インコーポレイティッド |
干渉rnaを使用したポロ様キナーゼ発現のサイレンシング方法
|
US7687027B2
(en)
*
|
2008-02-27 |
2010-03-30 |
Becton, Dickinson And Company |
Cleaning compositions, methods and materials for reducing nucleic acid contamination
|
FR2928373B1
(fr)
|
2008-03-05 |
2010-12-31 |
Centre Nat Rech Scient |
Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
|
US8058069B2
(en)
|
2008-04-15 |
2011-11-15 |
Protiva Biotherapeutics, Inc. |
Lipid formulations for nucleic acid delivery
|
JP2011516094A
(ja)
|
2008-04-15 |
2011-05-26 |
プロチバ バイオセラピューティクス インコーポレイティッド |
干渉rnaを用いたcsn5遺伝子発現のサイレンシング方法
|
EP2631297B1
(de)
*
|
2008-05-15 |
2017-04-12 |
National Research Council Of Canada |
Verfahren, Vektoren und manipulierte Zelllinien für Transfektion in grossem Massstab
|
CN104119242B
(zh)
|
2008-10-09 |
2017-07-07 |
泰米拉制药公司 |
改善的氨基脂质和递送核酸的方法
|
US20100167271A1
(en)
*
|
2008-12-30 |
2010-07-01 |
Streck, Inc. |
Method for screening blood using a preservative that may be in a substantially solid state form
|
US11634747B2
(en)
*
|
2009-01-21 |
2023-04-25 |
Streck Llc |
Preservation of fetal nucleic acids in maternal plasma
|
DE102009006606A1
(de)
|
2009-01-29 |
2010-08-05 |
Philipps-Universität Marburg |
Nicht-virales Transfektionsmittel
|
US8304187B2
(en)
|
2009-02-18 |
2012-11-06 |
Streck, Inc. |
Preservation of cell-free RNA in blood samples
|
EP2623117A1
(de)
|
2009-04-30 |
2013-08-07 |
Genetic Immunity Kft. |
Immunogene Nanomedizinzusammensetzung sowie ihre Herstellung und Verwendung
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
ES2613498T3
(es)
|
2009-07-01 |
2017-05-24 |
Protiva Biotherapeutics Inc. |
Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
GB0917792D0
(en)
|
2009-10-12 |
2009-11-25 |
Fermentas Uab |
Delivery agent
|
US9856456B2
(en)
|
2009-10-12 |
2018-01-02 |
Thermo Fisher Scientific Baltics Uab |
Delivery agent
|
US20130079382A1
(en)
|
2009-10-12 |
2013-03-28 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
EP2499259B1
(de)
|
2009-11-09 |
2016-04-06 |
Streck Inc. |
Stabilisierung von rna in und extraktion aus intakten zellen in einer blutprobe
|
US9247720B2
(en)
|
2010-03-24 |
2016-02-02 |
Institut National de la Santé et de la Recherche Médicale |
Primate model from the family cercopithecidae infected by a HBV strain of human genotype
|
US8945927B2
(en)
|
2010-03-29 |
2015-02-03 |
Universite De Strasbourg |
Polymers for delivering molecules of interest
|
AU2011268146A1
(en)
|
2010-06-17 |
2013-01-10 |
Actogenix Nv |
Compositions and methods for treating inflammatory conditions
|
EP3689381A1
(de)
|
2010-06-22 |
2020-08-05 |
Onxeo |
Optimiertes in-vivo-abgabesystem mit endosomolytischen wirkstoffen für nukleinsäurekonjugate
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
US9956281B2
(en)
|
2011-05-04 |
2018-05-01 |
Streck, Inc. |
Inactivated virus compositions and methods of preparing such compositions
|
US20140234373A1
(en)
|
2011-09-16 |
2014-08-21 |
Georfia Regents University |
Methods of Promoting Immune Tolerance
|
AU2012340086A1
(en)
|
2011-11-17 |
2014-05-29 |
The Regents Of The University Of California |
Therapeutic RNA switches compositions and methods of use
|
CN109097398A
(zh)
|
2011-11-24 |
2018-12-28 |
吉尼松公司 |
与工业制药应用相容的可放大的慢病毒载体生产系统
|
US9035039B2
(en)
|
2011-12-22 |
2015-05-19 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing SMAD4
|
KR20150020288A
(ko)
*
|
2012-06-08 |
2015-02-25 |
에트리스 게엠베하 |
메신저 rna의 폐전달
|
CN103059295B
(zh)
*
|
2012-09-26 |
2016-01-13 |
上海交通大学 |
疏水修饰的聚乙烯亚胺及其作为蛋白质载体的用途
|
HUE059435T2
(hu)
|
2012-10-05 |
2022-11-28 |
Biontech Delivery Tech Gmbh |
Hidroxilált poliamin-származékok mint transzfekciós reagensek
|
CN104703629B
(zh)
|
2012-10-08 |
2020-12-01 |
生物技术传送科技有限责任公司 |
作为转染试剂的羧化多胺衍生物
|
DE102012111891A1
(de)
*
|
2012-12-06 |
2014-06-12 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Verbesserung der Zielfindungskapazität von Stammzellen
|
CA2917912C
(en)
|
2013-07-24 |
2019-09-17 |
Streck, Inc. |
Compositions and methods for stabilizing circulating tumor cells
|
WO2015073727A1
(en)
|
2013-11-13 |
2015-05-21 |
Aequus Biopharma, Inc. |
Engineered glycoproteins and uses thereof
|
CR20170174A
(es)
|
2014-10-02 |
2017-11-07 |
Protiva Biotherapeutics Inc |
Composiciones y métodos para el silenciamiento de la expresión cénica del virus de la hepatitis b
|
EP3034539A1
(de)
*
|
2014-12-19 |
2016-06-22 |
Ethris GmbH |
Zusammensetzungen zur Einführung von Nukleinsäure in Zellen
|
US11168351B2
(en)
|
2015-03-05 |
2021-11-09 |
Streck, Inc. |
Stabilization of nucleic acids in urine
|
EP3291799A1
(de)
|
2015-05-05 |
2018-03-14 |
Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. |
Kationische nukleinsäurepolymerzusammensetzungen und verfahren zur herstellung und verwendung davon
|
WO2016197132A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics Inc. |
Treating hepatitis b virus infection using crispr
|
EP3329003A2
(de)
|
2015-07-29 |
2018-06-06 |
Arbutus Biopharma Corporation |
Zusammensetzungen und verfahren zur ausschaltung einer hepatitis-b-virus-genexpression
|
US20170145475A1
(en)
|
2015-11-20 |
2017-05-25 |
Streck, Inc. |
Single spin process for blood plasma separation and plasma composition including preservative
|
US10010627B2
(en)
|
2016-06-03 |
2018-07-03 |
International Business Machines Corporation |
Modified polycationic polymers
|
WO2018022991A1
(en)
|
2016-07-29 |
2018-02-01 |
Streck, Inc. |
Suspension composition for hematology analysis control
|
WO2018093932A2
(en)
|
2016-11-16 |
2018-05-24 |
Immunomic Therapeutics, Inc. |
Nucleic acids for treatment of allergies
|
EP3570814B1
(de)
|
2017-01-19 |
2023-11-29 |
Universiteit Gent |
Modulare adjuvanzien zur verbesserten verabreichung von wirkstoffen
|
CN110799529A
(zh)
|
2017-04-22 |
2020-02-14 |
免疫治疗有限公司 |
改良lamp构建物
|
IL297073B2
(en)
|
2017-05-02 |
2023-12-01 |
Immunomic Therapeutics Inc |
LAMP constructs containing cancer antigens
|
JP2021523185A
(ja)
|
2018-05-15 |
2021-09-02 |
イミュノミック セラピューティックス, インコーポレイテッドImmunomic Therapeutics, Inc. |
アレルゲンを含む改善されたlamp構築物
|
TW202043256A
(zh)
|
2019-01-10 |
2020-12-01 |
美商健生生物科技公司 |
前列腺新抗原及其用途
|
WO2021077051A1
(en)
|
2019-10-18 |
2021-04-22 |
Immunomic Therapeutics, Inc |
Improved lamp constructs comprising cancer antigens
|
EP4061405A1
(de)
|
2019-11-18 |
2022-09-28 |
Janssen Biotech, Inc. |
Impfstoffe auf der basis von mutantem calr und jak2 und deren verwendungen
|
US20230024133A1
(en)
|
2020-07-06 |
2023-01-26 |
Janssen Biotech, Inc. |
Prostate Neoantigens And Their Uses
|
US20230029453A1
(en)
|
2020-07-06 |
2023-02-02 |
Janssen Biotech, Inc. |
Prostate Neoantigens And Their Uses
|
WO2022009051A1
(en)
|
2020-07-06 |
2022-01-13 |
Janssen Biotech, Inc. |
A method for determining responsiveness to prostate cancer treatment
|
CN112237633B
(zh)
*
|
2020-10-22 |
2023-06-27 |
林君玉 |
一种pei/on复合物及其制备方法和用途
|
WO2022115645A1
(en)
|
2020-11-25 |
2022-06-02 |
Akagera Medicines, Inc. |
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|
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|
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