ZA821637B - Oxazaphosphorin-4-thio-alkanesulfonic acids, neutral salts thereof, processes for the production thereof and pharmaceutical preparations containing them - Google Patents
Oxazaphosphorin-4-thio-alkanesulfonic acids, neutral salts thereof, processes for the production thereof and pharmaceutical preparations containing themInfo
- Publication number
- ZA821637B ZA821637B ZA821637A ZA821637A ZA821637B ZA 821637 B ZA821637 B ZA 821637B ZA 821637 A ZA821637 A ZA 821637A ZA 821637 A ZA821637 A ZA 821637A ZA 821637 B ZA821637 B ZA 821637B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxazaphosphorin
- thio
- processes
- production
- pharmaceutical preparations
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813111428 DE3111428A1 (de) | 1981-03-24 | 1981-03-24 | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA821637B true ZA821637B (en) | 1983-02-23 |
Family
ID=6128090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA821637A ZA821637B (en) | 1981-03-24 | 1982-03-11 | Oxazaphosphorin-4-thio-alkanesulfonic acids, neutral salts thereof, processes for the production thereof and pharmaceutical preparations containing them |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US4623742A (fi) |
| JP (1) | JPS57169496A (fi) |
| AT (1) | AT381317B (fi) |
| AU (1) | AU544493B2 (fi) |
| BE (1) | BE892589A (fi) |
| BG (1) | BG38489A3 (fi) |
| CA (1) | CA1194479A (fi) |
| CH (1) | CH648852A5 (fi) |
| DD (1) | DD201799A5 (fi) |
| DE (1) | DE3111428A1 (fi) |
| DK (1) | DK171843B1 (fi) |
| EG (1) | EG15703A (fi) |
| ES (1) | ES8303440A1 (fi) |
| FI (1) | FI69849C (fi) |
| FR (1) | FR2502626B1 (fi) |
| GB (1) | GB2095256B (fi) |
| GR (1) | GR75533B (fi) |
| HU (1) | HU186915B (fi) |
| IE (1) | IE53054B1 (fi) |
| IL (1) | IL65255A (fi) |
| IT (1) | IT1150499B (fi) |
| LU (1) | LU84032A1 (fi) |
| NL (1) | NL192741C (fi) |
| NO (1) | NO163692C (fi) |
| PL (1) | PL129426B1 (fi) |
| PT (1) | PT74641B (fi) |
| RO (1) | RO84661B (fi) |
| SE (1) | SE452159B (fi) |
| SU (1) | SU1318167A3 (fi) |
| YU (1) | YU61582A (fi) |
| ZA (1) | ZA821637B (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3279834D1 (en) * | 1981-12-31 | 1989-08-31 | Asta Pharma Ag | 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression |
| DE3569737D1 (en) * | 1984-03-01 | 1989-06-01 | Asta Pharma Ag | Salts of oxazaphosphorine derivatives |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| DE3415726A1 (de) * | 1984-04-27 | 1985-10-31 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten |
| FR2567129B1 (fr) * | 1984-07-06 | 1986-12-05 | Adir | Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US5204335A (en) * | 1986-10-31 | 1993-04-20 | Asta Pharma Aktiengesellschaft | Ifosfamide lyophilisate and process for its preparation |
| ATE65402T1 (de) * | 1988-03-19 | 1991-08-15 | Asta Pharma Ag | Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung. |
| US5190929A (en) * | 1988-05-25 | 1993-03-02 | Research Corporation Technologies, Inc. | Cyclophosphamide analogs useful as anti-tumor agents |
| RO113611B1 (ro) * | 1990-08-03 | 1998-09-30 | Asta Pharma Ag | Preparate solide de ifosfamida, administrate oral si procedeu de obtinere |
| US5661188A (en) * | 1995-06-07 | 1997-08-26 | Medical Research Foundation and Infrastructure Development for Health Services--Nahariya Hospital Branch | Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna) |
| US20080223826A1 (en) * | 2007-03-13 | 2008-09-18 | Stephen Mazur | Reagent Delivery using a Membrane-Mediated Process |
| FR2968662B1 (fr) | 2010-12-10 | 2013-11-22 | Roussy Inst Gustave | Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2107936C3 (de) * | 1971-02-19 | 1978-06-08 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | Alkylsulfonsäureester von 2-Oxo-13,2-oxazaphosphorinanen und diese enthaltende pharmazeutische Präparate |
| DE1645921C3 (de) * | 1966-07-11 | 1978-10-12 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DE2201675A1 (de) * | 1972-01-14 | 1973-07-19 | Asta Werke Ag Chem Fab | Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate |
| JPS5159886A (fi) * | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| JPS54157580A (en) | 1978-05-29 | 1979-12-12 | Otsuka Pharmaceut Co Ltd | Optically active oxazaphosphorine derivative |
| JPS5826919B2 (ja) | 1978-11-07 | 1983-06-06 | 大塚製薬株式会社 | シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法 |
| JPS55154984A (en) * | 1979-05-24 | 1980-12-02 | Shionogi & Co Ltd | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
| DE3220672A1 (de) | 1981-03-24 | 1983-12-08 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3111428A1 (de) | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3220432A1 (de) | 1981-03-24 | 1983-12-01 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
-
1981
- 1981-03-24 DE DE19813111428 patent/DE3111428A1/de active Granted
-
1982
- 1982-03-08 CH CH1390/82A patent/CH648852A5/de not_active IP Right Cessation
- 1982-03-09 IE IE531/82A patent/IE53054B1/en unknown
- 1982-03-11 ZA ZA821637A patent/ZA821637B/xx unknown
- 1982-03-12 GB GB8207375A patent/GB2095256B/en not_active Expired
- 1982-03-12 AU AU81344/82A patent/AU544493B2/en not_active Ceased
- 1982-03-15 IL IL65255A patent/IL65255A/xx unknown
- 1982-03-17 AT AT0106382A patent/AT381317B/de not_active IP Right Cessation
- 1982-03-17 GR GR67621A patent/GR75533B/el unknown
- 1982-03-22 RO RO106989A patent/RO84661B/ro unknown
- 1982-03-22 SE SE8201807A patent/SE452159B/sv not_active IP Right Cessation
- 1982-03-22 YU YU00615/82A patent/YU61582A/xx unknown
- 1982-03-22 FR FR8204823A patent/FR2502626B1/fr not_active Expired
- 1982-03-23 DD DD82238374A patent/DD201799A5/de unknown
- 1982-03-23 BE BE2/59642A patent/BE892589A/fr not_active IP Right Cessation
- 1982-03-23 NO NO820957A patent/NO163692C/no not_active IP Right Cessation
- 1982-03-23 JP JP57044779A patent/JPS57169496A/ja active Granted
- 1982-03-23 DK DK129882A patent/DK171843B1/da not_active IP Right Cessation
- 1982-03-23 ES ES510677A patent/ES8303440A1/es not_active Expired
- 1982-03-23 HU HU82879A patent/HU186915B/hu unknown
- 1982-03-23 SU SU823414100A patent/SU1318167A3/ru active
- 1982-03-23 IT IT20351/82A patent/IT1150499B/it active
- 1982-03-23 CA CA000399098A patent/CA1194479A/en not_active Expired
- 1982-03-23 EG EG82156A patent/EG15703A/xx active
- 1982-03-23 FI FI821021A patent/FI69849C/fi not_active IP Right Cessation
- 1982-03-23 PT PT74641A patent/PT74641B/pt unknown
- 1982-03-24 BG BG8255941A patent/BG38489A3/xx unknown
- 1982-03-24 LU LU84032A patent/LU84032A1/de unknown
- 1982-03-24 NL NL8201227A patent/NL192741C/nl not_active IP Right Cessation
- 1982-08-24 PL PL1982235606A patent/PL129426B1/pl unknown
-
1984
- 1984-12-19 US US06/683,374 patent/US4623742A/en not_active Expired - Lifetime
-
1988
- 1988-02-02 US US07/149,954 patent/US4929607A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3269625D1 (en) | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use | |
| KE3545A (en) | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids,processes for their preparation and medicaments containing these compounds | |
| DE3273948D1 (en) | Pharmaceutical preparations | |
| EP0044453A3 (en) | New benzisoselenazolones, process for producing the same and pharmaceutical preparations containing the same | |
| EP0055465A3 (en) | 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof | |
| ZA821637B (en) | Oxazaphosphorin-4-thio-alkanesulfonic acids, neutral salts thereof, processes for the production thereof and pharmaceutical preparations containing them | |
| ZA821957B (en) | Acylquinolinone derivatives, processes for their manufacture, pharmaceutical preparations containing them and their use | |
| IL65247A0 (en) | Amido-amino acids,process for their preparation and pharmaceutical compositions containing them | |
| AU542157B2 (en) | Epoxycycloalkylalkanecarboxylic acids, processes for their preparation, their use and medicaments containing them | |
| IL69164A0 (en) | Diphosphonic acid derivatives,processes for the manufacture thereof and pharmaceutical preparations containing the same | |
| IL57360A0 (en) | Phenylaminothiophenacetic acids,processes for their preparation and medicaments containing them | |
| SG11288G (en) | N-acytylneuraminic acid derivatives and process for the preparation thereof | |
| IL65541A0 (en) | Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same | |
| PH18457A (en) | Pharmaceutical preparations | |
| ZW15985A1 (en) | Benzazole derivatives,processes for their production and pharmaceutical preparations containing such compounds and the use thereof | |
| DE3161125D1 (en) | Process for the preparation of o,o-disubstituted benzoic acids and their salts | |
| IL65484A0 (en) | Prostaglandins and prostacyclins,process for their preparation and pharmaceutical preparations containing the same | |
| EP0216585A3 (en) | 2,6,7-trisubstituted-3-methylenebicyclo û3.3.0¨octanes and process for production thereof | |
| ZA826528B (en) | Ascochlorin derivatives,process for preparing the same and pharmaceutical composition containing the same | |
| DE3267376D1 (en) | Quinidines, process for their preparation and their pharmaceutical application | |
| AU1475583A (en) | Substituted picolinic acids, processes for their preparation,their use and medicaments containing them | |
| IL62176A0 (en) | 5-sulfamoyl-orthanilic acids,processes,for their preparation and their use as medicaments | |
| GR80434B (en) | 7b-acylamido-3-cephem -4-carbon acid ester, method for the preparation thereof pharmaceutical preparations containing them and use thereof | |
| ZA792504B (en) | Phenylaminothiophenacetic acids,processes for their preparation and medicaments containing them | |
| IL67469A0 (en) | Ergotanilide derivatives,pharmaceutical preparations containing the same,and a process for the preparation thereof |