BE892589A - Acides oxazaphosphorin-4-thio-alcanesulfoniques, leurs sels neutres, procede pour leur preparation et preparations pharmaceutiques qui les contiennent - Google Patents

Acides oxazaphosphorin-4-thio-alcanesulfoniques, leurs sels neutres, procede pour leur preparation et preparations pharmaceutiques qui les contiennent

Info

Publication number
BE892589A
BE892589A BE2/59642A BE2059642A BE892589A BE 892589 A BE892589 A BE 892589A BE 2/59642 A BE2/59642 A BE 2/59642A BE 2059642 A BE2059642 A BE 2059642A BE 892589 A BE892589 A BE 892589A
Authority
BE
Belgium
Prior art keywords
alcanesulfonic
oxazaphosphorin
thio
acids
preparation
Prior art date
Application number
BE2/59642A
Other languages
English (en)
Original Assignee
Asta Werke Ag Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke Ag Chem Fab filed Critical Asta Werke Ag Chem Fab
Publication of BE892589A publication Critical patent/BE892589A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BE2/59642A 1981-03-24 1982-03-23 Acides oxazaphosphorin-4-thio-alcanesulfoniques, leurs sels neutres, procede pour leur preparation et preparations pharmaceutiques qui les contiennent BE892589A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813111428 DE3111428A1 (de) 1981-03-24 1981-03-24 Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Publications (1)

Publication Number Publication Date
BE892589A true BE892589A (fr) 1982-07-16

Family

ID=6128090

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2/59642A BE892589A (fr) 1981-03-24 1982-03-23 Acides oxazaphosphorin-4-thio-alcanesulfoniques, leurs sels neutres, procede pour leur preparation et preparations pharmaceutiques qui les contiennent

Country Status (31)

Country Link
US (2) US4623742A (fr)
JP (1) JPS57169496A (fr)
AT (1) AT381317B (fr)
AU (1) AU544493B2 (fr)
BE (1) BE892589A (fr)
BG (1) BG38489A3 (fr)
CA (1) CA1194479A (fr)
CH (1) CH648852A5 (fr)
DD (1) DD201799A5 (fr)
DE (1) DE3111428A1 (fr)
DK (1) DK171843B1 (fr)
EG (1) EG15703A (fr)
ES (1) ES8303440A1 (fr)
FI (1) FI69849C (fr)
FR (1) FR2502626B1 (fr)
GB (1) GB2095256B (fr)
GR (1) GR75533B (fr)
HU (1) HU186915B (fr)
IE (1) IE53054B1 (fr)
IL (1) IL65255A (fr)
IT (1) IT1150499B (fr)
LU (1) LU84032A1 (fr)
NL (1) NL192741C (fr)
NO (1) NO163692C (fr)
PL (1) PL129426B1 (fr)
PT (1) PT74641B (fr)
RO (1) RO84661B (fr)
SE (1) SE452159B (fr)
SU (1) SU1318167A3 (fr)
YU (1) YU61582A (fr)
ZA (1) ZA821637B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158057A1 (fr) * 1984-03-01 1985-10-16 ASTA Pharma AG Sels de dérivés d'oxazaphosphorine
JPS60222494A (ja) * 1984-03-01 1985-11-07 アスタ・メディカ・アクチエンゲゼルシャフト オキサザホスホリン誘導体の塩及びその製法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111428A1 (de) 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
EP0083439B1 (fr) * 1981-12-31 1989-07-26 ASTA Pharma AG 4-Sulfido-oxazaphosphorines et leur utilisation dans le traitement du cancer et pour l'immunosuppression
DE3415726A1 (de) * 1984-04-27 1985-10-31 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5204335A (en) * 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
DE58900183D1 (de) * 1988-03-19 1991-08-29 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
US5190929A (en) * 1988-05-25 1993-03-02 Research Corporation Technologies, Inc. Cyclophosphamide analogs useful as anti-tumor agents
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5661188A (en) * 1995-06-07 1997-08-26 Medical Research Foundation and Infrastructure Development for Health Services--Nahariya Hospital Branch Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna)
US20080223826A1 (en) * 2007-03-13 2008-09-18 Stephen Mazur Reagent Delivery using a Membrane-Mediated Process
FR2968662B1 (fr) 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2107936C3 (de) * 1971-02-19 1978-06-08 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld Alkylsulfonsäureester von 2-Oxo-13,2-oxazaphosphorinanen und diese enthaltende pharmazeutische Präparate
DE1645921C3 (de) * 1966-07-11 1978-10-12 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2201675A1 (de) * 1972-01-14 1973-07-19 Asta Werke Ag Chem Fab Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate
JPS5159886A (fr) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
JPS54157580A (en) 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS5826919B2 (ja) 1978-11-07 1983-06-06 大塚製薬株式会社 シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法
JPS55154984A (en) * 1979-05-24 1980-12-02 Shionogi & Co Ltd Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative
DE3111428A1 (de) 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE3220432A1 (de) 1981-03-24 1983-12-01 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3220672A1 (de) 1981-03-24 1983-12-08 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158057A1 (fr) * 1984-03-01 1985-10-16 ASTA Pharma AG Sels de dérivés d'oxazaphosphorine
JPS60222494A (ja) * 1984-03-01 1985-11-07 アスタ・メディカ・アクチエンゲゼルシャフト オキサザホスホリン誘導体の塩及びその製法

Also Published As

Publication number Publication date
LU84032A1 (de) 1982-07-08
ZA821637B (en) 1983-02-23
NL192741C (nl) 1998-01-06
PL129426B1 (en) 1984-05-31
FI821021A0 (fi) 1982-03-23
NL192741B (nl) 1997-09-01
SE452159B (sv) 1987-11-16
RO84661A (fr) 1984-10-31
US4929607A (en) 1990-05-29
PT74641A (de) 1982-04-01
FI69849C (fi) 1986-05-26
IL65255A (en) 1986-03-31
NO163692B (no) 1990-03-26
DE3111428A1 (de) 1982-10-07
NO163692C (no) 1990-07-04
IT8220351A0 (it) 1982-03-23
EG15703A (en) 1986-06-30
DE3111428C2 (fr) 1990-06-13
FI69849B (fi) 1985-12-31
NL8201227A (nl) 1982-10-18
CA1194479A (fr) 1985-10-01
BG38489A3 (en) 1985-12-16
IE53054B1 (en) 1988-05-25
GB2095256A (en) 1982-09-29
CH648852A5 (de) 1985-04-15
FR2502626B1 (fr) 1986-01-03
JPS57169496A (en) 1982-10-19
IE820531L (en) 1982-09-24
IL65255A0 (en) 1982-05-31
DK129882A (da) 1982-09-25
GB2095256B (en) 1984-08-22
SE8201807L (sv) 1982-09-25
FI821021L (fi) 1982-09-25
ES510677A0 (es) 1983-02-01
HU186915B (en) 1985-10-28
DD201799A5 (de) 1983-08-10
ES8303440A1 (es) 1983-02-01
JPH0240680B2 (fr) 1990-09-12
GR75533B (fr) 1984-07-27
PL235606A1 (fr) 1982-11-08
RO84661B (ro) 1984-11-30
FR2502626A1 (fr) 1982-10-01
AU8134482A (en) 1982-09-30
PT74641B (de) 1983-10-20
NO820957L (no) 1982-09-27
AU544493B2 (en) 1985-05-30
SU1318167A3 (ru) 1987-06-15
YU61582A (en) 1985-03-20
IT1150499B (it) 1986-12-10
ATA106382A (de) 1986-02-15
AT381317B (de) 1986-09-25
DK171843B1 (da) 1997-06-30
US4623742A (en) 1986-11-18

Similar Documents

Publication Publication Date Title
FR2568472B1 (fr) Preparations pharmaceutiques retard et procede pour les fabriquer
PT77488A (fr) Procede de preparation de derives de phenyl-1-piperidino-2-propanol et de compositions pharmaceutiques les contenant
BE892758A (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
FR2504920B1 (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
FR2562889B1 (fr) Composes de phenethanolamine. procede pour leur preparation et compositions pharmaceutiques les comprenant
PT73916A (en) Process for preparing 1-carboxy-aza-alkanoyl-indoline-2- carboxylic acids pharmaceutical preparations containing these compounds and their therapeutic application
FR2502626B1 (fr) Acides oxazaphosphorin-4-thio-alcanesulfoniques, leurs sels neutres, procede pour leur preparation et preparations pharmaceutiques qui les contiennent
FR2585018B1 (fr) Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques
FR2537584B1 (fr) Pyrazoloquinoleines substituees particulieres, procede pour leur preparation, preparations pharmaceutiques contenant ces composes et leur application therapeutique
MC1243A1 (fr) Derives peptidiques,procede pour leur preparation et leur application dans des preparations pharmaceutiques
BE874252A (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2560195B1 (fr) Derives d'alanyl-proline, leur procede de preparation et leurs applications pharmaceutiques
BE874253A (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
PT84933A (fr) Procede de preparation de cyclodepsipeptides et compositions pharmaceutiques qui les contiennent
PT75868A (fr) Procede de preparation de derives benzylideniques et de compositions pharmaceutiques les contenant
OA06776A (fr) Procédé de préparations pharmaceutiques.
BE892602A (fr) Esters de mercaptoacyl-carnitines, procede pour leur preparation et leurs utilisations therapeutiques
FR2543546B1 (fr) Derives de gonadoreline contenant un groupe b-aspartyle, procede pour leur preparation et preparations pharmaceutiques les contenant
PT77767B (fr) Procede de preparation de 3',5'-diarabinosides et de compositi-ons pharmaceutiques les contenant
FR2551440B1 (fr) Aminocyclopentanes, leur procede de preparation et compositions pharmaceutiques les contenant
MA20150A1 (fr) Derives de l'acide bicyclo (3,2-1) octane carboxylique et leur procede de preparation et leur application therapeutique.
MA20706A1 (fr) Sels de 3-acylaminobenzisothiazol-5, 5-dioxydes, procede pour leur preparation et leur application dans la lutte anti-parasitaire
FR2497668B1 (fr) Emulsions lipoproteiques injectables, leur procede de preparation et leurs applications en therapeutique
FR2529549B1 (fr) Oxime-ethers d'eburnane, procede pour leur preparation et compositions pharmaceutiques qui les contiennent
FR2519638B1 (fr) Derives d'aminopropylaminobleomycine, leurs applications therapeutiques et procede pour leur preparation

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ASTA-WERKE A.G. CHEMISCHE FABRIK

Effective date: 20020323