JPS55154984A - Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative - Google Patents

Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative

Info

Publication number
JPS55154984A
JPS55154984A JP6417679A JP6417679A JPS55154984A JP S55154984 A JPS55154984 A JP S55154984A JP 6417679 A JP6417679 A JP 6417679A JP 6417679 A JP6417679 A JP 6417679A JP S55154984 A JPS55154984 A JP S55154984A
Authority
JP
Japan
Prior art keywords
formula
oxaazaphospholine
oxide derivative
substituted
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6417679A
Other languages
Japanese (ja)
Inventor
Hiroshi Harada
Norihiro Matsushita
Yoshio Hamashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP6417679A priority Critical patent/JPS55154984A/en
Publication of JPS55154984A publication Critical patent/JPS55154984A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An oxide derivative shown by the formula I (X and Y are halogen or lower alkylsulfonyloxy; Z is H or lower alkyl; Q is alkoxy, cycloalkyloxy, heterocyclic oxy, alkanoylthio, etc.).
EXAMPLE: 2-( 2-Chloroethylamino )-3-( 2-chloroethyl )-4-benzyloxy-tetrahydro-2H,- 1,3,2-oxaazaphospholine-2-oxide.
USE: Antitumor drugs. The introduction of a substitutded group at 4-position characteristically improves solubility, side effect, etc.
PROCESS: For example, a compound shown by the formula II is reacted with an alcohol shown by the formula III (R is alkyl, cycloalkyl, etc.) to give a compound shown by the formula Ia. The reaction is preferably carried out in the presence of an acid catalyst, e.g., p-toluenesulfonic acid.
COPYRIGHT: (C)1980,JPO&Japio
JP6417679A 1979-05-24 1979-05-24 Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative Pending JPS55154984A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6417679A JPS55154984A (en) 1979-05-24 1979-05-24 Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6417679A JPS55154984A (en) 1979-05-24 1979-05-24 Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative

Publications (1)

Publication Number Publication Date
JPS55154984A true JPS55154984A (en) 1980-12-02

Family

ID=13250485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6417679A Pending JPS55154984A (en) 1979-05-24 1979-05-24 Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative

Country Status (1)

Country Link
JP (1) JPS55154984A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2502626A1 (en) * 1981-03-24 1982-10-01 Asta Werke Ag Chem Fab OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS, THEIR NEUTRAL SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CN103328494A (en) * 2010-12-10 2013-09-25 法国古士塔柏罗斯学院 Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2502626A1 (en) * 1981-03-24 1982-10-01 Asta Werke Ag Chem Fab OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS, THEIR NEUTRAL SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CN103328494A (en) * 2010-12-10 2013-09-25 法国古士塔柏罗斯学院 Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
US20130261088A1 (en) * 2010-12-10 2013-10-03 Institut Gustave Roussy Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
US9073957B2 (en) * 2010-12-10 2015-07-07 Institut Gustave Roussy Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
CN103328494B (en) * 2010-12-10 2016-08-10 法国古士塔柏罗斯学院 Novel preactivated oxazaphosphorin derivant, application and preparation method
US9428530B2 (en) 2010-12-10 2016-08-30 Institut Gustave Roussy Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
CN106083932A (en) * 2010-12-10 2016-11-09 法国古士塔柏罗斯学院 Novel preactivated oxazaphosphorin derivant, application and preparation method
US10125157B2 (en) 2010-12-10 2018-11-13 Institut Gustave Roussy Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
CN106083932B (en) * 2010-12-10 2019-08-06 法国古士塔柏罗斯学院 Novel preactivated oxazaphosphorin derivative, application and preparation method

Similar Documents

Publication Publication Date Title
PT74912A (en) Process for preparing anti-hypertensive 1-substituted siro <piperidine-oxobenzoxazine>s
DE3063144D1 (en) Substituted oxirane carboxylic acids, process for their preparation, their use and medicines containing them
PT87277A (en) PROCESS FOR THE PREPARATION OF NEW BICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
JPS56103168A (en) Thiazole derivative, its preparation, and antihistaminic agent containing the same
JPS55154984A (en) Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative
IL94947A0 (en) 3-methoximinopropionic acid esters,their manufacture and their use as fungicides
JPS5540628A (en) Novel hydroxamic acid compound, its preparation, and medicine containing the same
ATE13882T1 (en) 1-((SUBSTITUTED-NAPHTHYL)AETHYL)IMIDAZOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE.
JPS5756425A (en) Hypotensor
JPS55151549A (en) Production of guanidinocaproic ester
JPS52133973A (en) Preparation of optically active lactam derivatives
NO179614C (en) Analogous Process for Preparing Therapeutically Active 2-Formylbenzylphosphonic Acid Derivatives
JPS55111483A (en) Novel phenothiazine derivative and psychotropic drug comprising it
JPS57154183A (en) Omega-piperazinylalkanoylalkylene dioxybenzenes and their acid addition salts
JPS52131572A (en) Dihydrobenzofuran derivatives
JPS643183A (en) Condensed heterocyclic compound, production thereof and herbicide containing said compound as active ingredient
JPS5524128A (en) Indane-1,3-dione derivative
JPS5668673A (en) Substituted methylidenehydrazinopyrimidine derivative and its preparation
JPS52113970A (en) Thiadiazoline-type organic phosphates, their preparation, and insectic ide or miticide containing the same
JPS5344575A (en) Preparation of hydantoin derivatives
JPS6485978A (en) Novel thienodiazepine derivative
JPS54141787A (en) Penicillamine derivative
JPS5540652A (en) Phosphoryl-ethanolamine derivative
JPS5564596A (en) Preparation of alkylmethyl-3-dialkoxy-propylphosphinate
JPS5473780A (en) Novel benzamide derivative