JPS55154984A - Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative - Google Patents
Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivativeInfo
- Publication number
- JPS55154984A JPS55154984A JP6417679A JP6417679A JPS55154984A JP S55154984 A JPS55154984 A JP S55154984A JP 6417679 A JP6417679 A JP 6417679A JP 6417679 A JP6417679 A JP 6417679A JP S55154984 A JPS55154984 A JP S55154984A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- oxaazaphospholine
- oxide derivative
- substituted
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An oxide derivative shown by the formula I (X and Y are halogen or lower alkylsulfonyloxy; Z is H or lower alkyl; Q is alkoxy, cycloalkyloxy, heterocyclic oxy, alkanoylthio, etc.).
EXAMPLE: 2-( 2-Chloroethylamino )-3-( 2-chloroethyl )-4-benzyloxy-tetrahydro-2H,- 1,3,2-oxaazaphospholine-2-oxide.
USE: Antitumor drugs. The introduction of a substitutded group at 4-position characteristically improves solubility, side effect, etc.
PROCESS: For example, a compound shown by the formula II is reacted with an alcohol shown by the formula III (R is alkyl, cycloalkyl, etc.) to give a compound shown by the formula Ia. The reaction is preferably carried out in the presence of an acid catalyst, e.g., p-toluenesulfonic acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6417679A JPS55154984A (en) | 1979-05-24 | 1979-05-24 | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6417679A JPS55154984A (en) | 1979-05-24 | 1979-05-24 | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55154984A true JPS55154984A (en) | 1980-12-02 |
Family
ID=13250485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6417679A Pending JPS55154984A (en) | 1979-05-24 | 1979-05-24 | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55154984A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2502626A1 (en) * | 1981-03-24 | 1982-10-01 | Asta Werke Ag Chem Fab | OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS, THEIR NEUTRAL SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
CN103328494A (en) * | 2010-12-10 | 2013-09-25 | 法国古士塔柏罗斯学院 | Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
-
1979
- 1979-05-24 JP JP6417679A patent/JPS55154984A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2502626A1 (en) * | 1981-03-24 | 1982-10-01 | Asta Werke Ag Chem Fab | OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS, THEIR NEUTRAL SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
CN103328494A (en) * | 2010-12-10 | 2013-09-25 | 法国古士塔柏罗斯学院 | Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
US20130261088A1 (en) * | 2010-12-10 | 2013-10-03 | Institut Gustave Roussy | Novel derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
US9073957B2 (en) * | 2010-12-10 | 2015-07-07 | Institut Gustave Roussy | Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
CN103328494B (en) * | 2010-12-10 | 2016-08-10 | 法国古士塔柏罗斯学院 | Novel preactivated oxazaphosphorin derivant, application and preparation method |
US9428530B2 (en) | 2010-12-10 | 2016-08-30 | Institut Gustave Roussy | Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
CN106083932A (en) * | 2010-12-10 | 2016-11-09 | 法国古士塔柏罗斯学院 | Novel preactivated oxazaphosphorin derivant, application and preparation method |
US10125157B2 (en) | 2010-12-10 | 2018-11-13 | Institut Gustave Roussy | Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation |
CN106083932B (en) * | 2010-12-10 | 2019-08-06 | 法国古士塔柏罗斯学院 | Novel preactivated oxazaphosphorin derivative, application and preparation method |
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