NL192741B - Oxazafosforin-4-thioalkaanzuurverbindingen en farmaceutisch preparaat met antineoplastische eigenschappen. - Google Patents

Oxazafosforin-4-thioalkaanzuurverbindingen en farmaceutisch preparaat met antineoplastische eigenschappen.

Info

Publication number
NL192741B
NL192741B NL8201227A NL8201227A NL192741B NL 192741 B NL192741 B NL 192741B NL 8201227 A NL8201227 A NL 8201227A NL 8201227 A NL8201227 A NL 8201227A NL 192741 B NL192741 B NL 192741B
Authority
NL
Netherlands
Prior art keywords
oxazaphosphorin
pharmaceutical preparation
acid compounds
antineoplastic properties
thioalkanoic acid
Prior art date
Application number
NL8201227A
Other languages
English (en)
Other versions
NL192741C (nl
NL8201227A (nl
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of NL8201227A publication Critical patent/NL8201227A/nl
Publication of NL192741B publication Critical patent/NL192741B/nl
Application granted granted Critical
Publication of NL192741C publication Critical patent/NL192741C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NL8201227A 1981-03-24 1982-03-24 Oxazafosforin-4-thioalkaanzuurverbindingen en farmaceutisch preparaat met antineoplastische eigenschappen. NL192741C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3111428 1981-03-24
DE19813111428 DE3111428A1 (de) 1981-03-24 1981-03-24 Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Publications (3)

Publication Number Publication Date
NL8201227A NL8201227A (nl) 1982-10-18
NL192741B true NL192741B (nl) 1997-09-01
NL192741C NL192741C (nl) 1998-01-06

Family

ID=6128090

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8201227A NL192741C (nl) 1981-03-24 1982-03-24 Oxazafosforin-4-thioalkaanzuurverbindingen en farmaceutisch preparaat met antineoplastische eigenschappen.

Country Status (31)

Country Link
US (2) US4623742A (nl)
JP (1) JPS57169496A (nl)
AT (1) AT381317B (nl)
AU (1) AU544493B2 (nl)
BE (1) BE892589A (nl)
BG (1) BG38489A3 (nl)
CA (1) CA1194479A (nl)
CH (1) CH648852A5 (nl)
DD (1) DD201799A5 (nl)
DE (1) DE3111428A1 (nl)
DK (1) DK171843B1 (nl)
EG (1) EG15703A (nl)
ES (1) ES8303440A1 (nl)
FI (1) FI69849C (nl)
FR (1) FR2502626B1 (nl)
GB (1) GB2095256B (nl)
GR (1) GR75533B (nl)
HU (1) HU186915B (nl)
IE (1) IE53054B1 (nl)
IL (1) IL65255A (nl)
IT (1) IT1150499B (nl)
LU (1) LU84032A1 (nl)
NL (1) NL192741C (nl)
NO (1) NO163692C (nl)
PL (1) PL129426B1 (nl)
PT (1) PT74641B (nl)
RO (1) RO84661B (nl)
SE (1) SE452159B (nl)
SU (1) SU1318167A3 (nl)
YU (1) YU61582A (nl)
ZA (1) ZA821637B (nl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE3279834D1 (en) * 1981-12-31 1989-08-31 Asta Pharma Ag 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression
DE3569737D1 (en) * 1984-03-01 1989-06-01 Asta Pharma Ag Salts of oxazaphosphorine derivatives
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
DE3415726A1 (de) * 1984-04-27 1985-10-31 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5204335A (en) * 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
ATE65402T1 (de) * 1988-03-19 1991-08-15 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
US5190929A (en) * 1988-05-25 1993-03-02 Research Corporation Technologies, Inc. Cyclophosphamide analogs useful as anti-tumor agents
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5661188A (en) * 1995-06-07 1997-08-26 Medical Research Foundation and Infrastructure Development for Health Services--Nahariya Hospital Branch Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna)
US20080223826A1 (en) * 2007-03-13 2008-09-18 Stephen Mazur Reagent Delivery using a Membrane-Mediated Process
FR2968662B1 (fr) 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2107936C3 (de) * 1971-02-19 1978-06-08 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld Alkylsulfonsäureester von 2-Oxo-13,2-oxazaphosphorinanen und diese enthaltende pharmazeutische Präparate
DE1645921C3 (de) * 1966-07-11 1978-10-12 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2201675A1 (de) * 1972-01-14 1973-07-19 Asta Werke Ag Chem Fab Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate
JPS5159886A (nl) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
JPS54157580A (en) 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS5826919B2 (ja) 1978-11-07 1983-06-06 大塚製薬株式会社 シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法
JPS55154984A (en) * 1979-05-24 1980-12-02 Shionogi & Co Ltd Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative
DE3220672A1 (de) 1981-03-24 1983-12-08 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3111428A1 (de) 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE3220432A1 (de) 1981-03-24 1983-12-01 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate

Also Published As

Publication number Publication date
NO820957L (no) 1982-09-27
IT8220351A0 (it) 1982-03-23
FI69849B (fi) 1985-12-31
BG38489A3 (en) 1985-12-16
ATA106382A (de) 1986-02-15
DD201799A5 (de) 1983-08-10
AU8134482A (en) 1982-09-30
ZA821637B (en) 1983-02-23
NL192741C (nl) 1998-01-06
JPS57169496A (en) 1982-10-19
IE820531L (en) 1982-09-24
SU1318167A3 (ru) 1987-06-15
RO84661A (ro) 1984-10-31
IL65255A0 (en) 1982-05-31
US4929607A (en) 1990-05-29
FI69849C (fi) 1986-05-26
PT74641A (de) 1982-04-01
CA1194479A (en) 1985-10-01
FI821021L (fi) 1982-09-25
NO163692C (no) 1990-07-04
HU186915B (en) 1985-10-28
SE452159B (sv) 1987-11-16
GB2095256B (en) 1984-08-22
NL8201227A (nl) 1982-10-18
FR2502626B1 (fr) 1986-01-03
ES510677A0 (es) 1983-02-01
RO84661B (ro) 1984-11-30
NO163692B (no) 1990-03-26
BE892589A (fr) 1982-07-16
AT381317B (de) 1986-09-25
PL129426B1 (en) 1984-05-31
AU544493B2 (en) 1985-05-30
DK171843B1 (da) 1997-06-30
EG15703A (en) 1986-06-30
ES8303440A1 (es) 1983-02-01
YU61582A (en) 1985-03-20
DK129882A (da) 1982-09-25
IE53054B1 (en) 1988-05-25
US4623742A (en) 1986-11-18
PL235606A1 (nl) 1982-11-08
DE3111428C2 (nl) 1990-06-13
GR75533B (nl) 1984-07-27
DE3111428A1 (de) 1982-10-07
FR2502626A1 (fr) 1982-10-01
FI821021A0 (fi) 1982-03-23
JPH0240680B2 (nl) 1990-09-12
IT1150499B (it) 1986-12-10
PT74641B (de) 1983-10-20
LU84032A1 (de) 1982-07-08
SE8201807L (sv) 1982-09-25
GB2095256A (en) 1982-09-29
CH648852A5 (de) 1985-04-15
IL65255A (en) 1986-03-31

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Legal Events

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Free format text: ASTA PHARMA AKTIENGESELLSCHAFT

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BB A search report has been drawn up
BC A request for examination has been filed
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

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V4 Discontinued because of reaching the maximum lifetime of a patent

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Effective date: 20020324