RO84661A - Procedeu pentru prepararea acidului oxazafosforin/4-tioalcan-sulfonicsau a sarurilor neutre ale acestuia - Google Patents
Procedeu pentru prepararea acidului oxazafosforin/4-tioalcan-sulfonicsau a sarurilor neutre ale acestuiaInfo
- Publication number
- RO84661A RO84661A RO82106989A RO10698982A RO84661A RO 84661 A RO84661 A RO 84661A RO 82106989 A RO82106989 A RO 82106989A RO 10698982 A RO10698982 A RO 10698982A RO 84661 A RO84661 A RO 84661A
- Authority
- RO
- Romania
- Prior art keywords
- oxazaphosphorin
- alkan
- thio
- preparation
- sulfonic acid
- Prior art date
Links
- 230000007935 neutral effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813111428 DE3111428A1 (de) | 1981-03-24 | 1981-03-24 | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO84661A true RO84661A (ro) | 1984-10-31 |
| RO84661B RO84661B (ro) | 1984-11-30 |
Family
ID=6128090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO106989A RO84661B (ro) | 1981-03-24 | 1982-03-22 | Procedeu pentru prepararea acidului oxazafosforin/4-tioalcan-sulfonic sau a sarurilor neutre ale acestuia |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US4623742A (ro) |
| JP (1) | JPS57169496A (ro) |
| AT (1) | AT381317B (ro) |
| AU (1) | AU544493B2 (ro) |
| BE (1) | BE892589A (ro) |
| BG (1) | BG38489A3 (ro) |
| CA (1) | CA1194479A (ro) |
| CH (1) | CH648852A5 (ro) |
| DD (1) | DD201799A5 (ro) |
| DE (1) | DE3111428A1 (ro) |
| DK (1) | DK171843B1 (ro) |
| EG (1) | EG15703A (ro) |
| ES (1) | ES8303440A1 (ro) |
| FI (1) | FI69849C (ro) |
| FR (1) | FR2502626B1 (ro) |
| GB (1) | GB2095256B (ro) |
| GR (1) | GR75533B (ro) |
| HU (1) | HU186915B (ro) |
| IE (1) | IE53054B1 (ro) |
| IL (1) | IL65255A (ro) |
| IT (1) | IT1150499B (ro) |
| LU (1) | LU84032A1 (ro) |
| NL (1) | NL192741C (ro) |
| NO (1) | NO163692C (ro) |
| PL (1) | PL129426B1 (ro) |
| PT (1) | PT74641B (ro) |
| RO (1) | RO84661B (ro) |
| SE (1) | SE452159B (ro) |
| SU (1) | SU1318167A3 (ro) |
| YU (1) | YU61582A (ro) |
| ZA (1) | ZA821637B (ro) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3279834D1 (en) * | 1981-12-31 | 1989-08-31 | Asta Pharma Ag | 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| DE3569737D1 (en) * | 1984-03-01 | 1989-06-01 | Asta Pharma Ag | Salts of oxazaphosphorine derivatives |
| DE3415726A1 (de) * | 1984-04-27 | 1985-10-31 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten |
| FR2567129B1 (fr) * | 1984-07-06 | 1986-12-05 | Adir | Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US5204335A (en) * | 1986-10-31 | 1993-04-20 | Asta Pharma Aktiengesellschaft | Ifosfamide lyophilisate and process for its preparation |
| ES2040394T3 (es) * | 1988-03-19 | 1993-10-16 | Asta Medica Aktiengesellschaft | Procedimiento para preparar un material liofilizado de ifosfamida y mesna. |
| US5190929A (en) * | 1988-05-25 | 1993-03-02 | Research Corporation Technologies, Inc. | Cyclophosphamide analogs useful as anti-tumor agents |
| RO113611B1 (ro) * | 1990-08-03 | 1998-09-30 | Asta Pharma Ag | Preparate solide de ifosfamida, administrate oral si procedeu de obtinere |
| US5661188A (en) * | 1995-06-07 | 1997-08-26 | Medical Research Foundation and Infrastructure Development for Health Services--Nahariya Hospital Branch | Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna) |
| US20080223826A1 (en) * | 2007-03-13 | 2008-09-18 | Stephen Mazur | Reagent Delivery using a Membrane-Mediated Process |
| FR2968662B1 (fr) | 2010-12-10 | 2013-11-22 | Roussy Inst Gustave | Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation |
| GB2626789A (en) * | 2023-02-03 | 2024-08-07 | Exactmer Ltd | Deprotection processes and cation scavengers for use in the same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2107936C3 (de) * | 1971-02-19 | 1978-06-08 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | Alkylsulfonsäureester von 2-Oxo-13,2-oxazaphosphorinanen und diese enthaltende pharmazeutische Präparate |
| DE1645921C3 (de) * | 1966-07-11 | 1978-10-12 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DE2201675A1 (de) * | 1972-01-14 | 1973-07-19 | Asta Werke Ag Chem Fab | Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate |
| JPS5159886A (ro) * | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| JPS54157580A (en) | 1978-05-29 | 1979-12-12 | Otsuka Pharmaceut Co Ltd | Optically active oxazaphosphorine derivative |
| JPS5826919B2 (ja) | 1978-11-07 | 1983-06-06 | 大塚製薬株式会社 | シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法 |
| JPS55154984A (en) * | 1979-05-24 | 1980-12-02 | Shionogi & Co Ltd | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
| DE3220672A1 (de) | 1981-03-24 | 1983-12-08 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3111428A1 (de) | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| DE3220432A1 (de) | 1981-03-24 | 1983-12-01 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
-
1981
- 1981-03-24 DE DE19813111428 patent/DE3111428A1/de active Granted
-
1982
- 1982-03-08 CH CH1390/82A patent/CH648852A5/de not_active IP Right Cessation
- 1982-03-09 IE IE531/82A patent/IE53054B1/en unknown
- 1982-03-11 ZA ZA821637A patent/ZA821637B/xx unknown
- 1982-03-12 AU AU81344/82A patent/AU544493B2/en not_active Ceased
- 1982-03-12 GB GB8207375A patent/GB2095256B/en not_active Expired
- 1982-03-15 IL IL65255A patent/IL65255A/xx unknown
- 1982-03-17 AT AT0106382A patent/AT381317B/de not_active IP Right Cessation
- 1982-03-17 GR GR67621A patent/GR75533B/el unknown
- 1982-03-22 FR FR8204823A patent/FR2502626B1/fr not_active Expired
- 1982-03-22 RO RO106989A patent/RO84661B/ro unknown
- 1982-03-22 SE SE8201807A patent/SE452159B/sv not_active IP Right Cessation
- 1982-03-22 YU YU00615/82A patent/YU61582A/xx unknown
- 1982-03-23 CA CA000399098A patent/CA1194479A/en not_active Expired
- 1982-03-23 ES ES510677A patent/ES8303440A1/es not_active Expired
- 1982-03-23 SU SU823414100A patent/SU1318167A3/ru active
- 1982-03-23 IT IT20351/82A patent/IT1150499B/it active
- 1982-03-23 JP JP57044779A patent/JPS57169496A/ja active Granted
- 1982-03-23 PT PT74641A patent/PT74641B/pt unknown
- 1982-03-23 NO NO820957A patent/NO163692C/no not_active IP Right Cessation
- 1982-03-23 DD DD82238374A patent/DD201799A5/de unknown
- 1982-03-23 EG EG82156A patent/EG15703A/xx active
- 1982-03-23 HU HU82879A patent/HU186915B/hu unknown
- 1982-03-23 BE BE2/59642A patent/BE892589A/fr not_active IP Right Cessation
- 1982-03-23 FI FI821021A patent/FI69849C/fi not_active IP Right Cessation
- 1982-03-23 DK DK129882A patent/DK171843B1/da not_active IP Right Cessation
- 1982-03-24 NL NL8201227A patent/NL192741C/nl not_active IP Right Cessation
- 1982-03-24 LU LU84032A patent/LU84032A1/de unknown
- 1982-03-24 BG BG055941A patent/BG38489A3/xx unknown
- 1982-08-24 PL PL1982235606A patent/PL129426B1/pl unknown
-
1984
- 1984-12-19 US US06/683,374 patent/US4623742A/en not_active Expired - Lifetime
-
1988
- 1988-02-02 US US07/149,954 patent/US4929607A/en not_active Expired - Lifetime
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