IT1150499B - Acidi ossazafosforin-4-tio-alcansolfonici,loro sali neutri,procedimento per la loro preparazione e preparati farmaceutici che li contengono - Google Patents

Acidi ossazafosforin-4-tio-alcansolfonici,loro sali neutri,procedimento per la loro preparazione e preparati farmaceutici che li contengono

Info

Publication number
IT1150499B
IT1150499B IT20351/82A IT2035182A IT1150499B IT 1150499 B IT1150499 B IT 1150499B IT 20351/82 A IT20351/82 A IT 20351/82A IT 2035182 A IT2035182 A IT 2035182A IT 1150499 B IT1150499 B IT 1150499B
Authority
IT
Italy
Prior art keywords
ossazafosforin
alcansolfonici
tio
acids
procedure
Prior art date
Application number
IT20351/82A
Other languages
English (en)
Other versions
IT8220351A0 (it
Inventor
Gerhard Scheffler
Ulf Niemeyer
Norbert Brock
Jorg Pohl
Original Assignee
Asta Werke Ag Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke Ag Chem Fab filed Critical Asta Werke Ag Chem Fab
Publication of IT8220351A0 publication Critical patent/IT8220351A0/it
Application granted granted Critical
Publication of IT1150499B publication Critical patent/IT1150499B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT20351/82A 1981-03-24 1982-03-23 Acidi ossazafosforin-4-tio-alcansolfonici,loro sali neutri,procedimento per la loro preparazione e preparati farmaceutici che li contengono IT1150499B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813111428 DE3111428A1 (de) 1981-03-24 1981-03-24 Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number Publication Date
IT8220351A0 IT8220351A0 (it) 1982-03-23
IT1150499B true IT1150499B (it) 1986-12-10

Family

ID=6128090

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20351/82A IT1150499B (it) 1981-03-24 1982-03-23 Acidi ossazafosforin-4-tio-alcansolfonici,loro sali neutri,procedimento per la loro preparazione e preparati farmaceutici che li contengono

Country Status (31)

Country Link
US (2) US4623742A (it)
JP (1) JPS57169496A (it)
AT (1) AT381317B (it)
AU (1) AU544493B2 (it)
BE (1) BE892589A (it)
BG (1) BG38489A3 (it)
CA (1) CA1194479A (it)
CH (1) CH648852A5 (it)
DD (1) DD201799A5 (it)
DE (1) DE3111428A1 (it)
DK (1) DK171843B1 (it)
EG (1) EG15703A (it)
ES (1) ES8303440A1 (it)
FI (1) FI69849C (it)
FR (1) FR2502626B1 (it)
GB (1) GB2095256B (it)
GR (1) GR75533B (it)
HU (1) HU186915B (it)
IE (1) IE53054B1 (it)
IL (1) IL65255A (it)
IT (1) IT1150499B (it)
LU (1) LU84032A1 (it)
NL (1) NL192741C (it)
NO (1) NO163692C (it)
PL (1) PL129426B1 (it)
PT (1) PT74641B (it)
RO (1) RO84661B (it)
SE (1) SE452159B (it)
SU (1) SU1318167A3 (it)
YU (1) YU61582A (it)
ZA (1) ZA821637B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
EP0083439B1 (de) * 1981-12-31 1989-07-26 ASTA Pharma AG 4-Sulfido-oxazaphosphorine und deren Verwendung bei der Krebsbekämpfung und zur Immunsuppression
EP0158057B1 (de) * 1984-03-01 1989-04-26 ASTA Pharma AG Neue Salze von Oxazaphosphorin-Derivaten
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
DE3415726A1 (de) * 1984-04-27 1985-10-31 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5204335A (en) * 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
ATE65402T1 (de) * 1988-03-19 1991-08-15 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
US5190929A (en) * 1988-05-25 1993-03-02 Research Corporation Technologies, Inc. Cyclophosphamide analogs useful as anti-tumor agents
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5661188A (en) * 1995-06-07 1997-08-26 Medical Research Foundation and Infrastructure Development for Health Services--Nahariya Hospital Branch Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna)
US20080223826A1 (en) * 2007-03-13 2008-09-18 Stephen Mazur Reagent Delivery using a Membrane-Mediated Process
FR2968662B1 (fr) 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2107936C3 (de) * 1971-02-19 1978-06-08 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld Alkylsulfonsäureester von 2-Oxo-13,2-oxazaphosphorinanen und diese enthaltende pharmazeutische Präparate
DE1645921C3 (de) * 1966-07-11 1978-10-12 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld 2-Oxo-13,2-osazaphosphorinane, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2201675A1 (de) * 1972-01-14 1973-07-19 Asta Werke Ag Chem Fab Alkylsulfonsaeureester 1,3,2-oxazaphospha-cyclischer verbindungen, verfahren zu ihrer herstellung und pharmazeutische praeparate
JPS5159886A (it) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
JPS54157580A (en) 1978-05-29 1979-12-12 Otsuka Pharmaceut Co Ltd Optically active oxazaphosphorine derivative
JPS5826919B2 (ja) 1978-11-07 1983-06-06 大塚製薬株式会社 シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法
JPS55154984A (en) * 1979-05-24 1980-12-02 Shionogi & Co Ltd Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative
DE3220672A1 (de) 1981-03-24 1983-12-08 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3220432A1 (de) 1981-03-24 1983-12-01 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate
DE3111428A1 (de) 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
FR2502626B1 (fr) 1986-01-03
FI821021L (fi) 1982-09-25
PL235606A1 (it) 1982-11-08
DE3111428A1 (de) 1982-10-07
RO84661B (ro) 1984-11-30
IE820531L (en) 1982-09-24
SU1318167A3 (ru) 1987-06-15
HU186915B (en) 1985-10-28
GB2095256B (en) 1984-08-22
US4929607A (en) 1990-05-29
PL129426B1 (en) 1984-05-31
CH648852A5 (de) 1985-04-15
NL8201227A (nl) 1982-10-18
FI69849B (fi) 1985-12-31
NO820957L (no) 1982-09-27
BE892589A (fr) 1982-07-16
ES510677A0 (es) 1983-02-01
NL192741B (nl) 1997-09-01
SE452159B (sv) 1987-11-16
GR75533B (it) 1984-07-27
EG15703A (en) 1986-06-30
IT8220351A0 (it) 1982-03-23
JPS57169496A (en) 1982-10-19
GB2095256A (en) 1982-09-29
IL65255A (en) 1986-03-31
SE8201807L (sv) 1982-09-25
RO84661A (ro) 1984-10-31
DK129882A (da) 1982-09-25
NO163692B (no) 1990-03-26
ATA106382A (de) 1986-02-15
DK171843B1 (da) 1997-06-30
JPH0240680B2 (it) 1990-09-12
FI69849C (fi) 1986-05-26
BG38489A3 (en) 1985-12-16
CA1194479A (en) 1985-10-01
IE53054B1 (en) 1988-05-25
YU61582A (en) 1985-03-20
AT381317B (de) 1986-09-25
PT74641A (de) 1982-04-01
AU544493B2 (en) 1985-05-30
FR2502626A1 (fr) 1982-10-01
NO163692C (no) 1990-07-04
DE3111428C2 (it) 1990-06-13
IL65255A0 (en) 1982-05-31
PT74641B (de) 1983-10-20
DD201799A5 (de) 1983-08-10
ZA821637B (en) 1983-02-23
FI821021A0 (fi) 1982-03-23
ES8303440A1 (es) 1983-02-01
NL192741C (nl) 1998-01-06
US4623742A (en) 1986-11-18
LU84032A1 (de) 1982-07-08
AU8134482A (en) 1982-09-30

Similar Documents

Publication Publication Date Title
IT1179029B (it) Preparati farmaceutici ad attivita antimicrobica e procedimento per la loro preparazione
IT1177501B (it) Resinato di un acido carbossilico sosituito, procedimento per la sua preparazione, suo impiego e preparati farmaceutici che contengono questo
IT1150499B (it) Acidi ossazafosforin-4-tio-alcansolfonici,loro sali neutri,procedimento per la loro preparazione e preparati farmaceutici che li contengono
IT8349450A0 (it) Determinate pirazolo-chinoline sostituite, procedimento per la loro preparazione, preparati farmaceutici contenenti questi composti e loro impiego terapeutico
IT1229563B (it) Composti tipo sali, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.
IT1147001B (it) Derivati di ossoimidazo chinossalina e loro sali, procedimento per la loro preparazione, loro impiego come medicamenti e composizione farmaceutiche che li contengono
IT1131936B (it) Acidi ossoimmidazolinalcanoici,loro sali ed esteri e anche procedimento per la loro preparazione e prodotti medicinali che contengono questi composti
IT1171361B (it) Amminociclopentanon-ammidi e procedimento per la loro preparazione e formulazione farmaceutica
IT8247762A0 (it) Ammine secondarie alifatiche sostituite e loro sali, procedimento per la loro preparazione, preparati farmaceutici chel le contengono e loro impiego
IT1177980B (it) Composti amminometilici, procetimento per produrli, preparati farmaceutici che li contengono
IT1212753B (it) Composti polienici,procedimento per la loro preparazione e preparati farmaceutici che li contengono
IT8322498A0 (it) Sali di acidi di 1-(cianalchil)-4-guanilpiperazine procedimenti per la loro preparazione e loro impiego.
IT1213059B (it) Sali imidazolici di acidi arilalcanoici antiflogistica,antipiretica, analgesica, loro preparazione e composizioni farmaceutiche che licontengono.
IT1211944B (it) Derivati azolici,procedimento per la loro produzione,preparati farmaceutici che li contengono,e loro impiego
IT8367537A0 (it) Acidi mercaptotetrazolilalcanoidrossamici e procedimento per la loro preparazione
IT1196396B (it) Derivati di acido (2-osso-pirrolidin-1-)- e (2-osso-piperidin-1-)--carbossilico,procedimento per la loro preparazione,loro ulteriore lavorazione e preparati farmaceutici che li contengono
IT7847545A0 (it) Preparati farmaceutici antidiarroici e procedimento per la loro produzione ed applicazione
IT8567216A0 (it) Composti pteridinici relativi procedimenti di preparazione e preparati farmaceutici che li contengono
IT8323157A0 (it) Sali di acidi amminoacil e idrossiacil-amminoacilnaftalensolfonici con attivita'farmacologica, procedimento per il loro ottenimento e composizioni farmaceutiche che li contengono.
IT1168615B (it) Composti di amminoimidazolile, procedimenti per la loro produzione e preparati farmaceutici che contengono questi composti
IT8447848A0 (it) Acidi 7-(1-pirril)- e 7-(1-pirrolidinil)-6-fluoro-1-etil-1,4-diidro4-chetochinolin-3-carbossilici adattivita' antimicrobiche, loro procedimento di preparazione e composti farmaceutici che li contengono
IT1212908B (it) Composti fisiologicamente attivi,loro derivati, procedimenti per la loro preparazione e prodotti farmaceutici che li contengono come principi attivi
IT8321607A1 (it) Preparati farmaceutici topici ad attività antisettica ed antiinfiammatoria spinta, e procedimento per la loro preparazione
IT1145382B (it) Derivato di salfa-pregnan-20-olo e relativi sali di addizione acida procedimento per la loro preparazione loro applicazione come farmaci e composizione che li includono
IT7949562A0 (it) Ossotiacomposti e procedimento per la loro produzione ed impiego in preparati farmaceutici

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990226