ZA200409694B - Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants. - Google Patents
Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants. Download PDFInfo
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- ZA200409694B ZA200409694B ZA200409694A ZA200409694A ZA200409694B ZA 200409694 B ZA200409694 B ZA 200409694B ZA 200409694 A ZA200409694 A ZA 200409694A ZA 200409694 A ZA200409694 A ZA 200409694A ZA 200409694 B ZA200409694 B ZA 200409694B
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| EP1188830B1 (en) | 1999-06-02 | 2010-01-20 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein ,nr10 |
| EP1221482B1 (en) | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | Hemopoietin receptor protein, nr12 |
| EP2351855A1 (en) | 2000-09-26 | 2011-08-03 | Duke University | RNA aptamers and methods for identifying the same |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| RS102404A (sr) * | 2002-05-01 | 2006-12-15 | Schering Aktiengesellschaft | Nova antitela koja ciljaju tkivni faktor kao antikoagulanti |
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| US7833978B2 (en) * | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
| CA2563176A1 (en) | 2004-04-22 | 2005-11-10 | Regado Biosciences, Inc. | Improved modulators of coagulation factors |
| CN103665168A (zh) * | 2005-06-03 | 2014-03-26 | 持田制药株式会社 | 抗cd14抗体融合蛋白质 |
| WO2008039206A2 (en) * | 2005-10-05 | 2008-04-03 | The Trustees Of The University Of Pennsylvania | Fusion proteins for inhibition and dissolution of coagulation |
| ATE485052T1 (de) * | 2006-04-07 | 2010-11-15 | Novo Nordisk Healthcare Ag | Kovalenter faktor vii-gewebefaktor-komplex |
| AU2007255753B2 (en) | 2006-06-08 | 2013-01-17 | Chugai Seiyaku Kabushiki Kaisha | Preventive or remedy for inflammatory disease |
| UA97961C2 (ru) * | 2006-10-06 | 2012-04-10 | Асахи Касеи Фарма Корпорейшн | Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови |
| US9649499B2 (en) * | 2007-03-28 | 2017-05-16 | Medtronic ATS Medical, Inc. | Method for inhibiting platelet interaction with biomaterial surfaces |
| AU2008300516A1 (en) * | 2007-09-20 | 2009-03-26 | Bracco Imaging Spa | Method for the preparation of new oligoclonal antibodies |
| RU2596397C2 (ru) | 2007-12-05 | 2016-09-10 | Чугаи Сейяку Кабусики Кайся | Терапевтическое средство от зуда |
| US8333973B2 (en) * | 2008-01-02 | 2012-12-18 | The Trustees Of The University Of Pennsylvania | Targeting recombinant therapeutics to circulating red blood cells |
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| EP2321338A1 (en) * | 2008-08-14 | 2011-05-18 | Merck Sharp & Dohme Corp. | Methods for purifying antibodies using protein a affinity chromatography |
| US20110262466A1 (en) * | 2008-10-16 | 2011-10-27 | The Trustees Of The University Of Pennsylvania | Compositions containing thrombomodulin domains and uses thereof |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| EP2230251A1 (en) * | 2009-03-19 | 2010-09-22 | Bracco Imaging S.p.A | Antibodies specifically active in the coronary plaque and method for their identification |
| EP2470201A4 (en) * | 2009-08-28 | 2013-01-30 | Bayer Healthcare Llc | COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| JP6143297B2 (ja) * | 2010-06-04 | 2017-06-07 | チウムバイオ・カンパニー・リミテッドＴｉｕｍＢｉｏ Ｃｏ．， Ｌｔｄ． | 第ｖｉｉ因子活性を有する融合タンパク質 |
| EP3281956A3 (en) | 2010-06-15 | 2018-04-18 | Genmab A/S | Human antibody drug conjugates against tissue factor |
| CN103179982A (zh) * | 2010-08-05 | 2013-06-26 | 科学与工业研究委员会 | 具有溶血栓和抗凝血性质的蛋白融合构建体 |
| RU2445365C1 (ru) * | 2010-11-03 | 2012-03-20 | Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") | Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты) |
| BR112017022101A2 (pt) | 2015-04-14 | 2018-07-31 | Chugai Seiyaku Kabushiki Kaisha | composição farmacêutica para prevenção e/ou tratamento de dermatite atópica contendo antagonista de il-31 como ingrediente ativo |
| FI3284480T3 (fi) | 2015-04-14 | 2025-09-11 | Chugai Pharmaceutical Co Ltd | IL-31-antagonistia vaikuttavana ainesosana sisältävä farmaseuttinen koostumus atooppisen ihottuman ehkäisemiseksi ja/tai hoitamiseksi |
| WO2016176440A2 (en) * | 2015-04-28 | 2016-11-03 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as protein c activators |
| US11085031B2 (en) | 2016-04-28 | 2021-08-10 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
| TW201831508A (zh) * | 2016-11-16 | 2018-09-01 | 美商拜耳保健有限責任公司 | 紅血球標靶因子ｖｉｉｉ及其使用方法 |
| BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| CA3099547A1 (en) | 2018-05-07 | 2019-11-14 | Reshma Abdulla RANGWALA | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| WO2020070237A1 (en) * | 2018-10-04 | 2020-04-09 | Thrombosis And Coagulation Ab | Method for the determination of protein s levels |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| IL293099B2 (en) | 2019-11-20 | 2025-07-01 | Chugai Pharmaceutical Co Ltd | Antibody-containing preparation |
| CN114686443B (zh) * | 2020-12-31 | 2023-11-03 | 广州万孚生物技术股份有限公司 | 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用 |
| CN114686444B (zh) * | 2020-12-31 | 2024-05-31 | 广州万孚生物技术股份有限公司 | 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用 |
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| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| ZA862768B (en) * | 1985-04-17 | 1986-12-30 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US5589173A (en) * | 1986-11-04 | 1996-12-31 | Genentech, Inc. | Method and therapeutic compositions for the treatment of myocardial infarction |
| US5437864A (en) * | 1987-03-31 | 1995-08-01 | The Scripps Research Institute | Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor |
| US5223427A (en) * | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
| DK299087D0 (da) | 1987-06-12 | 1987-06-12 | Novo Industri As | Proteins and derivatives thereof |
| US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
| EP0458903A4 (en) * | 1989-02-17 | 1992-06-17 | Codon | Soluble analogs of thrombomodulin |
| US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| US5256770A (en) * | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| US5466668A (en) * | 1989-04-28 | 1995-11-14 | Schering Aktiengesellschaft | Superior thrombomodulin analogs for pharmaceutical use |
| KR930008093B1 (ko) * | 1990-08-03 | 1993-08-25 | 아사히가세이고오교 가부시끼가이샤 | 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물 |
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| US5843442A (en) * | 1990-10-22 | 1998-12-01 | Corvas International, Inc. | Blood coagulation protein antagonists and uses therefor |
| JPH0578397A (ja) * | 1991-01-29 | 1993-03-30 | Sumitomo Pharmaceut Co Ltd | 血栓溶解タンパク質 |
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| US5916874A (en) * | 1994-04-20 | 1999-06-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for treating liver injury |
| US5736364A (en) * | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| AU752730B2 (en) * | 1998-04-03 | 2002-09-26 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (TF) and process for constructing humanized antibody |
| JP2003527861A (ja) * | 2000-03-16 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 増強した抗血液凝固能を持つ抗組織因子抗体 |
| US6632791B1 (en) * | 2000-06-21 | 2003-10-14 | Schering Aktiengesellschaft | Thrombomodulin analogs for pharmaceutical use |
| TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
| WO2003057911A2 (en) | 2002-01-08 | 2003-07-17 | Bayer Healthcare Ag | Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy |
| US7579000B2 (en) * | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| RS102404A (sr) * | 2002-05-01 | 2006-12-15 | Schering Aktiengesellschaft | Nova antitela koja ciljaju tkivni faktor kao antikoagulanti |
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- 2003-04-30 WO PCT/US2003/013521 patent/WO2003093422A2/en not_active Ceased
- 2003-04-30 TW TW092110159A patent/TWI343388B/zh not_active IP Right Cessation
- 2003-04-30 CA CA002483909A patent/CA2483909A1/en not_active Abandoned
- 2003-04-30 MX MXPA04010851A patent/MXPA04010851A/es active IP Right Grant
- 2003-04-30 RS YUP-1045/04A patent/RS104504A/sr unknown
- 2003-04-30 AU AU2003225255A patent/AU2003225255B2/en not_active Ceased
- 2003-04-30 EP EP03721974A patent/EP1549341B1/en not_active Expired - Lifetime
- 2003-04-30 IL IL16473303A patent/IL164733A0/xx unknown
- 2003-04-30 WO PCT/US2003/013522 patent/WO2003092602A2/en not_active Ceased
- 2003-12-30 NO NO20035848A patent/NO20035848L/no not_active Application Discontinuation
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2004
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- 2004-11-24 CR CR7584A patent/CR7584A/es not_active Application Discontinuation
- 2004-11-30 EC EC2004005467A patent/ECSP045467A/es unknown
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2007
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