ATE485052T1 - Kovalenter faktor vii-gewebefaktor-komplex - Google Patents

Kovalenter faktor vii-gewebefaktor-komplex

Info

Publication number
ATE485052T1
ATE485052T1 AT07727577T AT07727577T ATE485052T1 AT E485052 T1 ATE485052 T1 AT E485052T1 AT 07727577 T AT07727577 T AT 07727577T AT 07727577 T AT07727577 T AT 07727577T AT E485052 T1 ATE485052 T1 AT E485052T1
Authority
AT
Austria
Prior art keywords
factor
covalent
complex
factor vii
tissue
Prior art date
Application number
AT07727577T
Other languages
English (en)
Inventor
Henrik Ystergaard
Ole Olsen
Anders Klarskov Petersen
Henning Ralf Stennicke
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Application granted granted Critical
Publication of ATE485052T1 publication Critical patent/ATE485052T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT07727577T 2006-04-07 2007-03-30 Kovalenter faktor vii-gewebefaktor-komplex ATE485052T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112358 2006-04-07
PCT/EP2007/053105 WO2007115953A1 (en) 2006-04-07 2007-03-30 Covalent factor vii-tissue factor complex

Publications (1)

Publication Number Publication Date
ATE485052T1 true ATE485052T1 (de) 2010-11-15

Family

ID=36781437

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07727577T ATE485052T1 (de) 2006-04-07 2007-03-30 Kovalenter faktor vii-gewebefaktor-komplex

Country Status (8)

Country Link
US (1) US20110040073A1 (de)
EP (1) EP2007417B1 (de)
JP (1) JP5759102B2 (de)
CN (1) CN101466400B (de)
AT (1) ATE485052T1 (de)
DE (1) DE602007009956D1 (de)
ES (1) ES2353084T3 (de)
WO (1) WO2007115953A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127640A1 (de) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Modifizierte azid-enthaltende Proteine
JP5762404B2 (ja) 2009-06-24 2015-08-12 コーニンクレッカ フィリップス エヌ ヴェ マイクロコントローラをプログラミングする方法及び装置
WO2011092242A1 (en) * 2010-01-28 2011-08-04 Novo Nordisk Health Care Ag Factor vii fusion polypeptides
CN104395465A (zh) * 2012-03-30 2015-03-04 诺和诺德保健Ag（股份有限公司） 表现出外位点介导的超级活性的FVIIa-sTF复合物
EP4079316A1 (de) 2012-06-08 2022-10-26 Bioverativ Therapeutics Inc. Prokoagulatorische verbindungen
JP2015525222A (ja) 2012-06-08 2015-09-03 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． キメラ性凝固因子
CN104704118A (zh) 2012-10-15 2015-06-10 诺和诺德保健Ag（股份有限公司） 凝血因子vii多肽
BR112018002838A2 (pt) * 2015-08-12 2019-01-15 Cell Machines Inc complexo do fator de coagulação, kit, método de tratamento
JP7297928B2 (ja) 2019-04-17 2023-06-26 ノヴォ ノルディスク アー／エス 二重特異性抗体
CN114836503B (zh) * 2022-04-29 2023-08-25 江苏祈瑞医药科技有限公司 一组具有肝损伤保护作用的乳清蛋白肽、高f值寡肽及其制备方法和应用
CN117860874B (zh) * 2024-03-12 2024-07-02 正大天晴药业集团南京顺欣制药有限公司 重组人凝血因子VIIa的药物组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5788965A (en) * 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
PT866870E (pt) * 1995-12-01 2003-08-29 Genentech Inc Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia
EP0979281B1 (de) * 1997-05-02 2005-07-20 Genentech, Inc. ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
DK1257295T3 (da) * 2000-02-11 2009-08-10 Bayer Healthcare Llc Faktor VII eller VIIA-lignende molekyler
EP1397484A4 (de) * 2001-03-27 2005-05-25 Massachusetts Inst Technology Verfahren und produkte im zusammenhang mit fgf-dimerisierung
CN1602354A (zh) * 2001-09-27 2005-03-30 诺和诺德医疗保健公司 人凝血因子ⅶ多肽
WO2003029420A2 (en) * 2001-10-02 2003-04-10 Genentech, Inc. Apo-2 ligand variants and uses thereof
AU2003225256B2 (en) * 2002-05-01 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants
EP1523504A2 (de) * 2002-07-12 2005-04-20 Novo Nordisk A/S Gewebe faktorbindende immunokonjugate die faktor viia enthalten
EP1673453A2 (de) * 2003-10-07 2006-06-28 Novo Nordisk Health Care AG Hybridmoleküle mit faktor vii/viia-aktivität

Also Published As

Publication number Publication date
JP2009532048A (ja) 2009-09-10
EP2007417A1 (de) 2008-12-31
US20110040073A1 (en) 2011-02-17
JP5759102B2 (ja) 2015-08-05
CN101466400B (zh) 2014-06-25
EP2007417B1 (de) 2010-10-20
ES2353084T3 (es) 2011-02-25
CN101466400A (zh) 2009-06-24
WO2007115953A1 (en) 2007-10-18
DE602007009956D1 (de) 2010-12-02

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