PT2382198E - Processos e intermediários para a preparação de um inibidor macrocíclico de protease do vhc - Google Patents

Processos e intermediários para a preparação de um inibidor macrocíclico de protease do vhc

Info

Publication number
PT2382198E
PT2382198E PT09801447T PT09801447T PT2382198E PT 2382198 E PT2382198 E PT 2382198E PT 09801447 T PT09801447 T PT 09801447T PT 09801447 T PT09801447 T PT 09801447T PT 2382198 E PT2382198 E PT 2382198E
Authority
PT
Portugal
Prior art keywords
intermediates
preparing
processes
hcv
protease inhibitor
Prior art date
Application number
PT09801447T
Other languages
English (en)
Inventor
Dominique Paul Michel Depre
Dominic John Ormerod
Andras Horvath
Veronique Cerpentier
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of PT2382198E publication Critical patent/PT2382198E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT09801447T 2008-12-23 2009-12-22 Processos e intermediários para a preparação de um inibidor macrocíclico de protease do vhc PT2382198E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08172691 2008-12-23

Publications (1)

Publication Number Publication Date
PT2382198E true PT2382198E (pt) 2013-10-01

Family

ID=40548041

Family Applications (1)

Application Number Title Priority Date Filing Date
PT09801447T PT2382198E (pt) 2008-12-23 2009-12-22 Processos e intermediários para a preparação de um inibidor macrocíclico de protease do vhc

Country Status (23)

Country Link
US (2) US8927722B2 (pt)
EP (1) EP2382198B1 (pt)
JP (1) JP5687631B2 (pt)
KR (1) KR101734507B1 (pt)
CN (1) CN102264715B (pt)
AR (1) AR074863A1 (pt)
AU (1) AU2009331530B2 (pt)
BR (1) BRPI0923393B1 (pt)
CA (1) CA2745565C (pt)
CY (1) CY1114488T1 (pt)
DK (1) DK2382198T3 (pt)
ES (1) ES2429013T3 (pt)
HK (1) HK1164839A1 (pt)
HR (1) HRP20130906T1 (pt)
IL (1) IL213246A (pt)
MX (1) MX2011006764A (pt)
PL (1) PL2382198T3 (pt)
PT (1) PT2382198E (pt)
RU (1) RU2016120007A (pt)
SI (1) SI2382198T1 (pt)
SM (1) SMT201300116B (pt)
TW (1) TWI461424B (pt)
WO (1) WO2010072742A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927722B2 (en) 2008-12-23 2015-01-06 Janssen Pharmaceutica N.V. Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
TWI565704B (zh) * 2011-09-22 2017-01-11 健生醫藥公司 用於製備ｈｃｖ巨環蛋白酶抑制劑之方法及中間物
WO2013061285A1 (en) * 2011-10-28 2013-05-02 Janssen Pharmaceuticals, Inc Improved process for preparing an intermediate of the macrocyclic protease inhibitor tmc 435
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
ES2624223T3 (es) 2012-06-08 2017-07-13 Gilead Sciences, Inc. Inhibidores macrocíclicos de los virus flaviviridae
IN2014MN02658A (pt) 2012-06-08 2015-08-21 Gilead Sciences Inc
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
CN105073758B (zh) 2013-03-15 2017-08-11 吉利德科学公司 丙型肝炎病毒抑制剂
WO2015180253A1 (zh) * 2014-05-29 2015-12-03 杭州普晒医药科技有限公司 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8300536A (nl) 1983-02-14 1984-09-03 Oce Andeno Bv Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan.
JPS6124539A (ja) * 1984-07-11 1986-02-03 Sagami Chem Res Center 光学活性（ｒ）−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオン−２−カルボン酸の取得方法
JP4218040B2 (ja) * 1997-12-26 2009-02-04 曽田香料株式会社 有機酸とアミンの複合塩の製造法
JP3844112B2 (ja) 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
ATE461209T1 (de) 2004-01-30 2010-04-15 Medivir Ab Hcv ns-3 serine protease inhibitoren
CN101146794A (zh) * 2005-01-21 2008-03-19 阿斯泰克斯治疗有限公司 用于抑制cdk和gsk的吡唑衍生物
AR054882A1 (es) * 2005-07-29 2007-07-25 Tibotec Pharm Ltd Inhibidores macrociclicos del virus de la hepatitis c
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US8212043B2 (en) * 2007-02-01 2012-07-03 Janssen R&D Ireland Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
KR20090111326A (ko) * 2007-02-08 2009-10-26 티보텍 파마슈티칼즈 리미티드 Ｈｃｖ 억제 마크로사이클릭 페닐카바메이트
US8927722B2 (en) 2008-12-23 2015-01-06 Janssen Pharmaceutica N.V. Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV

Also Published As

Publication number Publication date
IL213246A (en) 2017-10-31
AR074863A1 (es) 2011-02-16
HRP20130906T1 (hr) 2013-10-25
RU2011130895A (ru) 2013-01-27
BRPI0923393B1 (pt) 2018-06-19
KR20110099048A (ko) 2011-09-05
US9115077B2 (en) 2015-08-25
ES2429013T3 (es) 2013-11-12
WO2010072742A1 (en) 2010-07-01
US8927722B2 (en) 2015-01-06
IL213246A0 (en) 2011-07-31
JP2012513381A (ja) 2012-06-14
MX2011006764A (es) 2011-08-03
BRPI0923393A2 (pt) 2015-07-28
CA2745565C (en) 2017-03-07
CA2745565A1 (en) 2010-07-01
CN102264715A (zh) 2011-11-30
US20150080577A1 (en) 2015-03-19
SI2382198T1 (sl) 2013-11-29
HK1164839A1 (zh) 2012-09-28
CN102264715B (zh) 2015-12-02
AU2009331530A1 (en) 2011-06-23
TWI461424B (zh) 2014-11-21
DK2382198T3 (da) 2013-09-30
PL2382198T3 (pl) 2013-11-29
EP2382198B1 (en) 2013-07-10
JP5687631B2 (ja) 2015-03-18
KR101734507B1 (ko) 2017-05-11
US20110257403A1 (en) 2011-10-20
AU2009331530B2 (en) 2015-04-09
TW201033205A (en) 2010-09-16
EP2382198A1 (en) 2011-11-02
CY1114488T1 (el) 2016-10-05
SMT201300116B (it) 2013-11-08
RU2016120007A (ru) 2018-11-13

Similar Documents

Publication Publication Date Title
MX2011006764A (es) Procedimiento y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc.
HK1186979A1 (zh) 大環脯氨酸衍生的 絲氨酸蛋白酶抑制劑
WO2011002808A8 (en) Hcv protease inhibitors and uses thereof
CA2830549C (en) Methods and compositions for preparing noribogaine from voacangine
WO2010111436A3 (en) Antiviral compounds and uses thereof
MX2011011272A (es) Procesos e intermediarios.
MY147732A (en) Process for the preparation of 2-substituted-5- (1-alkylthio) alkylpyridines
WO2012082672A3 (en) Process and intermediates for preparing macrolactams
AP2757A (en) Process for preparation of HIV protease inhibitors
MX2011008621A (es) Proceso para la purificacion de lipopeptidos.
MY155330A (en) Methods for salt production
MX2012007341A (es) Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.
TW200728310A (en) Process for the preparation of ferri-succinylcasein
WO2011004402A3 (en) Improved process for the preparation of ambrisentan and novel intermediates thereof
WO2008021346A3 (en) Pure paliperidone and processes for preparing thereof
WO2010015656A3 (en) Alkoxypyrazoles and the process for their preparation
UA91733C2 (ru) Способ получения кристаллической формы орлистата
AU2012248013B2 (en) Intermediate for synthesizing caspofungin and preparation method therefor
UA110626C2 (uk) Спосіб одержання пан-інгібіторів циклінзалежної кінази формули (i), а також проміжні продукти цього процесу одержання
WO2010059916A3 (en) Preparation of docetaxel
MX2010001962A (es) Procedimiento para preparar 4-aminobut-2-enolidos.
WO2010027889A3 (en) Process for synthesizing substituted isoquinolines
UA34487U (en) Aquananomagnesium
TW200728267A (en) Processes and intermediates for the preparation of prostaglandins
WO2008111018A3 (en) Process for the preparation of crystals of prulifloxacin