SMT201300116B - Procedimenti e intermedi per la preparazione di uninibitore macrociclico di proteasi di hcv - Google Patents

Procedimenti e intermedi per la preparazione di uninibitore macrociclico di proteasi di hcv

Info

Publication number
SMT201300116B
SMT201300116B SM201300116T SM201300116T SMT201300116B SM T201300116 B SMT201300116 B SM T201300116B SM 201300116 T SM201300116 T SM 201300116T SM 201300116 T SM201300116 T SM 201300116T SM T201300116 B SMT201300116 B SM T201300116B
Authority
SM
San Marino
Prior art keywords
intermediates
preparation
hcv
procedures
protease inhibitor
Prior art date
Application number
SM201300116T
Other languages
English (en)
Inventor
Andras Horvath
Dominic John Ormerod
Dominique Paul Michel Depre
Veronique Cerpentier
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of SMT201300116B publication Critical patent/SMT201300116B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SM201300116T 2008-12-23 2013-10-10 Procedimenti e intermedi per la preparazione di uninibitore macrociclico di proteasi di hcv SMT201300116B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08172691 2008-12-23
PCT/EP2009/067715 WO2010072742A1 (en) 2008-12-23 2009-12-22 Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (1)

Publication Number Publication Date
SMT201300116B true SMT201300116B (it) 2013-11-08

Family

ID=40548041

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201300116T SMT201300116B (it) 2008-12-23 2013-10-10 Procedimenti e intermedi per la preparazione di uninibitore macrociclico di proteasi di hcv

Country Status (23)

Country Link
US (2) US8927722B2 (it)
EP (1) EP2382198B1 (it)
JP (1) JP5687631B2 (it)
KR (1) KR101734507B1 (it)
CN (1) CN102264715B (it)
AR (1) AR074863A1 (it)
AU (1) AU2009331530B2 (it)
BR (1) BRPI0923393B1 (it)
CA (1) CA2745565C (it)
CY (1) CY1114488T1 (it)
DK (1) DK2382198T3 (it)
ES (1) ES2429013T3 (it)
HK (1) HK1164839A1 (it)
HR (1) HRP20130906T1 (it)
IL (1) IL213246A (it)
MX (1) MX2011006764A (it)
PL (1) PL2382198T3 (it)
PT (1) PT2382198E (it)
RU (1) RU2016120007A (it)
SI (1) SI2382198T1 (it)
SM (1) SMT201300116B (it)
TW (1) TWI461424B (it)
WO (1) WO2010072742A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2382198T1 (sl) 2008-12-23 2013-11-29 Janssen Pharmaceuticals, Inc. Postopek in vmesne spojine za pripravo makrocikličnega inhibitorja HCV proteaze
AU2012311461B2 (en) * 2011-09-22 2017-07-06 Janssen Pharmaceuticals, Inc. Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
BR112014009849A2 (pt) 2011-10-28 2016-07-05 Janssen Pharmaceuticals Inc processo melhorado para preparação de intermediário do inibidor de protease macrocíclico tmc 435
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
JP6209601B2 (ja) 2012-06-08 2017-10-04 ギリアード サイエンシーズ， インコーポレイテッド フラビウイルス科ウイルスの大環状阻害剤
AR091279A1 (es) * 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
ES2656087T3 (es) * 2012-06-08 2018-02-23 Gilead Sciences, Inc. Inhibidores macrocíclicos de virus Flaviviridae
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
ES2735355T3 (es) 2013-03-15 2019-12-18 Gilead Sciences Inc Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C
CN105308043B (zh) * 2014-05-29 2018-01-30 杭州普晒医药科技有限公司 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8300536A (nl) 1983-02-14 1984-09-03 Oce Andeno Bv Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan.
JPS6124539A (ja) 1984-07-11 1986-02-03 Sagami Chem Res Center 光学活性（ｒ）−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオン−２−カルボン酸の取得方法
JP4218040B2 (ja) 1997-12-26 2009-02-04 曽田香料株式会社 有機酸とアミンの複合塩の製造法
JP3844112B2 (ja) 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
ES2336009T3 (es) * 2004-01-30 2010-04-07 Medivir Ab Inhibidores de la ns-3 serina proteasa del vhc.
CN101146795A (zh) 2005-01-21 2008-03-19 阿斯泰克斯治疗有限公司 用于抑制cdk和gsk的吡唑衍生物
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
PL1919904T3 (pl) * 2005-07-29 2014-06-30 Janssen R&D Ireland Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
AU2008209697B2 (en) * 2007-02-01 2014-02-20 Janssen Sciences Ireland Uc Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
JP5554570B2 (ja) * 2007-02-08 2014-07-23 ヤンセン・アールアンドデイ・アイルランド Ｈｃｖ阻害大環状フェニルカルバメート
SI2382198T1 (sl) 2008-12-23 2013-11-29 Janssen Pharmaceuticals, Inc. Postopek in vmesne spojine za pripravo makrocikličnega inhibitorja HCV proteaze

Also Published As

Publication number Publication date
AU2009331530B2 (en) 2015-04-09
AU2009331530A1 (en) 2011-06-23
US20110257403A1 (en) 2011-10-20
WO2010072742A1 (en) 2010-07-01
MX2011006764A (es) 2011-08-03
CN102264715B (zh) 2015-12-02
US20150080577A1 (en) 2015-03-19
JP2012513381A (ja) 2012-06-14
IL213246A0 (en) 2011-07-31
US8927722B2 (en) 2015-01-06
IL213246A (en) 2017-10-31
TW201033205A (en) 2010-09-16
CA2745565A1 (en) 2010-07-01
PL2382198T3 (pl) 2013-11-29
ES2429013T3 (es) 2013-11-12
JP5687631B2 (ja) 2015-03-18
US9115077B2 (en) 2015-08-25
RU2011130895A (ru) 2013-01-27
PT2382198E (pt) 2013-10-01
RU2016120007A (ru) 2018-11-13
HK1164839A1 (zh) 2012-09-28
CY1114488T1 (el) 2016-10-05
CN102264715A (zh) 2011-11-30
DK2382198T3 (da) 2013-09-30
KR101734507B1 (ko) 2017-05-11
BRPI0923393B1 (pt) 2018-06-19
TWI461424B (zh) 2014-11-21
AR074863A1 (es) 2011-02-16
HRP20130906T1 (hr) 2013-10-25
CA2745565C (en) 2017-03-07
EP2382198B1 (en) 2013-07-10
BRPI0923393A2 (pt) 2015-07-28
EP2382198A1 (en) 2011-11-02
SI2382198T1 (sl) 2013-11-29
KR20110099048A (ko) 2011-09-05

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