AR074863A1 - Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc - Google Patents
Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhcInfo
- Publication number
- AR074863A1 AR074863A1 ARP090105059A AR074863A1 AR 074863 A1 AR074863 A1 AR 074863A1 AR P090105059 A ARP090105059 A AR P090105059A AR 074863 A1 AR074863 A1 AR 074863A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- macrociclic
- hcv
- prepare
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Abstract
La presente también se refiere a procesos que involucran esta sal. Reivindicación 1: Un proceso para preparar un compuesto de fórmula (4), comenzando a partir de una sal de cinconidina de fórmula (1), la cual se hace reaccionar con N-metil-hexenamina (NMHA) de fórmula (2) en una reacción de formación de amida para proporcionar la amida de lactona bicíclica de fórmula (3), en donde el grupo lactona se abre para proporcionar el producto deseado de fórmula (4), donde R1 es alquilo C1-4. Reivindicación 14: La sal de cinconidina de fórmula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08172691 | 2008-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074863A1 true AR074863A1 (es) | 2011-02-16 |
Family
ID=40548041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090105059 AR074863A1 (es) | 2008-12-23 | 2009-12-22 | Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc |
Country Status (23)
Country | Link |
---|---|
US (2) | US8927722B2 (es) |
EP (1) | EP2382198B1 (es) |
JP (1) | JP5687631B2 (es) |
KR (1) | KR101734507B1 (es) |
CN (1) | CN102264715B (es) |
AR (1) | AR074863A1 (es) |
AU (1) | AU2009331530B2 (es) |
BR (1) | BRPI0923393B1 (es) |
CA (1) | CA2745565C (es) |
CY (1) | CY1114488T1 (es) |
DK (1) | DK2382198T3 (es) |
ES (1) | ES2429013T3 (es) |
HK (1) | HK1164839A1 (es) |
HR (1) | HRP20130906T1 (es) |
IL (1) | IL213246A (es) |
MX (1) | MX2011006764A (es) |
PL (1) | PL2382198T3 (es) |
PT (1) | PT2382198E (es) |
RU (1) | RU2016120007A (es) |
SI (1) | SI2382198T1 (es) |
SM (1) | SMT201300116B (es) |
TW (1) | TWI461424B (es) |
WO (1) | WO2010072742A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0923393B1 (pt) | 2008-12-23 | 2018-06-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | "processos para preparar um inibidor de protease de hcv macrocíclico e intermediários e uso". |
CN103906739B (zh) * | 2011-09-22 | 2016-12-28 | 杨森制药公司 | 用于制备hcv的大环蛋白酶抑制剂的方法和中间体 |
AR088568A1 (es) | 2011-10-28 | 2014-06-18 | Janssen Pharmaceuticals Inc | Proceso mejorado para preparar un compuesto intermedio del inhibidor macrociclico de la proteasa tmc 435 |
CN103387509B (zh) * | 2012-05-11 | 2016-06-08 | 重庆博腾制药科技股份有限公司 | 一种hcv蛋白酶抑制剂中间体的制备方法 |
CA2875718A1 (en) | 2012-06-08 | 2013-12-12 | Selcia Limited | Macrocyclic inhibitors of flaviviridae viruses |
AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
EA026235B1 (ru) * | 2012-06-08 | 2017-03-31 | Джилид Сайэнс, Инк. | Макроциклические ингибиторы вирусов flaviviridae |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
EP2970335B1 (en) | 2013-03-15 | 2019-05-08 | Gilead Sciences, Inc. | Macrocyclic and bicyclic inhibitors of hepatitis c virus |
WO2015180253A1 (zh) * | 2014-05-29 | 2015-12-03 | 杭州普晒医药科技有限公司 | 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途 |
MA41812A (fr) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8300536A (nl) | 1983-02-14 | 1984-09-03 | Oce Andeno Bv | Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan. |
JPS6124539A (ja) * | 1984-07-11 | 1986-02-03 | Sagami Chem Res Center | 光学活性(r)−2,5,12−トリヒドロキシ−1,2,3,4−テトラヒドロナフタセン−6,11−ジオン−2−カルボン酸の取得方法 |
JP4218040B2 (ja) * | 1997-12-26 | 2009-02-04 | 曽田香料株式会社 | 有機酸とアミンの複合塩の製造法 |
JP3844112B2 (ja) * | 2000-08-23 | 2006-11-08 | 高砂香料工業株式会社 | 3,5,6−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法 |
DE602005017582D1 (en) | 2004-01-30 | 2009-12-24 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
CN101146794A (zh) * | 2005-01-21 | 2008-03-19 | 阿斯泰克斯治疗有限公司 | 用于抑制cdk和gsk的吡唑衍生物 |
CN101273030B (zh) * | 2005-07-29 | 2012-07-18 | 泰博特克药品有限公司 | 丙型肝炎病毒的大环抑制剂 |
PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
TWI455936B (zh) * | 2007-02-01 | 2014-10-11 | Tibotec Pharm Ltd | 用於製備hcv之大環蛋白酶抑制劑之方法及中間物 |
WO2008096001A1 (en) * | 2007-02-08 | 2008-08-14 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting macrocyclic phenylcarbamates |
BRPI0923393B1 (pt) | 2008-12-23 | 2018-06-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | "processos para preparar um inibidor de protease de hcv macrocíclico e intermediários e uso". |
-
2009
- 2009-12-22 BR BRPI0923393-8A patent/BRPI0923393B1/pt not_active IP Right Cessation
- 2009-12-22 JP JP2011541509A patent/JP5687631B2/ja not_active Expired - Fee Related
- 2009-12-22 AU AU2009331530A patent/AU2009331530B2/en not_active Ceased
- 2009-12-22 ES ES09801447T patent/ES2429013T3/es active Active
- 2009-12-22 SI SI200930731T patent/SI2382198T1/sl unknown
- 2009-12-22 CN CN200980152851.5A patent/CN102264715B/zh not_active Expired - Fee Related
- 2009-12-22 EP EP09801447.5A patent/EP2382198B1/en active Active
- 2009-12-22 DK DK09801447.5T patent/DK2382198T3/da active
- 2009-12-22 MX MX2011006764A patent/MX2011006764A/es active IP Right Grant
- 2009-12-22 TW TW98144049A patent/TWI461424B/zh not_active IP Right Cessation
- 2009-12-22 US US13/141,715 patent/US8927722B2/en not_active Expired - Fee Related
- 2009-12-22 RU RU2016120007A patent/RU2016120007A/ru not_active Application Discontinuation
- 2009-12-22 CA CA2745565A patent/CA2745565C/en not_active Expired - Fee Related
- 2009-12-22 AR ARP090105059 patent/AR074863A1/es unknown
- 2009-12-22 KR KR1020117017333A patent/KR101734507B1/ko active IP Right Grant
- 2009-12-22 WO PCT/EP2009/067715 patent/WO2010072742A1/en active Application Filing
- 2009-12-22 PL PL09801447T patent/PL2382198T3/pl unknown
- 2009-12-22 PT PT09801447T patent/PT2382198E/pt unknown
-
2011
- 2011-05-31 IL IL213246A patent/IL213246A/en not_active IP Right Cessation
-
2012
- 2012-05-29 HK HK12105238.7A patent/HK1164839A1/zh not_active IP Right Cessation
-
2013
- 2013-09-24 HR HRP20130906AT patent/HRP20130906T1/hr unknown
- 2013-10-10 SM SM201300116T patent/SMT201300116B/xx unknown
- 2013-10-10 CY CY20131100890T patent/CY1114488T1/el unknown
-
2014
- 2014-11-25 US US14/552,550 patent/US9115077B2/en not_active Expired - Fee Related
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Legal Events
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