AR056181A1 - Procedimiento para producir nonapeptido leuprolida - Google Patents

Procedimiento para producir nonapeptido leuprolida

Info

Publication number
AR056181A1
AR056181A1 ARP060105195A ARP060105195A AR056181A1 AR 056181 A1 AR056181 A1 AR 056181A1 AR P060105195 A ARP060105195 A AR P060105195A AR P060105195 A ARP060105195 A AR P060105195A AR 056181 A1 AR056181 A1 AR 056181A1
Authority
AR
Argentina
Prior art keywords
nonapeptide
leuprolated
procedure
produce
leucyl
Prior art date
Application number
ARP060105195A
Other languages
English (en)
Inventor
Daniel Kadzimirzs
Gerhard Jas
Volker Autze
Original Assignee
Nanokem S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanokem S A filed Critical Nanokem S A
Publication of AR056181A1 publication Critical patent/AR056181A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Proceso para producir el nonapéptido leuprolida, en donde al menos un enlace peptídico del compuesto se forma haciendo reaccionar un ácido carboxílico activado y un componente amina en un flujo contínuo Reivindicacion 2: Proceso de acuerdo con la reivindicacion 1, caracterizado porque la leuprolida es un compuesto de formula 5-oxo-L-propil-L-histidil-L-triptofil-L-seril-L-tirosilo-D-leucilo-L-leucil-L-arginil-N-etil-L-prolinamida.
ARP060105195A 2005-11-25 2006-11-24 Procedimiento para producir nonapeptido leuprolida AR056181A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05025801A EP1790656A1 (en) 2005-11-25 2005-11-25 Solution-phase synthesis of leuprolide

Publications (1)

Publication Number Publication Date
AR056181A1 true AR056181A1 (es) 2007-09-19

Family

ID=36337483

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105195A AR056181A1 (es) 2005-11-25 2006-11-24 Procedimiento para producir nonapeptido leuprolida

Country Status (5)

Country Link
US (1) US8013117B2 (es)
EP (2) EP1790656A1 (es)
AR (1) AR056181A1 (es)
DE (1) DE602006013028D1 (es)
WO (1) WO2007059921A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060580A1 (en) * 2007-11-19 2009-05-20 SOLVAY (Société Anonyme) Process for the manufacture of persilylated peptides
EP2409982A3 (en) * 2010-02-25 2012-02-08 Corning Incorporated Chemical processes generating solid(s) carried out continuously within microreactors
US20130060004A1 (en) * 2010-05-07 2013-03-07 Ananda Kuppanna Novel Process For The Preparation Of Leuprolide And Its Pharmaceutically Acceptable Salts Thereof
CN105753762B (zh) * 2016-04-21 2018-10-30 南京工业大学 一种吲哚c3衍生物及其制备方法
CN109593118A (zh) * 2018-12-18 2019-04-09 江苏诺泰澳赛诺生物制药股份有限公司 一种亮丙瑞林的液相合成方法
WO2023030278A1 (zh) * 2021-08-30 2023-03-09 湖南三太药业有限公司 一种全液相合成瑞林类药物的方法
CN113880920B (zh) * 2021-12-06 2022-02-22 浙江湃肽生物有限公司南京分公司 一种亮丙瑞林衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS180644B2 (en) * 1973-09-29 1978-01-31 Takeda Chemical Industries Ltd Process for preparing nonapeptides
JPS5726506B2 (es) * 1974-03-08 1982-06-04
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US4005063A (en) * 1973-10-11 1977-01-25 Abbott Laboratories [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
IL150601A (en) * 2001-07-19 2010-06-30 Organon Nv Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
IL150600A (en) 2001-07-19 2005-09-25 Akzo Nobel Nv Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component

Also Published As

Publication number Publication date
DE602006013028D1 (de) 2010-04-29
EP1790656A1 (en) 2007-05-30
US8013117B2 (en) 2011-09-06
EP1951746A1 (en) 2008-08-06
US20090005535A1 (en) 2009-01-01
EP1951746B1 (en) 2010-03-17
WO2007059921A1 (en) 2007-05-31

Similar Documents

Publication Publication Date Title
AR056181A1 (es) Procedimiento para producir nonapeptido leuprolida
MY151017A (en) 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
NZ598277A (en) Process for preparing azabicyclic compounds
MX2012000973A (es) Compuestos para la reduccion de produccion de beta- amiloide.
NZ595942A (en) Processes for the preparation of rivaroxaban and intermediates thereof
MY146084A (en) Benzyl amines, a process for their production and their use as anti-inflammatory agents
AR067281A1 (es) Un procedimiento de fabricacion de poliamida
EA200901563A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
ATE500215T1 (de) Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide
RS54485B1 (en) C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS
MX2009006865A (es) Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico.
CY1111904T1 (el) Διεργασιες για την παρασκευη επτιφιβατιδης και των συναφων ενδιαμεσων ενωσεων
UY28246A1 (es) Procedimiento para la preparación de telmisartan
UA100367C2 (uk) Спосіб одержання мемантину і його гідрохлориду
TW200716138A (en) Stable active compound complex of salts of O-acetylsalicylic acid with basic amino acids and glycine
AR062504A1 (es) Procedimientos para preparar acidos d,l-2hidroxi-4-alquiltiobutiricos
AR074863A1 (es) Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc
PL1943290T3 (pl) Poliamidy z m-ksylilenodiaminy i kwasu adypinowego, zawierające końcowe grupy aminowe w ilości poniżej 15 mmoli/kg
MX2009003823A (es) Nueva difenilazetidinona sustituida con acido piperazina-1-sulfonico y que tiene propiedades farmacologicas mejoradas.
UA107779C2 (en) Method of synthetic 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one and use in the synthesis ivabradynu and its addition salts with pharmaceutically acceptable acid
TW200724567A (en) Amide-containing polymers for rheology control
JO2781B1 (en) A new process for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acid.
EA201200498A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
UY31681A1 (es) Procedimiento de preparcion de combretastatina
JO2782B1 (en) A new process for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acid.

Legal Events

Date Code Title Description
FB Suspension of granting procedure