DE602006013028D1 - Lösungsphasensynthese von leuprolid und dessen zwischenprodukten - Google Patents

Lösungsphasensynthese von leuprolid und dessen zwischenprodukten

Info

Publication number
DE602006013028D1
DE602006013028D1 DE602006013028T DE602006013028T DE602006013028D1 DE 602006013028 D1 DE602006013028 D1 DE 602006013028D1 DE 602006013028 T DE602006013028 T DE 602006013028T DE 602006013028 T DE602006013028 T DE 602006013028T DE 602006013028 D1 DE602006013028 D1 DE 602006013028D1
Authority
DE
Germany
Prior art keywords
leuprolide
phase synthesis
solution phase
intermediate products
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006013028T
Other languages
English (en)
Inventor
Daniel Kadzimirzs
Gerhard Jas
Volker Autze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanokem SA
Original Assignee
Nanokem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanokem SA filed Critical Nanokem SA
Publication of DE602006013028D1 publication Critical patent/DE602006013028D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
DE602006013028T 2005-11-25 2006-11-21 Lösungsphasensynthese von leuprolid und dessen zwischenprodukten Active DE602006013028D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05025801A EP1790656A1 (de) 2005-11-25 2005-11-25 Lösungsphasesynthese von Leuprolid
PCT/EP2006/011144 WO2007059921A1 (en) 2005-11-25 2006-11-21 Solution-phase synthesis of leuprolide and its intermediates

Publications (1)

Publication Number Publication Date
DE602006013028D1 true DE602006013028D1 (de) 2010-04-29

Family

ID=36337483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006013028T Active DE602006013028D1 (de) 2005-11-25 2006-11-21 Lösungsphasensynthese von leuprolid und dessen zwischenprodukten

Country Status (5)

Country Link
US (1) US8013117B2 (de)
EP (2) EP1790656A1 (de)
AR (1) AR056181A1 (de)
DE (1) DE602006013028D1 (de)
WO (1) WO2007059921A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060580A1 (de) * 2007-11-19 2009-05-20 SOLVAY (Société Anonyme) Verfahren zur Herstellung von persilylierten Peptiden
EP2409982A3 (de) * 2010-02-25 2012-02-08 Corning Incorporated Chemische, innerhalb von Mikroreaktoren kontinuierlich ausgeführte Verfahren zur Feststofferzeugung
US20130060004A1 (en) * 2010-05-07 2013-03-07 Ananda Kuppanna Novel Process For The Preparation Of Leuprolide And Its Pharmaceutically Acceptable Salts Thereof
CN105753762B (zh) * 2016-04-21 2018-10-30 南京工业大学 一种吲哚c3衍生物及其制备方法
CN109593118A (zh) * 2018-12-18 2019-04-09 江苏诺泰澳赛诺生物制药股份有限公司 一种亮丙瑞林的液相合成方法
WO2023030278A1 (zh) * 2021-08-30 2023-03-09 湖南三太药业有限公司 一种全液相合成瑞林类药物的方法
CN113880920B (zh) * 2021-12-06 2022-02-22 浙江湃肽生物有限公司南京分公司 一种亮丙瑞林衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS180644B2 (en) 1973-09-29 1978-01-31 Takeda Chemical Industries Ltd Process for preparing nonapeptides
JPS5726506B2 (de) * 1974-03-08 1982-06-04
US4005063A (en) * 1973-10-11 1977-01-25 Abbott Laboratories [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
US3914412A (en) 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
IL150600A (en) 2001-07-19 2005-09-25 Akzo Nobel Nv Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component
IL150601A (en) 2001-07-19 2010-06-30 Organon Nv Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component

Also Published As

Publication number Publication date
EP1790656A1 (de) 2007-05-30
AR056181A1 (es) 2007-09-19
US20090005535A1 (en) 2009-01-01
WO2007059921A1 (en) 2007-05-31
EP1951746B1 (de) 2010-03-17
EP1951746A1 (de) 2008-08-06
US8013117B2 (en) 2011-09-06

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Legal Events

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