MX2009006865A - Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico. - Google Patents

Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico.

Info

Publication number
MX2009006865A
MX2009006865A MX2009006865A MX2009006865A MX2009006865A MX 2009006865 A MX2009006865 A MX 2009006865A MX 2009006865 A MX2009006865 A MX 2009006865A MX 2009006865 A MX2009006865 A MX 2009006865A MX 2009006865 A MX2009006865 A MX 2009006865A
Authority
MX
Mexico
Prior art keywords
dimethyl
azabicyclo
hexane
preparation
compounds utilizing
Prior art date
Application number
MX2009006865A
Other languages
English (en)
Inventor
Thierry Berranger
Patrice Demonchaux
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009006865A publication Critical patent/MX2009006865A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses

Abstract

La presente invención provee un proceso para preparar 6,6-dimetil-3-aza-biciclo[3.1.0]hexan-2-sulfonato, un intermediario útil en la preparación eficiente de (1R, 2S, 5S)-6,6-dimetil-3-azabiciclo[3.1.0]hexan-2-carboxilato de metilo y sus ésteres y sales, procesos para preparar (1R, 2S, 5S)-6,6-dimetil-3-azabiciclo[3.1.0]hexan-2-carboxilato de metilo y ésteres y sales del mismo a partir del sulfonato intermediario y procesos para preparar 6,6-dimetil-3-aza-biciclo[3.1.0]hexan-2-s ulfonato.
MX2009006865A 2006-12-20 2007-12-18 Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico. MX2009006865A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87629606P 2006-12-20 2006-12-20
PCT/US2007/025809 WO2008082508A2 (en) 2006-12-20 2007-12-18 Process for the preparation of 6,6-dimethyl-3-azabicyclo- [3.1.0]- hexane compounds utilizing bisulfite intermediate

Publications (1)

Publication Number Publication Date
MX2009006865A true MX2009006865A (es) 2009-08-20

Family

ID=39589116

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006865A MX2009006865A (es) 2006-12-20 2007-12-18 Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico.

Country Status (9)

Country Link
US (1) US8158807B2 (es)
EP (1) EP2129658A2 (es)
JP (1) JP5431956B2 (es)
CN (1) CN101611001B (es)
AR (1) AR064432A1 (es)
CA (1) CA2672701A1 (es)
MX (1) MX2009006865A (es)
WO (1) WO2008082508A2 (es)
ZA (1) ZA200904333B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009073380A1 (en) * 2007-11-28 2009-06-11 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
EP2307419B1 (en) * 2008-06-24 2013-11-06 Codexis, Inc. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
WO2012049688A1 (en) 2010-10-12 2012-04-19 Arch Pharmalabs Limited An improved process for the preparation of racemic 6, 6- dimethyl-3-azabicyclo-[3.1.0]-hexane and its salts, a key raw material for hcv inhibitor.
WO2012158515A1 (en) * 2011-05-13 2012-11-22 Vertex Phamaceuticals Incorporated Process for the preparation of protease inhibitors
WO2012158513A1 (en) * 2011-05-13 2012-11-22 Vertex Pharmaceuticals Incorporated Processes and intermediates
JP2013010732A (ja) 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd プロリン化合物の製造方法
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN103664739B (zh) * 2013-12-10 2016-04-27 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
CN103910669B (zh) * 2014-04-04 2015-10-21 苏州景泓生物技术有限公司 沙格列汀关键中间体的制备方法
CN113999160B (zh) * 2021-10-21 2022-12-27 江苏省药物研究所有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷的制备方法
CN114163375B (zh) * 2021-12-10 2023-09-05 浙江新和成股份有限公司 6,6-二甲基-3-氮杂双环[3.1.0]己烷或其衍生物的合成方法
CN114544801B (zh) * 2022-01-20 2023-02-28 汉瑞药业(荆门)有限公司 一种azabicyclo[3.1.0]hexane的GC-FID检测方法
CN114591217B (zh) * 2022-03-18 2024-04-16 浙江新和成股份有限公司 6,6-二甲基-3-氮杂双环-[3．1．0]-己烷及其内酯中间体的制备方法
CN114751853B (zh) * 2022-04-11 2023-10-13 扬州联澳生物医药有限公司 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
CN114605311B (zh) * 2022-05-16 2022-07-15 南京桦冠生物技术有限公司 用于治疗新型冠状病毒的药物Nirmatrelvir的中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
CA1117125A (en) 1978-03-01 1982-01-26 Ronald F. Mason 2-cyano-3-azabicyclo¬3.1.0|hexane compounds
US4225499A (en) 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
EP0010799B1 (en) 1978-10-27 1982-05-19 Shell Internationale Researchmaatschappij B.V. A process for the preparation of 3-azabicyclo(3.1.0)hexane derivatives and modifications thereof
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
EP1963267B1 (en) * 2005-12-22 2013-08-14 Merck Sharp & Dohme Corp. Process for the preparation of 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof

Also Published As

Publication number Publication date
ZA200904333B (en) 2010-04-28
WO2008082508A2 (en) 2008-07-10
US8158807B2 (en) 2012-04-17
JP5431956B2 (ja) 2014-03-05
CA2672701A1 (en) 2008-07-10
CN101611001A (zh) 2009-12-23
CN101611001B (zh) 2015-11-25
EP2129658A2 (en) 2009-12-09
US20100145069A1 (en) 2010-06-10
WO2008082508A3 (en) 2008-09-18
AR064432A1 (es) 2009-04-01
JP2010513501A (ja) 2010-04-30

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