CN101611001B - 利用亚硫酸氢盐中间体制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物的方法 - Google Patents

利用亚硫酸氢盐中间体制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物的方法 Download PDF

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CN101611001B
CN101611001B CN200780051474.7A CN200780051474A CN101611001B CN 101611001 B CN101611001 B CN 101611001B CN 200780051474 A CN200780051474 A CN 200780051474A CN 101611001 B CN101611001 B CN 101611001B
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CN101611001A (zh
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T·贝朗热
P·德蒙肖瓦
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200780051474.7A 2006-12-20 2007-12-18 利用亚硫酸氢盐中间体制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物的方法 Expired - Fee Related CN101611001B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87629606P 2006-12-20 2006-12-20
US60/876,296 2006-12-20
PCT/US2007/025809 WO2008082508A2 (en) 2006-12-20 2007-12-18 Process for the preparation of 6,6-dimethyl-3-azabicyclo- [3.1.0]- hexane compounds utilizing bisulfite intermediate

Publications (2)

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CN101611001A CN101611001A (zh) 2009-12-23
CN101611001B true CN101611001B (zh) 2015-11-25

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CN200780051474.7A Expired - Fee Related CN101611001B (zh) 2006-12-20 2007-12-18 利用亚硫酸氢盐中间体制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物的方法

Country Status (9)

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US (1) US8158807B2 (es)
EP (1) EP2129658A2 (es)
JP (1) JP5431956B2 (es)
CN (1) CN101611001B (es)
AR (1) AR064432A1 (es)
CA (1) CA2672701A1 (es)
MX (1) MX2009006865A (es)
WO (1) WO2008082508A2 (es)
ZA (1) ZA200904333B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2225203A1 (en) * 2007-11-28 2010-09-08 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
CN102131813B (zh) 2008-06-24 2014-07-30 科德克希思公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
WO2012049688A1 (en) 2010-10-12 2012-04-19 Arch Pharmalabs Limited An improved process for the preparation of racemic 6, 6- dimethyl-3-azabicyclo-[3.1.0]-hexane and its salts, a key raw material for hcv inhibitor.
EP2707347A1 (en) * 2011-05-13 2014-03-19 Vertex Pharmaceuticals Inc. Processes and intermediates
EP2707346A1 (en) * 2011-05-13 2014-03-19 Vertex Pharmaceuticals Inc. Process for the preparation of protease inhibitors
JP2013010732A (ja) 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd プロリン化合物の製造方法
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN103664739B (zh) * 2013-12-10 2016-04-27 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
CN103910669B (zh) * 2014-04-04 2015-10-21 苏州景泓生物技术有限公司 沙格列汀关键中间体的制备方法
CN113999160B (zh) * 2021-10-21 2022-12-27 江苏省药物研究所有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷的制备方法
CN114163375B (zh) * 2021-12-10 2023-09-05 浙江新和成股份有限公司 6,6-二甲基-3-氮杂双环[3.1.0]己烷或其衍生物的合成方法
CN114544801B (zh) * 2022-01-20 2023-02-28 汉瑞药业(荆门)有限公司 一种azabicyclo[3.1.0]hexane的GC-FID检测方法
CN114591217B (zh) * 2022-03-18 2024-04-16 浙江新和成股份有限公司 6,6-二甲基-3-氮杂双环-[3．1．0]-己烷及其内酯中间体的制备方法
CN114751853B (zh) * 2022-04-11 2023-10-13 扬州联澳生物医药有限公司 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
CN114605311B (zh) * 2022-05-16 2022-07-15 南京桦冠生物技术有限公司 用于治疗新型冠状病毒的药物Nirmatrelvir的中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004107A1 (en) * 1978-03-01 1979-09-19 Shell Internationale Researchmaatschappij B.V. 3-Azabicyclo(3.1.0)hexane derivatives, a process for their preparation, biologically active compositions containing them and herbicidal method using them
EP0008813A1 (en) * 1978-07-06 1980-03-19 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of 3-azabicyclo(3.1.0)hexane derivatives
EP0010799A1 (en) * 1978-10-27 1980-05-14 Shell Internationale Researchmaatschappij B.V. A process for the preparation of 3-azabicyclo(3.1.0)hexane derivatives and modifications thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
AR044694A1 (es) 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
CA2634397A1 (en) 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004107A1 (en) * 1978-03-01 1979-09-19 Shell Internationale Researchmaatschappij B.V. 3-Azabicyclo(3.1.0)hexane derivatives, a process for their preparation, biologically active compositions containing them and herbicidal method using them
EP0008813A1 (en) * 1978-07-06 1980-03-19 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of 3-azabicyclo(3.1.0)hexane derivatives
EP0010799A1 (en) * 1978-10-27 1980-05-14 Shell Internationale Researchmaatschappij B.V. A process for the preparation of 3-azabicyclo(3.1.0)hexane derivatives and modifications thereof

Also Published As

Publication number Publication date
EP2129658A2 (en) 2009-12-09
ZA200904333B (en) 2010-04-28
MX2009006865A (es) 2009-08-20
US20100145069A1 (en) 2010-06-10
JP2010513501A (ja) 2010-04-30
CA2672701A1 (en) 2008-07-10
WO2008082508A2 (en) 2008-07-10
CN101611001A (zh) 2009-12-23
JP5431956B2 (ja) 2014-03-05
US8158807B2 (en) 2012-04-17
AR064432A1 (es) 2009-04-01
WO2008082508A3 (en) 2008-09-18

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