UA97961C2 - Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови - Google Patents
Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания кровиInfo
- Publication number
- UA97961C2 UA97961C2 UAA200904468A UAA200904468A UA97961C2 UA 97961 C2 UA97961 C2 UA 97961C2 UA A200904468 A UAA200904468 A UA A200904468A UA A200904468 A UAA200904468 A UA A200904468A UA 97961 C2 UA97961 C2 UA 97961C2
- Authority
- UA
- Ukraine
- Prior art keywords
- therapy
- therapeutic
- intravascular coagulation
- disseminated intravascular
- amelioration method
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Изобретение касается способа лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови (ДВС) и способа снижения вероятности смерти у пациентов, страдающих ДВС, путем введения тромбомодулина пациентам, страдающим ДВС, у которых активность антитромбина в плазме составляет 40 % или менее.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006274573 | 2006-10-06 | ||
PCT/JP2007/069560 WO2008044631A1 (fr) | 2006-10-06 | 2007-10-05 | Agent thérapeutique et/ou améliorant pour la coagulation intravasculaire disséminée |
Publications (1)
Publication Number | Publication Date |
---|---|
UA97961C2 true UA97961C2 (ru) | 2012-04-10 |
Family
ID=39282827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200904468A UA97961C2 (ru) | 2006-10-06 | 2007-10-05 | Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови |
Country Status (17)
Country | Link |
---|---|
US (1) | US20100152106A1 (ru) |
EP (1) | EP2062589A4 (ru) |
JP (1) | JP5579385B2 (ru) |
KR (1) | KR20090051777A (ru) |
CN (1) | CN101522206B (ru) |
AU (1) | AU2007305550B2 (ru) |
BR (1) | BRPI0720158A2 (ru) |
CA (1) | CA2665691A1 (ru) |
CO (1) | CO6160332A2 (ru) |
HK (1) | HK1130209A1 (ru) |
IL (1) | IL197509A (ru) |
MX (1) | MX2009003384A (ru) |
MY (1) | MY148565A (ru) |
NZ (1) | NZ575632A (ru) |
RU (1) | RU2433829C2 (ru) |
UA (1) | UA97961C2 (ru) |
WO (1) | WO2008044631A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011005005A (es) * | 2008-11-12 | 2011-05-25 | Lilly Co Eli | Composiciones y metodos de uso para variantes de trombomodulina. |
AU2019347406B9 (en) * | 2018-09-28 | 2023-11-16 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
CA3116686A1 (en) * | 2018-10-22 | 2020-04-30 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy |
RU2716492C1 (ru) * | 2019-05-14 | 2020-03-12 | Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) | Способ регулирования активации нейтрофилов в модели in vitro |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0816495A1 (en) * | 1987-01-08 | 1998-01-07 | Asahi Kasei Kogyo Kabushiki Kaisha | DNA coding for a peptide promoting the activation of protein C by thrombin and dprocess for producing the same |
DE3876124T2 (de) | 1987-04-01 | 1993-05-06 | Mitsubishi Gas Chemical Co | Immunoassay fuer thrombomodulin. |
DK299087D0 (da) | 1987-06-12 | 1987-06-12 | Novo Industri As | Proteins and derivatives thereof |
JPS646219U (ru) | 1987-06-30 | 1989-01-13 | ||
JPS6445398U (ru) | 1987-09-11 | 1989-03-20 | ||
JPH0720997B2 (ja) | 1988-08-29 | 1995-03-08 | 興和株式会社 | 新規なトロンビン結合性物質及びその製法 |
US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
JPH0798840B2 (ja) | 1988-12-27 | 1995-10-25 | 持田製薬株式会社 | 尿由来の抗血液疑固物質、その製法およびそれを含有する医薬組成物 |
JPH02255699A (ja) | 1989-03-28 | 1990-10-16 | Asahi Chem Ind Co Ltd | 新規血液抗凝固物質及びその製法 |
US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
CA2022713A1 (en) | 1989-08-11 | 1991-02-12 | Nils U. Bang | Human thrombomodulin derivatives |
JPH03259084A (ja) | 1990-03-06 | 1991-11-19 | Kowa Co | トロンビン結合性物質の製造法 |
AU643306B2 (en) * | 1990-06-27 | 1993-11-11 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant polypeptides |
KR930008093B1 (ko) * | 1990-08-03 | 1993-08-25 | 아사히가세이고오교 가부시끼가이샤 | 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물 |
JPH05213998A (ja) | 1990-08-03 | 1993-08-24 | Asahi Chem Ind Co Ltd | 新規なポリペプチド及びこれを有効成分とする 医薬組成物 |
ES2170747T3 (es) | 1990-08-15 | 2002-08-16 | Paion Gmbh | Analogos superiores de trombomodulina para uso farmaceutico. |
JP3220174B2 (ja) | 1990-12-12 | 2001-10-22 | 第一製薬株式会社 | 組換ヒトトロンボモジュリン誘導体 |
AU675422B2 (en) | 1992-02-05 | 1997-02-06 | David Richard Light | Protease-resistant thrombomodulin analogs |
JPH05310787A (ja) | 1992-05-01 | 1993-11-22 | Asahi Chem Ind Co Ltd | 新規なポリペプチド |
JPH06205692A (ja) | 1993-01-08 | 1994-07-26 | Asahi Chem Ind Co Ltd | 新規な抗ヒトトロンボモジュリンモノクロ−ナル抗体およびその抗体を用いたヒトトロンボモジュリンの高感度測定方法 |
US5916874A (en) * | 1994-04-20 | 1999-06-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for treating liver injury |
JP2824392B2 (ja) | 1994-05-31 | 1998-11-11 | 旭化成工業株式会社 | トロンビンによるプロテインcの活性化を促進する作用を有するペプチドを含有する培養上澄液 |
JP3745805B2 (ja) | 1995-10-24 | 2006-02-15 | 日本ケミカルリサーチ株式会社 | トロンボモジュリンの精製方法 |
JP4157644B2 (ja) | 1998-03-30 | 2008-10-01 | 旭化成ファーマ株式会社 | 高純度可溶性トロンボモジュリンの製造方法 |
AU2003213598A1 (en) * | 2002-02-27 | 2003-09-09 | Biomerieux, Inc. | Method for diagnosing and monitoring hemostatic dysfunction, severe infection and systematic inflammatory response syndrome |
AU2003225255B2 (en) * | 2002-05-01 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Novel tissue factor targeted antibodies as anticoagulants |
-
2007
- 2007-10-05 BR BRPI0720158-3A2A patent/BRPI0720158A2/pt not_active Application Discontinuation
- 2007-10-05 JP JP2008538700A patent/JP5579385B2/ja active Active
- 2007-10-05 NZ NZ575632A patent/NZ575632A/en unknown
- 2007-10-05 MX MX2009003384A patent/MX2009003384A/es active IP Right Grant
- 2007-10-05 EP EP07829298A patent/EP2062589A4/en not_active Withdrawn
- 2007-10-05 UA UAA200904468A patent/UA97961C2/ru unknown
- 2007-10-05 CA CA002665691A patent/CA2665691A1/en not_active Abandoned
- 2007-10-05 CN CN2007800368187A patent/CN101522206B/zh active Active
- 2007-10-05 RU RU2009117253/15A patent/RU2433829C2/ru active
- 2007-10-05 KR KR1020097006989A patent/KR20090051777A/ko active Search and Examination
- 2007-10-05 US US12/444,342 patent/US20100152106A1/en not_active Abandoned
- 2007-10-05 MY MYPI20091065A patent/MY148565A/en unknown
- 2007-10-05 WO PCT/JP2007/069560 patent/WO2008044631A1/ja active Application Filing
- 2007-10-05 AU AU2007305550A patent/AU2007305550B2/en active Active
-
2009
- 2009-03-10 IL IL197509A patent/IL197509A/en active IP Right Grant
- 2009-03-20 CO CO09029277A patent/CO6160332A2/es unknown
- 2009-11-05 HK HK09110256.9A patent/HK1130209A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007305550A1 (en) | 2008-04-17 |
JPWO2008044631A1 (ja) | 2010-02-12 |
US20100152106A1 (en) | 2010-06-17 |
EP2062589A1 (en) | 2009-05-27 |
MY148565A (en) | 2013-04-30 |
WO2008044631A1 (fr) | 2008-04-17 |
EP2062589A4 (en) | 2010-07-28 |
RU2433829C2 (ru) | 2011-11-20 |
CN101522206B (zh) | 2013-03-27 |
IL197509A0 (en) | 2011-08-01 |
AU2007305550B2 (en) | 2010-09-30 |
CA2665691A1 (en) | 2008-04-17 |
NZ575632A (en) | 2011-12-22 |
CN101522206A (zh) | 2009-09-02 |
RU2009117253A (ru) | 2010-11-20 |
MX2009003384A (es) | 2009-04-08 |
KR20090051777A (ko) | 2009-05-22 |
CO6160332A2 (es) | 2010-05-20 |
JP5579385B2 (ja) | 2014-08-27 |
IL197509A (en) | 2015-06-30 |
HK1130209A1 (en) | 2009-12-24 |
BRPI0720158A2 (pt) | 2014-05-20 |
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