ZA200405905B - Cycloalkyl inhibitors of potassium channel function - Google Patents
Cycloalkyl inhibitors of potassium channel function Download PDFInfo
- Publication number
- ZA200405905B ZA200405905B ZA200405905A ZA200405905A ZA200405905B ZA 200405905 B ZA200405905 B ZA 200405905B ZA 200405905 A ZA200405905 A ZA 200405905A ZA 200405905 A ZA200405905 A ZA 200405905A ZA 200405905 B ZA200405905 B ZA 200405905B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- heterocyclo
- independently
- Prior art date
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- 125000000753 cycloalkyl group Chemical group 0.000 title claims description 79
- 239000003112 inhibitor Substances 0.000 title claims description 14
- 102000004257 Potassium Channel Human genes 0.000 title description 14
- 108020001213 potassium channel Proteins 0.000 title description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 554
- 125000001072 heteroaryl group Chemical group 0.000 claims description 142
- 125000003118 aryl group Chemical group 0.000 claims description 138
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 82
- 125000003342 alkenyl group Chemical group 0.000 claims description 45
- -1 nitro, hydroxy Chemical group 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 34
- 125000000304 alkynyl group Chemical group 0.000 claims description 26
- 125000004104 aryloxy group Chemical group 0.000 claims description 26
- 125000001188 haloalkyl group Chemical group 0.000 claims description 24
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
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- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 230000006793 arrhythmia Effects 0.000 claims description 14
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 8
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- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 claims description 4
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- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical group CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 claims description 3
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US35388402P | 2002-02-01 | 2002-02-01 |
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