YU66204A - Cikloalkilni inhibitori funkcije kalijevog kanala - Google Patents

Cikloalkilni inhibitori funkcije kalijevog kanala

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Publication number
YU66204A
YU66204A YU66204A YUP66204A YU66204A YU 66204 A YU66204 A YU 66204A YU 66204 A YU66204 A YU 66204A YU P66204 A YUP66204 A YU P66204A YU 66204 A YU66204 A YU 66204A
Authority
YU
Yugoslavia
Prior art keywords
inhibitors
potassium channel
channel function
compounds
cycloalkyl
Prior art date
Application number
YU66204A
Other languages
English (en)
Inventor
John Lloyd
Yoon T. Jeon
Heather Finlay
Lin Yan
Michael F. Gross
Serge Beaudoin
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU66204A publication Critical patent/YU66204A/sh

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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Abstract

Nova cikloalkilna jedinjenja, koja su korisna kao inhibitori funkcije kalijumovog kanala (posebno kao inhibitori Kv1 podfamilije K+ kanala sa naponskim vratima, a specijalno kao inhibitori Kv1.5, koji su vezani na odloženu ispravljačku K+ struju IKur, koja se ultra-brzo aktivira), postupci korišćenja takvih jedinjenja u prevenciji i lečenju aritmija i stanja koja su u vezi sa IKur i farmaceutske smeše, koje sadrže takva jedinjenja.[Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1subfamily of voltage gated K+ channels, especially inhibitors Kv 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current lKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur -associated conditions, and pharmaceutical compositions containing such compounds.
YU66204A 2002-02-01 2003-01-31 Cikloalkilni inhibitori funkcije kalijevog kanala YU66204A (sh)

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EP1507504A1 (en) 2005-02-23
WO2003063797A2 (en) 2003-08-07
TW200307539A (en) 2003-12-16
AU2009222566A1 (en) 2009-10-22
AU2003210817B9 (en) 2009-10-29
US20040072880A1 (en) 2004-04-15
CO5601004A2 (es) 2006-01-31
JP2010180208A (ja) 2010-08-19
AR038466A1 (es) 2005-01-19
JP4598397B2 (ja) 2010-12-15
CA2474451A1 (en) 2003-08-07
US20050234106A1 (en) 2005-10-20
HRP20040667A2 (en) 2005-08-31
ZA200405905B (en) 2006-05-31
BR0307329A (pt) 2006-04-11
EP2253328A1 (en) 2010-11-24
IS7370A (is) 2004-07-23
NO329356B1 (no) 2010-10-04
US7202253B2 (en) 2007-04-10
UA87434C2 (ru) 2009-07-27
RU2343143C2 (ru) 2009-01-10
NZ534098A (en) 2007-04-27
US20070142333A1 (en) 2007-06-21
KR20040096542A (ko) 2004-11-16
CN100558697C (zh) 2009-11-11
CN101704810A (zh) 2010-05-12
MXPA04007365A (es) 2005-03-31
CN1732146A (zh) 2006-02-08
WO2003063797A8 (en) 2004-12-16
JP5148646B2 (ja) 2013-02-20
PL375359A1 (en) 2005-11-28
JP2006508016A (ja) 2006-03-09
AU2003210817B2 (en) 2009-07-16
EP1507504A4 (en) 2006-07-05
RU2004126608A (ru) 2005-05-10
GEP20063923B (en) 2006-09-11

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