ZA200302921B - Novel medicament compositions based on tiotropium salts and on salmeterol salts. - Google Patents
Novel medicament compositions based on tiotropium salts and on salmeterol salts. Download PDFInfo
- Publication number
- ZA200302921B ZA200302921B ZA200302921A ZA200302921A ZA200302921B ZA 200302921 B ZA200302921 B ZA 200302921B ZA 200302921 A ZA200302921 A ZA 200302921A ZA 200302921 A ZA200302921 A ZA 200302921A ZA 200302921 B ZA200302921 B ZA 200302921B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid
- inhalable
- pharmaceutical composition
- inhalation
- composition according
- Prior art date
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- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical class C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 title claims description 36
- 239000000203 mixture Substances 0.000 title claims description 35
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title claims description 25
- 239000003814 drug Substances 0.000 title claims 3
- 239000013543 active substance Substances 0.000 claims description 48
- 229960000257 tiotropium bromide Drugs 0.000 claims description 41
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims description 40
- 239000000443 aerosol Substances 0.000 claims description 40
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- 229960004017 salmeterol Drugs 0.000 claims description 27
- 239000000843 powder Substances 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 21
- 239000002671 adjuvant Substances 0.000 claims description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 19
- 239000004615 ingredient Substances 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
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- 239000002253 acid Substances 0.000 claims description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
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- 239000003380 propellant Substances 0.000 claims description 12
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- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 claims description 10
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- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 235000006708 antioxidants Nutrition 0.000 claims description 7
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 7
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
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- 150000004677 hydrates Chemical class 0.000 claims description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 4
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10056104A DE10056104A1 (de) | 2000-11-13 | 2000-11-13 | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200302921B true ZA200302921B (en) | 2004-04-19 |
Family
ID=7663071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200302921A ZA200302921B (en) | 2000-11-13 | 2003-04-14 | Novel medicament compositions based on tiotropium salts and on salmeterol salts. |
Country Status (32)
| Country | Link |
|---|---|
| EP (3) | EP1335728B1 (fr) |
| JP (2) | JP4282322B2 (fr) |
| KR (2) | KR100886094B1 (fr) |
| CN (1) | CN1678318A (fr) |
| AT (2) | ATE291428T1 (fr) |
| AU (3) | AU2791002A (fr) |
| BG (1) | BG107781A (fr) |
| BR (1) | BR0115226A (fr) |
| CA (1) | CA2429012A1 (fr) |
| CY (1) | CY1106774T1 (fr) |
| CZ (1) | CZ20031444A3 (fr) |
| DE (3) | DE10056104A1 (fr) |
| DK (2) | DK1335728T3 (fr) |
| EA (1) | EA007904B1 (fr) |
| EC (1) | ECSP034571A (fr) |
| EE (1) | EE200300228A (fr) |
| ES (2) | ES2240549T3 (fr) |
| HR (1) | HRP20030378A2 (fr) |
| HU (1) | HUP0301447A3 (fr) |
| IL (2) | IL155718A0 (fr) |
| MX (1) | MXPA03004164A (fr) |
| NO (1) | NO20032111L (fr) |
| NZ (1) | NZ526400A (fr) |
| PL (1) | PL205330B1 (fr) |
| PT (2) | PT1335728E (fr) |
| RS (2) | RS20090105A (fr) |
| SG (1) | SG167657A1 (fr) |
| SI (2) | SI1514546T1 (fr) |
| SK (2) | SK286950B6 (fr) |
| UA (1) | UA74853C2 (fr) |
| WO (1) | WO2002038154A1 (fr) |
| ZA (1) | ZA200302921B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| US7214687B2 (en) | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
| ES2234694T3 (es) * | 1999-11-23 | 2005-07-01 | Glaxo Group Limited | Formulaciones farmaceuticas de salmeterol. |
| WO2003024452A1 (fr) * | 2001-09-14 | 2003-03-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Agents pharmaceutiques d'inhalation |
| US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
| US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
| DE10214263A1 (de) * | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
| US7250426B2 (en) | 2002-11-29 | 2007-07-31 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Tiotropium-containing pharmaceutical combination for inhalation |
| DE10256080A1 (de) * | 2002-11-29 | 2004-06-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropiumhaltige Arzneimittelkombination für die Inhalation |
| KR20050085650A (ko) * | 2002-12-16 | 2005-08-29 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 타이오트로피움 함유 ｈｆｃ 용액 제형 |
| DE10351663A1 (de) * | 2002-12-20 | 2004-07-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverförmige Arzneimittel enthaltend ein Tiotropiumsalz und Salmeterolxinafoat |
| DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
| SG137859A1 (en) * | 2003-11-03 | 2007-12-28 | Boehringer Ingelheim Int | Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same |
| CN1875020B (zh) * | 2003-11-03 | 2010-04-28 | 贝林格尔.英格海姆国际有限公司 | 新颖的噻托铵盐,其制备方法及其药物制剂 |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| DE602005022499D1 (de) * | 2004-05-31 | 2010-09-02 | Almirall Sa | Kombinationen mit Antimuskarin-Wirkstoffen und PDE4-Hemmern |
| AU2006243238B2 (en) | 2005-05-02 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
| CA2617897A1 (fr) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Procede pour le traitement de la dyspnee comprenant l'administration combinee de sels de tiotropium et de sels de salmeterol |
| ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| EP2100599A1 (fr) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques |
| EP2100598A1 (fr) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques |
| US20120220557A1 (en) * | 2011-02-17 | 2012-08-30 | Chiesi Farmaceutici S.P.A. | Liquid propellant-free formulation comprising an antimuscarinic drug |
| EP2510928A1 (fr) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires |
| WO2013127738A1 (fr) * | 2012-02-28 | 2013-09-06 | Boehringer Ingelheim International Gmbh | Nouvelle formulation de tiotropium contenant un gaz propulseur |
| WO2015065222A1 (fr) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Préparation pharmaceutique inhalable pour le traitement de l'asthme bronchial et de maladies à obstruction chronique des poumons contenant du bromure de tiotropium micronisé en qualité de substance active, et procédé de production |
| TW201835041A (zh) | 2017-02-17 | 2018-10-01 | 印度商托仁特生技有限公司 | 具β-腎上腺素促效劑及抗蕈毒活性化合物 |
| WO2019142214A1 (fr) * | 2018-01-19 | 2019-07-25 | Cipla Limited | Composition pharmaceutique comprenant du tiotropium destinée à être inhalée |
| CN116173025A (zh) * | 2018-07-26 | 2023-05-30 | 四川海思科制药有限公司 | 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用 |
| CN111971034A (zh) * | 2018-07-26 | 2020-11-20 | 四川海思科制药有限公司 | 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用 |
| WO2022119661A1 (fr) * | 2020-12-04 | 2022-06-09 | Tygrus, LLC | Matériau thérapeutique à faible ph et faible toxicité, actif contre au moins un pathogène pour la prise en charge de patients atteints de maladies respiratoires |
| US11642372B2 (en) | 2020-05-01 | 2023-05-09 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
| US11826382B2 (en) | 2020-05-01 | 2023-11-28 | Tygrus, LLC | Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses |
Family Cites Families (6)
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|---|---|---|---|---|
| ATE283033T1 (de) * | 1998-07-24 | 2004-12-15 | Jago Res Ag | Medizinische aerosolformulierungen |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| DE19847970A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähige Wirkstoff-Formulierung |
| DE19847971A1 (de) * | 1998-10-17 | 1999-09-02 | Schiering | Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter) |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
-
2000
- 2000-11-13 DE DE10056104A patent/DE10056104A1/de not_active Withdrawn
-
2001
- 2001-09-11 UA UA2003065486A patent/UA74853C2/uk unknown
- 2001-11-09 PL PL365989A patent/PL205330B1/pl not_active IP Right Cessation
- 2001-11-09 CN CNA018187773A patent/CN1678318A/zh active Pending
- 2001-11-09 RS RSP-2009/0105A patent/RS20090105A/sr unknown
- 2001-11-09 EP EP01989446A patent/EP1335728B1/fr not_active Expired - Lifetime
- 2001-11-09 KR KR1020037006434A patent/KR100886094B1/ko not_active IP Right Cessation
- 2001-11-09 HU HU0301447A patent/HUP0301447A3/hu unknown
- 2001-11-09 WO PCT/EP2001/012962 patent/WO2002038154A1/fr active Application Filing
- 2001-11-09 EP EP07104722A patent/EP1808174A1/fr not_active Withdrawn
- 2001-11-09 SI SI200130751T patent/SI1514546T1/sl unknown
- 2001-11-09 CA CA002429012A patent/CA2429012A1/fr not_active Abandoned
- 2001-11-09 PT PT01989446T patent/PT1335728E/pt unknown
- 2001-11-09 DE DE50112535T patent/DE50112535D1/de not_active Expired - Lifetime
- 2001-11-09 RS YUP-355/03A patent/RS50286B/sr unknown
- 2001-11-09 MX MXPA03004164A patent/MXPA03004164A/es active IP Right Grant
- 2001-11-09 PT PT04028508T patent/PT1514546E/pt unknown
- 2001-11-09 ES ES01989446T patent/ES2240549T3/es not_active Expired - Lifetime
- 2001-11-09 SI SI200130347T patent/SI1335728T1/xx unknown
- 2001-11-09 CZ CZ20031444A patent/CZ20031444A3/cs unknown
- 2001-11-09 DK DK01989446T patent/DK1335728T3/da active
- 2001-11-09 AT AT01989446T patent/ATE291428T1/de active
- 2001-11-09 SG SG200505149-5A patent/SG167657A1/en unknown
- 2001-11-09 SK SK50015-2009A patent/SK286950B6/sk not_active IP Right Cessation
- 2001-11-09 NZ NZ526400A patent/NZ526400A/en unknown
- 2001-11-09 AT AT04028508T patent/ATE362761T1/de active
- 2001-11-09 AU AU2791002A patent/AU2791002A/xx active Pending
- 2001-11-09 BR BR0115226-2A patent/BR0115226A/pt active Pending
- 2001-11-09 ES ES04028508T patent/ES2287629T3/es not_active Expired - Lifetime
- 2001-11-09 JP JP2002540737A patent/JP4282322B2/ja not_active Expired - Lifetime
- 2001-11-09 EE EEP200300228A patent/EE200300228A/xx unknown
- 2001-11-09 AU AU2002227910A patent/AU2002227910B2/en not_active Ceased
- 2001-11-09 EA EA200300503A patent/EA007904B1/ru not_active IP Right Cessation
- 2001-11-09 DK DK04028508T patent/DK1514546T3/da active
- 2001-11-09 IL IL15571801A patent/IL155718A0/xx unknown
- 2001-11-09 KR KR1020087020177A patent/KR100940752B1/ko not_active IP Right Cessation
- 2001-11-09 SK SK741-2003A patent/SK286939B6/sk not_active IP Right Cessation
- 2001-11-09 DE DE50105729T patent/DE50105729D1/de not_active Expired - Lifetime
- 2001-11-09 EP EP04028508A patent/EP1514546B1/fr not_active Expired - Lifetime
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2003
- 2003-04-14 ZA ZA200302921A patent/ZA200302921B/en unknown
- 2003-04-28 EC EC2003004571A patent/ECSP034571A/es unknown
- 2003-05-01 IL IL155718A patent/IL155718A/en not_active IP Right Cessation
- 2003-05-08 BG BG107781A patent/BG107781A/bg active Pending
- 2003-05-12 NO NO20032111A patent/NO20032111L/no not_active Application Discontinuation
- 2003-05-12 HR HR20030378A patent/HRP20030378A2/hr not_active Application Discontinuation
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2004
- 2004-12-08 JP JP2004355226A patent/JP4282594B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-22 AU AU2007202303A patent/AU2007202303B2/en not_active Ceased
- 2007-07-30 CY CY20071101011T patent/CY1106774T1/el unknown
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